Suzanne Elvidge

128 posts · 124,350 views

Genome Engineering
128 posts

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  • March 14, 2013
  • 05:12 AM

You are what your mother ate…

by Suzanne Elvidge in Genome Engineering

What your mother ate around your conception could have affected your genes, or at least how they function, by switching certain genes on and off through DNA methylation.... Read more »

Robert A. Waterland, Richard Kellermayer, Eleonora Laritsky, Pura Rayco-Solon, R. Alan Harris, Michael Travisano, Wenjuan Zhang, Maria S. Torskaya, Jiexin Zhang, Lanlan Shen.... (2010) Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles. PLoS Genetics, 6(12). DOI: 10.1371/journal.pgen.1001252.g001  

  • March 2, 2013
  • 12:51 PM

Sequencing the bamboo genome

by Suzanne Elvidge in Genome Engineering

Researchers in China have created a draft of the moso bamboo genome. China is the largest grower and consumer of bamboo worldwide, and has around 3.9 million hectares of moso bamboo (Phyllostachys heterocycla var. pubescens), the largest temperate subtype of bamboo. The team has been working on this since 2007.... Read more »

  • February 17, 2013
  • 06:00 AM

Shifting mutations in leukaemia

by Suzanne Elvidge in Genome Engineering

Research published in March 2012 showed differences in the genetics of kidney cancers within the same patients – and even within the same tumours. Now research from Dana-Farber Cancer Institute and the Broad Institute has shown that the genetic profiles of chronic lymphocytic leukaemia (CLL) also shift and change, allowing a glimpse into the past, present and future of the cancer. the results are published in Cell.... Read more »

Landau, D., Carter, S., Stojanov, P., McKenna, A., Stevenson, K., Lawrence, M., Sougnez, C., Stewart, C., Sivachenko, A., Wang, L.... (2013) Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia. Cell, 152(4), 714-726. DOI: 10.1016/j.cell.2013.01.019  

  • January 28, 2013
  • 06:43 AM

Sequencing the chickpea genome

by Suzanne Elvidge in Genome Engineering

The chickpea (Cicer arietinum), one of the most widely grown legume crops in the world has joined the roll call of sequenced legume genomes this week, with a draft genome from the International Chickpea Genome Sequencing Consortium (ICGSC).... Read more »

Varshney, R., Song, C., Saxena, R., Azam, S., Yu, S., Sharpe, A., Cannon, S., Baek, J., Rosen, B., Tar'an, B.... (2013) Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement. Nature Biotechnology. DOI: 10.1038/nbt.2491  

  • January 24, 2013
  • 03:15 AM

How the dog (and its genes) came out of the Wild Woods…

by Suzanne Elvidge in Genome Engineering

In his Just So Story The Cat That Walked by Itself, Rudyard Kipling’s Wild Dog comes out of the Wild Woods to eat the Woman’s roasted mutton bone. According to a paper published in Nature, Kipling wasn’t so far wrong – the steps in the dog’s evolution away from the wolf is marked by the appearance of genes that enable it to digest human food.... Read more »

Axelsson, E., Ratnakumar, A., Arendt, M., Maqbool, K., Webster, M., Perloski, M., Liberg, O., Arnemo, J., Hedhammar, �., & Lindblad-Toh, K. (2013) The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature. DOI: 10.1038/nature11837  

  • January 21, 2013
  • 06:00 AM

Mouse house blueprints are built from DNA

by Suzanne Elvidge in Genome Engineering

It’s easy to see how genes can control simple behaviour, but something as complex as mice digging sets of burrows to specific lengths and constructing escape routes – it seems unlikely. But actually, according to a team of researchers publishing in Nature and nearly a decade of work, four gene regions could control just this.... Read more »

  • January 18, 2013
  • 06:21 AM

How your genes and your earwax confirm whether you really need a roll-on…

by Suzanne Elvidge in Genome Engineering

Around 2% of people carry a variant of the ABCC11 gene that means they don't actually produce any under-arm odour. People who carry this rare genetic variant are also more likely to have dry (rather than sticky) ear wax. ... Read more »

  • January 9, 2013
  • 06:00 AM

Spitting in a cup could improve your asthma care

by Suzanne Elvidge in Genome Engineering

A spit-based genetic test could help doctors pick out those children who would benefit from asthma inhalers and those who would be better on other treatments, according to research from scientists at the University of Dundee and the University of Brighton.... Read more »

Lipworth, B., Basu, K., Donald, H., Tavendale, R., Macgregor, D., Ogston, S., Palmer, C., & Mukhopadhyay, S. (2013) Tailored second-line therapy in asthmatic children with the Arg genotype . Clinical Science, 124(8), 521-528. DOI: 10.1042/CS20120528  

  • December 24, 2012
  • 06:00 AM

The genetics of gout – the ‘disease of kings’

by Suzanne Elvidge in Genome Engineering

Gout, sometimes known as the king of diseases and the disease of kings, is on the increase, with hospital admissions doubling over the last decade as the population ages and obesity and alcohol intake increases. But why don’t all of us who over-indulge at Christmas get it?... Read more »

Köttgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C., Haller, T.... (2012) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics. DOI: 10.1038/ng.2500  

  • December 11, 2012
  • 02:26 AM

Genome engineering algae to make ‘designer’ protein drugs

by Suzanne Elvidge in Genome Engineering

Researchers at the University of California San Diego have used genome engineering to create algae that can produce expensive biological drugs more cheaply and in larger quantities than bacteria or mammalian cells.... Read more »

Miller Tran, Christina Van, Daniel J. Barrera, Pär L. Pettersson, Carlos D. Peinado, Jack Bui, & Stephen P. Mayfielda. (2012) Production of unique immunotoxin cancer therapeutics in algal chloroplasts. PNAS. info:/

  • December 9, 2012
  • 12:59 PM

Nobody’s perfect – at least not in his or her genes…

by Suzanne Elvidge in Genome Engineering

However fit and well you feel, however good your genetic inheritance, nobody’s genes are perfect, according to research published in the American Journal of Human Genetics – everyone carries an estimated 400 damaging gene variants and two disease-causing mutations. This figure is likely to increase as studies become more capable of picking up rare variants.... Read more »

  • December 9, 2012
  • 12:52 PM

Milling down to the wheat genome

by Suzanne Elvidge in Genome Engineering

A team of European and US researchers have analysed the genome of bread wheat (Triticum aestivum; also known as common wheat), identifying almost 100,000 genes, and potentially opening the door to advances in wheat breeding.... Read more »

Brenchley, R., Spannagl, M., Pfeifer, M., Barker, G., D’Amore, R., Allen, A., McKenzie, N., Kramer, M., Kerhornou, A., Bolser, D.... (2012) Analysis of the bread wheat genome using whole-genome shotgun sequencing. Nature, 491(7426), 705-710. DOI: 10.1038/nature11650  

  • December 6, 2012
  • 06:00 PM

Romani people arose in India 1500 years ago

by Suzanne Elvidge in Genome Engineering

According to recent DNA studies from a team of researchers for a number of institutions in Europe, the Romani people arose in India around 1500 years ago, earlier than previously thought.... Read more »

Mendizabal, I., Lao, O., Marigorta, U., Wollstein, A., Gusmão, L., Ferak, V., Ioana, M., Jordanova, A., Kaneva, R., Kouvatsi, A.... (2012) Reconstructing the Population History of European Romani from Genome-wide Data. Current Biology. DOI: 10.1016/j.cub.2012.10.039  

  • December 6, 2012
  • 05:00 PM

Different genes keep Ethiopians and Tibetans breathing in thin air

by Suzanne Elvidge in Genome Engineering

Through adaptation, Ethiopians and Tibetans have made similar changes to cope with living at high altitudes and breathing thin air, but using different genetic routes, according to research from the US and Ethiopia published in PLoS Genetics. Ethiopians can live and work more than a mile and a half above sea level without getting altitude sickness (acute mountain sickness), despite breathing lower pressure air with lower levels of oxygen.... Read more »

Gorka Alkorta-Aranburu, Cynthia M. Beall, David B. Witonsky, Amha Gebremedhin, Jonathan K. Pritchard, & Anna Di Rienzo. (2012) The genetic architecture of adaptations to high altitude in Ethiopia. PLoS Genetics. arXiv: 1211.3053v1

  • December 5, 2012
  • 05:00 PM

Old genes expose Tasmanian devils to new risks

by Suzanne Elvidge in Genome Engineering

Low levels of diversity in the genes of the immune systems of Tasmanian devils (Sarcophilus harrisii) make the animals more vulnerable to the deadly and infectious devil facial tumor disease – however, according to researchers at the University of Sydney and University of Adelaide, this low immune gene diversity has been around for hundreds, or even possibly thousands, of years.... Read more »

  • November 27, 2012
  • 12:42 AM

Squeezing the pips out of the watermelon genome

by Suzanne Elvidge in Genome Engineering

Researchers from China, the US and Europe have sequenced the genome of the watermelon (Citrullus lanatus), a large juicy fruit, usually with pink or red flesh and dark pips that is grown throughout the world.... Read more »

Guo, S., Zhang, J., Sun, H., Salse, J., Lucas, W., Zhang, H., Zheng, Y., Mao, L., Ren, Y., Wang, Z.... (2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nature Genetics. DOI: 10.1038/ng.2470  

  • November 15, 2012
  • 07:05 AM

A step in the evolution of the human brain

by Suzanne Elvidge in Genome Engineering

An international team of researchers, including researchers from China, Germany, and the University of Edinburgh in Scotland, has discovered a new piece of genetic information that could give a clue to how the human brain evolved, and what makes humans and apes different from each other.... Read more »

Hu, H., He, L., Fominykh, K., Yan, Z., Guo, S., Zhang, X., Taylor, M., Tang, L., Li, J., Liu, J.... (2012) Evolution of the human-specific microRNA miR-941. Nature Communications, 1145. DOI: 10.1038/ncomms2146  

  • November 15, 2012
  • 06:31 AM

DNA sequencing could save MRSA babies

by Suzanne Elvidge in Genome Engineering

For the first time, whole genome sequencing of bacterial DNA has been used to map an infection outbreak, helping the successful control of methicillin-resistant Staphylococcus aureus (MRSA) in a special care baby unit (SCBU) at Rosie Hospital in Cambridge (UK). Around one in a hundred people can carry MRSA for a few hours, up to months or even years, with no apparent symptoms. However, in young babies, the elderly, or people with weakened immune systems, MRSA infection can be life-threatening.... Read more »

Harris, S., Cartwright, E., Török, M., Holden, M., Brown, N., Ogilvy-Stuart, A., Ellington, M., Quail, M., Bentley, S., Parkhill, J.... (2012) Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(12)70268-2  

  • November 9, 2012
  • 07:19 AM

The genetics of red-headedness – red hair and melanoma risk

by Suzanne Elvidge in Genome Engineering

People with fair skin and red hair, and who don’t tan, are the most vulnerable to melanoma (skin cancer). However, the increased risk of melanoma may be down to more than just a lack of protective dark melanin – the skin pigment behind their beautiful pale skin might play a role too, according to research published in Nature.... Read more »

  • October 25, 2012
  • 02:04 PM

A new step to combat inherited mitochondrial disease: Creating a three-parent baby

by Suzanne Elvidge in Genome Engineering

In an new technique that’s not without controversy, researchers at Oregon Health & Science University have developed a three-person IVF technique that could prevent inherited mitochondrial disease being passed on to the next generation, and have been able to create healthy-appearing early stage embryos. The results are published in Nature.... Read more »

Tachibana, M., Amato, P., Sparman, M., Woodward, J., Sanchis, D., Ma, H., Gutierrez, N., Tippner-Hedges, R., Kang, E., Lee, H.... (2012) Towards germline gene therapy of inherited mitochondrial diseases. Nature. DOI: 10.1038/nature11647  

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