116 posts · 93,788 views
BodyInMind looks at the relationship between the body, the brain and the mind and how they interact particularly in chronic and complex pain disorders. Lorimer Moseley and collaborators explore how the mind influences physiological regulation of the body and how we can teach people about it all in a way that is both interesting and accurate.
BodyInMind
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- April 15, 2010
- 05:00 PM
- 1,965 views
When the pain of carpal tunnel syndrome spreads, we should be thinking dorsal horn not malingering
by Lorimer Moseley in BodyInMind
Here is an important study. A couple of Italian Neurologists have investigated people with carpal tunnel syndrome who report that their pain has spread beyond the boundaries of the median nerve. Unfortunately, such reports are often misinterpreted by clinicians as evidence of malingering, or hysteria. Well, these fellows did quantitative sensory testing and came up [...]... Read more »
[1] Caliandro P, La Torre G, Aprile I, Pazzaglia C, Commodari I, Tonali P, & Padua L. (2006) Distribution of paresthesias in Carpal Tunnel Syndrome reflects the degree of nerve damage at wrist. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 117(1), 228-31. PMID: 16325467
[2] Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, & Porreca F. (2000) Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain, 86(1-2), 185-94. PMID: 10779675
[3] Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, & Serra J. (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, 70(18), 1630-5. PMID: 18003941
[4] Wilder-Smith EP, Ng ES, Chan YH, & Therimadasamy AK. (2008) Sensory distribution indicates severity of median nerve damage in carpal tunnel syndrome. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 119(7), 1619-25. PMID: 18467170
[5] Zanette G, Marani S, & Tamburin S. (2006) Extra-median spread of sensory symptoms in carpal tunnel syndrome suggests the presence of pain-related mechanisms. Pain, 122(3), 264-70. PMID: 16530966
[6] Zanette G, Marani S, & Tamburin S. (2007) Proximal pain in patients with carpal tunnel syndrome: a clinical-neurophysiological study. Journal of the peripheral nervous system : JPNS, 12(2), 91-7. PMID: 17565533
[7] Zanette G, Cacciatori C, & Tamburin S. (2010) Central sensitization in carpal tunnel syndrome with extraterritorial spread of sensory symptoms. Pain, 148(2), 227-36. PMID: 20004060
- February 24, 2011
- 07:43 AM
- 1,300 views
Does smoking hurt as well as harm? (or, as if you needed another reason)
by Lorimer Moseley in BodyInMind
TweetI have a couple of mates who are veritable smoke-stacks. They love smoking but sort of hate being a smoker. I must confess that, at least within my community, smoking is now officially uncool and my mates are sick of people telling them good reasons to give up. Well, as if they needed another reason, [...]... Read more »
Pisinger C, Aadahl M, Toft U, Birke H, Zytphen-Adeler J, & Jørgensen T. (2011) The association between active and passive smoking and frequent pain in a general population. European journal of pain (London, England), 15(1), 77-83. PMID: 20627783
- March 7, 2011
- 02:30 PM
- 1,249 views
Sadness, soreness and staying alert—all in the same place
by Lorimer Moseley in BodyInMind
Sadness, soreness and staying alert - are they all in the same place of the brain?... Read more »
Shackman AJ, Salomons TV, Slagter HA, Fox AS, Winter JJ, & Davidson RJ. (2011) The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature reviews. Neuroscience, 12(3), 154-67. PMID: 21331082
Dum RP, Levinthal DJ, & Strick PL. (2009) The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(45), 14223-35. PMID: 19906970
Kanske P, Heissler J, Schönfelder S, Bongers A, & Wessa M. (2010) How to Regulate Emotion? Neural Networks for Reappraisal and Distraction. Cerebral cortex (New York, N.Y. : 1991). PMID: 21041200
- January 8, 2010
- 04:00 PM
- 1,239 views
Stuart Derbyshire on I feel your pain
by Lorimer Moseley in BodyInMind
Several studies have demonstrated that people can share in the emotion of someone else’s pain. Typically, when seeing someone else injured, there is a tendency to share in the aversion and feel the unpleasantness of what is going on. But there have also been a few cases of people reporting not just a shared [...]... Read more »
Stuart Derbyshire. (2009) Stuart Derbyshire on I feel your pain. BodyInMind. info:/
- June 14, 2010
- 03:00 PM
- 1,163 views
Back Pain Myths Closing Sale Everything must go
by Lorimer Moseley in BodyInMind
Everyone knows all about low back pain. This is probably by virtue of the fact that most of us have or will experience it at some stage. Everyone is an expert, clinicians and patients alike and there are a whole host of accepted truths about back pain that we all cling on to. Ideas that [...]... Read more »
Claus A, Hides J, Moseley GL, & Hodges P. (2008) Sitting versus standing: does the intradiscal pressure cause disc degeneration or low back pain?. Journal of electromyography and kinesiology, 18(4), 550-8. PMID: 17346987
Claus AP, Hides JA, Moseley GL, & Hodges PW. (2009) Is 'ideal' sitting posture real? Measurement of spinal curves in four sitting postures. Manual therapy, 14(4), 404-8. PMID: 18793867
Roffey DM, Wai EK, Bishop P, Kwon BK, & Dagenais S. (2010) Causal assessment of occupational sitting and low back pain: results of a systematic review. The spine journal , 10(3), 252-61. PMID: 20097618
Roffey DM, Wai EK, Bishop P, Kwon BK, & Dagenais S. (2010) Causal assessment of occupational standing or walking and low back pain: results of a systematic review. The spine journal , 10(3), 262-72. PMID: 20207335
- February 3, 2010
- 04:00 PM
- 1,149 views
Where is my back?
by Lorimer Moseley in BodyInMind
Chronic pain is associated with a loss of the normal capacity to know where your body is. Chronic pain is also associated with odd bodily feelings. To find out if people with chronic back pain had trouble ‘feeling’ their back, they were asked to draw on a piece of paper the outline of where they felt [...]... Read more »
Lorimer Moseley. (2010) I can't find it!. BodyinMind. info:/
- December 12, 2010
- 02:05 PM
- 1,102 views
The painful legacy of torture
by Lorimer Moseley in BodyInMind
Torture has received a great deal of deserved media attention in recent years. In large part this is due to people who should know better somewhat shamelessly jumping through legal hoops in attempts to distinguish which ways of abusing their fellow humans are acceptable and distinct from torture. This should be surprising in the current [...]... Read more »
Williams AC, Peña CR, & Rice AS. (2010) Persistent pain in survivors of torture: a cohort study. Journal of pain and symptom management, 40(5), 715-22. PMID: 20678891
- July 8, 2010
- 04:00 PM
- 1,096 views
Time to brush up on your acting
by Lorimer Moseley in BodyInMind
We are lucky enough to have three rather clever and certainly friendly med students working on some research studies. This post is from Rahul – it is about a paper we thought was interesting. We wonder if there might be something in it for our quest for better treatments. Here’s Rahul- After a nauseating movie-going [...]... Read more »
Dowrick, P. (1999) A review of self modeling and related interventions. Applied and Preventive Psychology, 8(1), 23-39. DOI: 10.1016/S0962-1849(99)80009-2
- May 20, 2010
- 03:30 PM
- 1,068 views
Of mice and men – Jeff Mogil on grimacing
by Lorimer Moseley in BodyInMind
You have almost certainly noticed that we grimace when we are in pain. But have you thought about that – I mean really thought about it? Why grimace? Well, someone who clearly thinks about such things more than most is a fellow called Jeff Mogil – Professor of Pain Type Stuff at the very pain-posh [...]... Read more »
Langford, D., Bailey, A., Chanda, M., Clarke, S., Drummond, T., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.... (2010) Coding of facial expressions of pain in the laboratory mouse. Nature Methods. DOI: 10.1038/nmeth.1455
- December 8, 2010
- 03:00 PM
- 1,058 views
Low back pain – time we sang from the same song sheet
by Lorimer Moseley in BodyInMind
Is it possible that a lack of centralisation reflects a predominance of centralisation? Well, the undisputed wrestling champion of physical therapy is wrestling with this very topic, having been motivated by an intruiging paper. Fortunately for BiM, John kindly agreed to write a post on it. Here it is: Here is a riddle for you. [...]... Read more »
Werneke, M., & Hart, D. (2005) Centralization: Association between repeated end-range pain responses and behavioral signs in patients with acute non-specific low back pain. Journal of Rehabilitation Medicine, 37(5), 286-290. DOI: 10.1080/16501970510032901
- September 9, 2010
- 08:00 AM
- 1,055 views
World Congress on Pain throws up a few gems
by Lorimer Moseley in BodyInMind
I have just been in Montreal for the World Congress on Pain – numerous presentations and about 1600 posters. It is the posters I really like – can be intimidating but there are always a few gems. Here is some preliminary work that I thought was interesting and which is relevant to work that our [...]... Read more »
Van Damme S, Gallace A, Spence C, Crombez G, & Moseley GL. (2009) Does the sight of physical threat induce a tactile processing bias? Modality-specific attentional facilitation induced by viewing threatening pictures. Brain research, 100-6. PMID: 19094970
- April 26, 2010
- 05:14 PM
- 1,054 views
Five questions you should ask a patient in pain
by Lorimer Moseley in BodyInMind
I recently did a talk for a bunch of GP’s. The brief I got was to make the really tough task of assessing someone in pain a little easier – ‘Perhaps you could tell them which questions to ask’ were the exact words I think. So, here are the slides. I have tried to make [...]... Read more »
Moseley G Lorimer. (2007) Reconceptualising pain according to modern pain science. Physical Therapy Reviews, 12(3), 169-178. info:/
Moseley GL. (2003) A pain neuromatrix approach to patients with chronic pain. Manual therapy, 8(3), 130-40. PMID: 12909433
Treede, R., Jensen, T., Campbell, J., Cruccu, G., Dostrovsky, J., Griffin, J., Hansson, P., Hughes, R., Nurmikko, T., & Serra, J. (2008) Neuropathic pain: Redefinition and a grading system for clinical and research purposes. Neurology, 70(18), 1630-1635. DOI: 10.1212/01.wnl.0000282763.29778.59
- January 5, 2010
- 05:30 PM
- 1,046 views
Further evidence to suggest we should learn something novel every decade
by Lorimer Moseley in BodyInMind
I remember sitting my folks down and sternly counselling them to make sure they learnt a completely novel skill once per decade, to ensure that their brain doesn’t turn to mush. There is plenty of evidence to support such advice (well, aside from the ‘mush’ bit), but here is a new finding that adds to [...]... Read more »
Lorimer Moseley. (2010) Further evidence to suggest we should learn something novel every decade. BodyinMind. info:/
- October 28, 2010
- 08:00 AM
- 1,044 views
Introducing DAMIEN – the brain’s default mode network
by Lorimer Moseley in BodyInMind
Numerous studies involving functional magnetic resonance imaging (fMRI) of the brain, tell us that chronic back pain (CBP) alters brain function well beyond the feeling of pain and can cause impairments like depression, impaired decision-making and sleep disturbance [1,2]. It was Baliki’s group in 2008 which confirmed for the first time that CBP disrupts the [...]... Read more »
[1] Apkarian AV, Sosa Y, Krauss BR, Thomas PS, Fredrickson BE, Levy RE, Harden RN, & Chialvo DR. (2004) Chronic pain patients are impaired on an emotional decision-making task. Pain, 108(1-2), 129-36. PMID: 15109516
[2] Baliki MN, Geha PY, Apkarian AV, & Chialvo DR. (2008) Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(6), 1398-403. PMID: 18256259
[3] Beckmann, C., DeLuca, M., Devlin, J., & Smith, S. (2005) Investigations into resting-state connectivity using independent component analysis. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1457), 1001-1013. DOI: 10.1098/rstb.2005.1634
[4] Craig AD. (2009) How do you feel--now? The anterior insula and human awareness. Nature reviews. Neuroscience, 10(1), 59-70. PMID: 19096369
- June 2, 2010
- 06:11 PM
- 1,040 views
Acupuncture, Adenosine and Cycling Fish
by Lorimer Moseley in BodyInMind
You may have heard this story as it is all over the popular press right now. We are told that scientists have discovered some of the mechanisms underlying acupuncture analgesia. As always with alternative therapy reports the media have enthusiastically bitten off the hand of the press release (see this great account from the blog [...]... Read more »
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X.... (2010) Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nature neuroscience. PMID: 20512135
Madsen, M., Gotzsche, P., & Hrobjartsson, A. (2009) Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups. BMJ, 338(jan27 2). DOI: 10.1136/bmj.a3115
- January 1, 2010
- 05:00 PM
- 1,031 views
Benedict Wand on Brain Changes in Chronic Pain
by Lorimer Moseley in BodyInMind
It now seems clear that the brain changes in patients with chronic pain problems. However, this is probably where the consensus ends as there is still much that remains unclear and speculative in this area. This elegant study by Rodriguez-Raecke and colleagues from the University of Hamburg (abstract at the end of this article) investigate [...]... Read more »
Benedict Wand. (2009) Benedict Wand on Brain Changes in Chronic Pain. BodyInMind. info:other/
- February 21, 2011
- 02:20 PM
- 1,030 views
Comments from the Lager Man – is NMDAr upregulation 4ever
by Lorimer Moseley in BodyInMind
TweetA little while ago, Paul Lagerman said this: “…. I was speaking to a colleague of mine who is a pain specialist and we were discussing central sensitisation. As I understand it there is a genetic change in the cell nucleus which causes an increase in the embedding of NMDA receptors in the cell synapse, oh [...]... Read more »
Petrenko, A., Yamakura, T., Baba, H., & Shimoji, K. (2003) The Role of N-Methyl-d-Aspartate (NMDA) Receptors in Pain: A Review. Anesthesia , 1108-1116. DOI: 10.1213/01.ANE.0000081061.12235.55
Scheetz AJ, & Constantine-Paton M. (1994) Modulation of NMDA receptor function: implications for vertebrate neural development. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 8(10), 745-52. PMID: 8050674
- July 5, 2010
- 06:06 AM
- 1,021 views
Large flat whites taste stronger than regular flat whites
by Lorimer Moseley in BodyInMind
Australia is, I think, the home of the Flat White – a coffee that is a bit like a latte with less milk and that has quite recently started infiltrating the UK coffee scene. Of course, Monmouth at Borough Market has been doing a very good flat white for a few years, but then again, [...]... Read more »
Crisinel AS, & Spence C. (2010) A sweet sound? Food names reveal implicit associations between taste and pitch. Perception, 39(3), 417-25. PMID: 20465176
- August 3, 2010
- 08:00 AM
- 1,019 views
Is CRPS an auto-immune disease
by Lorimer Moseley in BodyInMind
Intravenous Immunoglobulin in Complex Regional Pain Syndrome Andreas Goebel on the results of his latest clinical trial .Just imagine the causes of some chronic pains are completely different from what you had thought. Complex Regional Pain Syndrome is a severe pain which persists after limb trauma. You are unlucky if you develop this nasty condition, [...]... Read more »
[1] Goebel A, Baranowski A, Maurer K, Ghiai A, McCabe C, & Ambler G. (2010) Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial. Annals of internal medicine, 152(3), 152-8. PMID: 20124231
- September 27, 2010
- 02:30 PM
- 1,013 views
The Brain Private Fort or Social Arena?
by Lorimer Moseley in BodyInMind
Mirror neurons are famous. Some would argue that they are too famous for their own good, others would say that they are the biggest discovery since Dennis Lillee got caught with an aluminium cricket bat. Well now we are realising that they are not just about movement – here Shikta Dey talks about an interesting [...]... Read more »
Rizzolatti, G., & Craighero, L. (2004) The Mirror-Neuron System. Annual Review of Neuroscience, 27(1), 169-192. DOI: 10.1146/annurev.neuro.27.070203.144230
[2] Keysers C, Kaas JH, & Gazzola V. (2010) Somatosensation in social perception. Nature reviews. Neuroscience, 11(6), 417-28. PMID: 20445542
[3] Moseley GL, Olthof N, Venema A, Don S, Wijers M, Gallace A, & Spence C. (2008) Psychologically induced cooling of a specific body part caused by the illusory ownership of an artificial counterpart. Proceedings of the National Academy of Sciences of the United States of America, 105(35), 13169-73. PMID: 18725630
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