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  • August 8, 2014
  • 08:01 AM

Researchers Uncover Stem Cell Behaviour of Human Bowel

by beredim in Stem Cells Freak

For the first time, researchers say they have uncovered new information on how stem cells in the human bowel behave, revealing vital clues about the earliest stages in bowel cancer development and how we may begin to prevent it.The research, led by Queen May University of London (QMUL) and published yesterday the journal Cell Reports, discovered how many stem cells exist within the human bowel and how they behave and evolve over time.Read More... Read more »

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. (2014) Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham. Cell Reports. info:/10.1016/j.celrep.2014.07.019

  • August 7, 2014
  • 01:06 PM

Researchers Grow Human Gastrointestinal Cells Using Epithelial Stem Cells

by beredim in Stem Cells Freak

Kelli L. VanDussen, PhD, and Matthew A. CiorbaA method of growing human cells from tissue removed from a patient's gastrointestinal (GI) tract may one day help scientists develop tailor-made therapies for inflammatory bowel disease and other GI-related conditions.Reporting online recently in the journal Gut, researchers from the Washington University School of Medicine in St. Louis said they have made cell lines from individual patients in as little as two weeks.They have created more than 6........ Read more »

  • August 7, 2014
  • 12:53 PM

Harvard Researchers Identify New Potential Treatment for Amyotrophic Lateral Sclerosis

by beredim in Stem Cells Freak

This image depicts graduate student Sophie De Boer, (left), and Prof. Kevin Eggan (right) discussing their latest work.Credit: B. D. Colen/Harvard UniversityAbout eight years ago, researchers at the Harvard Stem Cell Institute (HSCI) begun a series of studies that led to a report published today which may be a major step forward in thequest to developing real treatments for amyotrophic lateral sclerosis (ALS).The findings by Harvard professor of Stem Cell and Regenerative Biology (HSCRB) Kevin E........ Read more »

de Boer, A., Koszka, K., Kiskinis, E., Suzuki, N., Davis-Dusenbery, B., & Eggan, K. (2014) Genetic validation of a therapeutic target in a mouse model of ALS. Science Translational Medicine, 6(248), 248-248. DOI: 10.1126/scitranslmed.3009351  

  • August 6, 2014
  • 03:46 PM

Molecular Competition Drives Adult Stem Cells to Specialize

by beredim in Stem Cells Freak

All adult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn-out or damaged organs and tissues.Understanding the molecular mechanisms that control the balance between self-renewal and differentiation in adult stem cells is an important foundation for developing therapies to regenerate diseased, injured or aged tissue.Now, in the latest issue of the ........ Read more »

  • August 5, 2014
  • 12:29 PM

Implanted Neurons Derived from Skin Become Part of the Brain

by beredim in Stem Cells Freak

Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have grafted neurons reprogrammed from skin cells into the brains of mice for the first time with long-term stability. Six months after implantation, the neurons had become fully functionally integrated into the brain.This successful, lastingly stable, implantation of neurons raises hope for future therapies that will replace sick neurons with healthy ones in the brains of Parkinson's disease ........ Read more »

Hemmer, K., Zhang, M., van Wüllen, T., Sakalem, M., Tapia, N., Baumuratov, A., Kaltschmidt, C., Kaltschmidt, B., Schöler, H., Zhang, W.... (2014) Induced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain. Stem Cell Reports. DOI: 10.1016/j.stemcr.2014.06.017  

  • August 5, 2014
  • 12:17 PM

Frankfurt-Based Researchers Discover Weakness of Leukemic Stem Cells

by beredim in Stem Cells Freak

Despite improvements in therapy, only one out of every two adult patients survive acute myeloid leukaemia (AML). The mean survival time for this disease, which predominantly occurs in the elderly, is less than a year for patients over 65 years. It is assumed that leukaemic stem cells, which cannot be completely eliminated during treatment, are the origin of relapse. However, as has been discovered by a team of Frankfurt-based researchers, these cells do have a weakness: In the current edition o........ Read more »

  • August 4, 2014
  • 09:17 AM

Knowing what to keep and what to trash: How the Dis3l2 protein distinguishes cellular messages

by beredim in Stem Cells Freak

Every once in a while, we are forced to sort that stack of papers on the kitchen counter. Interspersed between the expired coupons and dozens of takeout menus are important documents like your car insurance or electric bill. So it isn't an option to simply drop it all in the trash at once – you need to read through the messages to be sure that you don't lose vital information.In the cell, proteins similarly read through messages to distinguish what needs to be saved and what needs to b........ Read more »

  • August 4, 2014
  • 09:07 AM

Coxsackie Virus Depletes Cardiac Stem Cells

by beredim in Stem Cells Freak

There is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.CVB infection is very common and affects mostly children. The symptoms range widely: over half of the infections are thought to be asymptomatic, the majority of children who get sick have only a mild fever, and a very........ Read more »

  • August 1, 2014
  • 02:37 PM

UCSF Scientist Discovers Key to Immune System Aging

by beredim in Stem Cells Freak

Emmanuelle Passegué, PhDThere's a good reason people over the age of sixty are not donor candidates for bone marrow transplantation. The immune system ages and weakens with time, making the elderly prone to life-threatening infection and other maladies, and a UC San Francisco research team now has discovered a reason why."We have found the cellular mechanism responsible for the inability of blood-forming cells to maintain blood production over time in an old organism, and have identifi........ Read more »

Flach, J., Bakker, S., Mohrin, M., Conroy, P., Pietras, E., Reynaud, D., Alvarez, S., Diolaiti, M., Ugarte, F., Forsberg, E.... (2014) Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. DOI: 10.1038/nature13619  

  • July 31, 2014
  • 02:25 AM

Sugar mimics guide embryonic stem cells toward neural fate

by beredim in Stem Cells Freak

Kamil GodulaCreditEmbryonic stem cells can develop into virtually all kinds of cells. However, researchers still don't understand how to guide their development into the specific types of mature cells that make up the organs and other structures of living organisms. Now, researchers say that one key to guiding the differentiation process are long chains of sugars that dangle from proteins on surfaces of cells. Kamil Godula's group at the University of California, San Diego, has created ........ Read more »

  • July 29, 2014
  • 03:53 AM

Stem Cell Discovery May Increase Efficiency of Tissue Regeneration

by beredim in Stem Cells Freak

Miguel Ramalho-Santos, PhDA new stem-cell discovery might one day lead to a more streamlined process for obtaining stem cells, which in turn could be used in the development of replacement tissue for failing body parts, according to UC San Francisco scientists who reported the findings in the current edition of Cell.The research builds on a strategy that involves reprogramming adult cells back to an embryonic state in which they again have the potential to become any type of cell.The efficiency ........ Read more »

Qin, H., Diaz, A., Blouin, L., Lebbink, R., Patena, W., Tanbun, P., LeProust, E., McManus, M., Song, J., & Ramalho-Santos, M. (2014) Systematic Identification of Barriers to Human iPSC Generation. Cell, 158(2), 449-461. DOI: 10.1016/j.cell.2014.05.040  

  • July 28, 2014
  • 10:06 AM

Researchers Develop iPSCs-Based Model for Insulin Resistance

by beredim in Stem Cells Freak

C. Ronald KahnIn 2012, Japanese biologist Shinya Yamanaka won a Nobel Prize for discovering the so-called induced pluripotent stem cells" (iPSCs), cells derived from normal adult cells that have the ability to differentiate into almost any other kind of cells. Now, researchers at Joslin Diabetes Center say they have created the first iPSCs line that offers a human model for insulin resistance, a key driver of type 2 diabetes. "This is one of the very first studies of human iPSC models ........ Read more »

  • July 26, 2014
  • 12:46 AM

Researchers Develop Naive Human Embryonic Stem Cells without Using Reprogramming Factors

by beredim in Stem Cells Freak

For a long time now, researchers and patients have hoped that embryonic stem cells (ESCs) -- capable of turning into any cell type of the body -- could provide insight into numerous diseases perhaps even be used to treat them. Yet progress has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are "primed" and slightly less plastic than the mouse cells. Now Thorold Theunissen, Benjamin Powell, and........ Read more »

  • July 23, 2014
  • 03:17 AM

Novel Methods May Improve Stem Cell Survival after Transplantation into Damaged Tissues

by beredim in Stem Cells Freak

BioResearch Open Access is published online six times per year.Stem cells are a very promising solution for treating damaged organs and tissues, but with current transplantation approaches stem cell survival is poor, greatly limiting their effectiveness.New methods are being developed and tested to improve the survival and optimize their therapeutic function after transplantation, as described in a Review article in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., pu........ Read more »

Sébastien Sart, Teng Ma, and Yan Li. (2014) Preconditioning Stem Cells for In Vivo Delivery . BioResearch Open Access. info:/10.1089/biores.2014.0012.

  • July 22, 2014
  • 04:55 AM

Mesenchymal stem cells promote muscle repair and strengthening after resistance exercise

by beredim in Stem Cells Freak

Professor Marni BoppartNew research in mice reveals that mesenchymal stem cells (MSCs) help rejuvenate skeletal muscle after resistance exercise. By injecting MSCs into mouse leg muscles prior to several bouts of eccentric exercise (similar to the lengthening contractions performed during resistance training in humans that result in mild muscle damage), researchers were able to increase the rate of repair and enhance the growth and strength of those muscles in the exercising mice.The findings, ........ Read more »

Zou K, Huntsman HD, Valero MC, Adams J, Skelton J, De Lisio M, Jensen T, & Boppart MD. (2014) Mesenchymal Stem Cells Augment the Adaptive Response to Eccentric Exercise. Medicine and science in sports and exercise. PMID: 24905768  

  • July 20, 2014
  • 04:57 AM

Role of Astroglia in Down's Syndrome Revealed Thanks to iPSCs

by beredim in Stem Cells Freak

David Pleasure, Chen Chen, Wenbin Deng and Peng Jiang(left to right)Researchers from UC Davis School of Medicine and Shriners Hospitals for Children -- Northern California have identified a group of cells in the brain that they say plays an important role in the abnormal neuron development in Down syndrome.After developing a new model for studying the syndrome using patient-derived induced pluripotent stem cells, the scientists also found that applying an inexpensive antibiotic to the cells appe........ Read more »

Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC.... (2014) Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nature communications, 4430. PMID: 25034944  

  • July 18, 2014
  • 06:38 AM

Scientists discover gene that links stem cells, aging and cancer

by beredim in Stem Cells Freak

Stem cells from adult mouse epidermis (green, Cytokeratin 6; blue, cell nucleus); Sox4 protein maintains tissue homeostasis in these cells.An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired.This process is not yet well understood, but it is known that stem cells in the organs play a key role, and that when repair fails, the organism ages more quickly. Researchers f........ Read more »

Foronda, M., Martínez, P., Schoeftner, S., Gómez-López, G., Schneider, R., Flores, J., Pisano, D., & Blasco, M. (2014) Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation. Cell Reports. DOI: 10.1016/j.celrep.2014.06.031  

  • July 18, 2014
  • 06:29 AM

Discovery May Make It Easier to Develop Life-Saving Induced Pluripotent Stem Cells

by beredim in Stem Cells Freak

Human oocyteNot unlike looking for the proverbial needle in a haystack, a team of Michigan State University researchers have found a gene that could be key to the development of induced pluripotent stem cells, cells that can potentially save millions of lives by morphing into practically any cell in the body.The gene, known as ASF1A, was not discovered by the team. However, it is at least one of the genes responsible for the mechanism of cellular reprogramming, a phenomenon that can turn one cel........ Read more »

  • July 15, 2014
  • 03:21 AM

Wisconsin researchers report new genetic recipe to turn stem cells to blood

by beredim in Stem Cells Freak

Igor SlukvinA group led by University of Wisconsin-Madison stem cell researcher Igor Slukvin reported yesterday the discovery of two genetic programs responsible for taking blank-slate stem cells and turning them into both red and the array of white cells that make up human blood.The research is important because it identifies how nature itself makes blood products at the earliest stages of development. The discovery gives scientists the tools to make the cells themselves, investigate how blood ........ Read more »

Irina Elcheva, Vera Brok-Volchanskaya, Akhilesh Kumar, Patricia Liu, Jeong-Hee Lee, et al. (2014) Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators. Nature Communications. info:/10.1038/ncomms5372

  • July 11, 2014
  • 02:42 AM

Induced pluripotent stem cells in the treatment of retinitis pigmentosa

by beredim in Stem Cells Freak

Researchers at the Columbia University Medical Center (CUMC) have have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem cells (iPSCs) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing.Using this approach, researchers led by Stephen H. Ts........ Read more »

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