593 posts · 661,246 views
I am a physician interested in clinical neuroscience research. I will use this blog to post more detailed analysis of recent studies in addition to my @WRY999 Twitter scientific reading log. I will also post some of my wildlife/sports photography. Aim to educate and amuse. Not selling anything.
Child development produces marked changes in attention, impulsivity and activity levels. Preschool children present a significant challenge for the diagnosis of ADHD because of their typical activity and attention levels. It is possible that the diagnosis of ADHD in some young children might be incorrect due to delayed maturation.Swedish researchers looked at this issue in a study of children examined in grades one and two and then re-studied in eighth grade. A child who was hyperactive/inatte........ Read more »
Gustafsson P, Holmström E, Besjakov J, & Karlsson MK. (2010) ADHD symptoms and maturity - a follow up study in school children. Acta paediatrica (Oslo, Norway : 1992). PMID: 20456272
Pawan Sinha is an MIT academic engineer who is involved in a combined humanitarian, medical and scientific effort to understand childhood blindness. He has established a program in India called Project Prakash to identify children with congenital cataracts who would benefit for early correction. Early correction is key to prevent persistent blindess as visual plasticity declines over time if the retina and brain are not stimulated. He has challenged the idea that vision cannot be established ........ Read more »
Alcohol abuse and dependence risk is influenced by a variety of mental disorders. Probably the strongest association is between antisocial personality, alcohol and drug abuse. But anxiety and mood disorders also commonly influence the risk of developing a substance abuse problem.A recent study examined the association between alcohol use disorder and social anxiety disorder. Social anxiety disorder is defined as a pervasive anxiety related to human interaction. Patients with social anxiety c........ Read more »
Schneier FR, Foose TE, Hasin DS, Heimberg RG, Liu SM, Grant BF, & Blanco C. (2010) Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and Related Conditions. Psychological medicine, 40(6), 977-88. PMID: 20441690
Kevin Hall, Ph.D. spoke at the May 2010 Frontiers of Neuroscience series in Tulsa, Oklahoma. Dr. Hall is a senior faculty member of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at NIH. His presentation was titled: "Modelling Weight Gain and Loss: Links Betweein Nutrition, Metabolism and Body Composition. I will summarize my notes for his presentation and his recent research publications. Dr. Hall has been working on a mathematical model to describe the physiolo........ Read more »
Hall KD, & Chow CC. (2010) Estimating the quantitative relation between food energy intake and changes in body weight. The American journal of clinical nutrition, 91(3). PMID: 20071643
Hall KD, & Jordan PN. (2008) Modeling weight-loss maintenance to help prevent body weight regain. The American journal of clinical nutrition, 88(6), 1495-503. PMID: 19064508
Hall KD, Guo J, Dore M, & Chow CC. (2009) The progressive increase of food waste in America and its environmental impact. PloS one, 4(11). PMID: 19946359
Hall KD. (2010) Predicting metabolic adaptation, body weight change, and energy intake in humans. American journal of physiology. Endocrinology and metabolism, 298(3). PMID: 19934407
I have been working on updating a lecture on substance-induced psychosis. In the last few years a significant amount of research has been published on methamphetamine psychosis. Methamphetamine can produce a psychotic state characterized by paranoia, agitation and behavioral problems. Not all individuals appear to experience this induced state. This leads to the question of what factors might be related to the risk of psychosis in those using methamphetamine. Certain dose and duration of met........ Read more »
Ujike H, Katsu T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Sora I.... (2009) Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis. Progress in neuro-psychopharmacology , 33(4), 625-9. PMID: 19275926
Tsunoka T, Kishi T, Kitajima T, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Inada T.... (2010) Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. Progress in neuro-psychopharmacology . PMID: 20211215
A recent study examined the correlation between chocolate consumption and self-reported depression symptoms. This study used a cross-sectional design and a self-report measure of nutritional intake--the Fred Hutchinson Food Frequency Questionnaire.Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D). Subjects were stratified into three groups: CES-D score of 16 or less (non-depressed), CES-D score of 16-22 (positive depression screen) and CES-D ........ Read more »
Rose N, Koperski S, & Golomb BA. (2010) Mood food: chocolate and depressive symptoms in a cross-sectional analysis. Archives of internal medicine, 170(8), 699-703. PMID: 20421555
Wolz M, Kaminsky A, Löhle M, Koch R, Storch A, & Reichmann H. (2009) Chocolate consumption is increased in Parkinson's disease. Results from a self-questionnaire study. Journal of neurology, 256(3), 488-92. PMID: 19277767
Strandberg TE, Strandberg AY, Pitkälä K, Salomaa VV, Tilvis RS, & Miettinen TA. (2008) Chocolate, well-being and health among elderly men. European journal of clinical nutrition, 62(2), 247-53. PMID: 17327862
A common clinical problem in aging is when should driving a motor vehicle be discontinued. When does driving become a significant safety hazard as cognition and motor skills decline?The American Academy of Neurology recently published a Practice Parameter update: Evaluation and management of driving risk in dementia. This important review provides clinicians and family members with assistance in making an accurate and timely decision.The authors of the guideline review research evidence of a v........ Read more »
Iverson, D., Gronseth, G., Reger, M., Classen, S., Dubinsky, R., & Rizzo, M. (2010) Practice Parameter update: Evaluation and management of driving risk in dementia: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 74(16), 1316-1324. DOI: 10.1212/WNL.0b013e3181da3b0f
Significant research focuses on the identification of biomarkers in a a variety of psychiatric disorders. A biomarker can be any biological variable that is associated with an illness. Biomarkers are important because they provide an opportunity to identify high-risk individuals prior to disease onset. Early intervention in these individuals may reduce the risk of illness or reduce the severity and impairment of the disorder. Biomarkers may also be valuable in identifying genes associated wi........ Read more »
Roberts ME, Tchanturia K, & Treasure JL. (2010) Exploring the neurocognitive signature of poor set-shifting in anorexia and bulimia nervosa. Journal of psychiatric research. PMID: 20398910
Migraine headaches are a common type of severe headache that can cause significant episodic disability. The one-year prevalence for migraine is estimated to be 18% for women and 6% for men in the U.S. Headaches typically last from four to 72 hours and can interfere with work and interpersonal function.A recent Cochrane Review examined the effectiveness of aspirin. The review included a comparison between aspirin and more recently developed triptan drugs such as sumatriptin (Imitrex). Thirtee........ Read more »
Kirthi V, Derry S, Moore RA, & McQuay HJ. (2010) Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane database of systematic reviews (Online). PMID: 20393963
This is the third in a series of posts from the NARSAD-sponsored Healthy Minds Across America 2010 symposium in Tulsa, Oklahoma. The first two posts covered deep brain stimulation in depression and the neurocircuitry of depression. Dr. Robert Kowatch presented a review of the key issues in pediatric mood disorder. Dr. Kowatch is a child and adolescent psychiatrist from the University of Cincinnati who has been involved in assessment of bipolar disorder and depression. A portion of his presen........ Read more »
Danner S, Fristad MA, Arnold LE, Youngstrom EA, Birmaher B, Horwitz SM, Demeter C, Findling RL, Kowatch RA, & LAMS Group. (2009) Early-onset bipolar spectrum disorders: diagnostic issues. Clinical child and family psychology review, 12(3), 271-93. PMID: 19466543
Zimmerman M, Ruggero CJ, Chelminski I, & Young D. (2010) Psychiatric diagnoses in patients previously overdiagnosed with bipolar disorder. The Journal of clinical psychiatry, 71(1), 26-31. PMID: 19646366
Zimmerman M, Ruggero CJ, Chelminski I, & Young D. (2010) Clinical characteristics of depressed outpatients previously overdiagnosed with bipolar disorder. Comprehensive psychiatry, 51(2), 99-105. PMID: 20152287
This is the second in a series of three posts from my notes at the NARSAD Healthy Minds Across American 2010 symposium in Tulsa, Oklahoma. The University of Oklahoma-Tulsa and OU-Tulsa President Dr. Gerry Clancy served as host for the event. Following a presentation by Dr. Helen Mayberg from Emory University (notes here), Dr. Wayne Drevets presented a review of neurocircuitry in depression.Dr. Drevets has been a leader in neuroimaging research in mood disorders. His studies have included usin........ Read more »
NARSAD, a leading private funding organization for brain disorders is sponsoring educational symposiums across the United States. One such symposium in the Healthy Minds Across America 2010 series was held in Tulsa, Oklahoma on April 10, 2010. Three internationally recognized researchers presented at the Tulsa symposium: Helen Mayberg, Wayne Drevets and Robert Kowatch. I will present some of my notes for these presentations over the next week. This post will summarize the key points for Dr......... Read more »
Mayberg HS. (2009) Targeted electrode-based modulation of neural circuits for depression. The Journal of clinical investigation, 119(4), 717-25. PMID: 19339763
There is some research evidence to support the cognitive benefits of omega 3 fatty acids. These natural compounds are found in a variety of dietary sources including tuna, salmon and sardines. McNamara et al and colleagues at the University of Cincinnati recently published an interesting brain fMRI study of DHA (docosahexaenoic acid) supplementation. DHA is a key component of omega-3 fatty acids. Here are the key elements of the design:33 healthily boys age 8 to 10 years were randomizedSubjec........ Read more »
McNamara, R., Able, J., Jandacek, R., Rider, T., Tso, P., Eliassen, J., Alfieri, D., Weber, W., Jarvis, K., DelBello, M.... (2010) Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. American Journal of Clinical Nutrition, 91(4), 1060-1067. DOI: 10.3945/ajcn.2009.28549
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