Post List

  • October 17, 2014
  • 03:00 AM
  • 61 views

BHD lung cysts are not degenerative, but may cause pneumothorax

by Lizzie Perdeaux in BHD Research Blog

Although 90% of BHD patients develop lung cysts, there is very little information about the natural history of BHD lung cysts. In order to determine how lung cysts change over time, Johannesma et al. (2014a) compared the results of two … Continue reading →... Read more »

Johannesma PC, Houweling AC, van Waesberghe JH, van Moorselaar RJ, Starink TM, Menko FH, & Postmus PE. (2014) The pathogenesis of pneumothorax in Birt-Hogg-Dubé syndrome: A hypothesis. Respirology (Carlton, Vic.), 19(8), 1248-50. PMID: 25302759  

  • October 16, 2014
  • 05:20 PM
  • 87 views

The “New” Roots of our Friends the Mitochondria

by Gabriel in Lunatic Laboratories

Mitochondria, the proverbial “powerhouse” of the cell. Mitochondria are found in virtually all eukaryotic cells, plant or animal and we thought that was pretty much the end of the story. It wasn’t a great explanation but it was Now new research is turning the idea– that our ancestor cells simply “swallowed up” bacterial cells that eventually became mitochondria– on its head.... Read more »

Zhang Wang, & Martin Wu. (2014) Phylogenomic Reconstruction Indicates Mitochondrial Ancestor Was an Energy Parasite . PLoS ONE. info:/10.1371/journal.pone.0110685

  • October 16, 2014
  • 04:18 PM
  • 112 views

Inherited Memories: Too Good To Be True?

by Neuroskeptic in Neuroskeptic_Discover

In December last year, researchers Brian Dias and Kerry Ressler made a splash with a paper seeming to show that memories can be inherited. This article, published in Nature Neuroscience, reported that if adult mice are taught to be afraid of a particular smell, then their children will also fear it. Which is pretty wild. […]The post Inherited Memories: Too Good To Be True? appeared first on Neuroskeptic.... Read more »

  • October 16, 2014
  • 02:19 PM
  • 79 views

Is Axon Guidance by Attraction and Repulsion, or by a Roll of the Dice?

by Wadsworth in Wadsworth Guidance

Attractants and repellants guide axons to their targets.  On its journey, a migrating axon may be confronted with multiple attractive and repulsive guidance cues.  This presents a conundrum. How does the axon avoid a tug-of-war between attractants and repellants?  Does the strongest cue win?  Can one cue negate the effects of another?  Can an axon switch its responsiveness to cues until they all match?   0 0 1 83 474 Robert Wood Johnson Medical School ........ Read more »

Tang, X., & Wadsworth, W. (2014) SAX-3 (Robo) and UNC-40 (DCC) Regulate a Directional Bias for Axon Guidance in Response to Multiple Extracellular Cues. PLoS ONE, 9(10). info:/10.1371/journal.pone.0110031

  • October 16, 2014
  • 01:11 PM
  • 75 views

Deceased & Living Liver Transplant Comparable For Hepatorenal Syndrome

by Cristy at Living Donor 101 in Living Donors Are People Too

30 patients with HRS receiving a live donor liver transplantation (LDLT) and 90 HRS patients (Hepatorenal Syndrome) receiving a full graft deceased donor liver transplantation (DDLT) were compared. No difference was detected between LDLT and DDLT patients regarding graft survival at 1 (80% vs. 82%), at 3 (69% vs. 76%) and 5 years (65% vs. 76%) …
Continue reading »
The post Deceased & Living Liver Transplant Comparable For Hepatorenal Syndrome appeared first on Living Donors Are........ Read more »

  • October 16, 2014
  • 09:40 AM
  • 84 views

Blood. It’s What’s For Dinner.

by Bill Sullivan in The 'Scope

The practice of feeding on blood, known as hematophagy, is actually a lot more common than you might realize.... Read more »

  • October 16, 2014
  • 07:40 AM
  • 72 views

Linking RAGE in Lung Transplants To Traumatic Brain Injury

by Rebekah Morrow in United Academics

Lung transplants are the least successful type of organ transplant. Now a group of scientists in Indiana has identified a possible cause of organ failure in lung transplants.... Read more »

Whitson BA, & Hayes D Jr. (2014) Indications and outcomes in adult lung transplantation. Journal of thoracic disease, 6(8), 1018-23. PMID: 25132968  

  • October 16, 2014
  • 04:59 AM
  • 79 views

MicroRNAs and Chronic Fatigue Syndrome

by Paul Whiteley in Questioning Answers

"No one User wrote me! I'm worth millions of their man-years!"Not so long ago I posted an entry talking about microRNAs and autism (see here). As well as including some rather interesting, if preliminary findings, that particular piece of work also served to introduce yet another layer of complexity to our genome and its expression: microRNAs.I was therefore always going to be more than a little intrigued by the results published by Ekua Brenu and colleagues [1] and their observations on ci........ Read more »

  • October 16, 2014
  • 02:18 AM
  • 75 views

World Food Day - Food Security through the Lens of Nutrition

by Wiley Asia Blog in Wiley Asia Blog - Life Sciences

The Foresight report has described an unprecedented confluence of pressures whereby a growing, and in some cases, increasingly prosperous global population, alongside increasing demand for limited resources and the pressing need to address environmental challenges, including climate change and changing weather patterns, means that food security is seriously and increasingly threatened. Much of the discussion has focused on greenhouse gas emissions associated with food production and the contribu........ Read more »

Buttriss, J. (2013) Food security through the lens of nutrition. Nutrition Bulletin, 38(2), 254-261. DOI: 10.1111/nbu.12031  

  • October 16, 2014
  • 02:03 AM
  • 75 views

JUST PUBLISHED: Resilience and Responses to Persistent Pain

by Mark Rubin in The University of Newcastle's School of Psychology Newsline

The concept of resilience is of considerable interest in clinical practice.  The resilient person shows relatively speedy recovery from a disturbance and an ability to resume their former work practices, habits and normal life.  In addition, they are able to maintain that recovery over the long-term.The maintenance of recovery is of particular interest in patients suffering from chronic pain, since the presence of persistent pain leads to a raft of behavioural and cognitive changes all........ Read more »

Newton-John TR, Mason C, & Hunter M. (2014) The role of resilience in adjustment and coping with chronic pain. Rehabilitation psychology, 59(3), 360-5. PMID: 25019306  

  • October 15, 2014
  • 02:49 PM
  • 72 views

A Random Walk into the Genetics of Axon Guidance

by Wadsworth in Wadsworth Guidance

The man claimed he was a wizard and had cast the “spell of attraction” on the target.  Now the target would guide his arrow to the mark.  So we gave the man a broken arrow and watched to see if this arrow could hit the target.  The man took the arrow and flung it at the target.  Indeed, this arrow too could hit the target. Credit: Nina Matthews PhotographyPerhaps we had asked the wrong question.  Instead of looking at whether the arrow made it to the target........ Read more »

  • October 15, 2014
  • 02:22 PM
  • 105 views

You can tell [my mood] by the way I walk

by Gabriel in Lunatic Laboratories

Ever see a guy walking down the street and know he’s depressed? Or how about someone happy, with a little bounce in their step? The way we walk says a lot and by some estimates roughly 90% of what we are telling people isn’t coming out our mouth, it’s all body language. Our walk says a lot about the kind of mood we are in, but in the question of what came first our mood or our walk, researchers have now shown that it works both ways.... Read more »

  • October 15, 2014
  • 01:52 PM
  • 71 views

My Dog Comes First: The Importance of Pets to Homeless Youth

by CAPB in Companion Animal Psychology Blog

Dogs and cats have both advantages and disadvantages for street-involved youth.Photo: everst / ShutterstockResearch by Michelle Lem et al (University of Guelph) asks homeless young people (aged 18-24) what their pet means to them. Previous studies have focussed on the benefits to homeless people of owning a dog or cat. The aim of this study was to get a balanced picture of both the advantages and disadvantages. Ten homeless young people took part in in-depth interviews about their pet. 8 of........ Read more »

Lem, M., Coe, J.B., Haley, D.B., Stone, E., & O'Grady, W. (2013) Effects of companion animal ownership among Canadian street-involved youth: A qualitative analysis. Journal of Sociology and Social Welfare, XL(4), 285-304. info:/

  • October 15, 2014
  • 12:43 PM
  • 73 views

Marburg Virus and Keap1: induction of antioxidant response whilst inhibiting selective autophagy ?

by thelonevirologist in Virology Tidbits

Under normal conditions, Keap1 interacts with Nrf2 via the Nrf2-ECH homology domain 2 (Neh2) located within the N-terminal end of Nrf2 and ubiquitinates Nrf2 in a Cullin-3 dependent manner., leading to the proteasomal degradation of Nrf2 via the 26S proteasome independent of autophagy. Inactivation of Keap1 by binding p62/SQSTM1 via the C-terminal KELCH domain of Keap1 and the Keap1 interacting domain (KIR) of p62/SQSTM1 induces the degradation of Keap1 via selective autophagy, thus releasing Nr........ Read more »

Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, & Zhong Q. (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy, 6(5), 614-21. PMID: 20495340  

Baird L, & Dinkova-Kostova AT. (2011) The cytoprotective role of the Keap1-Nrf2 pathway. Archives of toxicology, 85(4), 241-72. PMID: 21365312  

Wu KC, Liu JJ, & Klaassen CD. (2012) Nrf2 activation prevents cadmium-induced acute liver injury. Toxicology and applied pharmacology, 263(1), 14-20. PMID: 22677785  

Ma, Q. (2013) Role of Nrf2 in Oxidative Stress and Toxicity. Annual Review of Pharmacology and Toxicology, 53(1), 401-426. DOI: 10.1146/annurev-pharmtox-011112-140320  

Mateo M, Carbonnelle C, Martinez MJ, Reynard O, Page A, Volchkova VA, & Volchkov VE. (2011) Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication. The Journal of infectious diseases. PMID: 21987766  

Noda, T., Ebihara, H., Muramoto, Y., Fujii, K., Takada, A., Sagara, H., Kim, J., Kida, H., Feldmann, H., & Kawaoka, Y. (2006) Assembly and Budding of Ebolavirus. PLoS Pathogens, 2(9). DOI: 10.1371/journal.ppat.0020099  

Edwards MR, Johnson B, Mire CE, Xu W, Shabman RS, Speller LN, Leung DW, Geisbert TW, Amarasinghe GK, & Basler CF. (2014) The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell reports, 6(6), 1017-25. PMID: 24630991  

Bamberg S, Kolesnikova L, Möller P, Klenk HD, & Becker S. (2005) VP24 of Marburg virus influences formation of infectious particles. Journal of virology, 79(21), 13421-33. PMID: 16227263  

Kosmider B, Messier EM, Janssen WJ, Nahreini P, Wang J, Hartshorn KL, & Mason RJ. (2012) Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus. Respiratory research, 43. PMID: 22672594  

  • October 15, 2014
  • 10:00 AM
  • 74 views

Trauma research needs to be more global and accessible

by Eva Alisic in Trauma Recovery

Imagine a 7-year old boy living in India. One day, his father gets drunk and kills his mother. The boy is a witness to the homicide, and develops a high fever as a response. Imagine you’re the mental health professional who is called to support the boy. Some of the things you would want to know are how children in India respond to severe trauma, what words they use, and what helps them to recover.

Unfortunately, that information is virtually nonexistent. T... Read more »

Fodor, K., Unterhitzenberger, J., Chou, C., Kartal, D., Leistner, S., Milosavljevic, M., Nocon, A., Soler, L., White, J., Yoo, S.... (2014) Is traumatic stress research global? A bibliometric analysis. European Journal of Psychotraumatology. DOI: 10.3402/ejpt.v5.23269  

  • October 15, 2014
  • 09:46 AM
  • 67 views

Video Tip of the Week: MedGen, GTR, and ClinVar

by Mary in OpenHelix

The terrific folks at NCBI have been increasing their outreach with a series of webinars recently. I talked about one of them not too long ago, and I mentioned that when I found the whole webinar I’d highlight that. This recording is now available, and if you are interested in using these medical genetics resources, […]... Read more »

Acland A., R. Agarwala, T. Barrett, J. Beck, D. A. Benson, C. Bollin, E. Bolton, S. H. Bryant, K. Canese, D. M. Church.... (2013) Database resources of the National Center for Biotechnology Information. Nucleic Acids Research, 42(D1). DOI: http://dx.doi.org/10.1093/nar/gkt1146  

  • October 15, 2014
  • 09:13 AM
  • 82 views

Remembering visual images

by Janet Kwasniak in Neuro-patch

There is an interesting recent paper (see citation) on visual memory. The researchers’ intent is to map and areas and causal directions between them for a particular process in healthy individuals so that sufferers showing lost of that process can be studied in the same way and the areas/connections which are faulty identified. In this […]... Read more »

Nenert, R., Allendorfer, J., & Szaflarski, J. (2014) A Model for Visual Memory Encoding. PLoS ONE, 9(10). DOI: 10.1371/journal.pone.0107761  

  • October 15, 2014
  • 08:34 AM
  • 60 views

Biochemical 'Memory' Can Help Bacteria to Grow

by This Science is Crazy! in This Science Is Crazy!

A new study explores ‘memory’ in E. coli to see how it impacts on their ability to grow in environments with fluctuating food sources. Recent exposure to a food source can reduce and even practically eliminate the 'lag' phase of growth when the food is reintroduced.... Read more »

  • October 15, 2014
  • 08:00 AM
  • 62 views

Frankenstein Meets Genetic Modification

by Mark Lasbury in As Many Exceptions As Rules

Halloween conjures up monsters, like Mary Shelly’s Frankenstein. Her story is just as applicable for us today – the story of science being responsible for what it creates. The so-called Frankenfoods are called dangerous – but why? Studies that label them dangerous have been retracted or are merely correlative. New studies have shown that genetically modified crops are safe for livestock and humans. However, there are valid concerns, so every GMO must be tested rigorously.... Read more »

Snell C, Bernheim A, Bergé JB, Kuntz M, Pascal G, Paris A, & Ricroch AE. (2012) Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 1134-48. PMID: 22155268  

McCall WV, Andrade C, & Sienaert P. (2014) Searching for the mechanism(s) of ECT's therapeutic effect. The journal of ECT, 30(2), 87-9. PMID: 24755719  

  • October 15, 2014
  • 05:16 AM
  • 59 views

Hookworm infection and microchallenge for coeliac disease?

by Paul Whiteley in Questioning Answers

I'm getting rather baffled by some of the literature appearing with the autoimmune condition coeliac (celiac) disease in mind. The paper by Kalliokoski and colleagues [1] started the bafflement ball rolling with their suggestion that: "administration of IgA-deficient celiac disease patient serum or total IgG induces both deterioration of the intestinal mucosa and clinical features of celiac disease in mice". Then came the paper from Namatovu and colleagues [2] who concluded that: ........ Read more »

Croese J, Giacomin P, Navarro S, Clouston A, McCann L, Dougall A, Ferreira I, Susianto A, O'Rourke P, Howlett M.... (2014) Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease. The Journal of allergy and clinical immunology. PMID: 25248819  

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