15 posts · 5,472 views
Functional Neurogenesis is devoted to understanding the function of adult-born neurons in the dentate gyrus of the hippocampus, and includes discussion of scientific research papers, methods and protocols, and other trends or observations of the field. However, since we cannot truly understand the function of adult hippocampal neurogenesis without also studying memory systems, other forms of plasticity, development etc., we invariably comment on findings in areas outside of the adult neurogenesis literature, that are interesting or are relevant.
Jason Snyder
15 posts
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- June 10, 2011
- 01:51 PM
- 101 views
New neurons mature very slowly in monkeys
by Jason Snyder in Functional Neurogenesis
So, it turns out that neurogenesis in primates is quite a bit different than in rodents. It’s been over 10 years since adult neurogenesis was first described in the adult primate hippocampus and yet much of the basic work has yet to be done. That’s where this new study by Kohler et al. come in. [...]... Read more »
Kohler SJ, Williams NI, Stanton GB, Cameron JL, & Greenough WT. (2011) Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21646517
- June 10, 2011
- 01:51 PM
- 100 views
New neurons mature very slowly in monkeys
by Jason Snyder in Functional Neurogenesis
So, it turns out that neurogenesis in primates is quite a bit different than in rodents. It’s been over 10 years since adult neurogenesis was first described in the adult primate hippocampus and yet much of the basic work has yet to be done. That’s where this new study by Kohler et al. come in. [...]... Read more »
Kohler SJ, Williams NI, Stanton GB, Cameron JL, & Greenough WT. (2011) Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21646517
- June 10, 2011
- 01:51 PM
- 98 views
New neurons mature very slowly in monkeys
by Jason Snyder in Functional Neurogenesis
So, it turns out that neurogenesis in primates is quite a bit different than in rodents. It’s been over 10 years since adult neurogenesis was first described in the adult primate hippocampus and yet much of the basic work has yet to be done. That’s where this new study by Kohler et al. come in. [...]... Read more »
Kohler SJ, Williams NI, Stanton GB, Cameron JL, & Greenough WT. (2011) Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21646517
- April 20, 2011
- 06:15 PM
- 99 views
Random roundup
by Jason Snyder in Functional Neurogenesis
“Random” roundup because any posts linking to articles or ideas I’ve recently found noteworthy will never occur on a regular basis (as others manage to do – I applaud you) but only when enough interesting material has accrued and I have a spare moment. The links will, however, not be random. For example, you can [...]... Read more »
Mu Y, Zhao C, & Gage FH. (2011) Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-Born Dentate Granule Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(11), 4113-23. PMID: 21411652
Sadowski RN, Canal CE, & Gold PE. (2011) Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala. Neurobiology of learning and memory. PMID: 21453778
Oudiette D, Constantinescu I, Leclair-Visonneau L, Vidailhet M, Schwartz S, & Arnulf I. (2011) Evidence for the Re-Enactment of a Recently Learned Behavior during Sleepwalking. PloS one, 6(3). PMID: 21445313
Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, & Hen R. (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. PMID: 21460835
Perera, T., Dwork, A., Keegan, K., Thirumangalakudi, L., Lipira, C., Joyce, N., Lange, C., Higley, J., Rosoklija, G., Hen, R.... (2011) Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0017600
Kimbrough A, Kwon B, Eckel LA, & Houpt TA. (2011) Systemic 5-bromo-2-deoxyuridine induces conditioned flavor aversion and c-Fos in the visceral neuraxis. Learning , 18(5), 292-5. PMID: 21498563
Singer BH, Gamelli AE, Fuller CL, Temme SJ, Parent JM, & Murphy GG. (2011) Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice. Proceedings of the National Academy of Sciences of the United States of America, 108(13), 5437-42. PMID: 21402918
- February 21, 2011
- 06:58 PM
- 423 views
Are new neurons really more excitable? (yes)
by Jason Snyder in Functional Neurogenesis
Some facts on neuronal excitability:
Excitable: the ability to fire action potentials.
More excitable: fires action potentials, but more.
More LTP: not the same as more excitable.
Less inhibition: also not the same as more excitable, though the two may go hand in hand.
The Scholarpedia page on neuronal excitability, which was last modified on 13 August 2009, has been [...]... Read more »
Mongiat LA, Espósito MS, Lombardi G, & Schinder AF. (2009) Reliable activation of immature neurons in the adult hippocampus. PloS one, 4(4). PMID: 19399173
- February 16, 2011
- 11:31 AM
- 440 views
How does the brain pick which neurons to use?
by Jason Snyder in Functional Neurogenesis
Wiring. That’s one answer to this question. We know this from topographic maps in the thalamus and neocortex, where the basic units of sensory information are neatly represented in spatially-arranged populations of neurons – the various body parts are represented in specific locations, as are the different frequencies of sound, the different parts of the retina, and [...]... Read more »
Yassin L, Benedetti BL, Jouhanneau JS, Wen JA, Poulet JF, & Barth AL. (2010) An embedded subnetwork of highly active neurons in the neocortex. Neuron, 68(6), 1043-50. PMID: 21172607
Dragoi G, & Tonegawa S. (2011) Preplay of future place cell sequences by hippocampal cellular assemblies. Nature, 469(7330), 397-401. PMID: 21179088
- August 31, 2010
- 12:22 AM
- 295 views
Someone finally dissects the role new neurons play in fear conditioning
by Jason Snyder in Functional Neurogenesis
Based on a true story – how progress is made in the field of adult neurogenesis*
A group of scientists reduce neurogenesis and report a memory deficit.
A second group repeats the experiment, with only a few minor differences in protocol, and fails to find a memory deficit.
A third group, using the same species as the first [...]... Read more »
Drew MR, Denny CA, & Hen R. (2010) Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning. Behavioral neuroscience, 124(4), 446-54. PMID: 20695644
- August 23, 2010
- 10:45 AM
- 426 views
Do new neurons go through a critical period and then retire, never to be used again?
by Jason Snyder in Functional Neurogenesis
And here we have the latest, craziest hypothesis of granule cell function. Crazy not because the authors have lost their minds but because the story of the dentate gyrus, where adult neurogenesis occurs, is becoming more peculiar every day. The underlying premise of this paper by Alme et al. (which we will examine later) is [...]... Read more »
Alme, C., Buzzetti, R., Marrone, D., Leutgeb, J., Chawla, M., Schaner, M., Bohanick, J., Khoboko, T., Leutgeb, S., Moser, E.... (2010) Hippocampal granule cells opt for early retirement. Hippocampus. DOI: 10.1002/hipo.20810
- May 12, 2010
- 03:30 AM
- 330 views
What IS the dentate gyrus doing to CA3?
by Jason Snyder in Functional Neurogenesis
A fundamental property of the hippocampus is its ability to rapidly encode memories while simultaneously keeping them distinct. Recording from hippocampal neurons one can clearly see that different populations of neurons are active as a rat explores two environments. This is thought to be one mechanism by which information is kept distinct in the brain.
For [...]... Read more »
Leutgeb JK, Leutgeb S, Moser MB, & Moser EI. (2007) Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science, 315(5814), 961-6. PMID: 17303747
- May 3, 2010
- 03:39 AM
- 395 views
Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
by Jason Snyder in Functional Neurogenesis
Dendrites are the extensions of neurons that receive incoming information. Neurons have primary dendrites that further split off into secondary and tertiary dendritic branches. On each of these branches are thousands of synaptic connections with axons of neurons carrying incoming information. The result is a dendritic tree that is capable of receiving and integrating a wide array [...]... Read more »
Tronel S, Fabre A, Charrier V, Oliet SH, Gage FH, & Abrous DN. (2010) Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7963-8. PMID: 20375283
- April 15, 2010
- 01:10 PM
- 483 views
Increased neurogenesis is not (necessarily) the opposite of reduced neurogenesis
by Jason Snyder in Functional Neurogenesis
Two recent papers have attracted a lot of media attention because they draw direct links between adult neurogenesis and behavioral disorders: Noonan et al. showed that rats lacking adult neurogenesis (stopped with irradiation) are more susceptible to cocaine addiction. Jin et al. showed that mice lacking adult neurogenesis (using a transgenic model) suffer greater infarct [...]... Read more »
Noonan MA, Bulin SE, Fuller DC, & Eisch AJ. (2010) Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(1), 304-15. PMID: 20053911
Jin K, Wang X, Xie L, Mao XO, & Greenberg DA. (2010) Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20385829
- March 22, 2010
- 04:17 PM
- 346 views
The first example of functional neurogenesis?
by Jason Snyder in Functional Neurogenesis
I recently became re-acquainted with the neurogenesis literature while writing the last post, re-finding data in papers whose gist, but not details, I had remembered. I reached out a little bit, asking others if I had forgot any studies and indeed I had, including this study by Okano, Pfaff and Gibbs from 1993.
I’ve been [...]... Read more »
Okano HJ, Pfaff DW, & Gibbs RB. (1993) RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2930-8. PMID: 8331381
- February 4, 2010
- 04:06 PM
- 590 views
Adult neurogenesis in humans: Murine Features of Neurogenesis in the Human Hippocampus
by Jason Snyder in Functional Neurogenesis
Studies of adult neurogenesis often begin with the following sentence: “Adult neurogenesis occurs in all mammals examined, including humans.” More detail-oriented papers might say, “Adult neurogenesis occurs in all mammals examined, including humans…but not bats.” Here, the similarities between bats and humans become more evident than one might expect: it could be an equally long [...]... Read more »
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R., Horvat, V., Volk, B., & Kempermann, G. (2010) Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008809
- January 25, 2010
- 01:22 PM
- 742 views
Decade in review #1: the neurogenesis-depression hypothesis
by Jason Snyder in Functional Neurogenesis
A major theme in the field of adult neurogenesis is the neurogenesis-depression hypothesis, the idea that newborn neurons are protective against depression. ... Read more »
Malberg JE, Eisch AJ, Nestler EJ, & Duman RS. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(24), 9104-10. PMID: 11124987
Santarelli, L. (2003) Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants. Science, 301(5634), 805-809. DOI: 10.1126/science.1083328
- December 22, 2009
- 11:42 AM
- 604 views
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory
by Jason Snyder in Functional Neurogenesis
A review of the Cell paper by Kitamura, Inokuchi and colleagues on the role of adult-born neurons in systems consolidation of memory.... Read more »
Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H, Sekiguchi M, Sugiyama H, & Inokuchi K. (2009) Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell, 139(4), 814-27. PMID: 19914173
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