nooffensebut

20 posts · 10,762 views

I am a doctor whose interests include genetics, psychiatry, fitness, and politics.

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  • September 13, 2011
  • 01:07 PM
  • 1,083 views

Attack of the Warrior Gene Babies!

by nooffensebut in The Unsilenced Science

This is a look at the first study on the warrior gene’s effect on babies, and I reviewed the scientific literature on monoamine oxidase A (MAOA) in women and Asians, including epigenetics and gene expression, and hormone-gene interactions in aggression.... Read more »

Zhang M, Chen X, Way N, Yoshikawa H, Deng H, Ke X, Yu W, Chen P, He C, Chi X.... (2011) The association between infants' self-regulatory behavior and MAOA gene polymorphism. Developmental science, 14(5), 1059-1065. PMID: 21884321  

  • December 2, 2011
  • 03:10 PM
  • 824 views

Blacks with Bullets Embedded in Bone

by nooffensebut in The Unsilenced Science

This essay disproves Steven Pinker’s extraordinary claim that “the racial disparity in American homicide has not always been with us” from The Better Angels of Our Nature.... Read more »

  • October 13, 2011
  • 10:48 AM
  • 713 views

Kill Popular Science

by nooffensebut in The Unsilenced Science

This is a preliminary review of Harvard psychologist Steven Pinker’s new book, The Better Angels of Our Nature. I reveal serious errors and distortions from his peer-reviewed sources.... Read more »

Kevin Beaver, Ashley Sak, Jamie Vaske, & Jessica Nilsson. (2010) Genetic risk, parent–child relations, and antisocial phenotypes in a sample of African-American males. Psychiatry Research, 175(1-2), 160-164. info:/

Lu RB, Lee JF, Ko HC, Lin WW, Chen K, & Shih JC. (2002) No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. Progress in neuro-psychopharmacology , 26(3), 457-61. PMID: 11999895  

Philibert RA, Gunter TD, Beach SR, Brody GH, & Madan A. (2008) MAOA methylation is associated with nicotine and alcohol dependence in women. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B(5), 565-70. PMID: 18454435  

  • April 25, 2012
  • 01:50 AM
  • 680 views

The SAT Bell Curve

by nooffensebut in The Unsilenced Science

SAT score distribution graphs shed new light on racial and gender disparities, while vindicating Larry Summers.... Read more »

Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D, Ke X, Le Hellard S, Christoforou A, Luciano M.... (2011) Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular psychiatry, 16(10), 996-1005. PMID: 21826061  

Hiscock, M. (2007) The Flynn effect and its relevance to neuropsychology. Journal of Clinical and Experimental Neuropsychology, 29(5), 514-529. DOI: 10.1080/13803390600813841  

Kanazawa, S. (2006) IQ and the wealth of states. Intelligence, 34(6), 593-600. DOI: 10.1016/j.intell.2006.04.003  

  • April 11, 2012
  • 09:31 PM
  • 679 views

Racial Amplitudes of Scholastic Aptitude

by nooffensebut in The Unsilenced Science

A complete review of the SAT racial data reveals the relative stagnation of African Americans and Hispanic Americans, the rapid progress of Asian Americans, and a possible decline of whites.... Read more »

Eidelman S, Crandall CS, Goodman JA, & Blanchar JC. (2012) Low-Effort Thought Promotes Political Conservatism. Personality . PMID: 22427384  

Frey, M., & Detterman, D. (2005) Regression Basics: Rejoinder to Bridgeman. Psychological Science, 16(9), 747-747. DOI: 10.1111/j.1467-9280.2005.01607.x  

Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, McDonald GJ, Tandon A, Schirmer C, Neubauer J, Bedoya G.... (2007) A Genomewide Admixture Map for Latino Populations. American Journal of Human Genetics, 80(6), 1024-36. PMID: 17503322  

Zakharia F, Basu A, Absher D, Assimes TL, Go AS, Hlatky MA, Iribarren C, Knowles JW, Li J, Narasimhan B.... (2009) Characterizing the admixed African ancestry of African Americans. Genome Biology, 10(12). PMID: 20025784  

  • June 10, 2013
  • 03:57 AM
  • 639 views

The SAT-ACT Score Map

by nooffensebut in The Unsilenced Science

Using multiple regression, I animate state college entrance exam scores controlled for state participation levels and test preference. Then, I review a study on “noncognitive predictors” of college outcomes, which might eventually replace the SAT and ACT.... Read more »

  • October 9, 2011
  • 12:00 AM
  • 615 views

Girls Versus Boys: The Final Battle

by nooffensebut in The Unsilenced Science

Here I review SAT score gender gaps by race, with special attention to the progress of Asian women. Plus, I detail the allele frequencies by race of body fat genes identified in a recent meta-analysis of genome-wide association studies.... Read more »

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

  • September 29, 2012
  • 05:00 AM
  • 604 views

The SAT Zombie Apocalypse

by nooffensebut in The Unsilenced Science

State SAT and ACT scores follow a North-South divide that somewhat fits the spread of racial diversity.... Read more »

Duckworth AL, Quinn PD, Lynam DR, Loeber R, & Stouthamer-Loeber M. (2011) Role of test motivation in intelligence testing. Proceedings of the National Academy of Sciences of the United States of America, 108(19), 7716-20. PMID: 21518867  

  • November 30, 1999
  • 12:00 AM
  • 564 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 550 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 533 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • July 5, 2012
  • 05:22 AM
  • 495 views

Just Say No Limit: Trayvon, Dextromethorphan, Marijuana, and MAOA

by nooffensebut in The Unsilenced Science

Here is the case that Trayvon Martin’s drug use and genetics could have influenced him to attack George Zimmerman.... Read more »

Amaladoss A, & O'Brien S. (2011) Cough syrup psychosis. CJEM, 13(1), 53-6. PMID: 21324299  

Ivan Berlin, & Robert Anthenelli. (2001) Monoamine oxidases and tobacco smoking. The International Journal of Neuropsychopharmacology, 4(01), 33-42. DOI: 10.1017/S1461145701002188  

Christopher Chabris, Benjamin Hebert, Daniel Benjamin, Jonathan Beauchamp, David Cesarini, Matthijs van der Loos, Magnus Johannesson, Patrik Magnusson, Paul Lichtenstein, Craig Atwood.... (2012) Most Reported Genetic Associations with General Intelligence are Probably False Positives. Psychological Science. info:/

Fergusson DM, Boden JM, Horwood LJ, Miller A, & Kennedy MA. (2012) Moderating role of the MAOA genotype in antisocial behaviour. The British journal of psychiatry : the journal of mental science, 200(2), 116-23. PMID: 22297589  

Fisar Z. (2010) Inhibition of monoamine oxidase activity by cannabinoids. Naunyn-Schmiedeberg's archives of pharmacology, 381(6), 563-72. PMID: 20401651  

Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, MacGregor R, Alexoff D, Shea C, Schlyer D, Wolf AP.... (1996) Inhibition of monoamine oxidase B in the brains of smokers. Nature, 379(6567), 733-6. PMID: 8602220  

Logan BK, Yeakel JK, Goldfogel G, Frost MP, Sandstrom G, & Wickham DJ. (2012) Dextromethorphan Abuse Leading to Assault, Suicide, or Homicide. Journal of forensic sciences. PMID: 22537430  

Satoshi Yamaori, Yasuka Okamoto, Ikuo Yamamoto, & Kazuhito Watanabe. (2011) Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6. Drug Metabolism , 39(11), 2049-2056. DOI: 10.1124/dmd.111.041384  

Zawertailo LA, Kaplan HL, Busto UE, Tyndale RF, & Sellers EM. (1998) Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study. Journal of clinical psychopharmacology, 18(4), 332-7. PMID: 9690700  

  • December 30, 2012
  • 05:23 AM
  • 479 views

Scientists Rediscover the Violence Gene, MAOA-2R

by nooffensebut in The Unsilenced Science

New research shows that MAOA-2R induces violence and delinquency far more than the so-called “warrior gene,” MAOA-3R. It is also far more common in African-American men than white men. Plus, MAOA’s designation as a cancer gene could influence the development of therapies.... Read more »

Alpini G, Invernizzi P, Gaudio E, Venter J, Kopriva S, Bernuzzi F, Onori P, Franchitto A, Coufal M, Frampton G.... (2008) Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth. Cancer research, 68(22), 9184-93. PMID: 19010890  

Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, & Shih JC. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science (New York, N.Y.), 268(5218), 1763-6. PMID: 7792602  

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, & Poulton R. (2002) Role of genotype in the cycle of violence in maltreated children. Science (New York, N.Y.), 297(5582), 851-4. PMID: 12161658  

Crabtree, G. (2013) Our fragile intellect. Part II. Trends in Genetics, 29(1), 3-5. DOI: 10.1016/j.tig.2012.10.003  

Fergusson DM, Boden JM, Horwood LJ, Miller A, & Kennedy MA. (2012) Moderating role of the MAOA genotype in antisocial behaviour. The British journal of psychiatry : the journal of mental science, 200(2), 116-23. PMID: 22297589  

Huang L, Frampton G, Rao A, Zhang KS, Chen W, Lai JM, Yin XY, Walker K, Culbreath B, Leyva-Illades D.... (2012) Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events. Laboratory investigation; a journal of technical methods and pathology, 92(10), 1451-60. PMID: 22906985  

Malorni W, Giammarioli AM, Matarrese P, Pietrangeli P, Agostinelli E, Ciaccio A, Grassilli E, & Mondovi B. (1998) Protection against apoptosis by monoamine oxidase A inhibitors. FEBS letters, 426(1), 155-9. PMID: 9598998  

McDermott R, Tingley D, Cowden J, Frazzetto G, & Johnson DD. (2009) Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation. Proceedings of the National Academy of Sciences of the United States of America, 106(7), 2118-23. PMID: 19168625  

Murphy SM, Puwanant A, Griggs RC, & Consortium for Clinical Investigations of Neurological Channelopathies (CINCH) and Inherited Neuropathies Consortium (INC) Consortia of the Rare Disease Clinical Research Network. (2012) Unintended effects of orphan product designation for rare neurological diseases. Annals of neurology, 72(4), 481-90. PMID: 23109143  

Pietrangeli, P. (2004) Amine Oxidases and Tumors. NeuroToxicology, 25(1-2), 317-324. DOI: 10.1016/S0161-813X(03)00109-8  

Reti IM, Xu JZ, Yanofski J, McKibben J, Uhart M, Cheng YJ, Zandi P, Bienvenu OJ, Samuels J, Willour V.... (2011) Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse. Comprehensive psychiatry, 52(2), 188-94. PMID: 21295226  

Roush, W. (1995) Conflict marks crime conference. Science, 269(5232), 1808-1809. DOI: 10.1126/science.7569909  

Shih JC, Ridd MJ, Chen K, Meehan WP, Kung MP, Seif I, & De Maeyer E. (1999) Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A. Brain research, 835(2), 104-12. PMID: 10415365  

Sjöberg, R., Ducci, F., Barr, C., Newman, T., Dell'Osso, L., Virkkunen, M., & Goldman, D. (2007) A Non-Additive Interaction of a Functional MAO-A VNTR and Testosterone Predicts Antisocial Behavior. Neuropsychopharmacology, 33(2), 425-430. DOI: 10.1038/sj.npp.1301417  

Tuinier S, Verhoeven WMA, Scherders MJWT, Fekkes D, & Pepplinkhuizen L. (1995) Neuropsychiatric and biological characteristics of X-linked MAOA deficiency syndrome: A single-intervention case study. New Trends in Experimental and Clinical Psychiatry, 11(4), 99-107. info:/

Wong CC, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, & Mill J. (2010) A longitudinal study of epigenetic variation in twins. Epigenetics : official journal of the DNA Methylation Society, 5(6), 516-26. PMID: 20505345  

  • November 30, 1999
  • 12:00 AM
  • 467 views

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • October 24, 2013
  • 04:16 AM
  • 466 views

Black Suits, Gowns, & Skin: SAT Scores by Income, Education, & Race

by nooffensebut in The Unsilenced Science

The latest SAT and ACT data show record declines for men, whites, and Native Americans. Analysis of state SAT data suggests that family income does not significantly affect scores when controlled for parents’ education and race.... Read more »

Anonymous. (2008) Why Family Income Differences Don't Explain the Racial Gap in SAT Scores. The Journal of Blacks in Higher Education, 10-12. info:/

  • September 10, 2012
  • 05:00 AM
  • 409 views

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able to reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • December 8, 2013
  • 10:03 AM
  • 373 views

The Stupid Stupidity Surrounding the Warrior Gene, MAOA, is Stupid

by nooffensebut in The Unsilenced Science

This is a thorough review of everything stupid ever said about the warrior gene, MAOA.... Read more »

  • December 23, 2013
  • 05:43 AM
  • 362 views

Dr. Kevin Beaver the Apostle

by nooffensebut in The Unsilenced Science

Dr. Kevin Beaver followed my advice and was able to show that black men with MAOA-2R are especially likely to shoot or stab. Self-righteous critics sternly wag their fingers.... Read more »

  • July 4, 2014
  • 10:48 AM
  • 143 views

Parents’ Income Poorly Predicts SAT Score

by nooffensebut in The Unsilenced Science

Here I publish my original study that disproves family income as an important influence on SAT scores, shows race as having its greatest influence on scores at the highest education and income levels, and provides some preliminary evidence for a hereditary influence.... Read more »

nooffensebut. (2014) Parents’ Income is a Poor Predictor of SAT Score. Open Differential Psychology, 1-19. info:other/

Bartels M, Rietveld MJ, Van Baal GC, & Boomsma DI. (2002) Heritability of educational achievement in 12-year-olds and the overlap with cognitive ability. Twin research : the official journal of the International Society for Twin Studies, 5(6), 544-53. PMID: 12573186  

Duckworth AL, Quinn PD, Lynam DR, Loeber R, & Stouthamer-Loeber M. (2011) Role of test motivation in intelligence testing. Proceedings of the National Academy of Sciences of the United States of America, 108(19), 7716-20. PMID: 21518867  

Duncan, J., Seitz, R.J., Kolodny, J., Bor, D., Herzog, H., Ahmed, A., Newell, F.N., & Emslie, H. (2000) A Neural Basis for General Intelligence. Science, 289(5478), 457-460. DOI: 10.1126/science.289.5478.457  

MacCallum RC, Wegener DT, Uchino BN, & Fabrigar LR. (1993) The problem of equivalent models in applications of covariance structure analysis. Psychological bulletin, 114(1), 185-99. PMID: 8346326  

Marioni RE, Davies G, Hayward C, Liewald D, Kerr SM, Campbell A, Luciano M, Smith BH, Padmanabhan S, Hocking LJ.... (2014) Molecular genetic contributions to socioeconomic status and intelligence. Intelligence, 44(100), 26-32. PMID: 24944428  

Trzaskowski M, Harlaar N, Arden R, Krapohl E, Rimfeld K, McMillan A, Dale PS, & Plomin R. (2014) Genetic influence on family socioeconomic status and children's intelligence. Intelligence, 42(100), 83-88. PMID: 24489417  

  • July 9, 2014
  • 01:18 AM
  • 84 views

The Warrior Gene, Back from the Grave

by nooffensebut in The Unsilenced Science

Recently two meta-analyses on the gene, monoamine oxidase A, and its relationship with violence came to opposite conclusions. I review those studies and pose the questions that the scientists were too afraid to answer.... Read more »

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