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ScienceLife
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- February 11, 2013
- 12:02 PM
- 59 views
A GPS for Personalized Medicine
by Matt Wood in ScienceLife
The 1200 Patients Project creates a database of how patients with particular genetic profiles react to specific drugs, and then puts that information online to help doctors make better decisions for their patients.... Read more »
O'Donnell PH, Bush A, Spitz J, Danahey K, Saner D, Das S, Cox NJ, & Ratain MJ. (2012) The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics. Clinical pharmacology and therapeutics, 92(4), 446-9. PMID: 22929923
- February 6, 2013
- 11:01 AM
- 88 views
The List of Explanations for Ocean Acidification Keeps Getting Smaller
by Matt Wood in ScienceLife
Over the past 20 years, Cathy Pfister and her husband Tim Wootton, both biologists in the Department of Ecology and Evolution, have been traveling to Tatoosh Island off the northwestern tip of Washington state to study the rich variety of plant and animal life in and around its coastal waters. And while they have turned [...]... Read more »
Wootton, J., & Pfister, C. (2012) Carbon System Measurements and Potential Climatic Drivers at a Site of Rapidly Declining Ocean pH. PLoS ONE, 7(12). DOI: 10.1371/journal.pone.0053396
- January 31, 2013
- 10:30 AM
- 65 views
Need a Pen? Drug Companies Start Early When it Comes to Marketing to Med Students
by Matt Wood in ScienceLife
Drug companies spend billions of dollars on advertising to consumers online, in print and TV. Their ads are such an everyday part of the media landscape that Saturday Night Live can run a skit mocking the hilarious and scary list of disclaimers about side effects and everyone is in on the joke. And that’s just [...]... Read more »
Hodges LE, Arora VM, Humphrey HJ, & Reddy ST. (2012) Premedical Students' Exposure to the Pharmaceutical Industry's Marketing Practices. Academic medicine : journal of the Association of American Medical Colleges. PMID: 23269292
- January 8, 2013
- 06:12 PM
- 61 views
A History Lesson from Genes: Using DNA to Tell Us How Populations Change
by Matt Wood in ScienceLife
When Charles Darwin first sketched how species evolved by natural selection, he drew what looked like a tree. The diagram started at a central point with a common ancestor, then the lines spread apart as organisms evolved and separated into distinct species. In the 175 years since, scientists have come to agree that Darwin’s original [...]... Read more »
Joseph K. Pickrell, & Jonathan K. Pritchard. (2012) Inference of population splits and mixtures from genome-wide allele frequency data. PLoS Genet 8(11): e1002967 (2012). arXiv: 1206.2332v1
- December 13, 2012
- 01:11 PM
- 141 views
Drug helps women who stop smoking keep weight off
by Matt Wood in ScienceLife
Naltrexone, a medication being tested to help smokers kick the habit also may help avoid the weight gain that is common after quitting but only in women, according to a study published in the December issue of Biological Psychiatry. This is the first medication shown to reduce weight gain for up to one year in [...]... Read more »
King, A., Cao, D., Zhang, L., & O’Malley, S. (2012) Naltrexone Reduction of Long-Term Smoking Cessation Weight Gain in Women But Not Men: A Randomized Controlled Trial. Biological Psychiatry. DOI: 10.1016/j.biopsych.2012.09.025
- December 11, 2012
- 12:12 PM
- 88 views
How Our Sense of Touch is a Lot Like the Way We Hear
by Matt Wood in ScienceLife
When you walk into a darkened room, your first instinct is to feel around for a light switch. You slide your hand along the wall, feeling the transition from the doorframe to the painted drywall, and then up and down until you find the metal or plastic plate of the switch. During the process you [...]... Read more »
Mackevicius EL, Best MD, Saal HP, & Bensmaia SJ. (2012) Millisecond precision spike timing shapes tactile perception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(44), 15309-17. PMID: 23115169
- November 28, 2012
- 12:18 PM
- 80 views
Ovarian Cancer Cells Trick Healthy Neighbors to Do Their Dirty Work
by Matt Wood in ScienceLife
Cancer cells play dirty, using all kinds of tricks to multiply and spread throughout the body. For instance, ovarian cancer cells trick the healthy fibroblasts around them to alter their production of three microRNAs—small strands of genetic material that are important regulators of gene expression. This turns the healthy cells into cancerous ones that pump [...]... Read more »
Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, & Lengyel E. (2012) MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer. Cancer discovery. PMID: 23171795
- October 31, 2012
- 10:00 AM
- 116 views
Formulating a Prescription to Improve Asthma Care with Technology
by Matt Wood in ScienceLife
Asthma is an extremely common disease, especially among adolescents: Almost 10 percent of children under the age of 17 in the United States have it. It’s also very treatable with inhaled corticosteroids. But, an estimated 50 percent of children don’t take their asthma medications on a regular basis. Ves Dimov, MD, assistant professor of pediatrics [...]... Read more »
Nickels A, & Dimov V. (2012) Innovations in Technology: Social Media and Mobile Technology in the Care of Adolescents with Asthma. Current allergy and asthma reports. PMID: 22976493
- October 23, 2012
- 10:40 AM
- 150 views
Permission to Be Parents: Support Groups for Families Dealing with an Eating Disorder
by Matt Wood in ScienceLife
Parents of a child with anorexia nervosa often feel embarrassed or isolated, like they’re on their own dealing with this difficult illness. For decades, the first line of treatment for an adolescent with anorexia was inpatient care to restore their weight, with little parental involvement. In the late 1970s and early 1980s, however, clinicians started [...]... Read more »
Binford Hopf RB, Le Grange D, Moessner M, & Bauer S. (2012) Internet-Based Chat Support Groups for Parents in Family-Based Treatment for Adolescent Eating Disorders: A Pilot Study. European eating disorders review : the journal of the Eating Disorders Association. PMID: 22949134
- October 18, 2012
- 12:07 PM
- 143 views
Yet Another Reason to Think Twice About Eating Meat
by Matt Wood in ScienceLife
Earlier this year, the USDA found itself in hot water after an internal newsletter promoted “Meatless Mondays” in its cafeterias as part of a healthy eating initiative. The USDA eventually retracted their endorsement of the campaign after outcry from the livestock industry and farm state Congressmen, but the health benefits of eating less meat have [...]... Read more »
Aschebrook-Kilfoy, B., Ollberding, N., Kolar, C., Lawson, T., Smith, S., Weisenburger, D., & Chiu, B. (2012) Meat intake and risk of non-Hodgkin lymphoma. Cancer Causes , 23(10), 1681-1692. DOI: 10.1007/s10552-012-0047-2
- October 17, 2012
- 12:23 PM
- 160 views
Even Fat Cells Need Sleep
by Matt Wood in ScienceLife
Here’s a study to make you hit the bed early tonight. Matthew Brady, PhD, associate professor of medicine and vice-chair of the Committee on Molecular Metabolism and Nutrition at the University of Chicago, found that not getting enough sleep has a harmful impact on fat cells in body, reducing their ability to absorb insulin by [...]... Read more »
Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, & Brady MJ. (2012) Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Annals of internal medicine, 157(8), 549-57. PMID: 23070488
- October 10, 2012
- 03:15 PM
- 131 views
Plenty Left to Learn from One Isolated Population
by Matt Wood in ScienceLife
The Hutterites are an isolated, religious “founder population,” similar to the Amish or Mennonites, descended from a group of about 1,200 settlers that migrated to North America from Europe in the late 19th century. They settled in South Dakota, and then spread to Montana and western Canada, forming several self-sufficient, communal agricultural colonies. Today’s Hutterites [...]... Read more »
Chong JX, Ouwenga R, Anderson RL, Waggoner DJ, & Ober C. (2012) A population-based study of autosomal-recessive disease-causing mutations in a founder population. American journal of human genetics, 91(4), 608-20. PMID: 22981120
- October 8, 2012
- 11:07 AM
- 133 views
Targeting Cancer With a Devilish Plant
by Matt Wood in ScienceLife
Urban legend has it that the cure for cancer is probably buried in the root of some obscure plant in the middle of the Amazon rainforest, and we just haven’t found it yet. While that’s overstating what any one medicine can do to fight what’s actually hundreds of different diseases, that doesn’t mean natural remedies [...]... Read more »
Jin HR, Zhao J, Zhang Z, Liao Y, Wang CZ, Huang WH, Li SP, He TC, Yuan CS, & Du W. (2012) The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell death . PMID: 22914324
- October 1, 2012
- 12:06 PM
- 152 views
The Hyperlocal Approach to Diabetes Disparities
by Matt Wood in ScienceLife
The epidemic of type 2 diabetes in the United States seems so widespread, so intractable, that only big solutions can make a difference. It feels like we need massive prime-time education campaigns, public fitness initiatives and diet counseling in every school cafeteria and dormitory. And yet for a disease that’s so closely tied to individual [...]... Read more »
Baig AA, Locklin CA, Wilkes AE, Oborski DD, Acevedo JC, Gorawara-Bhat R, Quinn MT, Burnet DL, & Chin MH. (2012) "One Can Learn From Other People's Experiences": Latino Adults' Preferences for Peer-Based Diabetes Interventions. The Diabetes educator, 38(5), 733-41. PMID: 22914046
- June 12, 2012
- 10:52 AM
- 179 views
A HIRO in Radiology
by Matt Wood in ScienceLife
Medical imaging has become a crucial tool for diagnosis and clinical research. Imaging services in an academic medical institution like the University of Chicago Medicine are used by dozens of departments for everyday patient care and clinical trials, making them subject to a bewildering array of policies and procedures to protect patient privacy and preserve [...]... Read more »
Armato, S., Gruszauskas, N., MacMahon, H., Torno, M., Li, F., Engelmann, R., Starkey, A., Pudela, C., Marino, J., Santiago, F.... (2012) Research Imaging in an Academic Medical Center. Academic Radiology, 19(6), 762-771. DOI: 10.1016/j.acra.2012.02.002
- November 2, 2011
- 03:59 PM
- 479 views
A Story of Climate Change Told Through Seashells
by Matt Wood in ScienceLife
By Matt Wood
Sometimes scientific discoveries happen by accident. Henri Becquerel discovered radioactivity when a uranium rock he left wrapped up in a drawer with some X-ray equipment imprinted itself on a photographic plate. Alexander Fleming discovered penicillin when he noticed that mold growing in a staphylococcus culture was killing all the bacteria around it. In [...]... Read more »
Pfister, C., McCoy, S., Wootton, J., Martin, P., Colman, A., & Archer, D. (2011) Rapid Environmental Change over the Past Decade Revealed by Isotopic Analysis of the California Mussel in the Northeast Pacific. PLoS ONE, 6(10). DOI: 10.1371/journal.pone.0025766
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