Dormivigilia

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167 posts · 86,451 views

This blog highlights current neuroscience news published in peer-reviewed journals, with a particular emphasis on sleep/circadian rhythms. Every Thursday, I feature the front-page photomicrograph and the respective article from the current week's Journal of Neuroscience in a segment titled Neury Thursday. I also incorporate a substantial amount of media, including the highlighted article and related video. I try to write for the lay person, but if I do inevitably use jargon, I will briefly explain and provide a wikipedia reference. I'd like to think I have a sense of humor reflected through my writing style and/or post topics

Allison
167 posts

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  • March 3, 2014
  • 09:00 AM
  • 105 views

Life (for a mouse) sucks without Bmal1

by Allison in Dormivigilia

Scientists have uncovered a host of pathological consequences in liver- and mitochondrial-pathways in the absence of Bmal1. These studies lend further credence to Bmal1 being important for rhythms of metabolism. These critters are certainly no star athletes. ... Read more »

Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C.... (2013) Circadian clock NAD cycle drives mitochondrial oxidative metabolism in mice. Science (New York, N.Y.), 342(6158), 1243417. PMID: 24051248  

  • February 13, 2014
  • 11:00 AM
  • 360 views

Neury Thursday: Genotypic Insights on Dopamine, Modafinil, and Sleep

by Allison in Dormivigilia

A recent study in the Journal of Neuroscience uncovers genetic sensitivity to drugs that increase dopamine concentrations and their subsequent effects on sleep in humans. These studies raise important concerns for primary care practitioners when prescribing meds. ... Read more »

Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, & Landolt HP. (2014) Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(2), 566-73. PMID: 24403155  

  • January 20, 2014
  • 11:07 AM
  • 182 views

Gender Influences Sleep Amount and Subsequent Physiology

by Allison in Dormivigilia

Very good friends of mine examined the relationship between actual bed time and underlying physiology in a huge cohort of male versus female college students. Perhaps we should be more sensitive to others' complaints of sleep. ... Read more »

Van Reen E, Sharkey KM, Roane BM, Barker D, Seifer R, Raffray T, Bond TL, & Carskadon MA. (2013) Sex of College Students Moderates Associations among Bedtime, Time in Bed, and Circadian Phase Angle. Journal of biological rhythms, 28(6), 425-31. PMID: 24336420  

  • December 24, 2013
  • 04:25 PM
  • 255 views

How not to Write an Original Science Paper

by Allison in Dormivigilia

A recent study in the Journal of Clinical Investigation is a good representative example of bad data organization and presentation. I usually refrain from criticizing studies because I'd like reviewers to give me the same benefit of the doubt, but this is beyond acceptable for such a high-impact journal. ... Read more »

Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP.... (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. The Journal of clinical investigation, 123(12), 5389-400. PMID: 24270424  

  • December 6, 2013
  • 01:00 PM
  • 192 views

Rethinking the Nucleus Accumbens: Regulating Sleep

by Allison in Dormivigilia

The accumbens is historically classified as a reward center. But recent research in animal models shows that it also regulates sleep-This is no surprise, right? Don't you have to hypothetically be awake in order to partake in something pleasurable?... Read more »

  • November 3, 2013
  • 11:22 AM
  • 215 views

Novel Means to Quantify Physiological Sleepiness

by Allison in Dormivigilia

My postdoctoral laboratory has published a methods paper in the recent issue of Sleep that provides a means to determine physiological sleepiness as it occurs, not de facto. They are mice after all, but if these findings were extrapolated to humans, then the scary reality of just a few hours of sleep loss is apparent-a moving body in a brain that is essentially asleep. ... Read more »

  • October 5, 2013
  • 04:30 PM
  • 234 views

Revisiting Caffeinated Alcoholic Beverages: Effects on Sleep

by Allison in Dormivigilia

After getting college students hammered via caffeine-infused alcohol (most like Red Bull-vodkas), the researchers surprisingly found that these drinks have little effect on sleep. Their effects on risks for addiction and brain health is a different story...... Read more »

  • October 5, 2013
  • 03:30 PM
  • 221 views

Neury Thursday: Sleep in Worms Cont'd

by Allison in Dormivigilia

Worms have a sleep-like state known as lethargus in between their molting cycles. Researchers in Germany carefully studied lethargus at behavioral, physiologically, and cellular levels providing convincing evidence that worms and their nervous system works in similar manners to control daily sleep. ... Read more »

  • September 14, 2013
  • 03:30 PM
  • 251 views

Neury Thursday: Neuroglia and Sleep

by Allison in Dormivigilia

Researchers have creatively examined the oligodendrocyte genome by exclusively studying mRNA bound to ribosomes. Not a surprise that biological factors regulating cell proliferation are augmented during sleep and see a sharp decline with sleep deprivation .... Read more »

Bellesi M, Pfister-Genskow M, Maret S, Keles S, Tononi G, & Cirelli C. (2013) Effects of sleep and wake on oligodendrocytes and their precursors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(36), 14288-300. PMID: 24005282  

  • July 6, 2013
  • 05:00 PM
  • 242 views

Basic Mechanisms of Sleep Cont'd

by Allison in Dormivigilia

Researchers used optogenetics to elucidate the role of MCH-containing neurons in the hypothalamus on daily sleep amounts. It's clear by this point that optogenetics is the preferred approach for understanding the mechanisms of sleep and wake. ... Read more »

Konadhode, R., Pelluru, D., Blanco-Centurion, C., Zayachkivsky, A., Liu, M., Uhde, T., Glen, W., van den Pol, A., Mulholland, P., & Shiromani, P. (2013) Optogenetic Stimulation of MCH Neurons Increases Sleep. Journal of Neuroscience, 33(25), 10257-10263. DOI: 10.1523/JNEUROSCI.1225-13.2013  

  • July 2, 2013
  • 05:30 PM
  • 221 views

Veggie Tales: Not far from the Truth

by Allison in Dormivigilia

A handful of really creative researchers found evidence for biological clocks in a variety of garden veggies. Further, the rates of herbivory varied with the type of light-dark cycle (normal vs abnormal). Cool stuff!... Read more »

  • June 16, 2013
  • 11:24 PM
  • 285 views

Rhythms of Songbirds: City vs Nature

by Allison in Dormivigilia

It's true. Light pollution doesn't treat a songbird nicely... Read more »

Dominoni, D., Helm, B., Lehmann, M., Dowse, H., & Partecke, J. (2013) Clocks for the city: circadian differences between forest and city songbirds. Proceedings of the Royal Society B: Biological Sciences, 280(1763), 20130593-20130593. DOI: 10.1098/rspb.2013.0593  

  • June 5, 2013
  • 11:09 PM
  • 263 views

Bmal1 and Body Composition

by Allison in Dormivigilia

Researchers investigated the effects of a null Bmal1 deletion on glucose and fat metabolism. The results are consistent with previous studies, providing more clarity that Bmal1 regulates metabolism. ... Read more »

  • May 26, 2013
  • 11:45 PM
  • 300 views

First Postdoc Paper: Jetlag, Inflammation, and Sleep Loss

by Allison in Dormivigilia

We re-evaluated the impact of jet lag and sleep loss on the inflammatory response. Jet lag wins, body loses. ... Read more »

  • May 5, 2013
  • 11:30 AM
  • 275 views

Chromosomes, Sex, and Sleep

by Allison in Dormivigilia

We have differentiated between chromosomal versus hormonal influences on normal sleep and sleep rebounds in hermaphroditic mice. The neural mechanisms are TBD, however. ... Read more »

  • April 30, 2013
  • 07:25 PM
  • 300 views

Molecular Evidence for Memory Consolidation during REM Sleep

by Allison in Dormivigilia

Molecular biologists have observed changes in common signaling cascades throughout the course of REM sleep episodes (in rodents) with disruption to these signaling cascades leading to memory deficits. It's good to see a paper focusing on mechanism now that we have a plethora of papers showing that depriving yourself of REM sleep can have detrimental effects on all types of memory (episodic, emotional, declarative, procedural) ... Read more »

  • April 23, 2013
  • 10:30 PM
  • 305 views

My Doctoral Diploma: Per2, Circadian Rhythms, and Coke

by Allison in Dormivigilia

This paper marks my official graduation from my doctoral program. I examined how clock genes modulate the ability of cocaine to shift rhythms of locomotor activity ... Read more »

  • April 21, 2013
  • 11:30 AM
  • 286 views

PET scans in rodents?

by Allison in Dormivigilia

Neuroimaging in rodents is now widely used. These researchers identified brain areas activated during wake and compared this activation with other common means of activation (optogenetics). While this study is more of a methods paper, I do think that there are a few important loopholes that the reviewers overlooked (sorry). ... Read more »

Thanos PK, Robison L, Nestler EJ, Kim R, Michaelides M, Lobo MK, & Volkow ND. (2013) Mapping Brain Metabolic Connectivity in Awake Rats with μPET and Optogenetic Stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(15), 6343-6349. PMID: 23575833  

  • April 13, 2013
  • 04:54 PM
  • 266 views

Influences of Genetic and Hormonal Sex on Circadian Rhythms

by Allison in Dormivigilia

Mice with the human equivalent of gender identity disorder (XX males and XY females) reveal unique aspects of circadian rhythms that are under the influences of genetic vs. hormonal sex.... Read more »

Kuljis, D., Loh, D., Truong, D., Vosko, A., Ong, M., McClusky, R., Arnold, A., & Colwell, C. (2013) Gonadal- and Sex-Chromosome-Dependent Sex Differences in the Circadian System. Endocrinology, 154(4), 1501-1512. DOI: 10.1210/en.2012-1921  

  • March 24, 2013
  • 11:00 AM
  • 335 views

Sleep in a worm, regulation by muscle

by Allison in Dormivigilia

Researchers at UPENN have provided evidence for muscle regulation of sleep in a simple model organism; the roundworm. Whether this has any replicational potential in mammalian species remains unknown, but I definitely think it will be a hott topic in research (and the media)... Read more »

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