Most parents don’t want to think about their children as depressed, but that can be a deadly mistake. Short of clinical diagnosis through cost prohibitive therapy, there is no real way to tell if a child is at risk for depression. However, according to new research from Binghamton University , how much a child’s pupil dilates in response to seeing an emotional image can predict his or her risk of depression over the next two years.... Read more »
Burkhouse, K., Siegle, G., Woody, M., Kudinova, A., & Gibb, B. (2015) Pupillary Reactivity to Sad Stimuli as a Biomarker of Depression Risk: Evidence From a Prospective Study of Children. Journal of Abnormal Psychology. DOI: 10.1037/abn0000072
While filleting a bass I found a dead snake inside, when the fish was caught it was a healthy fighting fish. My question is: Is it safe to eat the fish? Thanks,
You better believe that this e-mail caught my attention. It reminded me of this letter about whether it was safe to eat a fish that had been bitten by a Cottonmouth. In that case, I probably would not eat the fish. But, I did... Read more »
R. Arbaugh, T. Arbaugh., & D. A. Steen. (2015) Nerodia fasciata (Southern Watersnake). Predation. Herpetological Review. info:/
If you already think everything at the bottom of the ocean is slightly terrifying, Iosactis vagabunda won't change your mind. It's transparent, can tunnel underground, and hunts animals 15 times its size. And scientists are now realizing that there might be way, way more of these roaming killers than they'd previously thought.
Iosactis vagabunda lives on the Porcupine Abyssal Plain, a seabed southwest of Ireland that ranges from 4,000 to nearly 5,000 meters deep. The species was already t... Read more »
Durden, J., Bett, B., & Ruhl, H. (2015) The hemisessile lifestyle and feeding strategies of Iosactis vagabunda (Actiniaria, Iosactiidae), a dominant megafaunal species of the Porcupine Abyssal Plain. Deep Sea Research Part I: Oceanographic Research Papers, 72-77. DOI: 10.1016/j.dsr.2015.04.010
One the early things I was taught in my neuroscience training was that new-onset visual hallucinations need to be assessed for medical or "organic causes".Auditory hallucinations were felt to be more characteristic of schizophrenia.One medical disorder linked to visual hallucinations is dementia with Lewy bodies (DLB). DLB is second to Alzheimer's disease in producing neurodegenerative dementia. Visual hallucinations is a hallmark of DLB and is found in up to 70% of clinical samples with the disorder.A recent study from France provides insight into the neuroanatomical correlates of visual hallucinations in DLB.Researchers in this study used single-photon emission computed tomography (SPECT) in a group of 36 subjects with DLB who reported visual hallucinations.This group of cases was compared to 30 subjects with DLD who did not report visual hallucinations.Specific differences in blood flow were noted with visual hallucinations. Visual hallucinations subjects had diminished cerebral perfusion in the following regions.Left anterior cingulate cortexLeft orbitofrontal cortexLeft cuneusDeficits in regional cerebral perfusion in several areas correlated with the severity of visual hallucinations:Bilateral anterior cingulate cortexLeft orbitofrontal cortexRight parahippocampal gyrusRight inferior temporal cortexLeft cuneusThe authors note the cuneus (also known as Brodmann's area 18). This region is known as a secondary visual integration area. Reduced blood flow to this region may contribute to visual processing errors and the subjective sensation of visual hallucinations. Perfusion deficits in more anterior regions may contribute to inability to recognize the visual hallucinations as abnormal.This study is one of many emerging showing specific clinical features of neuropsychiatric disorders may relate to specific neuroanatomical deficits and impairment.Readers with more interest in this topic can access the free full-text manuscript by clicking on the citation below.Image of left cingulate cortex is an iPad screen shot from the app 3D Brain from the author's files.Follow the author on Twitter @WRY999Heitz C, Noblet V, Cretin B, Philippi N, Kremer L, Stackfleth M, Hubele F, Armspach JP, Namer I, & Blanc F (2015). Neural correlates of visual hallucinations in dementia with Lewy bodies. Alzheimer's research & therapy, 7 (1) PMID: 25717349... Read more »
Heitz C, Noblet V, Cretin B, Philippi N, Kremer L, Stackfleth M, Hubele F, Armspach JP, Namer I, & Blanc F. (2015) Neural correlates of visual hallucinations in dementia with Lewy bodies. Alzheimer's research , 7(1), 6. PMID: 25717349
Two studies that investigate the effectiveness of activity trackers.... Read more »
Diaz K, Krupka D, Chang M, Peacock J, Ma Y, Goldsmith J, Schwartz J, & Davidson K. (2015) Fitbit®: An accurate and reliable device for wireless physical activity tracking. International Journal of Cardiology, 138-140. DOI: 10.1016/j.ijcard.2015.03.038
Ferguson T, Rowlands A, Olds T, & Maher C. (2015) The validity of consumer-level, activity monitors in healthy adults worn in free-living conditions: a cross-sectional study. International Journal of Behavioral Nutrition and Physical Activity, 12(1). DOI: 10.1186/s12966-015-0201-9
Human error is now the leading cause of plane crashes, and one of the principal factors that provokes pilots to make mistakes is stress. Some pilots cope heroically in the face of stress, such as Chesley Sullenberger who steered his plane and passengers to safety, landing on the Hudson river after a double engine failure. Others fare less well, with sometimes fatal results. Knowing in advance how pilots will respond to stressful situations is therefore of paramount of importance to flight safety – for example, to indicate whether they need more training.A new study reports that, more than relevant facts such as age and years of experience, pilots' answers to two simple questions can more accurately forecast how they will respond to a stressful situation.Samuel Vine and his colleagues recruited 16 experienced commercial airline pilots (average age 35; two women) to complete a Bombardier Dash 8 flight simulator exercise. After they readied the plane for take-off, the pilots were told that the exercise would involve an engine failure occurring shortly after take off (widely considered one of the most stressful situations a pilot can face) and their task would be to land the plane safely. It was at this point that the two key questions were posed to the pilots:"How demanding do you expect the task to be?""How able are you to cope with the demands of the task?"The pilots scored their answer to each question on a scale of 1 (not at all) to 6 (extremely). The difference between the two provided a single measure of whether the pilots interpreted the forthcoming emergency as a challenge (when coping ability outweighs demands) or a threat (coping ability insufficient for the demands).The important finding was that this single measure accurately predicted how well the pilots subsequently coped with the engine failure during the flight simulation. Pilots who rated the upcoming situation as more of a threat tended to perform worse than those who rated it more as a challenge.This was true whether the pilots' performance was judged subjectively by a flight instructor (who was naive as to the aims of the study) or through objective measures of aircraft control, such as the speed and heading of the plane and the pilots' gaze (in terms of how much they looked where they should on the control panel).Moreover, the these two simple questions predicted the pilots' coping abilities above and beyond other relevant factors such as age and years of experience. After age and experience were accounted for, the threat/challenge score explained 61 per cent of the variance on the instructor's subjective ratings of performance and 33 per cent of the variance in the heading of the plane. Further analysis showed that one of the key ways that a threat response adversely affected the pilots' handling of the plane was through its effect on their gaze: specifically, a threat reaction was associated with more fixations overall, and looking in the wrong places.The study isn't perfect – of course it relied on a flight simulator for one thing – but the results are important. They have "implications for safety and error avoidance in safety critical industries (e.g. aviation, surgery, and driving) and for improved performance in stressful applied environments (e.g. sport and military)," the researchers concluded, "... the current study provides further support for the validity of expedient self-report measures that can be easily collected in applied environments."_________________________________ Vine, S., Uiga, L., Lavric, A., Moore, L., Tsaneva-Atanasova, K., & Wilson, M. (2015). Individual reactions to stress predict performance during a critical aviation incident Anxiety, Stress, & Coping, 28 (4), 467-477 DOI: 10.1080/10615806.2014.986722 --further reading--If your plane gets lost you'd better hope there's an orienteer on boardImproving aircraft safetyPost written by Christian Jarrett (@psych_writer) for the BPS Research Digest.
... Read more »
Vine, S., Uiga, L., Lavric, A., Moore, L., Tsaneva-Atanasova, K., & Wilson, M. (2014) Individual reactions to stress predict performance during a critical aviation incident. Anxiety, Stress, , 28(4), 467-477. DOI: 10.1080/10615806.2014.986722
To assess the value of spirituality, this article aims to give a clear, imaginable and humble impression of spirituality research. It describes research of spiritual practices, which are practiced by people of multiple religious affiliations and even by irreligious people.... Read more »
Vickhoff, B., Malmgren, H., Åström, R., Nyberg, G., Ekström, S., Engwall, M., Snygg, J., Nilsson, M., & Jörnsten, R. (2013) Music structure determines heart rate variability of singers. Frontiers in Psychology. DOI: 10.3389/fpsyg.2013.00334
de Ridder D, Kroese F, Adriaanse M, & Evers C. (2014) Always gamble on an empty stomach: hunger is associated with advantageous decision making. PloS one, 9(10). PMID: 25340399
Friese M, Schweizer L, Arnoux A, Sutter F, & Wänke M. (2014) Personal prayer counteracts self-control depletion. Consciousness and cognition, 90-5. PMID: 25277947
Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, & Libermann TA. (2013) Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PloS one, 8(5). PMID: 23650531
Ybarra O, Burnstein E, Winkielman P, Keller MC, Manis M, Chan E, & Rodriguez J. (2008) Mental exercising through simple socializing: social interaction promotes general cognitive functioning. Personality , 34(2), 248-59. PMID: 18212333
"Parents of children with ASD [autism spectrum disorder] living in Stockholm, Sweden in 2006 were more likely to be on sick leave, not in the labor force, or earning low income when compared to parents who did not have a child with ASD and these results remained after adjusting for familial socioeconomic factors and parental psychiatric care."That was the rather grim conclusion reached by Miranda McEvilly and colleagues  (open-access) following their analysis of families taking part in the Stockholm Youth Cohort (SYC) initiative  - "a record-linkage study comprising all individuals aged 0–17 years, ever resident in Stockholm County in 2001–2007 (N = 589,114)." From the huge number of participants, researchers identified 2,982 mothers/fathers with a child diagnosed on the autism spectrum: "1,207 had ASD with ID [intellectual disability] (or more than one child with ASD where at least one of the children had ASD with ID) and 1,685 had ASD without ID.""Four outcomes, two for sick leave and two for work participation, were obtained using data from LISA in 2006." LISA by the way, refers to "the longitudinal integration database for health insurance and labor market studies (LISA)" based in Sweden and carries quite a bit of information about employment and related parameters. Participant data were analysed according to the presence of offspring autism and whether or not said autism was accompanied by ID or not. Various potential confounding variables were also added into the statistical mix as per the headline sentence above.Results: well, we already know that parents with a child (or children) with autism were quite a bit more likely to be taking sick leave or not to be in work or to be on a low income compared to those without. This trend was particularly notable in mothers of children with autism. Researchers also reported that when comparing families with a child with autism and ID with those with a child with autism but no ID, several differences were also apparent. So: "Increased sick leave (15–365 days) is associated with parents of children with ASD without ID but not ASD with ID" (again, with mothers faring worse than fathers)."Parents who have a child with ASD are more likely to experience stress, depression, and fatigue. Therefore it is not surprising that these parents take sick leave more frequently or participate less in the work force." As per this excerpt, the authors frame their findings within the perspective that parenting a child diagnosed with an ASD can carry its own particular stresses and strains outside of those more generally associated with parenting. I've covered this topic before on this blog and how, without blaming or stigmatising, there is a growing recognition of the need for additional support services for those parents (see here). The fact that Sweden has specific policies "aimed at helping families of children with ASD, both with well-being and with ability to work" also seemed not to be as effective as perhaps initially thought as "these parents remain a vulnerable group for which additional support might be warranted."This is valuable data that adds to previous discussions about how the presence of familial autism can [variably] impact well beyond individuals and contribute to some of the societal inequalities that have been noted. One might quibble with some of the study mechanics such as the inclusion of "parents with children with other disabilities" in the comparison group or the lack of emphasis on other autism-associated comorbidities (in these days of ESSENCE) outside of ID and how they may impact on parental employment and earnings, but this is perhaps research fodder for a different time."It can also be noted that being on sick leave, outside of the work force or earning a low income will have long reaching impact on these parents because of Sweden’s pension system which is based on an individual’s life time earnings." This is another potential outcome that the authors focus in on as a consequence of their findings. One might put forward the viewpoint that where noted both inside and outside of Sweden, further preferential economic policies could be put in place as and when a child is diagnosed to secure both their future and that of their parents too. Also: "It is recommended that further studies be done to see what support mothers and fathers would find most beneficial and what support they are lacking." I cannot disagree with that last sentiment.Music: David Bowie - Five Years.---------- McEvilly M. et al. Sick Leave and Work Participation Among Parents of Children with Autism Spectrum Disorder in the Stockholm Youth Cohort: A Register Linkage Study in Stockholm, Sweden. Journal of Autism and Developmental Disorders. 2015; 45: 2381. Idring S. et al. Autism Spectrum Disorders in the Stockholm Youth Cohort: Design, Prevalence and Validity. PLoS One. 2012; 7(7): e41280.----------McEvilly M, Wicks S, & Dalman C (2015). Sick Leave and Work Participation Among Parents of Children with Autism Spectrum Disorder in the Stockholm Youth Cohort: A Register Linkage Study in Stockholm, Sweden. Journal of autism and developmental disorders PMID: 25697737... Read more »
McEvilly M, Wicks S, & Dalman C. (2015) Sick Leave and Work Participation Among Parents of Children with Autism Spectrum Disorder in the Stockholm Youth Cohort: A Register Linkage Study in Stockholm, Sweden. Journal of autism and developmental disorders. PMID: 25697737
Mohamed Boutjdir, PhD, professor of medicine, cell biology, and physiology and pharmacology at SUNY Downstate Medical Center, has led a study with international collaborators identifying the mechanism by which patients with various autoimmune and connective tissue disorders may be at risk for life-threatening cardiac events if they take certain anti-histamine or anti-depressant medications. Dr. Boutjdir is also director of the Cardiac Research Program at VA New York Harbor Healthcare System.... Read more »
Yue, Y., Castrichini, M., Srivastava, U., Fabris, F., Shah, K., Li, Z., Qu, Y., El-Sherif, N., Zhou, Z., January, C.... (2015) Pathogenesis of the Novel Autoimmune-Associated Long QT Syndrome. Circulation. DOI: 10.1161/CIRCULATIONAHA.115.009800
Providers of mental-health services still rely on intervention techniques such as physical restraint and confinement to control some psychiatric hospital patients, a practice which can cause harm to both patients and care facilities, according to a new study from the University of Waterloo. The study found that almost one in four psychiatric patients in Ontario hospitals are restrained using control interventions, such as chairs that prevent rising, wrist restraints, seclusion rooms or acute control medications.... Read more »
Mah, T., Hirdes, J., Heckman, G., & Stolee, P. (2015) Use of control interventions in adult in-patient mental health services. Healthcare Management Forum, 28(4), 139-145. DOI: 10.1177/0840470415581230
A talking white elephant called Slizamandee could save the world with his wisdom and "teach us with the deepest voice of history", according to an academic paper published today.
The article appeared in the journal Progress in Biophysics and Molecular Biology. The authors are led by Otto E. Rössler, a biochemist. It's called Is it Ethical to heal a young white Elephant from his physiological Autism? Many thanks to Michelle Dawson for bringing it to my attention.
Rössler et al. start ou... Read more »
Rossler, O., Theis, C., Heiter, J., Fleischer, W., & Student, A. (2015) Is it Ethical to heal a young white Elephant from his physiological Autism?. Progress in Biophysics and Molecular Biology. DOI: 10.1016/j.pbiomolbio.2015.06.020
A few years ago, I wrote a post about the problems with saying “I’ll be ready in 5 minutes.” It turns out, there’s now research that — in a way — supports the point I was trying to make. In this … Continue reading →... Read more »
Lewis, N., & Oyserman, D. (2015) When Does the Future Begin? Time Metrics Matter, Connecting Present and Future Selves. Psychological Science, 26(6), 816-825. DOI: 10.1177/0956797615572231
Radicalization is an analyzable process, rather than the outcome of an ‘evil’ personality.... Read more »
Karagiannis, E. (2012) European Converts to Islam: Mechanisms of Radicalization. Politics, Religion , 13(1), 99-113. DOI: 10.1080/21567689.2012.659495
In answer to the question posed in the title of this post on whether coeliac disease (CD) might show some connection to intellectual (learning) disability, 'probably not' is the finding reported by Taner Sezer and colleagues .Researchers initially looked at "serum levels of tissue transglutaminase antibody and total IgA" in over 230 children diagnosed with nonsyndromic intellectual disability compared with about the same number of asymptomatic controls. Nonsyndromic intellectual disability by the way, is "defined by the presence of intellectual disability as the sole clinical feature" according to other sources . They reported that "3 patients in the nonsyndromic intellectual disability group (5.45%) and 1 in the control group (0.41%) had positive serum tissue transglutaminase antibody." But when it came to the diagnosis of CD only 1 patient who had nonsyndromic intellectual disability fulfilled the gold-standard criteria of "Duodenal biopsy confirmed celiac disease."The authors conclude by saying that the: "screening test for celiac disease should not be necessary as a part of the management of mild and moderate nonsyndromic intellectual disability." But further: "cases of severe nonsyndromic intellectual disability could be examined for celiac disease."These are important data but as you may imagine, I'm minded to suggest that there may be other issues that require further attention. First, and in keeping with a recurrent theme on this blog, CD has a hallowed place in the whole 'gluten affects health' arena as the archetypal gluten-linked autoimmune condition. In recent years however, we've been introduced to the concept of a wider spectrum of issues with gluten not necessarily CD and not necessarily other gluten-related ills such as wheat allergy: non-coeliac gluten sensitivity (NCGS). I know there are ums-and-ahs about how real NCGS is and what constitutes diagnostic criteria (see here) but I'm of the opinion that we need to look at this wider concept with much greater assiduity.Second, and allied to the idea that CD might not be the be-all-and-end-all of gluten issues is the idea that the serology of CD but not the histology might show some connection to behaviour. I say this with the Ludvigsson paper in mind (see here) and what it might mean for autism, a label that shares quite a bit of overlap with learning disability (see here).Finally, I do find it interesting that whilst Sezer et al suggest that population-wide screening for CD should not be carried out for nonsyndromic intellectual disability they do suggest that specific cases might warrant further investigation. Drawing on the data from research on Down's syndrome for example, manifesting intellectual disability and carrying something of quite an elevated risk of CD (see here), it is evident that there may in some cases be a heightened risk of CD or other gluten-related issues co-occurring within this population. If one also considers that a gluten-free diet (the primary tool to manage CD) might also show some effect on EEG findings (see here) bearing in mind the connection between EEG findings, epilepsy / seizure-type disorders and intellectual disability , it's also not beyond the realms of possibility that further relationships might be noted with continued investigations in this area.Music: The Libertines - What A Waster.---------- Sezer T. et al. Is Celiac Disease an Etiological Factor in Children with Nonsyndromic Intellectual Disability? J Child Neurol. 2015 Jun 15. pii: 0883073815589759. Kaufman L. et al. The genetic basis of non-syndromic intellectual disability: a review. Journal of neurodevelopmental disorders. 2010;2(4):182-209. Robertson J. et al. Prevalence of epilepsy among people with intellectual disabilities: A systematic review. Seizure. 2015 Jul;29:46-62.----------Sezer T, Balcı O, Özçay F, Bayraktar N, & Alehan F (2015). Is Celiac Disease an Etiological Factor in Children with Nonsyndromic Intellectual Disability? Journal of child neurology PMID: 26078418... Read more »
Sezer T, Balcı O, Özçay F, Bayraktar N, & Alehan F. (2015) Is Celiac Disease an Etiological Factor in Children with Nonsyndromic Intellectual Disability?. Journal of child neurology. PMID: 26078418
Horror video games target evolved defence mechanismsby confronting the player with fright-inducing stimulisuch as darkness and hostile entities. By guest blogger Mathias ClasenThe video game industry outpaced the movie industry several years ago, and video games remain a rapidly growing market. In 2014, US consumers spent more than $22 billion on game content, hardware, and accessories. While researchers in media psychology have been busy investigating and discussing the effects of violent video games, another peculiar and persistent game genre—horror—has attracted very little empirical research. What are the effects of horror video games like Amnesia: The Dark Descent and Resident Evil, how do they work, and why do people play them?A new study addresses these questions. Teresa Lynch and Nicole Martins of Indiana University looked at college students’ experiences with horror video games and found that about half of their sample (53 per cent) had tried playing such games and been frightened by them. They also found that: horror games produce these fright responses by targeting our evolved defence system (evolution has shaped us to be easily scared by the dangers that threatened our ancestors); that there are predictable individual differences in how likely people are to seek out and be scared by horror video games; and that interactivity is crucial to these effects. Moreover, the researchers found that horror video games can have strong spill-over effects, causing disrupted sleep and increased fearfulness after playing.The researchers had 269 undergrad students complete online forms on their experiences with frightening video games. They were asked to indicate which games had scared them, identify the game stimuli that scared them, and list the kinds of fright reactions they experienced during and after gameplay. Most of the respondents (97 per cent) were 18-24 years old. The researchers used a combination of forced-choice and open-ended questions.The list of games that had produced fright reactions in players is dominated by so-called survival horror games such as Slender: The Eight Pages. These games typically use a first-person perspective to situate the player in a game world that teems with danger, usually from hostile non-player characters (monsters, more often than not). The game objective is to survive while overcoming a number of challenges, such as finding concealed resources necessary for progressing in the game. The game features that participants identified as particularly scary included darkness, the unknown, and disfigured humans (including zombies). This makes psychological sense because all these features target our evolved defence mechanisms.Our fearful instincts evolved to protect us from dangers in the real world, so why do horror video games use patently unrealistic stimuli such as zombies and other supernatural monsters? The researchers found that perceived realism in horror video games is important in producing fright responses. Strikingly, though, they found that graphic realism (the quality of a visual representation) is more important in scaring players than is manifest realism (how likely something is to occur in the real world). Even though zombies don’t exist in reality, a realistically rendered representation of a walking, rotting, infectious, homicidal corpse combines stimuli that evoke strong fear-and-disgust emotions in players.The study found some reliable individual differences in horror video game susceptibility and consumption. Men play more horror video games, and enjoy playing them more, than do women. Contrary to expectations, however, the study found no gender-mediated difference in the frequency of experienced fright. Guys may be more drawn to horror video games, but they are just as spooked by those games, it appears. The study found a weak correlation between sensation-seeking—a personality trait that makes people susceptible to boredom and eager to seek out stimulating experiences—and enjoyment of horror video games. Sensation-seekers enjoy horror video games more and experience less fright while playing, but curiously they don’t seem to spend more time playing horror video games than do non-sensation-seekers.The researchers also found that player perceptions of interactivity were crucial to the games’ function of producing fright responses. This is perhaps unsurprising, given that horror in whatever medium works by transporting the audience into a fictional world teeming with danger. Horror video games are particularly effective because they ease such imaginative transportation via the illusion of agency—the player interfaces with the game and interacts with the game world, using for example keyboard keys to control the avatar’s movements and actions. You may have noticed that when people recount their game experiences, they tend to use a first-person narrator: “I went into the warehouse and ganked all the zombies with my shotgun.” This suggests that horror video games foster immersion much more strongly than do films and fiction, even those stories that are told from a first-person point-of-view.This study, however, did not operationalize interactivity. What makes some games feel more interactive than others, and does higher interactivity—for example, having more in-game behavioral options— produce stronger fright responses? The nascent technology of virtual reality suggests that interactivity is not the only route to immersion. Many of the horror video games designed for the Oculus Rift, a portable virtual reality headset, have very little interactivity, but they are still notoriously immersive. There’s a whole YouTube industry of Oculus Rift players filming themselves reacting strongly to primitive horror simulations.Horror video games are here to stay, but we still know little about their short- and long-term effects, and while the present study makes important inroads, it does not tell us why so many people are attracted to the kinds of video games that are designed to make them feel bad. The researchers suggest that the games may function as a kind of training for real-life emergencies, but that hypothesis awaits experimental investigation._________________________________ ... Read more »
Lynch, T., & Martins, N. (2015) Nothing to Fear? An Analysis of College Students' Fear Experiences With Video Games. Journal of Broadcasting , 59(2), 298-317. DOI: 10.1080/08838151.2015.1029128
Prior concussion that resulted in loss of consciousness is a risk factor for decreased hippocampal regions and mild cognitive impairment later in life.... Read more »
Strain JF, Womack KB, Didehbani N, Spence JS, Conover H, Hart J Jr, Kraut MA, & Cullum CM. (2015) Imaging Correlates of Memory and Concussion History in Retired National Football League Athletes. JAMA Neurology. PMID: 25985094
Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there’s no guarantee the strains against which they protect will be the ones circulating once the season arrives. New research by Rockefeller University scientists suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.... Read more »
Wang, T., Maamary, J., Tan, G., Bournazos, S., Davis, C., Krammer, F., Schlesinger, S., Palese, P., Ahmed, R., & Ravetch, J. (2015) Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell, 162(1), 160-169. DOI: 10.1016/j.cell.2015.06.026
MedicalResearch.com Interview with: Igho Onakpoya MD MSc Clarendon Scholar University of Oxford Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health Sciences Oxford UK MedicalResearch: What is the background for this study? What are the main findings? Dr. Onakpoya: Several … Continue reading →
The post Evidence of Value of Orphan Drugs Inconsistent appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Igho Onakpoya MD MSc, & Clarendon Scholar. (2015) Evidence of Value of Orphan Drugs Inconsistent. medicalresearch.com. info:/
Research from Columbia University Medical Center (CUMC) has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works in the same way as mechanisms that cause mad cow disease, kuru, and other degenerative brain diseases.... Read more »
Fioriti, L., Myers, C., Huang, Y., Li, X., Stephan, J., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E.... (2015) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron, 86(6), 1433-1448. DOI: 10.1016/j.neuron.2015.05.021
Drisaldi, B., Colnaghi, L., Fioriti, L., Rao, N., Myers, C., Snyder, A., Metzger, D., Tarasoff, J., Konstantinov, E., Fraser, P.... (2015) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports, 11(11), 1694-1702. DOI: 10.1016/j.celrep.2015.04.061
Stephan, J., Fioriti, L., Lamba, N., Colnaghi, L., Karl, K., Derkatch, I., & Kandel, E. (2015) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton. Cell Reports, 11(11), 1772-1785. DOI: 10.1016/j.celrep.2015.04.060
Fiumara, F., Rajasethupathy, P., Antonov, I., Kosmidis, S., Sossin, W., & Kandel, E. (2015) MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets. Cell Reports, 11(12), 1866-1875. DOI: 10.1016/j.celrep.2015.05.034
Mudambi (2008) notes that “value-added is becoming increasingly concentrated at the upstream and downstream ends of the value chain” and that “activities at both ends of the value chain are intensive in their application of knowledge and creativity”. Value-added along the value chain is, thus, represented by a “smiling curve”. Mudambi, R. (2008). Location, Control […]... Read more »
Mudambi, R. (2008) Location, Control and Innovation in Knowledge-intensive Industries. Journal of Economic Geography, 8(5), 699-725. DOI: 10.1093/jeg/lbn024
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