96 posts · 67,417 views
denialism blog
24 posts
Science-Based Medicine
13 posts
White Coat Underground
59 posts
IM Notes
0 posts
Sort by Latest Post, Most Popular
View by Condensed, Full
- August 25, 2011
- 03:00 PM
- 1,920 views
When a “scientific study” is neither
by Peter Lipson in Science-Based Medicine
There is quite a bit of art to the practice of medicine: knowing how to get and to give information to a patient, how to create a sense of worry without creating a feeling of panic, how to use the best available science to help them maintain or return to health. Underlying all of the [...]... Read more »
Jain S, Pavlik D, Distefan J, Bruyere RR, Acer J, Garcia R, Coulter I, Ives J, Roesch SC, Jonas W.... (2011) Complementary medicine for fatigue and cortisol variability in breast cancer survivors: A Randomized Controlled Trial. Cancer. PMID: 21823103
- August 27, 2008
- 07:32 PM
- 1,604 views
Where do you get your mercury?
by PalMD in denialism blog
The Infectious Disease Promotion Movement (let by such intellectual luminaries as Jenny McCarthy) may be worried about "toxins" in vaccines, but the real problem may hiding in plain sight.
Today's issue of JAMA has an interesting study of Ayurvedic (traditional Indian) medicines. It turns out that many of them contain a significant amount of toxic heavy metals. Read the rest of this post... | Read the comments on this post...... Read more »
Robert Saper, & et al. (2008) Lead, Mercury, and Arsenic in US- and Indian-Manufactured Ayurvedic Medicines Sold via the Internet. Journal of the American Medical Association, 300(8), 915-923. http://jama.ama-assn.org/cgi/content/full/300/8/915
- March 27, 2009
- 03:03 PM
- 1,544 views
The kindest cut?
by Peter Lipson in Science-Based Medicine
The best way to prevent sexually transmitted infections is the proper use of condoms. That being said, it’s not the only way to prevent STI’s. Abstinence is one way, but it involves an amputation of sorts—the removal of a critical human behavior. Another amputation (of sorts) that prevents STIs is circumcision. [...]... Read more »
Aaron A.R. Tobian, M.D., Ph.D., David Serwadda, M.Med., M.P.H., Thomas C. Quinn, M.D., M.Sc., Godfrey Kigozi, M.B., Ch.B., M.P.H., Patti E. Gravitt, Ph.D., Oliver Laeyendecker, M.S., M.B.A., Blake Charvat, M.Sc., Victor Ssempijja, B.Stat., Melissa Riedese. (2009) Male Circumcision for the Prevention of HSV-2 and HPV Infections and Syphilis. The New England Journal of Medicine, 360(13), 1298-1309. DOI: http://content.nejm.org/cgi/content/full/360/13/1298
FINK, K., CARSON, C., & DEVELLIS, R. (2002) Adult Circumcision Outcomes Study: Effect on Erectile Function, Penile Sensitivity, Sexual Activity and Satisfaction. The Journal of Urology, 167(5), 2113-2116. DOI: 10.1016/S0022-5347(05)65098-7
- October 4, 2008
- 06:04 PM
- 1,510 views
Exciting news on the HIV front
by PalMD in denialism blog
In my earlier post about HIV therapy (a post I strongly recommend), I wrote, "After entering a cell (never mind how for now), HIV needs to find a way to makes copies of itself, which requires DNA." Because of some recently released data, it's time to look at how HIV enters the cell, and to expand a bit on the biology of HIV infection (but this is really a "Part II" so please refer to the above-linked post, even though this should stand on its own). This will also allow us another glimpse into how real science works. proceeding from observation, though hypothesis, and hypothesis testing.
Once again, as in all of my science-y posts, please forgive any oversimplification. Read the rest of this post... | Read the comments on this post...... Read more »
Roy M. Gulick, M.D., Jacob Lalezari, M.D., James Goodrich, M.D., Ph.D., Nathan Clumeck, M.D., Ph.D.,, Edwin DeJesus, M.D., Andrzej Horban, M.D., Ph.D., Jeffrey Nadler, M.D., Bonaventura Clotet, M.D., Ph.D.,, Anders Karlsson, Ph.D., Michael Wohlfeiler, M.D., John B. Montana, M.D., Mary McHale, M.B., B.S., M.R.C., John Sullivan, B.Sc., Caroline Ridgway, M.Sc., Steve Felstead, M.B., Ch.B., Michael W. Dunne, M.D.,, & Elna van der Ryst, M.B., Ch.B., Ph.D., and Howard Mayer, M.D., for the MOTIVATE Study Teams*. (2008) Maraviroc for Previously Treated Patients with R5 HIV-1 Infection. New England Journal of Medicine, 359(14), 1429-1441. DOI: http://content.nejm.org/cgi/content/full/359/14/1429
Gerd Fätkenheuer, M.D., Mark Nelson, F.R.C.P., Adriano Lazzarin, M.D., Irina Konourina, M.D., Andy I.M. Hoepelman, M.D., Ph.D., Harry Lampiris, M.D., Bernard Hirschel, M.D., Pablo Tebas, M.D., François Raffi, M.D., Ph.D., Benoit Trottier, M.D., Nicholao. (2008) Subgroup Analyses of Maraviroc in Previously Treated R5 HIV-1 Infection. New England Journal of Medicine, 359(14), 1442-1455. DOI: http://content.nejm.org/cgi/content/short/359/14/1442
- July 29, 2008
- 02:02 PM
- 1,362 views
I get questions...
by PalMD in denialism blog
I frequently get questions by email or by comment. If it's simple, I might fire off an answer. If it's about a personal medical problem, I either don't answer, or send a standard disclaimer to seek medical care. If it's a really interesting question, I blog. Today, I blog.
The question regarded the ubiquitous commercials for erectile dysfunction treatments (see this excellent post for an overview of the topic of ED drugs). As anyone who has a TV knows, the commercials always have the pleasant warning of "if you have an erection lasting more than four hours, seek immediate medic... Read more »
James Taylor, Vikki G Nolan, Laurel Mendelsohn, Gregory J Kato, Mark T Gladwin, Martin H Steinberg, & Pieter H Reitsma. (2008) Chronic Hyper-Hemolysis in Sickle Cell Anemia: Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain. PLoS ONE, 3(5). DOI: 10.1371/journal.pone.0002095
V Nolan. (2005) Hemolysis-associated priapism in sickle cell disease. Blood, 106(9), 3264-3267. DOI: 10.1182/blood-2005-04-1594
Arthur Burnett. (2006) Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism . Urology, 67(5), 1043-1048.
- February 6, 2009
- 11:06 AM
- 1,350 views
The editors of PLoS should read PLoS
by PalMD in denialism blog
What do this cartoon and the latest edition of PLoS One have in common? Well, reading Bora's blog this week I saw an article entitled, Risks for Central Nervous System Diseases among Mobile Phone Subscribers: A Danish Retrospective Cohort Study and my ears perked up. We have been mocking the idea that cell phones cause everything from brain cancer to colony collapse disorder and it's always fun to see what cell phones are being blamed for based on weak associations and correlations.
In this article the authors identified more than four hundred thousand cell phone subscribers and linked their cell phone use to their medical records in the Danish Hospital Discharge Registry which has collected records of hospitalizations since 1977. They then tried to identify an association between cell phone use and various CNS disorders over the last few decades. These disorders include epilepsy, ALS, vertigo, migraines, MS, Parkinsons and dementia, a broad spectrum of diseases with a variety of pathologies and causes. Basically, they're fishing. Well, what did they find? Read the rest of this post... | Read the comments on this post...... Read more »
Joachim Schüz, Gunhild Waldemar, Jørgen H. Olsen, & Christoffer Johansen. (2009) Risks for Central Nervous System Diseases among Mobile Phone Subscribers: A Danish Retrospective Cohort Study. PLoS ONE, 4(2). DOI: 10.1371/journal.pone.0004389
- November 21, 2008
- 02:10 PM
- 1,339 views
Ginkgo does not prevent dementia, or "I can't remember what NCCAM is good for"
by PalMD in denialism blog
Here's a question for you: is there, or should there be, any difference between studies of "alternative" and non-alternative medicine? I've argued before that there is no such thing as alternative medicine. So why do we need a separate agency to study "alternative" medicine? The National Center for Complementary and Alternative Medicine seems to be just such an agency. For example, the latest study of Gingko biloba for the prevention of dementia could have been funded by other agencies, such as NIMH. Why NCCAM? Read the rest of this post... | Read the comments on this post...... Read more »
Steven T. DeKosky, MD; Jeff D. Williamson, MD, MHS; Annette L. Fitzpatrick, PhD; Richard A. Kronmal, PhD; Diane G. Ives, MPH; Judith A. Saxton, MD; Oscar L. Lopez, MD; Gregory Burke, MD; Michelle C. Carlson, PhD; Linda P. Fried, MD, MPH; Lewis H. Kuller, . (2008) Ginkgo biloba for Prevention of Dementia. The Journal of the American Medical Association, 300(19), 2253-2262. DOI: http://jama.ama-assn.org/cgi/content/full/300/19/2253
- December 1, 2008
- 01:32 PM
- 1,301 views
Where do you get your mercury?
by PalMD in denialism blog
There is an ongoing discussion amongst our Sciblings regarding our German counterparts at scienceblogs.de. Apparently they have some odd folks as science bloggers over there, including people who think ayurvedic heavy metals are good for you. In the tradition of countering speech with speech, I'm giving you this repost. More to come, I'm sure. --PalMD
The Infectious Disease Promotion Movement (let by such intellectual luminaries as Jenny McCarthy) may be worried about "toxins" in vaccines, but the real problem may hiding in plain sight.
Today's issue of JAMA has an interesting study of Ayurvedic (traditional Indian) medicines. It turns out that many of them contain a significant amount of toxic heavy metals. Read the rest of this post... | Read the comments on this post...... Read more »
Robert Saper, & et al. (2008) Lead, Mercury, and Arsenic in US- and Indian-Manufactured Ayurvedic Medicines Sold via the Internet. Journal of the American Medical Association, 300(8), 915-923. http://jama.ama-assn.org/cgi/content/full/300/8/915
- April 23, 2008
- 08:02 PM
- 1,299 views
Domestic violence is bad for your health
by PalMD in denialism blog
A new study this month in The Lancet examined the health impact of domestic violence (of women by men). This was a very large WHO-funded study looking at multiple physical and mental health problems in abused vs. non-abused women. This is necessarily an observational study, but appears to be well done, and included a large and diverse sample of women.
A few findings are worth a specific mention.
First, intimate partner violence is very common across cultures, with numbers ranging from 15-71% of women who had ever been partnered with a man.
Next, mental health probl... Read more »
Mary Ellsberg, Henrica Jansen, & et al. (2008) Intimate partner violence and women\'s physical and mental health in the WHO multi-country study on women\'s health and domestic violence: an observational study. The Lancet, 371(9619), 1165-1172.
- March 31, 2008
- 01:11 PM
- 1,278 views
Hey! Look! Science works! Zetia, not so much.
by PalMD in denialism blog
I love this story because it shows how evidence-based medicine works, even in the face of corporate greed.
A while back I told you about a cholesterol study with negative results; that is, it failed to show a drug to be helpful. Intimately entwined with the study design was a potential conflict of interest on the part of the drug company, but science won out---data, after all, is data.
Then, few months ago, another set of (preliminary) cholesterol data was released by Merck and Schering-Plough, after much prodding, regarding their drugs Vytorin and Zetia.
Zetia has ... Read more »
J Kastelein, F Akdim, E SG Stroes, A H Zwinderman, M L Bots, A FH Stalenhoef, F LJ Visseren, E JG Sijbrands, M D Trip, E A Stein.... (2008) Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia. New England Journal of Medicine, 358(14), 1431-1443. DOI: 10.1056/NEJMoa0800742
C Jackevicius, J V Tu, J S Ross, D T Ko, & H M Krumholz. (2008) Use of Ezetimibe in the United States and Canada. New England Journal of Medicine. DOI: 10.1056/NEJMsa0801461
- June 9, 2009
- 03:27 PM
- 1,242 views
What is disease? Diabetes, diagnosis, and real science
by Peter Lipson in Science-Based Medicine
One of the concepts we often discuss around here is “what is disease?” As we’ve seen in the discussion of Lyme disease and so-called Morgellons syndrome, this is not always an easy question to answer. Knowing what states are disease states does not always yield a black-or-white answer. The first step is [...]... Read more »
The International Expert Committee. (2009) International Expert Committee Report on the Role of the A1C Assay in the Diagnosis of Diabetes. Diabetes Care. DOI: 10.2337/dc09-9033
- December 4, 2008
- 05:50 PM
- 1,227 views
tobacco and mental illness
by PalMD in denialism blog
Anyone who works with the mentally ill knows that they smoke more than other people. In fact, people with mental illness (hereafter, MI, not to be confused with myocardial infarction) are about twice as likely to smoke as people without mental illness, with smoking rates of 60-90%. One of my favorite stats is that "44% of the cigarettes smoked in the United States are by individuals with a psychiatric or substance-abuse disorder." People with MI are also heavier smokers, and may even be better at extracting nicotine from the cigs that they smoke.
Studies have shown that people with MI can in fact quit, but from a front line perspective, this is really, really tough. In fact, quit rates aren't all that great for people without the added burden of mental illness, so any barriers to quitting are formidable ones.
The reasons for high smoking rates in schizophrenics and others with serious mental illness are both socio-psychological and physiologic, with nicotine acting on CNS nicotine receptors and dopamine pathways. Smoking is sometimes viewed as a form of "self-medication", but it can be difficult to differentiate the symptoms of nicotine withdrawal from symptoms attributable to the pre-existing mental illness. Read the rest of this post... | Read the comments on this post...... Read more »
Karen Lasser, MD; J. Wesley Boyd, MD, PhD; Steffie Woolhandler, MD, MPH; David U. Himmelstein, MD; Danny McCormick, MD, MPH; David H. Bor, MD. (2000) Smoking and Mental Illness: A Population-Based Prevalence Study . The Journal of the American Medical Association, 284(20), 2606-2610. DOI: http://jama.ama-assn.org/cgi/content/full/284/20/2606
Nady el-Guebaly, M.D., Janice Cathcart, B.S.N., M.Ed., Shawn Currie, Ph.D., Diane Brown, R.N. and Susan Gloster, R.N., B.N. (2002) Smoking Cessation Approaches for Persons With Mental Illness or Addictive Disorders . Psychiatric Services, 53(9), 1166-1170. DOI: 12221317
J WILLIAMS. (2004) Addressing tobacco among individuals with a mental illness or an addiction. Addictive Behaviors, 29(6), 1067-1083. DOI: 10.1016/j.addbeh.2004.03.009
- May 18, 2009
- 08:05 AM
- 1,127 views
Denialism in the Literature
by PalMD in denialism blog
It's good news though! A description of the tactics and appropriate response to denialism was published in the European Journal of Public Health by authors Pascal Diethelm and Martin McKee. It's entitled "Denialism: what is it and how should scientists respond?" and I think it does an excellent job explaining the harms of deniailsm, critical elements of denialism, as well as providing interesting historical examples of corporate denialism on the part of tobacco companies.
HIV does not cause AIDS. The world was created in 4004 BCE. Smoking does not cause cancer. And if climate change is happening, it is nothing to do with man-made CO2 emissions. Few, if any, of the readers of this journal will believe any of these statements. Yet each can be found easily in the mass media.
The consequences of policies based on views such as these can be fatal. Thabo Mbeki's denial that that HIV caused AIDS prevented thousands of HIV positive mothers in South Africa receiving anti-retrovirals so that they, unnecessarily, transmitted the disease to their children.1 His health minister, Manto Tshabalala-Msimang, famously rejected evidence of the efficacy of these drugs, instead advocating treatment with garlic, beetroot and African potato. It was ironic that their departure from office coincided with the award of the Nobel Prize to Luc Montagnier and Françoise Barré-Sinoussi for their discovery that HIV is indeed the case of AIDS. The rejection of scientific evidence is also apparent in the popularity of creationism, with an estimated 45% of Americans in 2004 believing that God created man in his present form within the past 10 000 years.2 While successive judgements of the US Supreme Court have rejected the teaching of creationism as science, many American schools are cautious about discussing evolution. In the United Kingdom, some faith-based schools teach evolution and creationism as equally valid 'faith positions'. It remains unclear how they explain the emergence of antibiotic resistance.
In particular I found their inclusion of a tactic of inversionism interesting: Read the rest of this post... | Read the comments on this post...... Read more »
Diethelm, P., & McKee, M. (2008) Denialism: what is it and how should scientists respond?. The European Journal of Public Health, 19(1), 2-4. DOI: 10.1093/eurpub/ckn139
- October 27, 2008
- 05:10 PM
- 1,043 views
Do physicians really believe in placebos?
by PalMD in denialism blog
This article is cross-posted at Science-Based Medicine. Check it out. --PalMD
In a previous post, I argued that placebo is an artifact of certain clinical interactions, rather than a treatment that we can exploit. Apparently, there are a whole lot of doctors out there who don't agree with me. Or are there?
A recent study published in the British Medical Journal is getting
a lot of enk (e-ink) in the blogosphere. As a practicing internist, I have some pretty strong opinions (based in fact, of course) about both this study and placebos in general.
The Study
The current BMJ study defines placebo as "positive clinical outcomes caused by a treatment that is not attributable to its known physical properties or mechanism of action." I've got a lot of problems with this definition, but we'll get to that later. It also allowed physiologically active medications to "count" as placebos. Oops.
Read the rest of this post... | Read the comments on this post...... Read more »
J. C Tilburt, E. J Emanuel, T. J Kaptchuk, F. A Curlin, & F. G Miller. (2008) Prescribing "placebo treatments": results of national survey of US internists and rheumatologists. BMJ, 337(oct23 2). DOI: 10.1136/bmj.a1938
T. J Kaptchuk, J. M Kelley, L. A Conboy, R. B Davis, C. E Kerr, E. E Jacobson, I. Kirsch, R. N Schyner, B. H. Nam, L. T Nguyen.... (2008) Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ, 336(7651), 999-1003. DOI: 10.1136/bmj.39524.439618.25
A Hróbjartsson. (2002) What are the main methodological problems in the estimation of placebo effects?. Journal of Clinical Epidemiology, 55(5), 430-435. DOI: 10.1016/S0895-4356(01)00496-6
- November 24, 2009
- 02:45 PM
- 1,022 views
Cannabis and cancer cachexia
by PalMD in White Coat Underground
One of the most frightening symptoms of advanced cancer is "cachexia", or severe, unintentional weight-loss and wasting. It's a terrible prognostic sign, and the only truly effective treatment is removal of the cancer. Treatment of this syndrome has the potential to improve quality of life in patients with advanced cancers. Various types of medications, including antidepressants, hormones, and cannabis derivatives have been tried with little effect. Treating the symptoms of incurable cancers is difficult and although we're pretty good at it, we sometimes fail. Cannabis seems a plausible intervention, given the anecdotal and clinical data associating it with increased appetite, although appetite in normal, healthy individuals may be mediated by different pathways than the cachexia in cancer patients. Still, it's worthy of investigation. Read the rest of this post... | Read the comments on this post...... Read more »
Strasser, F. (2006) Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabi. Journal of Clinical Oncology, 24(21), 3394-3400. DOI: 10.1200/JCO.2005.05.1847
- June 30, 2009
- 03:00 PM
- 1,016 views
I get mail–chiroquacktic edition
by Peter Lipson in Science-Based Medicine
A long while back, at the original wordpress incarnation of my usual blog, I wrote a piece on the reasons that chiropractic is unscientific nonsense. Because it was popular, I resurrected it. Well, a chiropractor has come to bravely defend his field and left me a comment.
A study in the May 2007 issue [...]... Read more »
SARNAT, R., WINTERSTEIN, J., & CAMBRON, J. (2007) Clinical Utilization and Cost Outcomes From an Integrative Medicine Independent Physician Association: An Additional 3-Year Update. Journal of Manipulative and Physiological Therapeutics, 30(4), 263-269. DOI: 10.1016/j.jmpt.2007.03.004
SARNAT, R., & WINTERSTEIN, J. (2004) Clinical and Cost Outcomes of an Integrative Medicine IPA. Journal of Manipulative and Physiological Therapeutics, 27(5), 336-347. DOI: 10.1016/j.jmpt.2004.04.007
- August 20, 2008
- 10:15 AM
- 1,012 views
Seeding trials---no relation to Seed Media Group, LLC
by PalMD in denialism blog
I've been having an internal debate about whether to write on this issue, not because it isn't interesting, not because it isn't important, but because it's getting so much coverage and I'm not sure how much I can add to the conversation.
But it so infuriated me that I must blog. Science-based medicine relies on medical evidence. It relies on being able to grade medical evidence by its quality and strength, and to do this, there must be a certain level of transparency.
I'm only a little bit idealistic. I know that drug companies must fund clinical trials if we ever want to see new drugs. That is why we have "conflict of interest" statements included in most medical studies---so that we may view the data with a somewhat jaundiced eye, if necessary.
Until two days ago, I'd never heard of a "seeding trial". Now I have, and I'm not happy. Read the rest of this post... | Read the comments on this post...... Read more »
Kevin P. Hill, MD, MHS; Joseph S. Ross, MD, MHS; David S. Egilman, MD, MPH; and Harlan M. Krumholz, MD, SM. (2008) The ADVANTAGE Seeding Trial: A Review of Internal Documents. Annals of Internal Medicine, 149(4), 251-258.
- October 7, 2010
- 12:46 PM
- 985 views
Do you have low T?
by Peter Lipson in Science-Based Medicine
If you google “low testosterone” you’ll see lots of ads for testosterone replacement. Some are from pharmaceutical companies that sell testosterone, others from obvious snake-oil salesmen.
Both types of ads list vague sets of symptoms, encourage you to believe that they are pathologic, and want to sell you something to make you better. For example, the [...]... Read more »
Corona, G., Mannucci, E., Ricca, V., Lotti, F., Boddi, V., Bandini, E., Balercia, G., Forti, G., & Maggi, M. (2009) The age-related decline of testosterone is associated with different specific symptoms and signs in patients with sexual dysfunction. International Journal of Andrology, 32(6), 720-728. DOI: 10.1111/j.1365-2605.2009.00952.x
Spetz, A., Palmefors, L., Skobe, R., Str??mstedt, M., Fredriksson, M., Theodorsson, E., & Hammar, M. (2007) Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population. Menopause. DOI: 10.1097/gme.0b013e318057786b
Allan, C., Forbes, E., Strauss, B., & McLachlan, R. (2008) Testosterone therapy increases sexual desire in ageing men with low–normal testosterone levels and symptoms of androgen deficiency. International Journal of Impotence Research, 20(4), 396-401. DOI: 10.1038/ijir.2008.22
Reyes-Vallejo, L., Lazarou, S., & Morgentaler, A. (2007) Subjective Sexual Response to Testosterone Replacement Therapy Based on Initial Serum Levels of Total Testosterone. The Journal of Sexual Medicine, 4(6), 1757-1762. DOI: 10.1111/j.1743-6109.2006.00381.x
Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM, & Task Force, Endocrine Society. (2010) Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism, 95(6), 2536-59. PMID: 20525905
Araujo, A., Esche, G., Kupelian, V., O'Donnell, A., Travison, T., Williams, R., Clark, R., & McKinlay, J. (2007) Prevalence of Symptomatic Androgen Deficiency in Men. Journal of Clinical Endocrinology , 92(11), 4241-4247. DOI: 10.1210/jc.2007-1245
- June 3, 2010
- 03:00 AM
- 952 views
Narcotic treatment contracts and the state of the evidence
by Peter Lipson in Science-Based Medicine
Opium derivatives—and later, synthetic opioids—have probably been used for millennia for the relief of pain. Given human biology, they’ve probably been abused for just as long. Opiate use disorders are a daily fact for primary care physicians; the use of these drugs has become more and more common for chronic non-cancer pain. [...]... Read more »
Starrels JL, Becker WC, Alford DP, Kapoor A, Williams AR, & Turner BJ. (2010) Systematic review: treatment agreements and urine drug testing to reduce opioid misuse in patients with chronic pain. Annals of internal medicine, 152(11), 712-20. PMID: 20513829
- November 22, 2010
- 04:26 PM
- 943 views
Omega-3′s and heart disease: where’s the evidence?
by PalMD in White Coat Underground
Omega-3 fatty acids (more properly called “n-3 fatty acids”) are a group of naturally occurring fat molecules. They are found mainly in fish and other marine-derived oils, but some can also be extracted from plants. Omega-3′s are currently very popular, but the evidence for their usefulness isn’t so clear. A recent study failed to [...]... Read more »
Kromhout, D., Giltay, E., & Geleijnse, J. (2010) n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction. New England Journal of Medicine, 363(21), 2015-2026. DOI: 10.1056/NEJMoa1003603
topics
join us!
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
News
Editor's Selections: Programmed cell death in unicellular parasites, a novel gene transfer agent from Baronella, and full-contact herpes gladiatorum
Editor's Selections: Family medical histories, a grave in the Bahamas, medieval malaria, and macaques
Editor's Selections: Blood Tests for Depression, the Axolotl, Dopamine, and The Bachelor
