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Susan Steinhardt
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by Susan Steinhardt in BioData Blogs
Scientist and blogger Gianpaolo Rando is BioData Blogs Featured Scientist for the month of April.
Tell us about your first encounter with science
I was 12: I was a strong reader and a loyal fellow of the civic library. Books being the main source of my knowledge, I thought everything in the world had already been discovered. At the beginning of the school year, my new science teacher introduced a small aquarium to the classroom. He put in a mug full of water from a waterhole and asked the cl........ Read more »
Rando, G., Horner, D., Biserni, A., Ramachandran, B., Caruso, D., Ciana, P., Komm, B., & Maggi, A. (2010) An Innovative Method to Classify SERMs Based on the Dynamics of Estrogen Receptor Transcriptional Activity in Living Animals. Molecular Endocrinology, 24(4), 735-744. DOI: 10.1210/me.2009-0514
by Susan Steinhardt in BioData Blogs
Uri Alon, a PI in the Weizmann Institute in Rehovot, Israel, recently published an article in Molecular Cell where he discusses how to build a motivated research group.
Motivation in a research group is very important as that is the way that work actually gets done. Its not enough to go uninspired through the motions and conduct experiments because if it doesn’t work out – what is going to push you to keep trying? I personally have spoken to many involved in research asking what i........ Read more »
Alon, U. (2010) How to Build a Motivated Research Group. Molecular Cell, 37(2), 151-152. DOI: 10.1016/j.molcel.2010.01.011
by Susan Steinhardt in BioData Blogs
In June I commented on the autism - vaccine controversy and the role that Oprah had in promoting it. Seven moths later, I am revisiting this issue. 12 years ago, Andrew Wakefield and his colleagues first published his findings in The Lancet providing ‘evidence’ suggesting they had tracked down a shocking cause of autism – that being the MMR Vaccine. Last week The Lancet published a retraction of Wakefield’s paper stating that “it has become clear that several elements of the 1998 paper........ Read more »
WAKEFIELD, A., MURCH, S., ANTHONY, A., LINNELL, J., CASSON, D., MALIK, M., BERELOWITZ, M., DHILLON, A., THOMSON, M., & HARVEY, P. (1998) Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. The Lancet, 351(9103), 637-641. DOI: 10.1016/S0140-6736(97)11096-0
The Editors of The Lancet, . (2010) Retraction—Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. The Lancet, 375(9713), 445-445. DOI: 10.1016/S0140-6736(10)60175-4
by Susan Steinhardt in BioData Blogs
Laboratory notebooks are essential for reproducing experiments. For years we have been raised in our labs knowing that every action must be written down in our lab notebook.... Read more »
Service, R. (2009) A Dark Tale Behind Two Retractions. Science, 326(5960), 1610-1611. DOI: 10.1126/science.326.5960.1610
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of January 3, 2009.... Read more »
Zhang, K., Sha, J., & Harter, M. (2010) Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells. The Journal of Cell Biology. DOI: 10.1083/jcb.200904144
Meacham, L., Chow, E., Ness, K., Kamdar, K., Chen, Y., Yasui, Y., Oeffinger, K., Sklar, C., Robison, L., & Mertens, A. (2010) Cardiovascular Risk Factors in Adult Survivors of Pediatric Cancer--A Report from the Childhood Cancer Survivor Study. Cancer Epidemiology Biomarkers , 19(1), 170-181. DOI: 10.1158/1055-9965.EPI-09-0555
by Susan Steinhardt in BioData Blogs
All she needed to know to fall in love with molecular biology, Dr. Tora Smulders-Srinivasan learned at 15 years old, in her tenth grade biology class. While she had been aware of basic hereditary concepts, Tora hadn’t been exposed to DNA, genetics, RNA, translation, or transcription until then. In that classroom, Tora says, she fell in love. “I loved the whole idea of DNA. The fact that there is a molecule that transfers between generations – and that is what sets up the whole organism. I........ Read more »
Smulders-Srinivasan TK, & Lin H. (2003) Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division. Genetics, 165(4), 1971-91. PMID: 14704180
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of October 11, 2009.... Read more »
Yamamoto, S., Humle, T., & Tanaka, M. (2009) Chimpanzees Help Each Other upon Request. PLoS ONE, 4(10). DOI: 10.1371/journal.pone.0007416
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of October 4, 2009.... Read more »
Brusatte, S., Carr, T., Erickson, G., Bever, G., & Norell, M. (2009) A long-snouted, multihorned tyrannosaurid from the Late Cretaceous of Mongolia. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0906911106
Parks, J., Guo, H., Momany, C., Liang, L., Miller, S., Summers, A., & Smith, J. (2009) Mechanism of Hg−C Protonolysis in the Organomercurial Lyase MerB. Journal of the American Chemical Society, 131(37), 13278-13285. DOI: 10.1021/ja9016123
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of September 27, 2009.... Read more »
Abidian, M., Ludwig, K., Marzullo, T., Martin, D., & Kipke, D. (2009) Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly(3,4-ethylenedioxythiophene) Nanotubes. Advanced Materials, 21(37), 3764-3770. DOI: 10.1002/adma.200900887
Billinger, M. (2009) Nontuberculous Mycobacteria–associated Lung Disease, United States in Hospitalized Persons, 1998–2005. Emerging Infectious Diseases. DOI: 10.3201/eid1510.090196
Bekinschtein, T., Shalom, D., Forcato, C., Herrera, M., Coleman, M., Manes, F., & Sigman, M. (2009) Classical conditioning in the vegetative and minimally conscious state. Nature Neuroscience, 12(10), 1343-1349. DOI: 10.1038/nn.2391
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of September 20, 2009.... Read more »
Duris, J., Haack, S., & Fogarty, L. (2009) Gene and Antigen Markers of Shiga-toxin Producing E. coli from Michigan and Indiana River Water: Occurrence and Relation to Recreational Water Quality Criteria. Journal of Environmental Quality, 38(5), 1878-1886. DOI: 10.2134/jeq2008.0225
Behan, J., Yun, J., Proektor, M., Ehsanipour, E., Arutyunyan, A., Moses, A., Avramis, V., Louie, S., Butturini, A., Heisterkamp, N.... (2009) Adipocytes Impair Leukemia Treatment in Mice. Cancer Research. DOI: 10.1158/0008-5472.CAN-09-0800
Cenna, J., Hunter, M., Tan, G., Papaneri, A., Ribka, E., Schnell, M., Marx, P., & McGettigan, J. (2009) Replication‐Deficient Rabies Virus–Based Vaccines Are Safe and Immunogenic in Mice and Nonhuman Primates. The Journal of Infectious Diseases, 200(8), 1251-1260. DOI: 10.1086/605949
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of September 13, 2009.... Read more »
Tingley, M., Monahan, W., Beissinger, S., & Moritz, C. (2009) Biogeography, Changing Climates, and Niche Evolution Sackler Colloquium: Birds track their Grinnellian niche through a century of climate change. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0901562106
Parks, A., Li, Z., Shi, Q., Owens, R., Jin, M., & Peters, J. (2009) Transposition into Replicating DNA Occurs through Interaction with the Processivity Factor. Cell, 138(4), 685-695. DOI: 10.1016/j.cell.2009.06.011
Gascoyne, D., Long, E., Veiga-Fernandes, H., de Boer, J., Williams, O., Seddon, B., Coles, M., Kioussis, D., & Brady, H. (2009) The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nature Immunology. DOI: 10.1038/ni.1787
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of September 6, 2009.... Read more »
Schnuelle P, Gottmann U, Hoeger S, Boesebeck D, Lauchart W, Weiss C, Fischereder M, Jauch KW, Heemann U, Zeier M.... (2009) Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial. JAMA : the journal of the American Medical Association, 302(10), 1067-75. PMID: 19738091
Münch, T., da Silveira, R., Siegert, S., Viney, T., Awatramani, G., & Roska, B. (2009) Approach sensitivity in the retina processed by a multifunctional neural circuit. Nature Neuroscience. DOI: 10.1038/nn.2389
Zelada-Guillén, G., Riu, J., Düzgün, A., & Rius, F. (2009) Immediate Detection of Living Bacteria at Ultralow Concentrations Using a Carbon Nanotube Based Potentiometric Aptasensor. Angewandte Chemie International Edition. DOI: 10.1002/anie.200902090
Childs, R., Palma, A., Wharton, S., Matrosovich, T., Liu, Y., Chai, W., Campanero-Rhodes, M., Zhang, Y., Eickmann, M., Kiso, M.... (2009) Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray. Nature Biotechnology, 27(9), 797-799. DOI: 10.1038/nbt0909-797
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of August 30, 2009.... Read more »
Maehr, R., Chen, S., Snitow, M., Ludwig, T., Yagasaki, L., Goland, R., Leibel, R., & Melton, D. (2009) Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0906894106
Reversade, B., Escande-Beillard, N., Dimopoulou, A., Fischer, B., Chng, S., Li, Y., Shboul, M., Tham, P., Kayserili, H., Al-Gazali, L.... (2009) Mutations in PYCR1 cause cutis laxa with progeroid features. Nature Genetics. DOI: 10.1038/ng.413
Siripattarapravat, K., Pinmee, B., Venta, P., Chang, C., & Cibelli, J. (2009) Somatic cell nuclear transfer in zebrafish. Nature Methods. DOI: 10.1038/nmeth.1369
by Susan Steinhardt in BioData Blogs
Christie Wilcox is now passionate toward conservation biology, although she didn’t originally start off that way. While she always had an affinity to nature and animals, she didn’t realize that she wanted to be a biologist until she “stumbled” upon it in college. “When I’m at the beach and everyone is running away from jellyfish, I get excited and run up closer to check it out!”... Read more »
Smith, N., Wilcox, C., & Lessmann, J. (2009) Fiddler crab burrowing affects growth and production of the white mangrove (Laguncularia racemosa) in a restored Florida coastal marsh. Marine Biology. DOI: 10.1007/s00227-009-1253-7
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of August 23, 2009.... Read more »
Cziko, A., McCann, C., Howlett, I., Barbee, S., Duncan, R., Luedemann, R., Zarnescu, D., Zinsmaier, K., Parker, R., & Ramaswami, M. (2009) Genetic Modifiers of dFMR1 Encode RNA Granule Components in Drosophila. Genetics, 182(4), 1051-1060. DOI: 10.1534/genetics.109.103234
Tachibana, M., Sparman, M., Sritanaudomchai, H., Ma, H., Clepper, L., Woodward, J., Li, Y., Ramsey, C., Kolotushkina, O., & Mitalipov, S. (2009) Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature. DOI: 10.1038/nature08368
Oh, J., Weng, S., Felton, S., Bhandare, S., Riek, A., Butler, B., Proctor, B., Petty, M., Chen, Z., Schechtman, K.... (2009) 1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus. Circulation, 120(8), 687-698. DOI: 10.1161/CIRCULATIONAHA.109.856070
by Susan Steinhardt in BioData Blogs
In a survey commissioned by BioData, 94 researchers from 74 institutions worldwide were asked a series of questions regarding their management of research data. The survey’s purpose was to learn about and prove the need for knowledge management systems in academic research. 80% of the researchers surveyed believe their labs are not run efficiently.... Read more »
Noble, W. (2009) A Quick Guide to Organizing Computational Biology Projects. PLoS Computational Biology, 5(7). DOI: 10.1371/journal.pcbi.1000424
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of August 16, 2009.... Read more »
Frumkin, D., Wasserstrom, A., Davidson, A., & Grafit, A. (2009) Authentication of forensic DNA samples. Forensic Science International: Genetics. DOI: 10.1016/j.fsigen.2009.06.009
Loui, P., Alsop, D., & Schlaug, G. (2009) Tone Deafness: A New Disconnection Syndrome?. Journal of Neuroscience, 29(33), 10215-10220. DOI: 10.1523/JNEUROSCI.1701-09.2009
Li, M., Chen, W., Papadopoulos, N., Goodman, S., Bjerregaard, N., Laurberg, S., Levin, B., Juhl, H., Arber, N., Moinova, H.... (2009) Sensitive digital quantification of DNA methylation in clinical samples. Nature Biotechnology. DOI: 10.1038/nbt.1559
Hattori, Y., Nagai, K., Furukawa, S., Song, X., Kawano, R., Sakakibara, H., Wu, J., Matsumoto, T., Yoshimura, A., Kitano, H.... (2009) The ethylene response factors SNORKEL1 and SNORKEL2 allow rice to adapt to deep water. Nature, 460(7258), 1026-1030. DOI: 10.1038/nature08258
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of August 9, 2009.... Read more »
Wiklund, E., Catts, V., Catts, S., Fong Ng, T., Whitaker, N., Brown, A., & Lutze-Mann, L. (2009) Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target. International Journal of Cancer. DOI: 10.1002/ijc.24813
Smith, M., Egerdie, B., Toriz, N., Feldman, R., Tammela, T., Saad, F., Heracek, J., Szwedowski, M., Ke, C., Kupic, A.... (2009) Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer. New England Journal of Medicine. DOI: 10.1056/NEJMoa0809003
Cummings, S., Martin, J., McClung, M., Siris, E., Eastell, R., Reid, I., Delmas, P., Zoog, H., Austin, M., Wang, A.... (2009) Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis. New England Journal of Medicine. DOI: 10.1056/NEJMoa0809493
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of August 2, 2009.... Read more »
Liu, M., Kuan, Y., Wang, J., Hen, R., & Gershon, M. (2009) 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. Journal of Neuroscience, 29(31), 9683-9699. DOI: 10.1523/JNEUROSCI.1145-09.2009
Paaijmans, K., Read, A., & Thomas, M. (2009) Understanding the link between malaria risk and climate. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0903423106
Plantier, J., Leoz, M., Dickerson, J., De Oliveira, F., Cordonnier, F., Lemée, V., Damond, F., Robertson, D., & Simon, F. (2009) A new human immunodeficiency virus derived from gorillas. Nature Medicine. DOI: 10.1038/nm.2016
Jean, Y., Chen, W., Sung, C., Duh, C., Huang, S., Lin, C., Tai, M., Tzeng, S., & Wen, Z. (2009) Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. British Journal of Pharmacology. DOI: 10.1111/j.1476-5381.2009.00323.x
Alto, L., Havton, L., Conner, J., Hollis II, E., Blesch, A., & Tuszynski, M. (2009) Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nature Neuroscience. DOI: 10.1038/nn.2365
Xu, Z., Gong, Q., Xia, B., Groves, B., Zimmermann, M., Mugler, C., Mu, D., Matsumoto, B., Seaman, M., & Ma, D. (2009) A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking. The Journal of Cell Biology. DOI: 10.1083/jcb.200902146
Gregory, T., Andrews, C., McGuire, J., & Witt, C. (2009) The smallest avian genomes are found in hummingbirds. Proceedings of the Royal Society B: Biological Sciences. DOI: 10.1098/rspb.2009.1004
by Susan Steinhardt in BioData Blogs
Our weekly compilation of science news for the week of July 26, 2009.... Read more »
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A., Benoist, C., Shoelson, S.... (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nature Medicine. DOI: 10.1038/nm.2002
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J., Gygi, S., & Spiegelman, B. (2009) Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex. Nature. DOI: 10.1038/nature08262
Orso, G., Pendin, D., Liu, S., Tosetto, J., Moss, T., Faust, J., Micaroni, M., Egorova, A., Martinuzzi, A., McNew, J.... (2009) Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin. Nature. DOI: 10.1038/nature08280
Page, R., Ambady, S., Holmes, W., Vilner, L., Kole, D., Kashpur, O., Huntress, V., Vojtic, I., Whitton, H., & Dominko, T. (2009) Induction of Stem Cell Gene Expression in Adult Human Fibroblasts without Transgenes. Cloning and Stem Cells, 2147483647. DOI: 10.1089/clo.2009.0015
Gentleman, E., Swain, R., Evans, N., Boonrungsiman, S., Jell, G., Ball, M., Shean, T., Oyen, M., Porter, A., & Stevens, M. (2009) Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation. Nature Materials. DOI: 10.1038/nmat2505
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