Post List

  • August 11, 2014
  • 01:30 PM
  • 169 views

New Hope for Autoimmune Diseases

by Gabriel in Lunatic Laboratories

Autoimmune diseases are on the rise. Since I have a history of over sharing, my Uncle suffered from a form of lupus. It caused him intense and — in my opinion — unbearable pain although he shouldered it like the incredible man he was and never complained. My sister unfortunately is suffering from a rare disease that has yet to be diagnosed, which in my opinion has autoimmune dysfunction as the root cause. If you or anyone you know suffers in a similar fashion then you know that the treatment........ Read more »

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK.... (2014) Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 24891519  

  • August 11, 2014
  • 12:00 PM
  • 70 views

IT’S NEVER LUPUS? THINK AGAIN…

by Robb Hollis in Antisense Science

Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?
... Read more »

  • August 11, 2014
  • 12:00 PM
  • 31 views

It's Never Lupus? Think Again...

by Robb Hollis in Antisense Science

Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?... Read more »

  • August 11, 2014
  • 11:42 AM
  • 134 views

Clinical Drug Trials for Pathological Gambling

by William Yates, M.D. in Brain Posts

Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269  

  • August 11, 2014
  • 11:05 AM
  • 126 views

Earth’s energy imbalance

by Ed Hawkins in Climate Lab Book

Global surface air temperatures have risen less rapidly over the past 15 years than the previous few decades. The causes of this ‘hiatus’ have been much debated. However, just considering surface temperatures does not tell the whole story – a … Continue reading →... Read more »

Allan, R., Liu, C., Loeb, N., Palmer, M., Roberts, M., Smith, D., & Vidale, P. (2014) Changes in global net radiative imbalance 1985-2012. Geophysical Research Letters. DOI: 10.1002/2014GL060962  

  • August 11, 2014
  • 10:42 AM
  • 121 views

Attraction in the World of Bats

by Denise O'Meara in Denise O'Meara

We spend much of our lives attempting to figure out the opposite sex in the hopes that it will lead to increased opportunities to attract a mate. But even when in a relationship, looking back to see how it all kicked off can still leave you scratching your head for answers. Understanding attraction and the rules (or lack of them) that govern it are complicated, but there is no shortage of purported help out there to be found in books, cinema and online. Midst the cloud of confusion, we sometime........ Read more »

  • August 11, 2014
  • 09:38 AM
  • 124 views

Lithium For Aging Brain

by Vivek Misra in The UberBrain

Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment inc........ Read more »

Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, & Manji HK. (2000) Enhancement of hippocampal neurogenesis by lithium. Journal of neurochemistry, 75(4), 1729-34. PMID: 10987856  

O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, & Klein PS. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(30), 6791-8. PMID: 15282284  

Berggren U, Tallstedt L, Ahlenius S, & Engel J. (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology, 59(1), 41-5. PMID: 100811  

Agam G, Bersudsky Y, Berry GT, Moechars D, Lavi-Avnon Y, & Belmaker RH. (2009) Knockout mice in understanding the mechanism of action of lithium. Biochemical Society transactions, 37(Pt 5), 1121-5. PMID: 19754464  

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS.... (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature, 507(7493), 448-54. PMID: 24670762  

  • August 11, 2014
  • 09:00 AM
  • 8 views

OCD Linked With Broad Impairments in Executive Function

by amikulak in Daily Observations

Obsessive-compulsive disorder (OCD), characterized by intrusive and persistent thoughts that are often accompanied by repetitive or ritualized acts, is a serious clinical disorder that can significantly impact a person’s ability […]... Read more »

  • August 11, 2014
  • 08:00 AM
  • 139 views

Weather Vs. Climate In Global Warming

by Mark E. Lasbury in The 'Scope

Last winter was horrible, and this summer has been mild – so global warming must not be real. This is the thought process for many people, but it points out the confusion between climate and weather. Climate is the average weather for a place over a given period, while weather is what you get day to day. New research is showing that climate change is causing more intense hurricanes - but is the number changing? Recent studies land on both sides of the issue.... Read more »

  • August 11, 2014
  • 07:14 AM
  • 106 views

A Wrinkly Purpose

by Bernadeta Dadonaite in The Question Gene

On what makes our fingers wrinkle in water... Read more »

  • August 11, 2014
  • 07:04 AM
  • 124 views

Do infant dummies (pacifiers) impede the emotional connection between adult and baby?

by BPS Research Digest in BPS Research Digest

Dummies (known as pacifiers in the US) can calm a crying baby in seconds, so their appeal is obvious. However, a new study warns there could be a price to pay. Magdalena Rychlowska and her colleagues claim that because dummies obscure babies' faces, they interfere with the way that adults respond to babies' emotions.The researchers used electrodes to record the facial muscles of 29 women (average age 21; two of them were mothers) while they looked at photographs of two young babies expressing ha........ Read more »

Rychlowska, M., Korb, S., Brauer, M., Droit-Volet, S., Augustinova, M., Zinner, L., & Niedenthal, P. (2014) Pacifiers Disrupt Adults’ Responses to Infants’ Emotions. Basic and Applied Social Psychology, 36(4), 299-308. DOI: 10.1080/01973533.2014.915217  

  • August 11, 2014
  • 07:02 AM
  • 107 views

Simple Jury Persuasion: When your Muslim female client wears a head-covering

by Rita Handrich in The Jury Room

We’ve written a number of times about bias against Muslims. But here’s a nice article with an easy to incorporate finding on how to reduce bias against your female client who wears a Muslim head-covering. (In case you have forgotten, we’ve already written about head-coverings for the Muslim man.) The graphic illustrating this post shows […]

Related posts:
Simple Jury Persuasion: Tilt your head. (no kidding)
Simple Jury Persuasion: In the face of ambiguity, we just make stuff up!
S........ Read more »

  • August 11, 2014
  • 05:56 AM
  • 119 views

Taste Isn’t Just For The Tongue

by Rebekah Morrow in United Academics

Taste is one of our five basic senses, and every child is taught that you use the tongue to taste things. But science is proving that many other tissues can taste what you ingest.... Read more »

Mosinger B, Redding KM, Parker MR, Yevshayeva V, Yee KK, Dyomina K, Li Y, & Margolskee RF. (2013) Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12319-24. PMID: 23818598  

  • August 11, 2014
  • 03:43 AM
  • 121 views

Risk of neurodevelopmental disorder in cases of hypospadias

by Paul Whiteley in Questioning Answers

"This is the first study to identify an increased risk for neurodevelopmental disorders in patients with hypospadias, as well as an increased risk for ASD [autism spectrum disorders] in their brothers, suggesting a common familial (genetic and/or environmental) liability".Rainy days and Mondays... @ Wikipedia That was the conclusion reached in the study by Agnieszka Butwicka and colleagues [1] looking at various neurodevelopmental outcomes associated with a diagnosis of ........ Read more »

Butwicka A, Lichtenstein P, Landén M, Nordenvall AS, Nordenström A, Nordenskjöld A, & Frisén L. (2014) Hypospadias and increased risk for neurodevelopmental disorders. Journal of child psychology and psychiatry, and allied disciplines. PMID: 25048198  

  • August 11, 2014
  • 12:05 AM
  • 143 views

Emergency Room Visits for Sports Injuries

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Sports-related injuries among teenagers accounts for over 430,000 emergency room visits in the United States in 2008 and represent a significant financial burden to the healthcare system.

Sports-related injuries in teenagers result in a significant number of emergency room visits, which can result in relatively large direct costs. However, little is known about national estimates of how many emergency room visits actually occur as well as the direct costs affiliated ........ Read more »

Nalliah RP, Anderson IM, Lee MK, Rampa S, Allareddy V, & Allareddy V. (2014) Epidemiology of Hospital-Based Emergency Department Visits Due to Sports Injuries. Pediatric Emergency Care, 30(8), 511-515. PMID: 25062295  

  • August 10, 2014
  • 07:01 PM
  • 135 views

“You’re all going to hate the word ‘recovery’”

by DJMac in Recovery Review

One of the problems with an aspirational and non-prescriptive definition of recovery is that it is hard to measure. The definitions most commonly featured in the literature share some elements including wellbeing or health, abstinence and citizenship. Clearly if you can’t define it precisely, then it’s hard to commission services to deliver on it. In [...]
The post “You’re all going to hate the word ‘recovery’” appeared first on Recovery Review.
... Read more »

  • August 10, 2014
  • 12:03 PM
  • 154 views

Pregnancy and Antibacterial Soap a Potentially Dangerous Combination

by Gabriel in Lunatic Laboratories

My wife likes to sanitize everything with bleach. I don’t really approve, but I bite my tongue because it makes her feel better. Germs are everywhere and honestly there is […]... Read more »

Pycke BF, Geer LA, Dalloul M, Abulafia O, Jenck AM, & Halden RU. (2014) Human biomonitoring of prenatal exposure to triclosan and triclocarban in a multiethnic urban population from Brooklyn, New York. Environmental Science , 8831-8838. info:/10.1021/es501100w

  • August 10, 2014
  • 05:18 AM
  • 164 views

Canine Science Forum 2014 - we come full circle!

by Cobb & Hecht in Do You Believe In Dog?

Aw - it's Us @ CSF2014! Thanks Tamás Faragó :)Dear Julie,while you've been off enjoying the fjords of Norway and I've been recovering from six legs of long haul flying with a three year old as hand luggage, I thought I'd put up a quick post to recap the wonderful week in Lincoln, UK that was the (Feline and) Canine Science Forum 2014.Such a fun, stimulating, inspiring week comprising the Feline Science day (Monday), public lecture by James Serpell (rhymes with purple) on Monday ........ Read more »

  • August 10, 2014
  • 01:30 AM
  • 132 views

Reducing Risk and Creating More Resilient Supply Chains

by Andreas Wieland in Supply Chain Management Research

That does a supply chain risk researcher’s heart good: MIT Sloan Management Review has recently published two interesting case studies about the interface between risk and supply chain management. First, in the magazine’s spring issue, Chopra and Sodhi call attention to a dilemma faced by most managers: “Solutions to reduce risk mean little unless they […]... Read more »

Chopra, S., & Sodhi, M.S. (2014) Reducing the Risk of Supply Chain Disruptions. MIT Sloan Management Review. info:/

  • August 9, 2014
  • 01:45 PM
  • 418 views

Marijuana and the Developing Brain

by Gabriel in Lunatic Laboratories

You can’t get away from it, the big marijuana debate here in the US. Is it good? Is it bad? What are other countries doing? There are also a lot of claims made about marijuana, most of which aren’t true, namely the big medical claims. Then there is the other side of that fence, what about some of the health issues that are claimed, where does science sit on that?[…]... Read more »

Giedd JN, Blumenthal J, Jeffries NO, Rajapakse JC, Vaituzis AC, Liu H, Berry YC, Tobin M, Nelson J, & Castellanos FX. (1999) Development of the human corpus callosum during childhood and adolescence: a longitudinal MRI study. Progress in neuro-psychopharmacology , 23(4), 571-88. PMID: 10390717  

Giedd, J. N. (2004) Structural magnetic resonance imaging of the adolescent brain. Adolescent Brain Development: Vulnerabilities and Opportunities. info:/

Choo EK, Benz M, Zaller N, Warren O, Rising KL, & McConnell KJ. (2014) The impact of state medical marijuana legislation on adolescent marijuana use. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 55(2), 160-6. PMID: 24742758  

Joffe A, American Academy of Pediatrics Committee on Substance Abuse, & American Academy of Pediatrics Committee on Adolescence. (2004) Legalization of marijuana: potential impact on youth. Pediatrics, 113(6), 1825-6. PMID: 15173518  

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