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- December 20, 2011
- 07:07 AM
- 203 views
Eye-ing the body electric
How do you make an eye? One early trigger for eye formation in Xenopus, as a new Development paper from Michael Levin’s lab shows, is a small change in bioelectric signals. In fact, that trigger alone is enough to induce eye development in other parts of the body. In an experiment that measured regions of [...]... Read more »
Pai, V., Aw, S., Shomrat, T., Lemire, J., & Levin, M. (2011) Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development. DOI: 10.1242/dev.073759
- October 3, 2011
- 07:30 AM
- 425 views
Today’s Nobel Prize is not immune to developmental biology
This year’s Nobel Prize in Physiology or Medicine has just been announced, and the winners are Bruce Beutler (The Scripps Research Institute), Jules Hoffmann (University of Strasbourg) and Ralph Steinman (Rockefeller University), for their research on the immune system. Steinman discovered dendritic cells, while Beutler and Hoffmann studied the genetics behind immunity. At first glance, [...]... Read more »
LEMAITRE, B., NICOLAS, E., MICHAUT, L., REICHHART, J., & HOFFMANN, J. (1996) The Dorsoventral Regulatory Gene Cassette Controls the Potent Antifungal Response in Drosophila Adults. Cell, 86(6), 973-983. DOI: 10.1016/S0092-8674(00)80172-5
Siggs, O., Arnold, C., Huber, C., Pirie, E., Xia, Y., Lin, P., Nemazee, D., & Beutler, B. (2011) The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nature Immunology, 12(5), 434-440. DOI: 10.1038/ni.2012
- June 9, 2011
- 07:37 AM
- 438 views
Embryonic development informs adult heart repair
After a heart attack, heart muscle is irreparably damaged, but a paper in Nature now reports that adult mouse hearts have a source of progenitor cells that can form new muscle cells after heart injury. A few years ago, studies showed that embryonic epicardial progenitor cells contribute to the cardiomyocyte lineage in developing mouse hearts. [...]... Read more »
Nicola Smart, Sveva Bollini, Karina N. Dubé, Joaquim M. Vieira, Bin Zhou, Sean Davidson, Derek Yellon, Johannes Riegler, Anthony N. Price, Mark F. Lythgoe.... (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature. info:/10.1038/nature10188
Nicola Smart, Catherine A. Risebro, Athalie A. D. Melville, Kelvin Moses, Robert J. Schwartz, Kenneth R. Chien, & Paul R. Riley. (2007) Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 177-182. info:/10.1038/nature05383
Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X.... (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature, 454(7200), 104-8. PMID: 18480752
Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR.... (2008) Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature, 454(7200), 109-13. PMID: 18568026
- May 11, 2011
- 06:00 AM
- 409 views
Interview with Beddington Medal winner Carlos Carmona-Fontaine
Each year, the British Society for Developmental Biology awards the Beddington Medal for the best PhD thesis in developmental biology. At the 2011 BSDB meeting, this award went to Carlos Carmona-Fontaine, who completed his PhD in Roberto Mayor’s lab at UCL. Now a postdoc at Sloan-Kettering Institute in New York, Carlos returned to the UK [...]... Read more »
Carmona-Fontaine, C., Matthews, H., Kuriyama, S., Moreno, M., Dunn, G., Parsons, M., Stern, C., & Mayor, R. (2008) Contact inhibition of locomotion in vivo controls neural crest directional migration. Nature, 456(7224), 957-961. DOI: 10.1038/nature07441
Bazazi, S., Buhl, J., Hale, J., Anstey, M., Sword, G., Simpson, S., & Couzin, I. (2008) Collective Motion and Cannibalism in Locust Migratory Bands. Current Biology, 18(10), 735-739. DOI: 10.1016/j.cub.2008.04.035
- April 7, 2011
- 06:40 AM
- 676 views
A new view on eye development
How do you make an eye? In the developing embryo, this process begins with the formation of the optic vesicle from the neural tube. This optic vesicle then invaginates to form an optic cup, which in turn develops into the outer pigmented layer of the retina and the inner neurosensory layer. Normally, this all takes [...]... Read more »
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature, 472(7341), 51-56. DOI: 10.1038/nature09941
- March 31, 2011
- 07:06 AM
- 665 views
Marion Silies wins GfE thesis award
Every two years, the German society for developmental biology (Gesellschaft für Entwicklungsbiologie - GfE) hands out an award for the best PhD thesis of the previous two years. At their society meeting last week, this award went to Marion Silies, for her PhD thesis on glial cell migration. I met up with Marion after her [...]... Read more »
Silies M, & Klämbt C. (2010) APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. Nature neuroscience, 13(11), 1357-64. PMID: 20890296
- January 6, 2011
- 09:50 AM
- 527 views
modENCODE
The modENCODE project (model organism encyclopedia of DNA elements) is a collaborative effort to identify all sequence-based functional elements of Drosophila and C. elegans. The project has now produced almost a thousand data sets with information about transcription, epigenetics, replication and gene regulation across different developmental stages and multiple cell lines.
Just before the holidays, [...]... Read more »
The modENCODE Consortium, ., Roy, S., Ernst, J., Kharchenko, P., Kheradpour, P., Negre, N., Eaton, M., Landolin, J., Bristow, C., Ma, L.... (2010) Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE. Science, 330(6012), 1787-1797. DOI: 10.1126/science.1198374
- September 27, 2010
- 12:19 PM
- 649 views
Pleiades Promoter Project
A recent paper in PNAS describes the development of MiniPromoters: human DNA promoters of less than 4 kb, designed to drive gene expression in specific areas of the brain. The initiative is called the Pleiades Promoter Project, and so far they have confirmed brain-region specific activity in knockin mice for 27 of their MiniPromoters. The [...]... Read more »
Portales-Casamar, E., Swanson, D., Liu, L., Leeuw, C., Banks, K., Ho Sui, S., Fulton, D., Ali, J., Amirabbasi, M., Arenillas, D.... (2010) A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proceedings of the National Academy of Sciences, 107(38), 16589-16594. DOI: 10.1073/pnas.1009158107
- September 2, 2010
- 12:01 PM
- 868 views
Evolution of cerebral cortex traced back to Precambrian era
In a paper published today in Cell, Detlev Arendt, Raju Tomer and colleagues reveal evidence that the cerebral cortex evolved much earlier than previously believed. Using a new technique to detect and image simultaneously expressed genes in a compact brain area, they discovered that the gene expression patterns in the olfactory processing region (mushroom bodies) [...]... Read more »
Raju Tomer, Alexandru S. Denes, Kristin Tessmar-Raible, & Detlev Arendt. (2010) Profiling by Image Registration Reveals Common Origin of Annelid Mushroom Bodies and Vertebrate Pallium. Cell, 142(5), 800-809. info:/10.1016/j.cell.2010.07.043
- September 1, 2010
- 10:17 AM
- 932 views
Phenologs and unlikely models
“You’re probably wondering why I’m here”, were the first words of Edward Marcotte’s talk at the SDB meeting last month. After all, he was about to speak about systems biology in a session on organogenesis. What followed was not only a new way to identify genes involved in developmental processes, but also a perfect example [...]... Read more »
Kriston L. McGary, Tae Joo Park, John O. Woods, Hye Ji Cha, John B. Wallingford, & Edward M. Marcotte. (2010) Systematic discovery of nonobvious human disease models through orthologous phenotypes. PNAS. DOI: 10.1073/pnas.0910200107
- August 2, 2010
- 04:17 AM
- 946 views
The Intestinal Crypt
It’s not often that the introductory part of a research talk is beautiful as well as informative, but Hans Clevers achieves both by using this video about the intestinal crypt in his presentations. (Click either screenshot to see the video)
The video shows how stem cells at the base of the intestinal crypt produce the epithelial [...]... Read more »
Barker, N., van Es, J., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P.... (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449(7165), 1003-1007. DOI: 10.1038/nature06196
Barker, N., Ridgway, R., van Es, J., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A., Sansom, O., & Clevers, H. (2008) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457(7229), 608-611. DOI: 10.1038/nature07602
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