Post List

  • November 30, -1
  • 12:00 AM

GPCR crystallization detergent space increased by 25%

by Peter Nollert in Emerald BioStructures Blog

The choice of detergents for GPCRs has just been increased by 25% with the introduction of MNGs - maltose neopentyl glycol amphiphiles. The agonist bound structure of the beta adrenergic receptor from crystals using this new detergent is announced in a recent paper.... Read more »

Newstead, S., Ferrandon, S., & Iwata, S. (2008) Rationalizing α-helical membrane protein crystallization. Protein Science, 17(3), 466-472. DOI: 10.1110/ps.073263108  

  • November 30, -1
  • 12:00 AM

Darwin's contributions and why this matters for Mexico's conifers

by Claire Williams in Conifer Reproductive Biology

For International Darwin Day, February 12. Darwin's birthday inspired an elegant treatise by UNAM professor Antonio Lazcano, published in Science back in 2005. His article traces the cultural, social and science history roots behind widespread acceptance of Darwin's ideas in Mexico. This careful analysis is worthwhile reading, particularly for those working in the USA.... Read more »

  • November 30, -1
  • 12:00 AM

Minding As and P: Can Arsenic Substitute for Phosphorus or Not?

by Sara Klink in Promega Connections

Back in December 2010, there was a press conference held by NASA to announce the discovery of a bacterium found in a high salt, high pH lake with high concentrations of arsenic that seemed to have substituted arsenic for phosphorus in the bacterium’s biomolecules. This set off a wave of response in the blogosphere regarding what Felisa Wolfe-Simon and her team did nor did not do to confirm arsenic was incorporated into DNA molecules. Controversy ranged from the ability of arsenic to form a sta........ Read more »

Wolfe-Simon, F., Blum, J., Kulp, T., Gordon, G., Hoeft, S., Pett-Ridge, J., Stolz, J., Webb, S., Weber, P., Davies, P.... (2011) Response to Comments on "A Bacterium That Can Grow Using Arsenic Instead of Phosphorus". Science. DOI: 10.1126/science.1202098  

  • November 30, -1
  • 12:00 AM

Coffee: a caffeinated chronicle

by Jordan Gaines in Gaines, on Brains

Because I like to understand what I'm putting in my body, I decided to explore coffee: its history, its neurological mechanism, and—what I'm sure everyone's dying to know—why it is so easy to become addicted and dependent on it.... Read more »

Cocker PJ, Hosking JG, Benoit J, & Winstanley CA. (2012) Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMID: 22453140  

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