Post List

  • November 23, 2016
  • 07:00 AM
  • 151 views

Hypertriacylglycerolaemia: Genetic and epigenetic factors jointly regulate circulating triacylglycerol levels

by Iris Oliva Rodriguez in EpiBeat

Apolipoprotein A5 gene (APOA5) is one of the genes implicated in contributing to a predisposition for hypertriacylglycerolaemia (HTG), a complex polygenic pathology that is highly influenced by environment. Hypertriacylglycerolaemia is characterized by having high circulating triacylglycerol levels and is a significant risk factor for cardiovascular disease and atherosclerosis. This genetic predisposition has an inherited component (based on polymorphisms) as well as an acquired component regu........ Read more »

Oliva, I., Guardiola, M., Vallve, J., Ibarretxe, D., Plana, N., Masana, L., Monk, D., & Ribalta, J. (2016) APOA5 genetic and epigenetic variability jointly regulate circulating triacylglycerol levels. Clinical Science, 130(22), 2053-2059. DOI: 10.1042/CS20160433  

  • November 23, 2016
  • 04:30 AM
  • 165 views

Tape (or Wait) for Stabilizers to Activate

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Shoulder taping is associated with early activation of scapular muscles; however, this only resulted in a minimal effect on shoulder kinematics. ... Read more »

  • November 23, 2016
  • 04:29 AM
  • 178 views

ADHD symptoms not methylphenidate treatment might prime for psychotic events

by Paul Whiteley in Questioning Answers

"This study does not support the hypothesis that MPH [methylphenidate] increases risk of incident psychotic events. It does indicate an increased risk of psychotic events before the first prescription of MPH, which may be because of an association between psychotic events and the behavioural and attentional symptoms that led to psychiatric assessment and initiation of MPH treatment."The results published by Man and colleagues [1] (open-access) sit right with me. I say that on the basis........ Read more »

Man, K., Coghill, D., Chan, E., Lau, W., Hollis, C., Liddle, E., Banaschewski, T., McCarthy, S., Neubert, A., Sayal, K.... (2016) Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system. Translational Psychiatry, 6(11). DOI: 10.1038/tp.2016.216  

  • November 22, 2016
  • 07:03 AM
  • 180 views

Energetic electrons generated during solar flares by Gottfried Mann

by CESRA in Solar Radio Science

The Sun is an active star. It manifests not only in everybody’s well-known Sun spots with the related 11-year cycle. This activity manifests not only as the well-known sun spot phenomenon with a related 11-year cycle, but also in flares, coronal mass ejections (CMEs), and solar energetic particle (SEP) events. Thus, [...]... Read more »

Gottfried Mann. (2016) Energetic electrons generated during solar flares. Journal of Plasma Physics. info:/

  • November 22, 2016
  • 03:43 AM
  • 169 views

Interview with Rosa Fernández, 2016 OMA Visiting Fellow

by Christophe Dessimoz in Open Reading Frame

Note: We are rebooting our “Life in the Lab” series, which features interviews of interns and visitors. This post is by our inaugural OMA Visiting Fellow Rosa Fernández García, who spent a month with us earlier this year. You can follow Rosa on Twitter at @Rosamygale. —Christophe

 

Please introduce yourself and your research interests.

I received my bachelor’s degree in Biology (major in Zoology) at Complutense University in Madrid, Spain. I got my master’s and PhD at the s........ Read more »

Fernández R, Laumer CE, Vahtera V, Libro S, Kaluziak S, Sharma PP, Pérez-Porro AR, Edgecombe GD, & Giribet G. (2014) Evaluating topological conflict in centipede phylogeny using transcriptomic data sets. Molecular biology and evolution, 31(6), 1500-13. PMID: 24674821  

Novo M, Fernández R, Andrade SC, Marchán DF, Cunha L, & Díaz Cosín DJ. (2016) Phylogenomic analyses of a Mediterranean earthworm family (Annelida: Hormogastridae). Molecular phylogenetics and evolution, 94(Pt B), 473-8. PMID: 26522608  

Sharma, P., Fernandez, R., Esposito, L., Gonzalez-Santillan, E., & Monod, L. (2015) Phylogenomic resolution of scorpions reveals multilevel discordance with morphological phylogenetic signal. Proceedings of the Royal Society B: Biological Sciences, 282(1804), 20142953-20142953. DOI: 10.1098/rspb.2014.2953  

  • November 22, 2016
  • 03:01 AM
  • 203 views

Probiotics and 'subclincial' psychological symptoms: meta-analysed

by Paul Whiteley in Questioning Answers

I'm gonna be fairly brief today and draw your attention to yet another systematic review and meta-analysis this time looking at how "probiotic supplementation can have a positive effect on mood and psychological symptoms such as depression and anxiety." [1] Probiotics by the way, include a variety of bacteria and related lifeforms that are thought to confer some health advantage.The review/re-analysis by Jennifer McKean and colleagues found 7 studies on this topic in the peer-reviewed resea........ Read more »

  • November 21, 2016
  • 11:55 AM
  • 193 views

How did Gall Identify his 27 Faculties?

by The Neurocritic in The Neurocritic





Franz Joseph Gall (1758-1828), a founding father of phrenology


Phrenology was the pseudoscience of identifying a person's character and mental abilities on the basis of skull morphology (“bumps on the head”). The enterprise was based on four assumptions (Gross, 2009):

intellectual abilities and personality traits are differentially developed in each individual
these abilities and traits

... Read more »

  • November 21, 2016
  • 11:10 AM
  • 189 views

Benefits of Physical Activity in Parkison's Disease

by William Yates, M.D. in Brain Posts

Parkinson's disease (PD) is a progressive neurodegerative disorder estimated to affect 7 to 10 million individual worldwide.The primary mechanism for Parkinson's disease is a reduction in the neurotransmitter dopamine in the midbrain region of the substantia nigra highlighted in red in the figure.PD impairs motor and cognitive functions and leads to significant decline in psychosocial functioning.Drugs for PD can be effective in reversing and slowing the progression of the illness. However, resp........ Read more »

Lauzé M, Daneault JF, & Duval C. (2016) The Effects of Physical Activity in Parkinson's Disease: A Review. Journal of Parkinson's disease, 6(4), 685-698. PMID: 27567884  

  • November 21, 2016
  • 04:48 AM
  • 211 views

On C-reactive protein and bipolar disorder

by Paul Whiteley in Questioning Answers

"CRP [C-reactive protein] concentrations are increased in bipolar disorder regardless of mood state, but are higher during mania than in depression and euthymia, suggesting an increased inflammatory burden in mania."So said the systematic review and meta-analysis published by Brisa Fernandes and colleagues [1] who surveyed the peer-reviewed literature on the topic of "measured serum and plasma CRP concentrations in adult patients with bipolar disorder (as defined by DSM-IV-TR) and........ Read more »

Fernandes BS, Steiner J, Molendijk ML, Dodd S, Nardin P, Gonçalves CA, Jacka F, Köhler CA, Karmakar C, Carvalho AF.... (2016) C-reactive protein concentrations across the mood spectrum in bipolar disorder: a systematic review and meta-analysis. The lancet. Psychiatry. PMID: 27838212  

  • November 20, 2016
  • 01:54 PM
  • 20 views

Pupil Size and Intelligence

by Neuroskeptic in Neuroskeptic_Discover

Are the eyes the windows to intelligence? In an interesting paper, Georgia psychologists Jason S. Tsukahara and colleagues report that there's a positive correlation between pupil size and cognitive ability.



It's well known that our pupil size varies over time due to changes in both emotional state and cognitive 'effort'. As Tsukahara et al. put it
Starting in the 1960s it became apparent to psychologists that the size of the pupil is related to more than just the amount of light enterin... Read more »

Tsukahara JS, Harrison TL, & Engle RW. (2016) The relationship between baseline pupil size and intelligence. Cognitive psychology, 109-123. PMID: 27821254  

  • November 19, 2016
  • 04:13 AM
  • 238 views

Low gestational age is associated with risk for autism

by Paul Whiteley in Questioning Answers

The results published by Robert Joseph and colleagues [1] provide some blogging fodder today, observing that as part of the ELGAN (Extremely Low Gestational Age Newborns) Research Study, gestational age might matter when it comes to offspring risk of autism spectrum disorder (ASD).Gestational age is a measure of how far along a pregnancy is but in the context of the Joseph study refers to premature birth or those "born at least 3 months early." Researchers included data for nearly 1000........ Read more »

  • November 18, 2016
  • 11:00 AM
  • 283 views

Imagine: Listening to Songs Which Make Us More Generous

by Jalees Rehman in The Next Regeneration

It does not come as a surprise that background music in a café helps create the ambience and affects how much customers enjoy sipping their cappuccinos. But recent research suggests that the choice of lyrics can even impact the social behavior of customers. The researcher Nicolas Ruth and his colleagues from the University of Würzburg (Bavaria, Germany) assembled a playlist of 18 songs with pro-social lyrics which they had curated by surveying 74 participants in an online questionnaire as to w........ Read more »

  • November 18, 2016
  • 10:30 AM
  • 225 views

Who is afraid of IBS?

by Aurametrix team in Aurametrix Blog

I don’t mean to brag, but I’ve got irritable bowel syndrome, says a character of a sitcom.
Irritable bowel syndrome used to be a rare condition, but became a problem of epidemic proportions, until the disease "came out of the closet". Then Internet searches and doctor visits started to dwindle down and less than halved compared to earlier decades.
Is IBS no longer a problem? [...]... Read more »

  • November 18, 2016
  • 08:31 AM
  • 242 views

Is anybody out there? Talking to the Galactic Zookeepers

by gdw in FictionalFieldwork

The Zoo Hypothesis Hello? Anybody out there in the starry skies? If there are extra-terrestrial civilizations, why haven’t we heard from them yet? The sheer magnitude of the universe with its billions upon billions of stars has led many to suggest that life must have arisen more than once in the cosmos. Some have gone […]... Read more »

  • November 18, 2016
  • 07:25 AM
  • 189 views

Mutated mTOR regulator RRAGC proteins decrease interactions with FLCN

by Joana Guedes in BHD Research Blog

Follicular lymphoma is a B-cell lymphoma that remains incurable with conventional therapies. Ying et al. (2016) present a new study exploring the biological and genetic features of follicular lymphoma and identifying potential new therapeutic targets. The authors identified recurrent mutations in the mTOR regulator RRAGC, a small G-protein, in approximately 10% of follicular lymphoma cases. Mutations in RRAGC localized to one protein surface area surrounding the GTP/GDP–binding sites. In s........ Read more »

Ying ZX, Jin M, Peterson LF, Bernard D, Saiya-Cork K, Yildiz M, Wang S, Kaminski MS, Chang AE, Klionsky DJ.... (2016) Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 22(21), 5383-5393. PMID: 27267853  

  • November 18, 2016
  • 04:40 AM
  • 203 views

Acute psychosis and urinary tract infection (again)

by Paul Whiteley in Questioning Answers

Consider this short blog post an extension of some previous discussions (see here and see here) on a rather peculiar 'association' between urinary tract infections (UTIs) and psychosis. UTIs basically refer to an infection in any part of the urinary system (kidneys, bladder, etc) typically treated with antibiotics. Psychosis is a state that causes a person to perceive or interpret things around them in an atypical way, usually accompanied by delusions or hallucinations. For a while now........ Read more »

  • November 17, 2016
  • 06:06 PM
  • 229 views

Breeding Made Dogs Less Athletic

by Elizabeth Preston in Inkfish



Is your dog a natural athlete or a couch pup-tato? The answer might depend on how far removed it is from its wild ancestors. Dogs that are more similar to wolves have kept more of their natural athleticism, while breeding has rendered other types of dogs a little...less impressive.

Caleb Bryce, a PhD candidate at UC Santa Cruz, says his study of canine athletes came about serendipitously. "We were just hoping to calibrate a new wildlife collar we’ve developed," he says; he planned to te........ Read more »

  • November 17, 2016
  • 11:00 AM
  • 271 views

Missed Opportunities in Stroke Prevention

by William Yates, M.D. in Brain Posts

Rates of myocardial infarction and stroke have been declining over the last decade in the U.S. and Europe. However, a recent manuscript suggests there are still significant missed opportunities to prevent stroke.This manuscript presents results of review of electronic primary care records in the United Kingdom.The authors examines a group of over 29,000 subjects with a diagnosis of stroke or transient ischemic attack over a 10 year period.Records were reviewed to assess for compliance with guide........ Read more »

  • November 17, 2016
  • 11:00 AM
  • 176 views

DNA damage and repair permanently change the chromatin and DNA: Mechanisms of DNA methylation polymorphism

by Enrico Avvedimento in EpiBeat

DNA methylation is a biological clock that ticks with age, and numerous studies have been able to construct age-prediction models based on methylation status. However in somatic cells, DNA methylation is highly polymorphic – though this is not always appreciated in genome wide studies because coverage is often limited and variants below 10% usually escape detection. In an effort to clarify the origin of somatic DNA methylation heterogeneity and the impact it has on chromatin domains and ge........ Read more »

Cuozzo, C., Porcellini, A., Angrisano, T., Morano, A., Lee, B., Pardo, A., Messina, S., Iuliano, R., Fusco, A., Santillo, M.... (2007) DNA Damage, Homology-Directed Repair, and DNA Methylation. PLoS Genetics, 3(7). DOI: 10.1371/journal.pgen.0030110  

Morano, A., Angrisano, T., Russo, G., Landi, R., Pezone, A., Bartollino, S., Zuchegna, C., Babbio, F., Bonapace, I., Allen, B.... (2013) Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene. Nucleic Acids Research, 42(2), 804-821. DOI: 10.1093/nar/gkt920  

Landan, G., Cohen, N., Mukamel, Z., Bar, A., Molchadsky, A., Brosh, R., Horn-Saban, S., Zalcenstein, D., Goldfinger, N., Zundelevich, A.... (2012) Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nature Genetics, 44(11), 1207-1214. DOI: 10.1038/ng.2442  

  • November 17, 2016
  • 02:57 AM
  • 192 views

Caring for the carer: what the science suggests

by Paul Whiteley in Questioning Answers

Papers such as the one published by Nikko Da Paz & Jan Wallander [1] I think represent one of the most important areas of autism research and practice when it comes to the practical translation of science to real-life. Tackling a very important topic - caring for the carers - the authors provide a "narrative review" of the peer-reviewed science literature looking at how "treatments that directly target parents' psychological well-being" in the context of autism are doing so far.Personally, I........ Read more »

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