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Science-Based Medicine
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- September 23, 2008
- 08:00 AM
- 2,032 views
FDA approval of drugs and transparency in clinical trial results
by SBMBlogger in Science-Based Medicine
Note: The reason that I am posting today rather than my usual Monday slot is because the article I discuss here was embargoed until last night. Consequently, I asked Harriet if she would trade days with me this week, and she was kind enough to do so.
One thing that science relies on almost absolutely is [...]... Read more »
Kirby Lee, Peter Bacchetti, Ida Sim, & Mike Clarke. (2008) Publication of Clinical Trials Supporting Successful New Drug Applications: A Literature Analysis. PLoS Medicine, 5(9). DOI: 10.1371/journal.pmed.0050191
PLoS Editors. (2008) Next Stop, Don't Block the Doors: Opening Up Access to Clinical Trials Results. PLoS Medicine, 5(7). DOI: 10.1371/journal.pmed.0050160
- August 18, 2008
- 09:00 AM
- 1,787 views
High dose vitamin C and cancer: Has Linus Pauling been vindicated?
by SBMBlogger in Science-Based Medicine
THE ZOMBIE RISES AGAIN
Vitamin C as a treatment for cancer is back in the news again.
I’m not surprised. This is one therapy favored by advocates of “alternative” medicine that keeps popping up periodically (seemingly every couple of years or so). This latest bit of news has turned up almost right on time after the last [...]... Read more »
Q Chen, M Espey, A Sun, C Pooput, K Kirk, M Krishna, D Khosh, J Drisko, & M Levine. (2008) From the Cover: Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proceedings of the National Academy of Sciences, 105(32), 11105-11109. DOI: 10.1073/pnas.0804226105
L Hoffer, M Levine, S Assouline, D Melnychuk, S J Padayatty, K Rosadiuk, C Rousseau, L Robitaille, & W H Miller. (2008) Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Annals of Oncology. DOI: 10.1093/annonc/mdn377
- October 13, 2008
- 01:01 AM
- 1,672 views
Fun with homeopaths and meta-analyses of homeopathy trials
by SBMBlogger in Science-Based Medicine
Homeopathy amuses me.
Well, actually it both amuses me and appalls me. The amusement comes from just how utterly ridiculous the concepts between homeopathy are. Think about it. It is nothing but pure magical thinking. Indeed, at the very core of homeopathy is a concept that can only be considered to be magic. In homeopathy, the [...]... Read more »
A SHANG, K HUWILERMUNTENER, L NARTEY, P JUNI, S DORIG, J STERNE, D PEWSNER, & M EGGER. (2005) Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. The Lancet, 366(9487), 726-732. DOI: 10.1016/S0140-6736(05)67177-2
R LUDTKE, & A RUTTEN. (2008) The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. Journal of Clinical Epidemiology. DOI: 10.1016/j.jclinepi.2008.06.015
- October 14, 2008
- 04:00 AM
- 1,652 views
Massage for AIDS
by SBMBlogger in Science-Based Medicine
I recently learned of a study entitled “Dominican Children with HIV not Receiving Antiretrovirals: Massage Therapy Influences their Behavior and Development.” It disturbed me, and I couldn’t get it out of my head. They’re massaging these kids but letting them die of AIDS? I went back and read the complete article, and it left me [...]... Read more »
M. Hernandez-Reif, G. Shor-Posner, J. Baez, S. Soto, R. Mendoza, R. Castillo, N. Quintero, E. Perez, & G. Zhang. (2006) Dominican Children with HIV not Receiving Antiretrovirals: Massage Therapy Influences their Behavior and Development. Evidence-based Complementary and Alternative Medicine, 5(3), 345-354. DOI: 10.1093/ecam/nem032
- August 25, 2008
- 09:00 AM
- 1,650 views
Threats to science-based medicine: When clinical trials for new drugs are designed by the marketing division
by SBMBlogger in Science-Based Medicine
When the marketing division designs clinical trials, scientific medicine loses.... Read more »
Kevin Hill, Joseph S. Ross, David S. Egilman, & Harlan M. Krumholz. (2008) The ADVANTAGE Seeding Trial: A Review of Internal Documents. Annals of Internal Medicine, 149(4), 251-258. http://annals.org/cgi/content/full/149/4/251
Harold Sox, & Drummond Rennie. (2008) Seeding Trials: Just Say \"No\". Annals of Internal Medicine, 149(4), 279-280. http://annals.org/cgi/content/full/149/4/279
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