Post List

  • March 19, 2014
  • 09:38 AM

Video Tip of the Week: ICGC portal for cancer genomics

by Mary in OpenHelix

A question at Biostar about cancer “gene sets” recently got me looking at one of my favorite data sources again–the ICGC, International Cancer Genome Consortium, and their data portal. Previous posts we’ve done were based on their legacy portal (which is still available on their site). They changed things up a bit with a release […]... Read more »

Hudson (Chairperson) Thomas J., Anderson Warwick, Aretz Axel, Barker Anna D., Bell Cindy, Bernabé Rosa R., Bhan M. K., Calvo Fabien, Eerola Iiro, & Gerhard Daniela S. (2010) International network of cancer genome projects. Nature, 464(7291), 993-998. DOI: 10.1038/nature08987  

Alexandrov Ludmil B., Nik-Zainal Serena, Wedge David C., Aparicio Samuel A. J. R., Behjati Sam, Biankin Andrew V., Bignell Graham R., Bolli Niccolò, Borg Ake, & Børresen-Dale Anne-Lise. (2013) Signatures of mutational processes in human cancer. Nature, 500(7463), 415-421. DOI: 10.1038/nature12477  

Gonzalez-Perez Abel, Mustonen Ville, Reva Boris, Ritchie Graham R S, Creixell Pau, Karchin Rachel, Vazquez Miguel, Fink J Lynn, Kassahn Karin S, & Pearson John V. (2013) Computational approaches to identify functional genetic variants in cancer genomes. Nature Methods, 10(8), 723-729. DOI: 10.1038/nmeth.2562  

  • March 19, 2014
  • 08:05 AM

Maybe We Do Taste The Burn

by Mark Lasbury in As Many Exceptions As Rules

Common perception is that capsaicin is a pain sensation, not a taste. But recent research is showing that capsaicin, while perhaps not tasted on its own, does influence what is tasted. It is know that capsaicin can suppress sweet and bitter tastes. A 2010 study indicated that TRPV1 expressing neurons are expressed in circumvallate taste buds, and can be co-expressed with sweet or bitter taste receptors. Other work shows that alterations in sweet, bitter, and metallic tastes do occur in TRPV1 kno........ Read more »

  • March 19, 2014
  • 07:55 AM

The mystery of the fish that change their sex

by Aileen Cudmore in Natural Reactions

Scientists puzzle over the possible circumstances that might lead a male fish to shift sex and become female. ... Read more »

  • March 19, 2014
  • 07:26 AM

March 19, 2014

by Erin Campbell in HighMag Blog

Migration fingers are the spirit fingers of a migrating epithelial sheet of cells. Woowoo!! Today’s image is from a cool paper on the forces exerted by a migration finger, so naturally I’m showing my enthusiasm with my own spirit fingers. Cells can migrate on their own or as part of an epithelial sheet of many cells. Collective migration features the forward movement of multicellular migration fingers, and can be seen throughout development, in spreading tumors and in healing wounds. The........ Read more »

Reffay, M., Parrini, M., Cochet-Escartin, O., Ladoux, B., Buguin, A., Coscoy, S., Amblard, F., Camonis, J., & Silberzan, P. (2014) Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells. Nature Cell Biology, 16(3), 217-223. DOI: 10.1038/ncb2917  

  • March 19, 2014
  • 07:02 AM

Shocking research: Generational stereotypes don’t make sense on the job

by Rita Handrich in The Jury Room

We’ve written about this a lot both here on the blog and over at The Jury Expert. So it isn’t news to us, but evidently it continues to surprise experts in other fields. Business journals are still urging differing management strategies for members of different generations in the workplace. But, as in other research, today’s […]

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Becton, J., Walker, H., & Jones-Farmer, A. (2014) Generational differences in workplace behavior. Journal of Applied Social Psychology, 44(3), 175-189. DOI: 10.1111/jasp.12208  

  • March 19, 2014
  • 06:57 AM

Maxwell Equations And Knot Theory

by Simone Munao in United Academics

Recently published computations show that there are structures of light that satisfy the Maxwell equations with the form of a knot. The simulations prove that the field lines do not lose their topological characteristics, that is to say that they maintain the same shape, up to continuous deformations.... Read more »

Hridesh Kedia, Iwo Bialynicki-Birula, Daniel Peralta-Salas, & William T. M. Irvine. (2013) Tying knots in light fields. Phys. Rev. Lett. 111, 150404 (2013) [5 pages]. arXiv: 1302.0342v1

  • March 19, 2014
  • 12:05 AM

ACL Risk – It’s In Your Genes

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Individuals with a history of an anterior cruciate ligament injury are more likely to have certain genetic variations compared with individuals without a history of a knee injury. While these findings are novel and interesting, researchers need to conduct more research to understand the multifactorial genetic risk behind anterior cruciate ligament injuries. ... Read more »

Mannion, S., Mtintsilana, A., Posthumus, M., van der Merwe, W., Hobbs, H., Collins, M., & September, A. (2014) Genes encoding proteoglycans are associated with the risk of anterior cruciate ligament ruptures. British Journal of Sports Medicine. DOI: 10.1136/bjsports-2013-093201  

  • March 18, 2014
  • 01:38 PM

Is Liangdao man the oldest Austronesian?

by nath in Imprints of Philippine Science

Genetic analyses say that the Liangdao Man “has the most ancestral haplogroup E sequence among extant Austronesian speakers [1].” Lingdao …Continue reading →... Read more »

Ko, A., Chen, C., Fu, Q., Delfin, F., Li, M., Chiu, H., Stoneking, M., & Ko, Y. (2014) Early Austronesians: Into and Out Of Taiwan. The American Journal of Human Genetics, 94(3), 426-436. DOI: 10.1016/j.ajhg.2014.02.003  

Soares, P., Trejaut, J., Loo, J., Hill, C., Mormina, M., Lee, C., Chen, Y., Hudjashov, G., Forster, P., Macaulay, V.... (2008) Climate Change and Postglacial Human Dispersals in Southeast Asia. Molecular Biology and Evolution, 25(6), 1209-1218. DOI: 10.1093/molbev/msn068  

Tabbada, K., Trejaut, J., Loo, J., Chen, Y., Lin, M., Mirazon-Lahr, M., Kivisild, T., & De Ungria, M. (2009) Philippine Mitochondrial DNA Diversity: A Populated Viaduct between Taiwan and Indonesia?. Molecular Biology and Evolution, 27(1), 21-31. DOI: 10.1093/molbev/msp215  

  • March 18, 2014
  • 11:47 AM

Immortality! - The story of Hydra

by Coffee Table Science in CTS

Immortality - a phenomenon, we admire in characters of fictional books, - the impossible, crazy scientists hope to attain in their labs and the unfulfilled desire of all human kind. We could do a 100,000 things if we were immortal; take up more reading, switch to a better job or simply take more vacation time when needed. Yet the constraint of time pushes us to maximise what we have at hand, make most of resources available and fit in a myriad of things into our timelines to make our lives more ........ Read more »

  • March 18, 2014
  • 11:46 AM

Short Sleep Duration in Children with Autism

by William Yates, M.D. in Brain Posts

Parents of children with autism and autism spectrum disorder commonly report sleep problems in their child.However, there have been few prospective systematic studies of sleep in this disorder.Joanna Humphreys from Canada and colleagues from England recently published an important manuscript addressing this topic.They used data from the Avon Longitudinal Study of Parents and Children. This data set includes prospective data collected from a cohort of over 14,000 children born between April 1991 ........ Read more »

Humphreys JS, Gringras P, Blair PS, Scott N, Henderson J, Fleming PJ, & Emond AM. (2014) Sleep patterns in children with autistic spectrum disorders: a prospective cohort study. Archives of disease in childhood, 99(2), 114-8. PMID: 24061777  

  • March 18, 2014
  • 10:00 AM

The Antiquity of Cancer

by Katy Meyers in Bones Don't Lie

Cancer is a leading cause of death in the world today, however it is something that archaeologists rarely identify in human remains from the past. The hypothesis behind this is […]... Read more »

  • March 18, 2014
  • 08:57 AM

Deleting The ‘I’ From CIAP

by Pieter Carrière in United Academics

Although similar symptoms are found in other polyneuropathies, CIAP is an exceptional disease, primarily because the cause is unknown. Researchers only recently found an interesting link between CIAP and other clinical conditions, which could lead to a better diagnosis.... Read more »

Notermans NC, Wokke JH, Franssen H, van der Graaf Y, Vermeulen M, van den Berg LH, Bär PR, & Jennekens FG. (1993) Chronic idiopathic polyneuropathy presenting in middle or old age: a clinical and electrophysiological study of 75 patients. Journal of neurology, neurosurgery, and psychiatry, 56(10), 1066-71. PMID: 7691991  

Visser, N., Vrancken, A., van der Schouw, Y., van den Berg, L., & Notermans, N. (2012) Chronic Idiopathic Axonal Polyneuropathy Is Associated With the Metabolic Syndrome. Diabetes Care, 36(4), 817-822. DOI: 10.2337/dc12-0469  

Singer MA, Vernino SA, & Wolfe GI. (2012) Idiopathic neuropathy: new paradigms, new promise. Journal of the peripheral nervous system : JPNS, 43-9. PMID: 22548623  

  • March 18, 2014
  • 07:48 AM

Fine-Tuning Stephen Hawking’s Theory of Mass

by Perikis Livas in Tracing Knowledge

If you want to know your body’s mass, you hop on a scale and watch the needle swing. But if you want to know the mass of a region out in space, there’s no cosmic equivalent — the best you can do is consult a geometric formula.... Read more »

Hubert L. Bray, Jeffrey L. Jauregui, & Marc Mars. (2014) Time flat surfaces and the monotonicity of the spacetime Hawking mass II. Cornell University Library. arXiv: 1402.3287v1

Hubert L. Bray, & Jeffrey L. Jauregui. (2013) Time flat surfaces and the monotonicity of the spacetime Hawking mass. Cornell University Library. arXiv: 1310.8638v2

  • March 18, 2014
  • 05:17 AM

How thinking in a foreign language makes you more rational in some ways but not others

by Christian Jarrett in BPS Research Digest

Back in 2012, US researchers showed that when people used their second, non-native language, they were less prone to a mental bias known as loss aversion. This bias means we're averse to the same outcome when it's framed in a way that highlights what's to be lost, as compared with when it's framed in a way that emphasises what's to be gained. For example, a vaccine is more appealing if it's stated that it will save 200,000 out of 600,000 people, far less unappealing if it's explained the vaccine........ Read more »

Costa A, Foucart A, Arnon I, Aparici M, & Apesteguia J. (2014) "Piensa" twice: on the foreign language effect in decision making. Cognition, 130(2), 236-54. PMID: 24334107  

  • March 18, 2014
  • 03:12 AM

What is conscious intent anyway?

by Janet Kwasniak in Neuro-patch

A recent paper (citation below) reports that conscious intent precedes motor preparation activity, and not that motor preparation is well underway before consciousness registers intent. Here is Zschorlich and Köhling conclusion: “Motor intention (intention in action) describes a process of motor preparation without executing an overt movement. In our study, we explored the link between […]... Read more »

  • March 18, 2014
  • 02:35 AM

Mixed Models in Sports and Health

by Altea Lorenzo in FreshBiostats, Young researchers in Biostatistics

Short literature review of papers using mixed models in the area of sports and health... Read more »

Casals, M., & Martinez, J.A. (2013) Modelling player performance in basketball through mixed models . Journal of Performance Analysis in Sport, 13(1), 64-82. info:/

McHale, I., & Szczepański, L. (2014) A mixed effects model for identifying goal scoring ability of footballers. Journal of the Royal Statistical Society: Series A (Statistics in Society), 177(2), 397-417. DOI: 10.1111/rssa.12015  

  • March 17, 2014
  • 11:33 PM

Soy infant formula and seizures in autism

by Paul Whiteley in Questioning Answers

Spring @ Wikipedia 'Association' is a word I'm sure many people with a connection to autism will have heard a lot about. Y'know gene X or compound Y is the plat du jour when it comes to autism aetiology; more often than not carrying the caveat 'requires further investigation'. As to whether such investigations are ever truly carried out would perhaps be an interesting piece of research on autism research.Today I'm talking about another association, another variable to throw into the st........ Read more »

  • March 17, 2014
  • 11:23 PM

Impact of injury on ultramarathon performance

by Craig Payne in Running Research Junkie

Impact of injury on ultramarathon performance... Read more »

Khodaee, M., Spittler, J., Hill, J., & Hoffman, M. (2014) IMPACT OF INJURY PATTERN DURING TRAINING ON ULTRAMARATHON PERFORMANCE. British Journal of Sports Medicine, 48(7), 619-619. DOI: 10.1136/bjsports-2014-093494.160  

  • March 17, 2014
  • 03:53 PM

Neuralstem publishes Phase I stem cell trial final results

by beredim in Stem Cells Freak

Neuralstem logoNeuralstem announced today that the final results from its Phase I safety trial using NSI-566 spinal cord stem cells in the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) were published in the peer-reviewed journal, "Annals of Neurology".In "Intraspinal Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis: Phase I Trial Outcomes," results were updated from Phase I interim data, reported earlier, to include data from th........ Read more »

Feldman EL, Boulis NM, Hur J, Johe K, Rutkove SB, Federici T, Polak M, Bordeau J, Sakowski SA, & Glass JD. (2014) Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes. Annals of neurology. PMID: 24510776  

  • March 17, 2014
  • 01:52 PM

‘Breathing’ Battery Could Extend EVs’ Range

by dailyfusion in The Daily Fusion

Researchers are reporting new progress on a “breathing” battery that has the potential to one day replace the lithium-ion technology of today’s EVs. This lithium-air battery technology could boost the range of EVs toward a 300 miles or even more.... Read more »

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