William Yates, M.D.

458 posts · 368,402 views

Physician, Writer and Bird Photographer. Translating Neuroscience Research Into Better Care for Brain Disorders.

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  • October 20, 2014
  • 10:56 AM
  • 20 views

Persistent Insomnia and Alcoholism

by William Yates, M.D. in Brain Posts

Sleep problems complicate the treatment and recovery in alcoholism. Heavy alcohol consumption modifies the nature of sleep architecture.A high blood alcohol concentration at bedtime may promote sleep early in the sleep cycle.However, as alcohol levels decline, sleep is often interrupted with limiting rapid eye movement (REM) sleep duration.Shortened total sleep time with alcohol can produce a lack of feeling well rested on awakening.For those with alcoholism or alcohol dependence, successfu........ Read more »

Brower KJ, Krentzman A, & Robinson EA. (2011) Persistent insomnia, abstinence, and moderate drinking in alcohol-dependent individuals. The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions, 20(5), 435-40. PMID: 21838842  

  • October 7, 2014
  • 04:21 PM
  • 103 views

Personality, Emotion and Psychopathology: David Watson Lecture Notes

by William Yates, M.D. in Brain Posts

I had the privilege to attend today the William K Warren Frontiers in Neuroscience Conference in Tulsa, OK by Dr. David Watson from Notre Dame University.Dr. Watson's lecture was titled: An integrative model of personality, emotion and psychopathology. This lecture summarized a body of research examining personality, psychological symptoms and a variety of brain disorders.Here are my lecture notes and links to relevant research citations. The first two citations have links to a free full-te........ Read more »

Stasik SM, Naragon-Gainey K, Chmielewski M, & Watson D. (2012) Core OCD symptoms: exploration of specificity and relations with psychopathology. Journal of anxiety disorders, 26(8), 859-70. PMID: 23026094  

  • October 2, 2014
  • 11:01 AM
  • 125 views

Parenting: Genetics and Environmental Effects

by William Yates, M.D. in Brain Posts

Effective parenting is a key element in child development.Both genetic and environmental factors appear to contribute to the cognitive, emotional and behavioral aspects of parenting.Childhood temperament also influences the process of parenting. A well-behaved, emotionally stable and loving child is obviously much easier to parent than a child with behavioral and emotional problems.Bonamy Oliver and colleagues from the United Kingdom have recently published an informative twin study of pare........ Read more »

Oliver BR, Trzaskowski M, & Plomin R. (2014) Genetics of parenting: The power of the dark side. Developmental psychology, 50(4), 1233-40. PMID: 24364831  

  • September 29, 2014
  • 10:32 AM
  • 126 views

Family Attachment and the Brain Cingulate Cortex

by William Yates, M.D. in Brain Posts

Healthy family attachment provides a key element for social support and successful interpersonal relationships.Several brain regions as well as hormonal factors appear to modulate positive emotional responses to family members.I have previously reviewed several studies involving the prosocial effects of the hormone oxytocin and the related hormone vasopressin.Nicolas Rusch from the Department of Psychiatry at Ulm University in Germany along with colleagues in Brazil and London recently published........ Read more »

  • September 24, 2014
  • 12:37 PM
  • 166 views

Why Women Give Better Gifts

by William Yates, M.D. in Brain Posts

Consumer spending on gifts for birthdays and holidays is a multi-billion dollar big business.Despite this large economic impact, little research examines factors associated with gift recipient satisfaction.Selecting good gifts for others involves a complex social decision-making process related to judging the value hierarchy of others.A study from the Netherlands recently published in the journal PLOS One featured three experiments on gift selection in a series of men and women.The design of the........ Read more »

Pollmann MM, & van Beest I. (2013) Women are better at selecting gifts than men. PloS one, 8(12). PMID: 24386082  

  • September 18, 2014
  • 11:11 AM
  • 168 views

Genetics of Social Skills: Oxytocin Receptor Gene

by William Yates, M.D. in Brain Posts

Social neuroscience is an emerging emphasis in the field of neuroscience research.Social cognition is the subset of cognitive functions related to social processes and includes factors such as facial recognition, social memory and ability to form friendships and other social bonds.Impairment in social cognition is a known feature in autism, schizophrenia and other mental disorders. This type of impairment can produce significant problems in life adjustment, employment and human attachment.Geneti........ Read more »

Skuse DH, Lori A, Cubells JF, Lee I, Conneely KN, Puura K, Lehtimäki T, Binder EB, & Young LJ. (2014) Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1987-92. PMID: 24367110  

  • September 17, 2014
  • 11:28 AM
  • 156 views

Antidepressants Modulate Memory in the Healthy Brain

by William Yates, M.D. in Brain Posts

The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the antidepr........ Read more »

  • September 16, 2014
  • 11:01 AM
  • 154 views

Cannabis-induced Paranoia: Cognitive Mechanisms

by William Yates, M.D. in Brain Posts

Some individuals appear vulnerable to paranoia induced by exposure to tetrahydrocannabinol (THC) in cannabis.The mechanism for this effect is poorly understood.Daniel Freeman from University of Oxford along with colleagues in England and Switzerland recently conducted an interventional research study on this issue.In this study, 121 subjects were recruited to receive injections of THC in a laboratory setting.These subjects were required to have taken cannabis at least once before participation i........ Read more »

  • August 28, 2014
  • 11:40 AM
  • 247 views

Gambler Sub-types: Three Distinct Profiles

by William Yates, M.D. in Brain Posts

One method to advance understanding of a disorder is to use statistical modeling for sub-type or class analysis.Lia Nower and colleagues recently published the results of such an analysis from the large general population data-set known as the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).In this sample, 851 adults 18 years and older were identified with disordered gambling.This group then underwent a type of latent class statistical analysis known as the Pathways........ Read more »

  • August 27, 2014
  • 10:58 AM
  • 196 views

Diagnostic Profile in Pathological Gamblers

by William Yates, M.D. in Brain Posts

Behavioral disorders like pathological gambling (PG) rarely occur alone as a single uncomplicated disorder.In a previous post, I noted the overlap of PG with personality disorder, anxiety disorder, depression, bipolar disorder and substance abuse.A recent study from Germany adds to our knowledge of the general diagnostic profile in the PG population.Erbas and Buchner reviewed German national data sources and other German studies to come up with a series of findings:Twelve month prevalence rates ........ Read more »

  • August 18, 2014
  • 10:16 AM
  • 189 views

Guidelines for Treatment of Problem Gambling

by William Yates, M.D. in Brain Posts

Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders".  In their summa........ Read more »

Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000  

  • August 14, 2014
  • 11:17 AM
  • 204 views

FDA Approves Novel Insomnia Drug Suvorexant (Belsomra)

by William Yates, M.D. in Brain Posts

Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »

  • August 11, 2014
  • 11:42 AM
  • 215 views

Clinical Drug Trials for Pathological Gambling

by William Yates, M.D. in Brain Posts

Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269  

  • August 6, 2014
  • 12:01 PM
  • 186 views

Brain Striatum and Loss-Chasing in Gambling

by William Yates, M.D. in Brain Posts

Pathological gambling (PG) is a pattern of gambling characterized by loss of control and large gambling debts.The near-miss phenomenon in gambling is the gaming scenario where gamblers sense they were very close to winning.This near-miss phenomenon can be programmed into slot machines. For example, a gambler might be presented frequently with four cherries when five cherries would result in a huge payout.The response to the near-miss in PG is often a sense that a big win is just around the corne........ Read more »

  • July 30, 2014
  • 11:24 AM
  • 221 views

Violent Death Rates Increased After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Anecdotal reports have linked traumatic brain injury with later violent death including death by suicide.Few large epidemiological studies have been published on this association.However, a recent Swedish population study published in JAMA Psychiatry provides valuable insight into this issue.Seena Fazel and colleagues from the University of Oxford, University College London and the Karolinksa Institute examined a large database of over 200,000 patients with TBI.Cases of TBI were identified from ........ Read more »

  • July 29, 2014
  • 11:17 AM
  • 264 views

Treating Sleep Problems Following Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Sleep problems are common following traumatic brain injury (TBI).In a previous post, I reviewed a study of the risk factors for sleep disorders following TBI.The most severe TBI is a risk factor for hypersomnia. Anxiety and depression following TBI increase risk for insomnia complaints.Few large studies of treatment for sleep problems after TBI exist. However, a recent manuscript outlined the potential benefit of treatment of sleep disorders in a series of 12 subjects.Catherine Wiseman-Hake........ Read more »

  • July 25, 2014
  • 11:02 AM
  • 266 views

Risk Factors For Sleep Disturbance After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Sleep disturbance following traumatic brain injury (TBI) is a common clinical challenge.Hypersomnia and insomnia can both been seen in the TBI population.The risk factors related to TBI-related sleep disturbance are not well known. Identification of risk factors can provide insight into clinical assessment and management.Lijun Hou and colleagues recently examined risk factors related to subjective sleep complaints in a series of 98 TBI subjects.The study sample include adults admitted to a ........ Read more »

  • July 14, 2014
  • 10:44 AM
  • 217 views

Cognitive Reserve Boosts Traumatic Brain Injury Recovery

by William Yates, M.D. in Brain Posts

Cognitive reserve (high educational attainment, high IQ) is known to reduce or delay the risk for Alzheimer's disease.However, the effect of cognitive reserve on recovery from traumatic brain injury (TBI) is less well studied.Two recent research studies support the beneficial effects of cognitive reserve on TBI.Schneider and colleagues examined a series of 769 adult TBI subjects using the TBI Model Systems Database.This cohort was followed during rehabilitation for a period of at least one year......... Read more »

Schneider EB, Sur S, Raymont V, Duckworth J, Kowalski RG, Efron DT, Hui X, Selvarajah S, Hambridge HL, & Stevens RD. (2014) Functional recovery after moderate/severe traumatic brain injury: a role for cognitive reserve?. Neurology, 82(18), 1636-42. PMID: 24759845  

  • July 9, 2014
  • 12:06 PM
  • 235 views

Brain Hippocampus Atrophy in Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Understanding the specific brain regions vulnerable to traumatic brain injury (TBI) is important for assessment and intervention research.Two areas of active research include studies of brain white matter using diffusion tensor imaging and assessment of regional brain atrophy using magnetic resonance imaging (MRI).Two recent MRI studies have suggested the brain hippocampus may be a region of vulnerability to TBI.A Canadian study by Robin Green and colleagues used brain MRI to examine a cohort of........ Read more »

Green RE, Colella B, Maller JJ, Bayley M, Glazer J, & Mikulis DJ. (2014) Scale and pattern of atrophy in the chronic stages of moderate-severe TBI. Frontiers in human neuroscience, 67. PMID: 24744712  

Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, Allen T, Teague TK, Nerio C, Polanski D.... (2014) Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA : the journal of the American Medical Association, 311(18), 1883-8. PMID: 24825643  

  • July 8, 2014
  • 11:15 AM
  • 236 views

Millions Lack Level I Trauma Care Access in the U.S.

by William Yates, M.D. in Brain Posts

Trauma results in 180,000 deaths per year in the U.S. and disproportionately affects children and young adults. The Centers for Disease Control (CDC) recently published a review highlighting unintentional injury and violence as the leading cause of death in the U.S. for those in the one to 30 year old age group. Additionally, trauma produces significant disability through residual effects such as like that often seen following traumatic brain injury.Trauma centers are hospital-affiliat........ Read more »

Haegerich, T., Dahlberg, L., Simon, T., Baldwin, G., Sleet, D., Greenspan, A., & Degutis, L. (2014) Prevention of injury and violence in the USA. The Lancet, 384(9937), 64-74. DOI: 10.1016/S0140-6736(14)60074-X  

Garwe T, Cowan LD, Neas B, Cathey T, Danford BC, & Greenawalt P. (2010) Survival benefit of transfer to tertiary trauma centers for major trauma patients initially presenting to nontertiary trauma centers. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(11), 1223-32. PMID: 21175521  

Bukur M, Felder SI, Singer MB, Ley EJ, Malinoski DJ, Margulies DR, & Salim A. (2013) Trauma center level impacts survival for cirrhotic trauma patients. The journal of trauma and acute care surgery, 74(4), 1133-7. PMID: 23511156  

MacKenzie, E., Weir, S., Rivara, F., Jurkovich, G., Nathens, A., Wang, W., Scharfstein, D., & Salkever, D. (2010) The Value of Trauma Center Care. The Journal of Trauma: Injury, Infection, and Critical Care, 69(1), 1-10. DOI: 10.1097/TA.0b013e3181e03a21  

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