It’s alive, ALIVE! No really and it could one day have big implications for you and me. So it is not quite Frankenstein’s monster… yet. However, a new study has revealed how a synthetic protein revives E. coli cells that lack a life-sustaining gene, offering insight into how life can adapt to survive and potentially be reinvented.
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Digianantonio, K., & Hecht, M. (2016) A protein constructed de novo enables cell growth by altering gene regulation. Proceedings of the National Academy of Sciences, 113(9), 2400-2405. DOI: 10.1073/pnas.1600566113
Zika Virus (ZIKV) was first isolated from monkeys in 1947 and until 2007 only isolated cases of infection in humans were reported although serologic studies suggested widespread distribution in Africa and Southeast Asia. In 2007 however ZIKV of the Asian lineage caused an outbreak in Yap/Federal Micronesia followed by an outbreak in French Polynesia in 2013 and the current outbreak in Central & South America and the Caribbean. ZIKV is mainly transmitted via infected Aedes spp.mosquitoes but sexu........ Read more »
DICK GW, KITCHEN SF, & HADDOW AJ. (1952) Zika virus. I. Isolations and serological specificity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 509-20. PMID: 12995440
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Calvet, G., Aguiar, R., Melo, A., Sampaio, S., de Filippis, I., Fabri, A., Araujo, E., de Sequeira, P., de Mendonça, M., de Oliveira, L.... (2016) Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(16)00095-5
Brasil, P., Pereira, Jr., J., Raja Gabaglia, C., Damasceno, L., Wakimoto, M., Ribeiro Nogueira, R., Carvalho de Sequeira, P., Machado Siqueira, A., Abreu de Carvalho, L., Cotrim da Cunha, D.... (2016) Zika Virus Infection in Pregnant Women in Rio de Janeiro — Preliminary Report. New England Journal of Medicine. DOI: 10.1056/NEJMoa1602412
Chan JF, Choi GK, Yip CC, Cheng VC, & Yuen KY. (2016) Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease?. The Journal of infection. PMID: 26940504
Adibi, J., Marques, E., Cartus, A., & Beigi, R. (2016) Teratogenic effects of the Zika virus and the role of the placenta. The Lancet. DOI: 10.1016/S0140-6736(16)00650-4
Bell TM, Field EJ, & Narang HK. (1971) Zika virus infection of the central nervous system of mice. Archiv fur die gesamte Virusforschung, 35(2), 183-93. PMID: 5002906
Tang, H., Hammack, C., Ogden, S., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. DOI: 10.1016/j.stem.2016.02.016
Biegel JM, & Pager CT. (2016) Hepatitis C Virus Exploitation of Processing Bodies. Journal of virology. PMID: 26937026
Katzenell S, & Leib DA. (2016) Herpes simplex virus and interferon signaling induce novel autophagic clusters in sensory neurons. Journal of virology. PMID: 26912623
Ryan EL, Hollingworth R, & Grand RJ. (2016) Activation of the DNA Damage Response by RNA Viruses. Biomolecules, 6(1). PMID: 26751489
Riz I, Hawley TS, & Hawley RG. (2015) KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget, 6(17), 14814-31. PMID: 26109433
Park JM, Choi JY, Yi JM, Chung JW, Leem SH, Koh SS, & Kang TH. (2015) NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair. Biochemical and biophysical research communications, 461(3), 543-8. PMID: 25912875
Joffre C, Codogno P, Fanto M, Hergovich A, & Camonis J. (2016) STK38 at the crossroad between autophagy and apoptosis. Autophagy, 1-2. PMID: 26890257
Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C.... (2015) The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy. Current biology : CB, 25(19), 2479-92. PMID: 26387716
Kanu N, & Behrens A. (2007) ATMIN defines an NBS1-independent pathway of ATM signalling. The EMBO journal, 26(12), 2933-41. PMID: 17525732
Matsui A, Kamada Y, & Matsuura A. (2013) The role of autophagy in genome stability through suppression of abnormal mitosis under starvation. PLoS genetics, 9(1). PMID: 23382696
Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147
Beller M, Thiel K, Thul PJ, & Jäckle H. (2010) Lipid droplets: a dynamic organelle moves into focus. FEBS letters, 584(11), 2176-82. PMID: 20303960
Bukong TN, Momen-Heravi F, Kodys K, Bala S, & Szabo G. (2014) Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS pathogens, 10(10). PMID: 25275643
Shrivastava S, Devhare P, Sujijantarat N, Steele R, Kwon YC, Ray R, & Ray RB. (2015) Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway. Journal of virology, 90(3), 1387-96. PMID: 26581990
Schorey JS, Cheng Y, Singh PP, & Smith VL. (2015) Exosomes and other extracellular vesicles in host-pathogen interactions. EMBO reports, 16(1), 24-43. PMID: 25488940
We've all had days when we got out of the wrong side of the bed and the world looked greyer than usual. This daily variation in mood is a potential problem for psychologists who want to use tests to compare people's mental ability – competing job candidates, for example. Mood, like tiredness and motivation, could be another factor that leads some people to perform below par, by their own standards, thus distorting the test results. Indeed, there's some evidence that being in a bad mood is dist........ Read more »
von Stumm, S. (2016) Is day-to-day variability in cognitive function coupled with day-to-day variability in affect?. Intelligence, 1-6. DOI: 10.1016/j.intell.2015.12.006
Gravitational waves, detected by LIGO, might have implications for finding black holes.... Read more »
Abbott, B. (2016) Observation of Gravitational Waves from a Binary Black Hole Merger. Physical Review Letters, 116(6). DOI: 10.1103/PhysRevLett.116.061102
Emanuele Berti. (2016) Viewpoint: The First Sounds of Merging Black Holes. APS Physics 9 (2016) 17. arXiv: 1602.04476v2
"As expected, adults with ASD [autism spectrum disorder] experienced more psychological symptoms and distress compared to a typically developing comparison group." But: "lifetime diagnoses for any psychiatric disorder were less often present in older than in younger adults with ASD, suggesting reduced psychopathology in late adulthood, a pattern that has been commonly observed in large typical aging studies."Those were some of the findings reported by Anne Lever & Hilde Geurts........ Read more »
Lever AG, & Geurts HM. (2016) Psychiatric Co-occurring Symptoms and Disorders in Young, Middle-Aged, and Older Adults with Autism Spectrum Disorder. Journal of autism and developmental disorders. PMID: 26861713
Minimalist Running Shoes and Injury Risk... Read more »
Grier, T., Canham-Chervak, M., Bushman, T., Anderson, M., North, W., & Jones, B. (2016) Minimalist Running Shoes and Injury Risk Among United States Army Soldiers. The American Journal of Sports Medicine. DOI: 10.1177/0363546516630926
Impact Related Factors and Running Injury... Read more »
van der Worp, H., Vrielink, J., & Bredeweg, S. (2016) Do runners who suffer injuries have higher vertical ground reaction forces than those who remain injury-free? A systematic review and meta-analysis. British Journal of Sports Medicine. DOI: 10.1136/bjsports-2015-094924
Yesterday we blogged about the emergent and increasing antibiotic resistance problem, which was good -- or bad timing -- depending on how you look at it. A new study of gut bacteria in premature infants reveals the vast scope of the problem of antibiotic resistance and gives new insight into the extreme vulnerability of these young patients, according to researchers.
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Gibson, M., Wang, B., Ahmadi, S., Burnham, C., Tarr, P., Warner, B., & Dantas, G. (2016) Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome. Nature Microbiology, 16024. DOI: 10.1038/nmicrobiol.2016.24
Alcohol-sensitizing drugs are used to ruin the experience of consuming alcohol. This can be helpful for people seeking treatment for alcohol dependence, but otherwise sounds absolutely terrible. After consuming an adult beverage, alcohol is absorbed into your bloodstream and carried to your liver. There, it is set upon by two enzymes. The first, alcohol dehydrogenase, converts alcohol into acetaldehyde. The second enzyme, aldehyde dehydrogenase, converts the acetaldehyde into acetic acid (the st........ Read more »
Lessenger J. (1998) Case study: Hypotension, nausea and vertigo linked to hydrogen cyanamide exposure. Journal of Agromedicine, 5(3), 5-11. DOI: 10.1300/J096v05n03_02
Suh JJ, Pettinati HM, Kampman KM, & O'Brien CP. (2006) The status of disulfiram: A half of a century later. Journal of Clinical Psychopharmacology, 26(3), 290-302. PMID: 16702894
Who is this, wandering around the crowded street, afraid of everything, trusting no one? “There must be something wrong, somewhere.”But maybe I’m safer since I look disheveled. Who are these people? Where is this place?Did I write that? When did that happen? I don’t remember. I can’t stop writing. I can’t stop walking, either, which is a problem because it’s hard to write and walk at the same time.In the early 1940s, Austrian Psychiatrist Dr. Erwin Stengel wrote a pair of papers........ Read more »
Stengel, E. (1943) Further Studies on Pathological Wandering (Fugues with the Impulse to Wander). The British Journal of Psychiatry, 89(375), 224-241. DOI: 10.1192/bjp.89.375.224
By guest blogger Richard StephensI have a professional interest in the naughty. In my recent book Black Sheep The Hidden Benefits of Being Bad I explored in a light hearted fashion the psychology around the upsides of various antisocial behaviours – things like swearing, drinking, affairs and untidiness to name a few. However, this post is about physical violence, a much more serious form of bad behaviour for which I see no upside at all.Thankfully there is some fascinating psychology into the........ Read more »
Murray, J., Hallal, P., Mielke, G., Raine, A., Wehrmeister, F., Anselmi, L., & Barros, F. (2016) Low resting heart rate is associated with violence in late adolescence: a prospective birth cohort study in Brazil. International Journal of Epidemiology. DOI: 10.1093/ije/dyv340
Once again the uncomfortable topic of euthanasia and assisted suicide (EAS) is covered on this blog (see here for the last entry) as I discuss the findings reported by Scott Kim and colleagues  who reported on the "characteristics of patients receiving EAS for psychiatric conditions and how the practice is regulated in the Netherlands."Accompanied by some media interest (see here), the Kim paper provides an important overview of the: "Clinical and social characteristics of patients, physician........ Read more »
Kim, S., De Vries, R., & Peteet, J. (2016) Euthanasia and Assisted Suicide of Patients With Psychiatric Disorders in the Netherlands 2011 to 2014. JAMA Psychiatry. DOI: 10.1001/jamapsychiatry.2015.2887
I recently spoke with Chief Scientist Shigeru Kuratani about evolutionary morphology, sci-fi monsters, the genius of Alien, and more.... Read more »
Sugahara, F., Pascual-Anaya, J., Oisi, Y., Kuraku, S., Aota, S., Adachi, N., Takagi, W., Hirai, T., Sato, N., Murakami, Y.... (2016) Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain. Nature, 531(7592), 97-100. DOI: 10.1038/nature16518
Atopic dermatitis (AD), which is also referred to as Eczema, is a very common dermatological disease, especially in children. It is estimated that AD affects 10% of children. The disease presents as dry, scaly, itchy skin. Atopic dermatitis can be especially problematic when the victim (often a child)...... Read more »
Bradley, C., Morris, D., Rankin, S., Cain, C., Misic, A., Houser, T., Mauldin, E., & Grice, E. (2016) Longitudinal evaluation of the skin microbiome and association with microenvironment and treatment in canine atopic dermatitis. Journal of Investigative Dermatology. DOI: 10.1016/j.jid.2016.01.023
Hi All! I haven't updated in a quite a while because work as a rehabilitation psychologist has taken up most of my time. However, I was able to get a paper published recently in the journal NeuroRehabilitation. It was based on work done during my postdoc. The aim was to investigate whether cognitive behavioral therapy for insomnia would treat not only insomnia, but fatigue, pain, and mood in individuals with traumatic brain injury. It was a small case study, but I included a lot of rich detail f........ Read more »
Lu W, Krellman JW, & Dijkers MP. (2016) Can Cognitive Behavioral Therapy for Insomnia also treat fatigue, pain, and mood symptoms in individuals with traumatic brain injury? - A multiple case report. NeuroRehabilitation, 38(1), 59-69. PMID: 26889799
Without the discovery of antibiotics we could not — and most certainly would not — be living in the world we do today. It was a discovery that would save countless lives, while simultaneously compromising our future. From the use (and unfortunate misuse) of antibiotics, we gave rise to more virulent bacteria that have become resistant to more and more types of antibiotics.
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When the first antibiotics became available 70 years ago, they were often described as miracles of human ingenuity, rather like plastics or bright permanent dyes, which were discovered at roughly the same time. Packaged in vials or pills, they seemed like our inventions rather a chance gift of evolution and one that evolution might also rescind.
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The development of haddock embryos is highly impacted by oil exposure as discussed in a previous
post. In a new study Sørhus et al. explored the link between transcriptional changes and developmental processes such as pattern formation and organogenesis. The question is to understand the abnormal development in fish.
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Sørhus, E., Incardona, J., Furmanek, T., Jentoft, S., Meier, S., & Edvardsen, R. (2016) Developmental transcriptomics in Atlantic haddock: Illuminating pattern formation and organogenesis in non-model vertebrates. Developmental Biology, 411(2), 301-313. DOI: 10.1016/j.ydbio.2016.02.012
Sørhus, E., Edvardsen, R., Karlsen, Ø., Nordtug, T., van der Meeren, T., Thorsen, A., Harman, C., Jentoft, S., & Meier, S. (2015) Unexpected Interaction with Dispersed Crude Oil Droplets Drives Severe Toxicity in Atlantic Haddock Embryos. PLOS ONE, 10(4). DOI: 10.1371/journal.pone.0124376
Misund, O., & Olsen, E. (2013) Lofoten-Vesteralen: for cod and cod fisheries, but not for oil?. ICES Journal of Marine Science, 70(4), 722-725. DOI: 10.1093/icesjms/fst086
“A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.” Max Planck Knowledge accumulation is of central importance to scientific progress and economic growth. Yet we know little about how this process works, and particularly […]... Read more »
According to a spectacularly misleading article in the Telegraph: Scientists discover how to 'upload knowledge to your brain'
Feeding knowledge directly into your brain, just like in sci-fi classic The Matrix, could soon take as much effort as falling asleep, scientists believe. Researchers claim to have developed a simulator which can feed information directly into a person’s brain and teach them new skills in a shorter amount of time...
Researchers from HRL Laboratories, based in Cali... Read more »
Choe J, Coffman BA, Bergstedt DT, Ziegler MD, & Phillips ME. (2016) Transcranial Direct Current Stimulation Modulates Neuronal Activity and Learning in Pilot Training. Frontiers in human neuroscience, 34. PMID: 26903841
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