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steppen wolf
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  • May 15, 2008
  • 06:13 PM

finally an excuse for my sweet tooth!

by steppen wolf in ***

Finally I can blame this (supposedly, as I have not got my genome sequenced) on a genetic variant of the glucose transporter GLUT2. Yes, it does remind you of gluttony.A glucose transporter is a channel that allows cells to import glucose, and apparently the variant of GLUT2 you possess will affect your intake of sugary foods and drinks. Or, at least, there is a positive correlation between possession of one variant and increased consumption of sugary foods. The study documenting this was publis........ Read more »

  • April 21, 2008
  • 06:23 PM

RAS is regulated by miRNAs

by steppen wolf in ***

I have already discussed one of the newest papers on miRNA-mediated control of oncogenes and cell pluripotency in the field a few days ago. Given the interest, also in the science blogosphere, for studies and news related to miRNAs, I thought I might write here about a few more papers focusing on how miRNAs are able to modulate the protein levels of several genes important for the regulation of major signal transduction pathways, as well as cell growth and differentiation.Today I am going to be ........ Read more »

S JOHNSON, H GROSSHANS, J SHINGARA, M BYROM, R JARVIS, A CHENG, E LABOURIER, K REINERT, D BROWN, & F SLACK. (2005) Is Regulated by the MicroRNA Family. Cell, 120(5), 635-647. DOI: 10.1016/j.cell.2005.01.014  

  • April 17, 2008
  • 07:11 PM

Take your vitamins...and die?

by steppen wolf in ***

This meta-analysis was published online only tow days ago, and it is already going all around the net and the press. Why? Because the authors of the analysisfound no evidence to support antioxidant supplements for primary or secondary prevention. Vitamin A, beta-carotene, and vitamin E may increase mortality.Moreover, the results for vitamin C were inconclusive. Does it mean that taking vitamins is not only useless, but can even increase your chance to die? I cannot seem to access the full text ........ Read more »

G Bjelakovic, D Nikolova, L Gluud, & R Simonetti. (2008) Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database of Systematic Reviews, ?(2).

  • April 13, 2008
  • 07:07 AM

Molecular and Cell Biology Carnival #1

by steppen wolf in ***

Welcome to the very first edition of the Molecular and Cell Biology Carnival. We have only three contributors for our inaugural edition, so this is going to be short. But one has to start from somewhere somehow!Our first contributor is Alex Palazzo, who presents Let7 miRNAs, Lin-28, Cancer and Stem Cells posted at The Daily Transcript. This is one of the first posts going over a recently published Science paper exploring the relationship between regulation of a family of microRNAs and pluripoten........ Read more »

  • March 31, 2008
  • 05:19 PM

from chance to function: the story of one gene (part III)

by steppen wolf in ***

This is the third and final post on the story of FAPP2. You might want to read part I and part II before diving into this one, unless you are already familiar with secretory transport and the various organelles involved in it.In this post, I am going to go over a 2006 paper written by Kai Simons and some of his grad students, in collaboration with other researchers from the University of Coimbra (Portugal). In this paper, the authors finally link FAPP2 to membrane polarization and cilium formati........ Read more »

  • March 28, 2008
  • 07:11 PM

from chance to function: the story of one gene (part II)

by steppen wolf in ***

This post is the continuation of part I. In the first post, you were introduced to a couple of recently discovered genes named FAPP1 and FAPP2. In this post, we will change authors (and country) and start looking more closely to the function of FAPP2. More below the fold.The principal investigator behind this paper [1] published in 2005 is Kai Simons. In case you have never heard of him, he is quite famous among scientists focusing on membrane biology as he was one of the main proponents and sup........ Read more »

  • March 26, 2008
  • 12:12 AM

bring 'em all together: cancer, stem cells, miRNAs

by steppen wolf in ***

I got to know about this paper through Alex Palazzo's blog over at ScienceBlogs, and I thought I'd check it out, as pretty much all the bases covered are things I am very interested in. The paper has been posted through the Science website ahead of print, and it resulted from work done at Harvard Medical School.The most intriguing thing about stem cells and how they relate to cancer is probably the fact that, while there is evidence of cancer stem cells that seem to have derived from previously ........ Read more »

  • March 24, 2008
  • 05:05 AM

from chance to function: the story of one gene (part I)

by steppen wolf in ***

This is the story of a gene. A gene that researchers have started to properly characterize only very recently, and whose precise function is still unclear. This story is therefore without an end, though we can maybe imagine a beginning. But the story is only a way to show you how "roads" are built in research, and how from one stone to the next, a path finally emerges.In research, it is hard to think of a beginning, or an end. Unlike a business man, who can flesh out a marketing strate........ Read more »

Anna Godi, Antonella Campli, Athanasios Konstantakopoulos, Giuseppe Tullio, Dario Alessi, Gursant Kular, Tiziana Daniele, Pierfrancesco Marra, John Lucocq, & M Matteis. (2004) FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nature Cell Biology, 6(5), 393-404. DOI: 10.1038/ncb1119  

  • March 24, 2008
  • 05:05 AM

is gene therapy going down (or do we just play dumb?)

by steppen wolf in ***

Maybe I am just having a bad day and you'll think otherwise. What is that disappoints me? The idea that another chance was missed, or the idea that these people chose a gene for their gene therapy trials that had a high chance to send everything to hell? Maybe it's more because of the second thing I've said. More below the fold..I have just found this through Science Daily, and I decided to follow the thread. This is the story:Journal of Clinical Investigation (2008, March 23). Ge........ Read more »

Xiao-Bing Zhang, Brian Beard, Grant Trobridge, Brent Wood, George Sale, Reeteka Sud, R Humphries, & Hans-Peter Kiem. (2008) High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector . Journal of Clinical Investigation. DOI: 10.1172/JCI34371  

Andre Larochelle, & Cynthia Dunbar. (2008) HOXB4 and retroviral vectors: adding fuel to the fire. Journal of Clinical Investigation. DOI: 10.1172/JCI35326  

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