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- May 14, 2013
- 01:40 PM
- 52 views
Alligator stem cell study paves the way for tooth regeneration in humans
by beredim in Stem Cells Freak
Unlike most vertebrates which can replace lost teeth through their entire lives, humans come with only two sets, baby teeth and adult teeth, then they simply lose the ability for tooth renewal.. However, a new study on alligators by researchers at the Keck School of Medicine, University of Southern California (USC) may someday allow doctors to stimulate tooth regeneration in humans as well.Read More... Read more »
Wu, P., Wu, X., Jiang, T., Elsey, R., Temple, B., Divers, S., Glenn, T., Yuan, K., Chen, M., Widelitz, R.... (2013) Specialized stem cell niche enables repetitive renewal of alligator teeth. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1213202110
- May 13, 2013
- 12:53 PM
- 47 views
Serotonin is crucial for exercise-induced neurogenesis
by beredim in Stem Cells Freak
It's a well known fact that exercise induces stem cells in the hippocampus, a important brain area, to become neurons, a process known as neurogenesis However, up until now little was known about the deeper mechanisms involved in this process. Now, a new study on mice by researchers at the Max Delbrück Centre (MDC), Berlin-Buch reveals that serotonin plays a direct role in exercise-induced neurogenesis.Read More... Read more »
Klempin, F., Beis, D., Mosienko, V., Kempermann, G., Bader, M., & Alenina, N. (2013) Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis. Journal of Neuroscience, 33(19), 8270-8275. DOI: 10.1523/JNEUROSCI.5855-12.2013
- May 9, 2013
- 04:21 PM
- 44 views
Merged mice lead to new heart failure treatment
by beredim in Stem Cells Freak
Heart failure (also known as congestive heart failure) is one of the most common and debilitating conditions associated with ageing. At present, there is no real cure for the condition and treatments focus on improving the symptoms and preventing the progression of the disease. Today, a new study was published by researchers at Harvard Stem Cell Institute (HSCI) that sheds new light on the condition and proposes a potential new treatment option.Read More... Read more »
Loffredo, F., Steinhauser, M., Jay, S., Gannon, J., Pancoast, J., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J.... (2013) Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell, 153(4), 828-839. DOI: 10.1016/j.cell.2013.04.015
- May 8, 2013
- 04:04 AM
- 32 views
Scaffold made of silk and cellulose effective for cartilage regeneration
by beredim in Stem Cells Freak
Osteoarthritis (OA) is a joint disease affecting more than 27 million people in the U. S, globally causing moderate to severe disability in more than 40 million people. In the past decade, stem cells have shown great promise in treating OA. Yesterday, researchers at the University of Bristol announced that they have created a 'smart material', composed of silk and cellulose, that according to them paves the wave for both affordable and effective cell based treatments for cartilage regene........ Read more »
Singh, N., Rahatekar, S., Koziol, K., Ng, T., Patil, A., Mann, S., Hollander, A., & Kafienah, W. (2013) Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk. Biomacromolecules, 2147483647. DOI: 10.1021/bm301762p
- May 7, 2013
- 03:02 PM
- 42 views
Researchers create disease-in-a-dish model for Ataxia Telangiectasia
by beredim in Stem Cells Freak
Researchers at the University of California, Los Angeles (UCLA) just announced that they have successfully used induced pluripotent stem cells (iPSCs) to create the first disease-in-a-dish model for Ataxia Telangiectasia (A-T), a rare, genetic, neurodegenerative, disease causing severe disability. The researchers consider their discovery to be a major advance for A-T research as now scientists have a reliable model to study the condition and to test new drugs.Read More... Read more »
Lee, P., Martin, N., Nakamura, K., Azghadi, S., Amiri, M., Ben-David, U., Perlman, S., Gatti, R., Hu, H., & Lowry, W. (2013) SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs. Nature Communications, 1824. DOI: 10.1038/ncomms2824
- May 7, 2013
- 01:49 PM
- 38 views
Researchers create personalised bone grafts from induced pluripotent stem cells
by beredim in Stem Cells Freak
Yesterday, researchers from the New York Stem Cell Foundation (NYSCF) reported that they have created personalised bone substitutes which can be used to treat large, bone defects. The grafts come with no risk of rejection and can cover the exact needs of any patient, say the researchers.Read More... Read more »
Giuseppe Maria de Peppoa, Iván Marcos-Camposb, David John Kahlera, Dana Alsalmana, Linshan Shanga, Gordana Vunjak-Novakovicb, & Darja Marolta. (2013) Engineering bone tissue substitutes from human induced pluripotent stem cells. Proceedings of the National Academy of Sciences. info:/
- May 6, 2013
- 03:20 PM
- 50 views
Researchers create patch for damaged hearts
by beredim in Stem Cells Freak
Researchers at the Duke University, Durham announced today that they have used human embryonic stem cells to create a "patch" for damaged hearts. The patch may one day be used to treat patients with cardiac damage after a heart attack or as a model for testing new experimental drugs.Read More... Read more »
Zhang, D., Shadrin, I., Lam, J., Xian, H., Snodgrass, H., & Bursac, N. (2013) Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials. DOI: 10.1016/j.biomaterials.2013.04.026
- May 6, 2013
- 11:41 AM
- 45 views
Gene thought to only form heart tissue revealed to form blood and muscle tissues as well
by beredim in Stem Cells Freak
A new study by researchers at the Lillehei Heart Institute, University of Minnesota reveals that the Mesp1 gene, previously thought to only be involved in the production of heart tissue, can be used to produce blood and muscle forming stem cells if manipulated properly.Read More... Read more »
Chan, S., Shi, X., Toyama, A., Arpke, R., Dandapat, A., Iacovino, M., Kang, J., Le, G., Hagen, H., Garry, D.... (2013) Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner. Cell Stem Cell, 12(5), 587-601. DOI: 10.1016/j.stem.2013.03.004
- May 6, 2013
- 09:55 AM
- 52 views
Researchers generate cortical interneurons from human embryonic stem cells
by beredim in Stem Cells Freak
In a recent study, researchers from The Children's Hospital of Philadelphia and the Sloan-Kettering Institute have presented a new method to derive cortical interneurons from human embruonic stem cells. The study has implications in the treatment of several neurodevelopmental disorders, like autism.Read More... Read more »
Asif M. Maroof, Sotirios Keros, Jennifer A. Tyson, Shui-Wang Ying, Yosif M. Ganat, Florian T. Merkle, Becky Liu, Adam Goulburn, Edouard G. Stanley, Andrew G. Elefanty.... (2013) Turning Human Stem Cells Into Brain Cells Sheds Light On Neural Development. Cell Stem Cell. info:/
- May 6, 2013
- 06:54 AM
- 50 views
Researchers announce "fundamental" discovery on how Oct-4 controls embryonic stem cell function
by beredim in Stem Cells Freak
A few days ago, researchers at the University of Edinburgh announced that they have made a "fundamental" discovery on how embryonic stem cells replicate and differentiate.Read More... Read more »
Karwacki-Neisius, V., Göke, J., Osorno, R., Halbritter, F., Ng, J., Weiße, A., Wong, F., Gagliardi, A., Mullin, N., Festuccia, N.... (2013) Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog. Cell Stem Cell, 12(5), 531-545. DOI: 10.1016/j.stem.2013.04.023
- May 6, 2013
- 06:24 AM
- 49 views
Stem cells can be used to investigate Dravet syndrome and other rare diseases
by beredim in Stem Cells Freak
Dravet syndrome (DS), also known as severe myoclonic epilepsy of infancy, is a rare and catastrophic form of intractable epilepsy that affects about 1 in every 30,000 infants. Unfortunately, research on DS is severely hampered by its extreme rareness. However, new findings by a team of researchers at the Fukuoka University, Japan not only shed new light into the condition, but may also help to increase our current understanding of other rare genetic disorders.Read More... Read more »
Higurashi, N., Uchida, T., Christoph, L., Misumi, Y., Okada, Y., Akamatsu, W., Imaizumi, Y., Zhang, B., Nabeshima, K., Mori, M.... (2013) A human Dravet syndrome model from patient induced pluripotent stem cells. Molecular Brain, 6(1), 19. DOI: 10.1186/1756-6606-6-19
- May 1, 2013
- 03:03 PM
- 23 views
Researchers decode the molecular signals used by tumours to recruit mesenchymal stem cells
by beredim in Stem Cells Freak
Its been known for years that tumours have the ability to recruit mesenchymal stem cells (MSCs), which is why they are sometimes so persistent and difficult to deal with. Unfortunately, this process is poorly understood on the molecular level. Today, a research team from the University of Michigan, led by Professor Russell Taichman, announced that it has successfully decoded "the molecular chatter" between cancer cells and MSCs.Read More... Read more »
Jung, Y., Kim, J., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Berry, J., McGee, S., Lee, E., Sun, H.... (2013) Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nature Communications, 1795. DOI: 10.1038/ncomms2766
- May 1, 2013
- 12:29 PM
- 59 views
Pericytes can be used for muscle regeneration
by beredim in Stem Cells Freak
Researchers from the Wake Forest Baptist Medical Center (WFBMC) announced today that they may have unveiled some of the mechanisms involved in obesity, diabetes mellitus type 2, muscular dystrophy and other diseases associated with fat replacing muscle tissue, causing it to weaken and degenerate. Their findings have the potential to lead to new therapies for the aforementioned diseases, say the researchers.Read More... Read more »
Birbrair, A., Zhang, T., Wang, Z., Messi, M., Enikolopov, G., Mintz, A., & Delbono, O. (2013) Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation. Stem Cells and Development, 2147483647. DOI: 10.1089/scd.2012.0647
- April 30, 2013
- 02:54 AM
- 67 views
Adult females lack oocyte-forming stem cells
by beredim in Stem Cells Freak
Many researchers have claimed in the past that some of the eggs (oocytes) formed by mammals may actually originate from stem cells. In turn, this gave hope for a new possible source of stem cells that could be used to treat infertility and perhaps other diseases. Unfortunately, a new study by two researchers reveals that mice and probably humans don't use stem cells to produce eggs. Read More... Read more »
Lei, L., & Spradling, A. (2013) Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1306189110
- April 29, 2013
- 02:26 AM
- 65 views
Mesenchymal stem cells against cancer
by beredim in Stem Cells Freak
Generally, the results from studies examining the effects of stem cells in treating cancer are mixed. Other studies indicate that stem cells promote tumour growth by forming new blood vessels while others suggest that stem cells halt tumour growth. Now, a new study on mice indicates that its all about "timing". The study was conducted by a collaborative team of researchers from the Université Joseph Fourier and the CHU de Grenoble hospital, both located in France.Read More... Read more »
Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, & Jean-Luc Coll and Claire Rome. (2013) The dual effect of MSCs on tumour growth and tumour angiogenesis. Stem Cell Research . info:/
- April 26, 2013
- 06:12 AM
- 48 views
Feathers stem cells provide new insight into the morphogenesis process
by beredim in Stem Cells Freak
A new study by researchers at the University of Southern California (USC), led by Professor Chuong Cheng Ming, reveals how stem cells contribute to the unique and complex patterns bird feathers have. Surprisingly, the study has implications in the field of regenerative medicine, say the researchers.Read More... Read more »
Lin, S., Foley, J., Jiang, T., Yeh, C., Wu, P., Foley, A., Yen, C., Huang, Y., Cheng, H., Chen, C.... (2013) Topology of Feather Melanocyte Progenitor Niche Allows Complex Pigment Patterns to Emerge. Science. DOI: 10.1126/science.1230374
- April 23, 2013
- 01:58 PM
- 113 views
Antibody triggers bone marrow stem cells to become brain cells
by beredim in Stem Cells Freak
In what they describe as a "serendipitous discovery", researchers from the Scripps Research Institute (SRI) have identified an antibody which can be used to turn bone marrow stem cells into brain cells. The newly developed technique is safer, simpler and more effective than then currently available ones, say the researchers.Read More... Read more »
Jia Xiea, Hongkai Zhanga, Kyungmoo Yeab, & Richard A. Lerner. (2013) Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells. Proceedings of the National Academy of Sciences. info:/
- April 22, 2013
- 08:33 AM
- 61 views
Human embryonic stem cells restore memory in mice
by beredim in Stem Cells Freak
Researchers from the University of Wisconsin–Madison (UW) announced today that they have successfully used human embryonic stem cells (hESCs) to help a group of mice regain their hindered ability to "learn and remember". The hESCs helped the mice by forming new GABA and cholinergic neurons.Read More... Read more »
Liu, Y., Weick, J., Liu, H., Krencik, R., Zhang, X., Ma, L., Zhou, G., Ayala, M., & Zhang, S. (2013) Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits. Nature Biotechnology. DOI: 10.1038/nbt.2565
- April 20, 2013
- 08:17 AM
- 54 views
Eosinophils trigger stem cells to repair damaged muscle tissue
by beredim in Stem Cells Freak
Eosinophil granulocytes, or simply Eosinophils, are white blood cells responsible for combating multicellular parasites and certain infections. However, a new study on mice, by researchers at the University of California, San Francisco (UCSF) suggests that they may also be crucial for muscle regeneration.Read More... Read more »
Heredia, J., Mukundan, L., Chen, F., Mueller, A., Deo, R., Locksley, R., Rando, T., & Chawla, A. (2013) Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration. Cell, 153(2), 376-388. DOI: 10.1016/j.cell.2013.02.053
- April 19, 2013
- 03:55 PM
- 121 views
Researchers discover new promising drug for amyotrophic lateral sclerosis
by beredim in Stem Cells Freak
Researchers from the Harvard University reported today that by using a new, stem cell-based, drug-screening technology they have found a compound, called kenpaullone, that is cost-effective and more efficient than current drugs are in treating patients suffering from Amyotrophic Lateral Sclerosis (ALS).Read More... Read more »
Yang, Y., Gupta, S., Kim, K., Powers, B., Cerqueira, A., Wainger, B., Ngo, H., Rosowski, K., Schein, P., Ackeifi, C.... (2013) A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS. Cell Stem Cell. DOI: 10.1016/j.stem.2013.04.003
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