Laika's Medliblog

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37 posts · 27,829 views

The Focus of the blog is on Medical Librarianship, Library Science, Medicine, EBM, Epidemiology and Science. I've a PhD in Medical Biology and work as an information specialist in a Medical Library (3 days) and for The Cochrane Collaboration (1 day).

Laika
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  • May 25, 2009
  • 11:58 PM
  • 1,305 views

CMV-infection, plaques and high blood pressure

by Laika in Laika's Medliblog

A recent experimental study shows that a common virus that hides (becomes latent) after infection can trigger high blood pressure, and hardening of the arteries (atherosclerosis), both leading causes of cardiovascular disease.

The virus is cytomegalovirus (CMV). It belongs to the herpesviruses, hence it’s alternative name Human Herpesvirus 5 (HHV-5). The herpesviruses have in common that [...]... Read more »

Cheng, J., Ke, Q., Jin, Z., Wang, H., Kocher, O., Morgan, J., Zhang, J., & Crumpacker, C. (2009) Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure. PLoS Pathogens, 5(5). DOI: 10.1371/journal.ppat.1000427  

  • April 26, 2009
  • 10:46 PM
  • 1,203 views

Some Sugars Worse than Others? The Bittersweet Fructose/Glucose Debate.

by Laika in Laika's Medliblog

Excessive consumption of sugar has been associated with increased incidences of type 2 diabetes, formerly called adult-onset diabetes, obesity and tooth decay.

There are many sugars around. Natural sugars and refined sugars. The refined table sugar and sugar cubes would be called “sucrose” by a chemist. Sucrose consists of two simple sugars (monosaccharides): 1 fructose and [...]... Read more »

  • April 12, 2009
  • 07:53 PM
  • 1,193 views

Still Confusion about the Usefulness of PSA-screening.

by Laika in Laika's Medliblog

Prostate cancer is the most commonly diagnosed cancer affecting older men and second-biggest cancer killer.

Prostate Specific Antigen (PSA), a protein mainly produced by the prostate gland, is often elevated in prostate cancer - and often proportional to the prostate cancer volume. Since more men are diagnosed with prostate cancer by using PSA screening, middle-aged [...]... Read more »

Andriole, G., Grubb, R., Buys, S., Chia, D., Church, T., Fouad, M., Gelmann, E., Kvale, P., Reding, D., Weissfeld, J.... (2009) Mortality Results from a Randomized Prostate-Cancer Screening Trial. New England Journal of Medicine. DOI: 10.1056/NEJMoa0810696  

Schroder, F., Hugosson, J., Roobol, M., Tammela, T., Ciatto, S., Nelen, V., Kwiatkowski, M., Lujan, M., Lilja, H., Zappa, M.... (2009) Screening and Prostate-Cancer Mortality in a Randomized European Study. New England Journal of Medicine. DOI: 10.1056/NEJMoa0810084  

Lee, T., Kantoff, P., & McNaughton-Collins, M. (2009) Screening for Prostate Cancer. New England Journal of Medicine, 360(13). DOI: 10.1056/NEJMp0901825  

  • February 8, 2009
  • 07:15 PM
  • 1,128 views

Personalized Genetics: Too Soon, Too Little?

by Laika in Laika's Medliblog

Personalized Medicine is the concept that managing patient’s health should be based on the individual patient’s specific characteristics instead of on the standards of care. Often the term ‘personalized medicine’ is restricted to the use of information about a patient’s genotype or gene expression profile to further tailor medical care to an individual’s needs (see [...]... Read more »

  • November 2, 2009
  • 08:37 PM
  • 1,091 views

Hot News: Curry, Curcumin, Cancer & Cure

by Laika in Laika's Medliblog

*Hot* News via Twitter and various news media a few days ago. Big headlines tell the following in respectively The Sun, Herald, Ireland, BBC News / NHS Health and Reuters:
Curry is a ‘cure for cancer‘
Spices in curry may help cure cancer
Curry spice ‘kills cancer cells‘
Scientists say curry compound kills cancer cells
The message of these headlines [...]... Read more »

  • September 14, 2009
  • 03:38 AM
  • 1,066 views

The Trouble with Wikipedia as a Source for Medical Information

by Laika in Laika's Medliblog

Image via Wikipedia



Do you ever use Wikipedia? I do and so do many other people. It is for free, easy to use, and covers many subjects.
But do you ever use Wikipedia to look up scientific or medical information? Probably everyone does so once in a while. Dave Munger (Researchblogging) concluded a discussion on Twitter as [...]... Read more »

Clauson, K., Polen, H., Boulos, M., & Dzenowagis, J. (2008) Scope, Completeness, and Accuracy of Drug Information in Wikipedia. Annals of Pharmacotherapy, 42(12), 1814-1821. DOI: 10.1345/aph.1L474  

Laurent, M., & Vickers, T. (2009) Seeking Health Information Online: Does Wikipedia Matter?. Journal of the American Medical Informatics Association, 16(4), 471-479. DOI: 10.1197/jamia.M3059  

Halavais, A., & Lackaff, D. (2008) An Analysis of Topical Coverage of Wikipedia. Journal of Computer-Mediated Communication, 13(2), 429-440. DOI: 10.1111/j.1083-6101.2008.00403.x  

Mühlhauser I, & Oser F. (2008) [Does WIKIPEDIA provide evidence-based health care information? A content analysis]. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen, 102(7), 441-8. PMID: 19209572  

Amichai–Hamburger, Y., Lamdan, N., Madiel, R., & Hayat, T. (2008) Personality Characteristics of Wikipedia Members. CyberPsychology , 11(6), 679-681. DOI: 10.1089/cpb.2007.0225  

Daub, J., Gardner, P., Tate, J., Ramskold, D., Manske, M., Scott, W., Weinberg, Z., Griffiths-Jones, S., & Bateman, A. (2008) The RNA WikiProject: Community annotation of RNA families. RNA, 14(12), 2462-2464. DOI: 10.1261/rna.1200508  

Mons, B., Ashburner, M., Chichester, C., van Mulligen, E., Weeber, M., den Dunnen, J., van Ommen, G., Musen, M., Cockerill, M., Hermjakob, H.... (2008) Calling on a million minds for community annotation in WikiProteins. Genome Biology, 9(5). DOI: 10.1186/gb-2008-9-5-r89  

Huss, J., Orozco, C., Goodale, J., Wu, C., Batalov, S., Vickers, T., Valafar, F., & Su, A. (2008) A Gene Wiki for Community Annotation of Gene Function. PLoS Biology, 6(7). DOI: 10.1371/journal.pbio.0060175  

  • December 18, 2009
  • 05:15 PM
  • 1,065 views

Overproduction of Th1 and Th17 Cytokines may be the Clue to why some H1N1 Patients get very ill

by Laika in Laika's Medliblog

The present H1N1 influenza virus (nvH1N1, nv=new variant) behaves very differently from other influenza strains. The majority of nvH1N1 infections are mild and self-limiting in nature, but a small percentage of the patients require hospitalization and sometimes emergency care. Unlike the seasonal flu virus, the people who seem to suffer serious complications from this [...]... Read more »

Bermejo-Martin, J., Ortiz de Lejarazu, R., Pumarola, T., Rello, J., Almansa, R., Ramirez, P., Martin-Loeches, I., Varillas, D., Gallegos, M., Seron, C.... (2009) Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Critical Care, 13(6). DOI: 10.1186/cc8208  

Wynn, T. (2005) TH-17: a giant step from TH1 and TH2. Nature Immunology, 6(11), 1069-1070. DOI: 10.1038/ni1105-1069  

Park, H., Li, Z., Yang, X., Chang, S., Nurieva, R., Wang, Y., Wang, Y., Hood, L., Zhu, Z., Tian, Q.... (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nature Immunology, 6(11), 1133-1141. DOI: 10.1038/ni1261  

  • May 16, 2009
  • 06:02 PM
  • 1,060 views

One Third of the Clinical Cancer Studies Report Conflict of Interest

by Laika in Laika's Medliblog

While many of us just recovered from the news that Elsevier was paid to produce fake Journals to promote pharmaceutical products, another news item has appeared about “conflicts of interests in scientific publications”

This news is based on a new journal article from researchers from the University of Michigan’s Comprehensive Cancer Center in Ann Arbor, published [...]... Read more »

  • July 6, 2009
  • 08:05 PM
  • 1,013 views

Does the insulin Lantus (glargine) cause cancer?

by Laika in Laika's Medliblog

Last week my eyes were caught by a post of Kevin MD at his blog entitled

“Does insulin cause cancer, and should you stop taking Lantus?”.

Kevin linked to the blog of Dr. Mintz, a board-certified internist, who had a strong opinion on this. Dr. Mintz  posted 3 blog articles on the matter, entitled: [...]... Read more »

  • February 22, 2009
  • 05:55 PM
  • 1,010 views

MnSOD, Carotenoids & Prostate Cancer - “You are what you eat” depends on who you are.

by Laika in Laika's Medliblog

When you type Cancer Food Prevention in Google you get about 9 million hits, many of them dotcom sites telling you which nutrients, pills or extracts you should take to prevent cancer. Much of this information is unreliable at least.

Although it is true that numerous observational studies (cohort and case-control) do indicate a relationship between [...]... Read more »

  • November 29, 2009
  • 10:05 PM
  • 938 views

Complementary Medicine & Pharmacists

by Laika in Laika's Medliblog

I don’t know if the situation is the same in other countries, but in the Netherlands we can only get prescribed medications in pharmacies. Drugstores are only allowed to sell over-the counter (OTC) medicines.
Most Pharmacies have a small shop of 5 square meters (besides a large storage room). What surprises me is that the counter [...]... Read more »

  • September 29, 2009
  • 04:50 PM
  • 900 views

Grand Rounds Vol. 6 No. 2

by Laika in Laika's Medliblog

Welcome to the latest edition of Grand Rounds, the weekly compilation of the best of the medical blogosphere! I presume you would rather take a tour through the Netherlands, visiting windmills and tulips, but we will save this for another time. Right now, let’s take a trip around the library.
Because you know what William [...]... Read more »

Andreas G. Anastasiou, & Athanasios Anastasiou. (2009) The effects of current dietary trends and consumption patterns on health: evidence from the UK. Int. J. Behavioural and Healthcare Research, 1(3), 318-333. info:/

  • March 15, 2009
  • 11:35 PM
  • 891 views

An Antibiotic Past May Save Lives at the ICU.

by Laika in Laika's Medliblog

Respiratory tract infections acquired in the intensive care unit (ICU) are important causes of morbidity and mortality, the most significant risk factor being mechanical ventilation. It is thought that hospital pneumonia commonly originates from flora colonized in the patient’s oropharynx (the area of the throat at the back of the mouth). Therefore, reduction of [...]... Read more »

de Smet, A., Kluytmans, J., Cooper, B., Mascini, E., Benus, R., van der Werf, T., van der Hoeven, J., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.... (2009) Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine, 360(1), 20-31. DOI: 10.1056/NEJMoa0800394  

de Smet, A., Kluytmans, J., Cooper, B., Mascini, E., Benus, R., van der Werf, T., van der Hoeven, J., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.... (2009) Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine, 360(1), 20-31. DOI: 10.1056/NEJMoa0800394  

de Smet, A., Kluytmans, J., Cooper, B., Mascini, E., Benus, R., van der Werf, T., van der Hoeven, J., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.... (2009) Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine, 360(1), 20-31. DOI: 10.1056/NEJMoa0800394  

de Smet, A., Kluytmans, J., Cooper, B., Mascini, E., Benus, R., van der Werf, T., van der Hoeven, J., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.... (2009) Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine, 360(1), 20-31. DOI: 10.1056/NEJMoa0800394  

de Smet, A., Kluytmans, J., Cooper, B., Mascini, E., Benus, R., van der Werf, T., van der Hoeven, J., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.... (2009) Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine, 360(1), 20-31. DOI: 10.1056/NEJMoa0800394  

de Smet, A., Kluytmans, J., Cooper, B., Mascini, E., Benus, R., van der Werf, T., van der Hoeven, J., Pickkers, P., Bogaers-Hofman, D., van der Meer, N.... (2009) Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine, 360(1), 20-31. DOI: 10.1056/NEJMoa0800394  

  • June 8, 2010
  • 11:45 AM
  • 865 views

PubMed versus Google Scholar for Retrieving Evidence

by Laika in Laika's Medliblog

A while ago a resident in dermatology told me she got many hits out of PubMed, but zero results out of TRIP. It appeared she had used the same search for both databases: alopecea areata and diphenciprone (a drug with a lot of synonyms). Searching TRIP for alopecea (in the title) only, we found a Cochrane [...]... Read more »

  • August 29, 2010
  • 11:32 PM
  • 848 views

Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.

by Laika in Laika's Medliblog

The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week [1]. The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors [2], because it contradicted [...]... Read more »

Lo SC, Pripuzova N, Li B, Komaroff AL, Hung GC, Wang R, & Alter HJ. (2010) Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20798047  

Erlwein, O., Kaye, S., McClure, M., Weber, J., Wills, G., Collier, D., Wessely, S., & Cleare, A. (2010) Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008519  

Groom, H., Boucherit, V., Makinson, K., Randal, E., Baptista, S., Hagan, S., Gow, J., Mattes, F., Breuer, J., Kerr, J.... (2010) Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology, 7(1), 10. DOI: 10.1186/1742-4690-7-10  

Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B.... (2009) Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (New York, N.Y.), 326(5952), 585-9. PMID: 19815723  

  • March 13, 2011
  • 07:48 PM
  • 798 views

A New Safe Blood Test to Diagnose Down Syndrome

by Laika in Laika's Medliblog

The established method to prenatally diagnose chromosomal gross abnormalities is to obtain fetal cells from the womb with a fine needle, either by Amniocentesis (a sample of the fluid surrounding the foetus in the womb)  or by Chorionic villus sampling (CVS, a sample of the placenta taken via the vaginal route). The procedures are not to be sneezed [...]... Read more »

LO, Y., CORBETTA, N., CHAMBERLAIN, P., RAI, V., SARGENT, I., REDMAN, C., & WAINSCOAT, J. (1997) Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485-487. DOI: 10.1016/S0140-6736(97)02174-0  

Papageorgiou, E., Karagrigoriou, A., Tsaliki, E., Velissariou, V., Carter, N., & Patsalis, P. (2011) Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21. Nature Medicine. DOI: 10.1038/nm.2312  

  • May 7, 2009
  • 10:41 PM
  • 791 views

Merck’s Ghostwriters, Haunted Papers and Fake Elsevier Journals

by Laika in Laika's Medliblog

What is the purpose of publications? (…) The purpose of data is to support, directly or indirectly, the marketing of our product.” [1, 2]

It is well known that studies with significant positive results are easier to find than those with ‘negative’ results. This so called publication bias can arise from the tendency to submit or [...]... Read more »

  • March 14, 2010
  • 07:59 AM
  • 784 views

Sugar-Sweetened Beverages, Diet Coke & Health. Part I.

by Laika in Laika's Medliblog

At Medical and Technology of Joseph Kim, the upcoming Grand Rounds host, I saw the blog post “Need your help on Facebook to get Diet Coke to Donate $50,000 to the Foundation for NIH”.
National Heart Lung and Blood Institute has started a national campaign in the US, The Heart Truth®. They issued a challenge in [...]... Read more »

Litsa K Lambrakos, Pamela Coxson, Lee Goldman, Kirsten Bibbins-Domingo. (2010) Sugar-Sweetened Beverage Consumption and the Attributable Burden to Diabetes and Coronary Heart Disease. Circulation. info:other/

Malik VS, Schulze MB, & Hu FB. (2006) Intake of sugar-sweetened beverages and weight gain: a systematic review. The American journal of clinical nutrition, 84(2), 274-88. PMID: 16895873  

Wolff E, & Dansinger ML. (2008) Soft drinks and weight gain: how strong is the link?. Medscape journal of medicine, 10(8), 189. PMID: 18924641  

Janssen I, Katzmarzyk PT, Boyce WF, Vereecken C, Mulvihill C, Roberts C, Currie C, Pickett W, & Health Behaviour in School-Aged Children Obesity Working Group. (2005) Comparison of overweight and obesity prevalence in school-aged youth from 34 countries and their relationships with physical activity and dietary patterns. Obesity reviews : an official journal of the International Association for the Study of Obesity, 6(2), 123-32. PMID: 15836463  

  • May 11, 2010
  • 01:18 PM
  • 733 views

What One Short Night’s Sleep does to your Glucose Metabolism

by Laika in Laika's Medliblog

As a blogger I regularly sleep 3-5 hours just to finish a post. I know that this has its effects on how I feel the next day. I also know short nights don’t promote my clear-headedness and I also recognize short-term effects on  memory, cognitive functions, reaction time and mood (irritability), as depicted in the [...]... Read more »

Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen KW, Corssmit EP, & Romijn JA. (2010) A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects. The Journal of clinical endocrinology and metabolism. PMID: 20371664  

Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen K, Hoogma RP, Corssmit EP, & Romijn JA. (2010) Partial sleep restriction decreases insulin sensitivity in type 1 diabetes. Diabetes care. PMID: 20357381  

Nielsen LS, Danielsen KV, & Sørensen TI. (2010) Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence. Obesity reviews : an official journal of the International Association for the Study of Obesity. PMID: 20345429  

Monasta L, Batty GD, Cattaneo A, Lutje V, Ronfani L, van Lenthe FJ, & Brug J. (2010) Early-life determinants of overweight and obesity: a review of systematic reviews. Obesity reviews : an official journal of the International Association for the Study of Obesity. PMID: 20331509  

  • June 22, 2010
  • 06:07 PM
  • 723 views

Will Nano-Publications & Triplets Replace The Classic Journal Articles?

by Laika in Laika's Medliblog

“Libraries and journals articles as we know them will cease to exists” said Barend Mons at the symposium in honor of our Library 25th Anniversary (June 3rd). “Possibly we will have another kind of party in another 25 years”…. he continued, grinning. What he had to say the next half hour intrigued me. And although [...]... Read more »

van Haagen HH, 't Hoen PA, Botelho Bovo A, de Morrée A, van Mulligen EM, Chichester C, Kors JA, den Dunnen JT, van Ommen GJ, van der Maarel SM.... (2009) Novel protein-protein interactions inferred from literature context. PloS one, 4(11). PMID: 19924298  

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