Erin Campbell

295 posts · 202,318 views

the Node
26 posts

HighMag Blog
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  • October 29, 2014
  • 12:59 PM
  • 42 views

October 28, 2014

by Erin Campbell in HighMag Blog

If you’ve ever tried to get your kids to share a donut, you understand the importance to dividing things equally (and learning crucial lessons…just buy more donuts next time...I mean, seriously!). Cell division is no different—chromosomes and organelles must all get divided equally. Today’s images are from a paper showing how mitochondria are positioned during cell division in order to allow equal segregation.Many years of research have focused on the equal segregation of chromosomes d........ Read more »

  • October 24, 2014
  • 11:22 AM
  • 65 views

October 24, 2014

by Erin Campbell in HighMag Blog

There is a party going on at the ends of microtubules, but I wasn’t invited. That won’t stop me, or countless cell biologists out there, from peeping in the window to check out all of the microtubule shenanigans. Today’s image is from a paper describing how Doublecortin binds to microtubule ends.The plus end of a microtubule is the primary site for growth and shrinkage, and interaction with several microtubule-associate proteins. Different microtubule end-binding proteins may interact with........ Read more »

  • October 17, 2014
  • 11:40 AM
  • 87 views

October 17, 2014

by Erin Campbell in HighMag Blog

For years the prettiest cells to image were flat cells in a dish. Thanks to the tireless work of many, beautiful high-resolution images can now come from tissue in a living organism. Today’s image is from a paper showing improved techniques for imaging fine cellular processes within large volumes, from the lab of recent Nobel prize winner, Eric Betzig. A material’s refractive index refers to how light travels through it; the simplest example being how light bends when passed through wat........ Read more »

Wang, K., Milkie, D., Saxena, A., Engerer, P., Misgeld, T., Bronner, M., Mumm, J., & Betzig, E. (2014) Rapid adaptive optical recovery of optimal resolution over large volumes. Nature Methods, 11(6), 625-628. DOI: 10.1038/nmeth.2925  

  • October 9, 2014
  • 01:47 PM
  • 108 views

October 9, 2014

by Erin Campbell in HighMag Blog

As Tom and Jerry have proven time and time again, repulsive forces are serious business and highly entertaining. Today’s image is from a paper describing how different cell types repel one another to help create boundaries between tissues. The study of how cells adhere to or repel one another is an important field of study in developmental biology. Ephrin ligands and their respective Eph receptors trigger repulsive cues between cells of different types. Many different tissue types expr........ Read more »

  • September 25, 2014
  • 11:34 AM
  • 174 views

September 25, 2014

by Erin Campbell in HighMag Blog

While taking an awesome cell biology course in college, I was coming to terms with my mother’s recent ovarian cancer diagnosis. The scientist in my head couldn’t shake the curiosity about how my mother’s cells could have betrayed her so royally. This intersection of basic cell biology and cancer kick-started my interest in cell biology research. Today’s image is from a paper showing a role for the ARF tumor suppressor in maintaining chromosomal stability. THIS paper is one of the mil........ Read more »

  • September 17, 2014
  • 02:49 PM
  • 138 views

September 17, 2014

by Erin Campbell in HighMag Blog

All good things must end—even the focal adhesions that are so key to cell migration. Today’s notable image is the first live cell visualization of ECM degradation at focal adhesions, in a recent paper that reports the link between CLASPs, exocytosis, and focal adhesion turnover. Cell migration depends on the precisely-timed formation of focal adhesions (FAs) that link the crawling cell to the extracellular matrix (ECM). FAs serve as anchor points for the crawling cell, yet must later di........ Read more »

  • September 11, 2014
  • 03:28 PM
  • 172 views

September 11, 2014

by Erin Campbell in HighMag Blog

As your therapist likely tells you, understanding where you came from is key to accepting where you are now. Take that therapist’s task and multiply it by several million—you now understand the tough job ahead of developmental biologists trying to track cell lineages in complex organisms. Today’s colorful image is from a paper describing a new computational framework for reconstructing cell lineages. The successful tracking of cell position, division, and movement in a developing or........ Read more »

Amat, F., Lemon, W., Mossing, D., McDole, K., Wan, Y., Branson, K., Myers, E., & Keller, P. (2014) Fast, accurate reconstruction of cell lineages from large-scale fluorescence microscopy data. Nature Methods, 11(9), 951-958. DOI: 10.1038/nmeth.3036  

  • September 5, 2014
  • 11:08 AM
  • 149 views

September 5, 2014

by Erin Campbell in HighMag Blog

It is so nice to have a friend who truly complements you…someone similar to you, but different enough to pick up the slack of your own shortcomings. Today’s image is from a paper about the Laverne and Shirley partnership of Ena/VASP and mDia2. Crawling cells extend finger-like filopodia to probe the environment for cues and to establish adhesion of the cell to the substrate. Filopodia are composed of parallel bundles of actin that are quickly dynamic. Countless actin regulators affec........ Read more »

Barzik, M., McClain, L., Gupton, S., & Gertler, F. (2014) Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function. Molecular Biology of the Cell, 25(17), 2604-2619. DOI: 10.1091/mbc.E14-02-0712  

  • August 29, 2014
  • 01:31 PM
  • 146 views

August 29, 2014

by Erin Campbell in HighMag Blog

Stem cells in adults are responsible for tissue renewal and many cancers. So, the hunt for stem cells is important and has already been successful, with stem cell populations identified in countless types of tissues. Stem cells in the ovary, however, were shy to show themselves until a recent study using a marker for the Wnt protein Lgr5.In adults, stem cells are responsible for maintaining homeostasis during normal wear and tear of a tissue. The ovary and its ovary surface epithelium (OSE) expe........ Read more »

Ng, A., Tan, S., Singh, G., Rizk, P., Swathi, Y., Tan, T., Huang, R., Leushacke, M., & Barker, N. (2014) Lgr5 marks stem/progenitor cells in ovary and tubal epithelia. Nature Cell Biology, 16(8), 745-757. DOI: 10.1038/ncb3000  

  • August 26, 2014
  • 02:50 PM
  • 195 views

August 26, 2014

by Erin Campbell in HighMag Blog

If you have little ones in your house, you might assume that the phrase “randomly fluctuating forces” is referring to your home. This phrase actually refers to the background force in a cell coming from active and motor-driven cell processes. Today’s image is from a study that developed a way to measure these forces. Actin- and microtubule-based motors move many types of material around a cell to drive critical cellular events. These motor-driven movements and other active processe........ Read more »

Guo, M., Ehrlicher, A., Jensen, M., Renz, M., Moore, J., Goldman, R., Lippincott-Schwartz, J., Mackintosh, F., & Weitz, D. (2014) Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy. Cell, 158(4), 822-832. DOI: 10.1016/j.cell.2014.06.051  

  • August 21, 2014
  • 10:48 AM
  • 200 views

August 21, 2014

by Erin Campbell in HighMag Blog

Microtubules are known for their fascinating dynamics, but some cellular processes require a more stable microtubule cytoskeleton. Thankfully, these stable, acetylated microtubules are just as photogenic as their non-modified microtubule pals. Today’s image is from a paper describing the role of the protein paxillin in microtubule acetylation. Crawling cells require coordination of adhesive forces, cytoskeletal rearrangements, and cell polarization. Cell polarization helps to direct newly........ Read more »

  • August 19, 2014
  • 12:18 PM
  • 181 views

August 19, 2014

by Erin Campbell in HighMag Blog

Think of life without tubes for a moment. Not only would our huge bodies cease to exist, but our homes’ plumbing would be a mess and my 5-year old’s marble run would be pretty boring. The formation of tubes during development is a fascinating topic. Today’s image is from a paper describing the role of endocytosis in seamless tube formation. The trachea of the fruit fly is a simple tubular system that functions as the respiratory system of the fly. The star-shaped tracheal terminal cel........ Read more »

  • August 14, 2014
  • 03:54 PM
  • 215 views

August 14, 2014

by Erin Campbell in HighMag Blog

Astrocytes used to be the red-headed stepchild of the neurology world, but no more! Once considered to be just filler material, astrocytes are now known to function in the development and function of synapses, though the mechanisms are unclear. Today’s stunning image is from a paper showing how astrocytes can stabilize synapses, possibly serving as an important component of learning and memory. The synapses of neurons in the central nervous system are dynamic in response to learning and m........ Read more »

Bernardinelli, Y., Randall, J., Janett, E., Nikonenko, I., König, S., Jones, E., Flores, C., Murai, K., Bochet, C., Holtmaat, A.... (2014) Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability. Current Biology, 24(15), 1679-1688. DOI: 10.1016/j.cub.2014.06.025  

  • August 7, 2014
  • 09:32 AM
  • 238 views

August 7, 2014

by Erin Campbell in HighMag Blog

No matter how many brilliant discoveries are made by countless brilliant scientists, there will always be a lot of unknowns out there. These unknowns are what keep our mental wheels turning, our imaginations running, and our labs busy. Today’s image is from a paper that describes a newly-discovered process of vascular development called “canalogenesis.” Schlemm’s canal (SC) is a flattened tube that encircles the anterior portion of the eye and drains fluid from the area. Abnormal drainag........ Read more »

  • July 31, 2014
  • 08:01 AM
  • 189 views

July 31, 2014

by Erin Campbell in HighMag Blog

Do you ever feel nostalgic for a specific paper? Maybe this paper inspired your own research, or maybe it was a paper you immediately knew would be game-changing. Maybe, like today’s TBT paper, it was a great paper about solidly executed research with a memorable giggle-inducing technique. Thanks to a nostalgic HighMag reader and friend, Omar Quintero, we are being re-introduced to gonad sandwiches. In mammals, sex determination refers to the changes during early development that lead ........ Read more »

Martineau, J., Nordqvist, K., Tilmann, C., Lovell-Badge, R., & Capel, B. (1997) Male-specific cell migration into the developing gonad. Current Biology, 7(12), 958-968. DOI: 10.1016/S0960-9822(06)00415-5  

  • July 24, 2014
  • 11:45 AM
  • 235 views

July 24, 2014

by Erin Campbell in HighMag Blog

How many times can you say the word “gonad” in a sentence without giggling? If the answer is one, then I congratulate you on turning thirteen. If the answer is many, then you must be a biologist. Biologists appreciate the value of a good gonad, and so should you. The gonad of the worm C. elegans serves as an important model in which to study tissue organization and development, as you’ll see in the paper that accompanies today’s image. At the end of cell division, cytokinesis typical........ Read more »

Amini, R., Goupil, E., Labella, S., Zetka, M., Maddox, A., Labbe, J., & Chartier, N. (2014) C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization. originally published in the Journal of Cell Biology, 206(1), 129-143. DOI: 10.1083/jcb.201310117  

  • July 18, 2014
  • 01:55 PM
  • 251 views

July 18, 2014

by Erin Campbell in HighMag Blog

Poor polar bodies typically go the way of that old container of Chinese take-out in your fridge and are eventually dumped. Thanks to a very clever study published in Cell, polar body transfer can prevent the transmission of inherited mitochondrial diseases. Waste not, want not. The meiotic divisions of an oocyte result in the production of an egg in the extrusion of two very small polar bodies. These polar bodies have the same genetic material as the egg but have only a small number of orga........ Read more »

  • July 10, 2014
  • 03:32 PM
  • 235 views

July 10, 2014

by Erin Campbell in HighMag Blog

Do your thoughts and feelings have colors? Do you feel red with rage during traffic, or green with envy when your lady swoons over Ryan Gosling? A recent methods paper introduces a very cool technique that allows the visualization and measurement of voltage within an excited neuron. Biologists build tools that are ideally accurate, fast, and non-damaging to the cells and organisms on which they are used. In a recent paper in Nature Methods, Hochbaum and colleagues describe the improved techn........ Read more »

Hochbaum, D., Zhao, Y., Farhi, S., Klapoetke, N., Werley, C., Kapoor, V., Zou, P., Kralj, J., Maclaurin, D., Smedemark-Margulies, N.... (2014) All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nature Methods. DOI: 10.1038/nmeth.3000  

  • June 30, 2014
  • 07:11 AM
  • 211 views

June 30, 2014

by Erin Campbell in HighMag Blog

Which came first, the primordial germ cell or the gamete? Unlike the old chicken or egg philosophical dilemma, we know for certain that the primordial germ cell came first. And, thanks to a recent paper about primordial germ cells in sea urchins, we now know that they can migrate across the urchin embryo. During development, germ cells produce gametes (eggs or sperm). In many organisms, including mammals, primordial germ cells (PGCs) are born far from the eventual location of gametes and must........ Read more »

Campanale, J., Gökirmak, T., Espinoza, J., Oulhen, N., Wessel, G., & Hamdoun, A. (2014) Migration of sea urchin primordial germ cells. Developmental Dynamics, 243(7), 917-927. DOI: 10.1002/dvdy.24133  

  • June 19, 2014
  • 11:46 AM
  • 245 views

June 19, 2014

by Erin Campbell in HighMag Blog

As the widespread therapeutic use of stem cells moves closer to reality, I just fasten my seatbelt a little tighter. An exciting time for stem cells and their scientist stalkers, a recent paper shows the regeneration of damaged monkey hearts by human embryonic stem cell-derived cardiomyocytes.  Human embryonic stem cells (hESCs) can be programmed to differentiate into countless different cell types. hESCs are already being tested in humans to treat retinal diseases and spinal cord inju........ Read more »

Chong, J., Yang, X., Don, C., Minami, E., Liu, Y., Weyers, J., Mahoney, W., Van Biber, B., Cook, S., Palpant, N.... (2014) Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature, 510(7504), 273-277. DOI: 10.1038/nature13233  

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