I have already made mention of the paper by Maya Shetreat-Klein and colleagues  on this blog as part of a post on the potential usefulness of kata training for at least some people on the autism spectrum (see here). Based on an analysis of 38 children diagnosed with autism spectrum disorder (ASD) and a similar number of asymptomatic controls (all medication free), researchers set about recording "the characteristics of gait and prevalence of toe walking, the range of passive joint mobility, a........ Read more »
Shetreat-Klein M, Shinnar S, & Rapin I. (2014) Abnormalities of joint mobility and gait in children with autism spectrum disorders. Brain , 36(2), 91-6. PMID: 22401670
Young pitchers who engage in “risk-prone” pitching activities are more likely to report arm tiredness and pain, which is related to shoulder and elbow injuries.... Read more »
Yang, J., Mann, B., Guettler, J., Dugas, J., Irrgang, J., Fleisig, G., & Albright, J. (2014) Risk-Prone Pitching Activities and Injuries in Youth Baseball: Findings From a National Sample. The American Journal of Sports Medicine, 42(6), 1456-1463. DOI: 10.1177/0363546514524699
A new experimental technique allows scientists to see conformational changes in photosynthetic systems without damaging the samples!... Read more »
Kupitz, C., Basu, S., Grotjohann, I., Fromme, R., Zatsepin, N., Rendek, K., Hunter, M., Shoeman, R., White, T., Wang, D.... (2014) Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser. Nature. DOI: 10.1038/nature13453
Accurately diagnosing alzheimer’s is not an easy thing to do. In fact most of the time people aren’t diagnosed until very late in the progression of the disease, long after […]... Read more »
Matthew E Growdon,, Aaron Schultz,, Alexander Dagley,, Rebecca Amariglio,, Trey Hedden,, Dorene M. Rentz,, Keith Johnson,, Reisa Sperling,, Mark W. Albers,, & Gad Marshall,. (2014) Olfactory identification and Alzheimer's disease biomarkers in clinically normal elderly. Nature Neuroscience. info:/
I am both left handed and dyslexic and so a recent paper on the connection in hemispheric dominance for hand and for language was a paper I had to read. The Mazoyer study seems to be the first to use a reasonable number of left- and as well as right-handed people to look at […]... Read more »
Mazoyer, B., Zago, L., Jobard, G., Crivello, F., Joliot, M., Perchey, G., Mellet, E., Petit, L., & Tzourio-Mazoyer, N. (2014) Gaussian Mixture Modeling of Hemispheric Lateralization for Language in a Large Sample of Healthy Individuals Balanced for Handedness. PLoS ONE, 9(6). DOI: 10.1371/journal.pone.0101165
It is evident that (a) higher body temperature leads to higher brain performance and (b) the sames holds true in an evolutionary context in terms of brain size. So hotter = smarter?... Read more »
James F. Gillooly. (2013) Hotter is Smarter: The temperature-dependence of brain size in vertebrates. PeerJ. info:/10.7287/peerj.preprints.155v1
Wright KP Jr, Hull JT, & Czeisler CA. (2002) Relationship between alertness, performance, and body temperature in humans. American journal of physiology. Regulatory, integrative and comparative physiology, 283(6). PMID: 12388468
Legal highs in Lothian The UK has the largest market for new psychoactive substances (NSP or “legal highs”) in Europe. Scotland is no stranger to them and, as a seminar in Edinburgh heard last week, the Lothian area is seeing a surge in demand, some worrying trends in injecting and significant new presentations due to problems [...]
The post Legal highs – not for human consumption appeared first on Recovery Review.
... Read more »
Baumann, M. (2014) Awash in a sea of ‘bath salts’: implications for biomedical research and public health. Addiction. DOI: 10.1111/add.12601
Barefoot running survey: Evidence from the field???... Read more »
I hate doing sad posts, it’s not my thing. But this is a big deal so I thought I would share it, the child known as the “Mississippi baby” – whom for […]... Read more »
Persaud, D., Gay, H., Ziemniak, C., Chen, Y., Piatak, M., Chun, T., Strain, M., Richman, D., & Luzuriaga, K. (2013) Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant. New England Journal of Medicine, 369(19), 1828-1835. DOI: 10.1056/NEJMoa1302976
Facebook recently carried out an experiment to change the emotions of over 600,000 users through a known psychological process called "emotional contagion". ... Read more »
Kramer, A., Guillory, J., & Hancock, J. (2014) Experimental evidence of massive-scale emotional contagion through social networks. Proceedings of the National Academy of Sciences, 111(24), 8788-8790. DOI: 10.1073/pnas.1320040111
Woolley, A., Chabris, C., Pentland, A., Hashmi, N., & Malone, T. (2010) Evidence for a Collective Intelligence Factor in the Performance of Human Groups. Science, 330(6004), 686-688. DOI: 10.1126/science.1193147
A very quick post to direct you to the paper by Barański and colleagues  which is currently making a few headlines and sparking some debate (see here and see here) with their assertions: "the concentrations of a range of antioxidants such as polyphenolics were found to be substantially higher in organic crops/crop-based foods" and "the frequency of occurrence of pesticide residues was found to be four times higher in conventional crops, which also contained significantly higher con........ Read more »
Barański M, Srednicka-Tober D, Volakakis N, Seal C, Sanderson R, Stewart GB, Benbrook C, Biavati B, Markellou E, Giotis C.... (2014) Higher antioxidant and lower cadmium concentrations and lower incidence of pesticide residues in organically grown crops: a systematic literature review and meta-analyses. The British journal of nutrition, 1-18. PMID: 24968103
Global warming has sharply increased the odds of serious problems because of declining harvests, find David Lobell from and Claudia Tebaldi from NCAR, and though that situation remains fairly unlikely, they advise countries to prepare for it. ... Read more »
Lobell, D., & Tebaldi, C. (2014) Getting caught with our plants down: the risks of a global crop yield slowdown from climate trends in the next two decades. Environmental Research Letters, 9(7), 74003. DOI: 10.1088/1748-9326/9/7/074003
Mora, C., Frazier, A., Longman, R., Dacks, R., Walton, M., Tong, E., Sanchez, J., Kaiser, L., Stender, Y., Anderson, J.... (2013) The projected timing of climate departure from recent variability. Nature, 502(7470), 183-187. DOI: 10.1038/nature12540
Hawkins, E., Anderson, B., Diffenbaugh, N., Mahlstein, I., Betts, R., Hegerl, G., Joshi, M., Knutti, R., McNeall, D., Solomon, S.... (2014) Uncertainties in the timing of unprecedented climates. Nature, 511(7507). DOI: 10.1038/nature13523
Gold standard addiction treatment Addiction to alcohol or other drugs is not easy to recover from. However there are many pathways to recovery, including through treatment. One group of patients does far better than most other groups. In fact their results are so impressive that many commentators have urged us to learn from what’s [...]
The post Gold standard addiction treatment appeared first on Recovery Review.
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DuPont, R., McLellan, A., White, W., Merlo, L., & Gold, M. (2009) Setting the standard for recovery: Physicians' Health Programs. Journal of Substance Abuse Treatment, 36(2), 159-171. DOI: 10.1016/j.jsat.2008.01.004
It's been a while since I've posted something substantial. My apologies to all 20 followers of TQLC. Academia and clinical cases have been taking up most of my time. However, some exciting news! My paper on variability of respiration during sleep in traumatic brain injury (TBI) has recently been accepted into Neurorehabilitation. In the paper my colleagues and I examined the sleep processes of individuals with TBI using polysomnography. Polysomnography is a tool used to measure biophysical ch........ Read more »
Lu W, Cantor J, Aurora RN, Nguyen M, Ashman T, Spielman L, Ambrose A, Krellman J, & Gordon W. (2014) Variability of respiration and sleep during polysomnography in individuals with TBI. NeuroRehabilitation. PMID: 24990025
The Coronaviridae, which include viruses capable of infecting animals as well as humans, belong to order of the Nidovirales and as such are enveloped positive strand ssRNA viruses.
As described before, they induce the formation of Replication Transcription Complexes (RTCs), essentially double membrane vesicles (DMVs) derived from the ER containing enzymes and viral RNA. The biogenesis of these DMVs has been connected with the early secretory pathway and involves components of the autophagic p........ Read more »
Cook KL, Soto-Pantoja DR, Abu-Asab M, Clarke PA, Roberts DD, & Clarke R. (2014) Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy. Cell , 4(1), 16. PMID: 24669863
Fujita N, Itoh T, Omori H, Fukuda M, Noda T, & Yoshimori T. (2008) The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Molecular biology of the cell, 19(5), 2092-100. PMID: 18321988
Liu, D., Fung, T., Chong, K., Shukla, A., & Hilgenfeld, R. (2014) Accessory proteins of SARS-CoV and other coronaviruses. Antiviral Research. DOI: 10.1016/j.antiviral.2014.06.013
Maier HJ, Cottam EM, Stevenson-Leggett P, Wilkinson JA, Harte CJ, Wileman T, & Britton P. (2013) Visualizing the autophagy pathway in avian cells and its application to studying infectious bronchitis virus. Autophagy, 9(4), 496-509. PMID: 23328491
Cottam EM, Whelband MC, & Wileman T. (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy, 10(8). PMID: 24991833
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, & Sabatini DM. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell, 141(2), 290-303. PMID: 20381137
Flinn RJ, Yan Y, Goswami S, Parker PJ, & Backer JM. (2010) The late endosome is essential for mTORC1 signaling. Molecular biology of the cell, 21(5), 833-41. PMID: 20053679
Bar-Peled L, Schweitzer LD, Zoncu R, & Sabatini DM. (2012) Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell, 150(6), 1196-208. PMID: 22980980
Kitano M, Nakaya M, Nakamura T, Nagata S, & Matsuda M. (2008) Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature, 453(7192), 241-5. PMID: 18385674
Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP, & Guan KL. (2010) Regulation of mTORC1 by the Rab and Arf GTPases. The Journal of biological chemistry, 285(26), 19705-9. PMID: 20457610
Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z.... (2014) The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism. Cell metabolism. PMID: 25002183
Oxidative stress on the body caused by free radicals, billed as a bad thing. Fruits, veggies and just about anything with the word healthy in the title is “jam packed” […]... Read more »
Phimister, E., Chandel, N., & Tuveson, D. (2014) The Promise and Perils of Antioxidants for Cancer Patients. New England Journal of Medicine, 371(2), 177-178. DOI: 10.1056/NEJMcibr1405701
Can one drink of alcohol increase risk of heart disease? Reporters are saying a new study says “Yes”. Many people have been advised through print or conversation that a daily glass of wine or beer is a healthy practice. And it might be for some. Many studies have found a longer lifespan in people who […]
The post Can one daily drink of alcohol increase risk of heart disease? . . . really? appeared first on WODMasters: Stiff Competition.
... Read more »
Holmes, M., Dale, C., Zuccolo, L., Silverwood, R., Guo, Y., Ye, Z., Prieto-Merino, D., Dehghan, A., Trompet, S., Wong, A.... (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ, 349(jul10 6). DOI: 10.1136/bmj.g4164
So researchers for the first time were evaluating the safety and reliability of the existing targeted gene correction technologies and in the process they successfully developed a new method of gene […]... Read more »
Suzuki, K., Yu, C., Qu, J., Li, M., Yao, X., Yuan, T., Goebl, A., Tang, S., Ren, R., Aizawa, E.... (2014) Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones. Cell Stem Cell, 15(1), 31-36. DOI: 10.1016/j.stem.2014.06.016
One of the perks to my job is that I can get access to just about any journal article I want for free. I know, it sounds like a dream life, but hey you go to college for 10 years and you get some favors thrown your way. A few years ago Science scanned all their historical archives put them online, so I begun to peruse a few and was pleasantly amused. In what may become a recurring theme to the LabHippo, I now present to you some of the more entertaining articles. We begin with the first year Sci........ Read more »
Unknown. (1880) APPLICATION OF THE PHOTOPHONE TO THE STUDY OF THE NOISES TAKING PLACE ON THE SURFACE OF THE SUN. Science, os-1(26), 304-304. DOI: 10.1126/science.os-1.26.304-b
Picture your parents having sex. No..no good, too weird? OK then, picture your grandparents having sex. Even weirder? Fine, picture your great-grandparents having sex. That one might not be as bad. Chances are you never met your great-grandparents, which makes them somewhat strangers to you. You had eight great-grandparents and though you might not even know their names, about 12.5 percent of your DNA was inherited from them. Now imagine your great-grandmother eating a ham sandwich while having ........ Read more »
Anway, M. (2005) Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility. Science, 308(5727), 1466-1469. DOI: 10.1126/science.1108190
Pembrey, M., Bygren, L., Kaati, G., Edvinsson, S., Northstone, K., Sjöström, M., & Golding, J. (2005) Sex-specific, male-line transgenerational responses in humans. European Journal of Human Genetics, 14(2), 159-166. DOI: 10.1038/sj.ejhg.5201538
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