I must admit that I cringe slightly every time I try to think about healthcare from an economics perspective. To me, this comes a little close to putting a dollar value on human beings, which feels uncomfortably post-humanistic to me. Nonetheless, there is no ignoring the ways in which economic concerns factor into policy decisions that drive our human services, including health care.
There are also a number of pragmatic reasons for thinking about the costs associated with illnesses; talki........ Read more »
A new study has gathered data throughout the literature showing that vegetarian diets are more sustainable than and reduce greenhouse gas emissions compared to meat-based diets. Find the details here!... Read more »
Sabate, J., & Soret, S. (2014) Sustainability of plant-based diets: back to the future. American Journal of Clinical Nutrition, 100(Supplement_1), 476-482. DOI: 10.3945/ajcn.113.071522
Scientists at the Carnegie Mellon University have quantified what the price of energy storage needs to be to justify the use of energy storage devices at remote wind farms.... Read more »
Lamy, J., Azevedo, I., & Jaramillo, P. (2014) The role of energy storage in accessing remote wind resources in the Midwest. Energy Policy, 123-131. DOI: 10.1016/j.enpol.2014.01.008
You know what technology hasn’t been able to keep pace with us? Well besides whatever tech the DMV uses, it’s batteries. Think about it, they are nasty, make a mess, are hazzardous, hard to recycle and weigh a freaking ton compared to the energy stored. Current battery technology is my number one problem with electric cars as it stands now. Between the weight, the resources, and the waste, electric cars are almost a wash. Not quite mind you, but almost.... Read more »
Yang, B., Hoober-Burkhardt, L., Wang, F., Surya Prakash, G., & Narayanan, S. (2014) An Inexpensive Aqueous Flow Battery for Large-Scale Electrical Energy Storage Based on Water-Soluble Organic Redox Couples. Journal of the Electrochemical Society, 161(9). DOI: 10.1149/2.1001409jes
Does the wire matter? This blog is about wire. I thought that I should illustrate it with an orthodontic wire sculpture from the University of Washington. Each year the residents hold a competition on who can construct the best sculpture and this was the winner several years ago. When I wrote last weeks blog, I […]
The post Does the wire matter? appeared first on Kevin O'Brien's Orthodontic Blog.
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Papageorgiou, S., Konstantinidis, I., Papadopoulou, K., Jäger, A., & Bourauel, C. (2014) A systematic review and meta-analysis of experimental clinical evidence on initial aligning archwires and archwire sequences. Orthodontics . DOI: 10.1111/ocr.12048
Jian F, Lai W, Furness S, McIntyre GT, Millett DT, Hickman J, & Wang Y. (2013) Initial arch wires for tooth alignment during orthodontic treatment with fixed appliances. The Cochrane database of systematic reviews. PMID: 23633347
This is the story behind our work on the function of the FoxP gene in the fruit fly Drosophila (more background info). As so many good things, it started with beer. Troy Zars and I were having a beer on […] ↓ Read the rest of this entry...... Read more »
Mendoza, E., Colomb, J., Rybak, J., Pflüger, H., Zars, T., Scharff, C., & Brembs, B. (2014) Drosophila FoxP Mutants Are Deficient in Operant Self-Learning. PLoS ONE, 9(6). DOI: 10.1371/journal.pone.0100648
Chemists at the Ludwig Maximilian University of Munich (LMU) have developed a new type of red phosphor material for application in light-emitting diodes (LEDs).... Read more »
Pust, P., Weiler, V., Hecht, C., Tücks, A., Wochnik, A., Henß, A., Wiechert, D., Scheu, C., Schmidt, P., & Schnick, W. (2014) Narrow-band red-emitting Sr[LiAl3N4]:Eu2 as a next-generation LED-phosphor material. Nature Materials. DOI: 10.1038/nmat4012
"Our findings lend support to anecdotal reports of increased rates of suicidal ideation in adults with Asperger's syndrome, and depression as an important potential risk factor for suicidality in adults with this condition".Sunrise @ Wikipedia That was the very stark conclusion reached by the study by Sarah Cassidy and colleagues  (open-access) looking at self-reported rates of suicide ideation and suicide plans/attempts in a sample of adults newly diagnosed with Asperger syndr........ Read more »
Sarah Cassidy, Paul Bradley, Janine Robinson, Carrie Allison, Meghan McHugh, & Simon Baron-Cohen. (2014) Suicidal ideation and suicide plans or attempts in adults with Asperger's syndrome attending a specialist diagnostic clinic: a clinical cohort study. Lancet Psychiatry. info:/doi:10.1016/S0140-6736(08)61345-8
When I get a craving for Cote d’Or chocolate, I always hit up London Drugs. It’s not the only grocer around that carries the brand,...... Read more »
Richards BA, Xia F, Santoro A, Husse J, Woodin MA, Josselyn SA, & Frankland PW. (2014) Patterns across multiple memories are identified over time. Nature neuroscience. PMID: 24880213
Dietary restriction holds the key to longevity. It’s no secret that as you drastically reduce calories, your metabolism will slow down with it [ask anyone who's tried to crash diet […]... Read more »
Yu Z, Wang R, Fok WC, Coles A, Salmon AB, & Pérez VI. (2014) Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver. The journals of gerontology. Series A, Biological sciences and medical sciences. PMID: 24755936
By guest blogger Dan JonesLike many parents, I often wonder what kind of world my two-year-old son will grow up to inhabit. Will the planet be ravaged by extreme climatic events, depleted of vital forests and biodiversity? Although some of our fears about the future may be overblown, if we don’t want to leave the planet in ruins for future generations, we need to think about how we act today — and maybe change our ways.Some changes are likely to involve minor sacrifices or small inconvenienc........ Read more »
Oliver P. Hauser, David G. Rand, Alexander Peysakhovich, & Martin A. Nowak. (2014) Cooperating with the future. Nature. info:/
Animal testing is an incredibly controversial subject, with strong opinions on both sides. Whilst animal testing for cosmetics has now been banned in the EU, animals continue to be used in science, where they serve a vital role in biomedical research and drug development. Their importance is often overshadowed by the ethical issues surrounding the treatment of animals in research environments, and it’s important that people understand why and how they are used, as well as what measures ar........ Read more »
Although I had other tips in the pipeline, I’m bumping this one up because it is time sensitive. It’s about a competition (or challenge, as they describe it) to use data from cases of leukemia to model make predictions about the outcomes, which could help drive treatment decisions someday. It is called the Acute Myeloid […]... Read more »
Boutros Paul C, Kyle Ellrott, Thea C Norman, Kristen K Dang, Yin Hu, Michael R Kellen, Christine Suver, J Christopher Bare, Lincoln D Stein, & Paul T Spellman. (2014) Global optimization of somatic variant identification in cancer genomes with a global community challenge. Nature Genetics, 46(4), 318-319. DOI: http://dx.doi.org/10.1038/ng.2932
Dolgin Elie. (2014) New platforms aim to obliterate silos of participatory science. Nature Medicine, 20(6), 565-566. DOI: http://dx.doi.org/10.1038/nm0614-565
by Zheng Yan in genome ecology evolution etc
Epistasis is the phenomenon whereby one polymorphism’s effect on a trait depends on other polymorphisms present in the genome(Hemani et al. 2014). Although it has been proved to shape genetic variation and contribute to differences within and between populations for … Continue reading →... Read more »
Corbett-Detig, R., Zhou, J., Clark, A., Hartl, D., & Ayroles, J. (2013) Genetic incompatibilities are widespread within species. Nature, 504(7478), 135-137. DOI: 10.1038/nature12678
Hemani, G., Shakhbazov, K., Westra, H., Esko, T., Henders, A., McRae, A., Yang, J., Gibson, G., Martin, N., Metspalu, A.... (2014) Detection and replication of epistasis influencing transcription in humans. Nature, 508(7495), 249-253. DOI: 10.1038/nature13005
The use of brain images is often criticized. A recent article by M Farah looks at what ‘the kernals of truth’ behind the critiques are and how safe we are to trust the images. (citation below). She is concerned by the confusion of legitimate worries about imaging and false ones. The first criticism that […]... Read more »
Farah MJ. (2014) Brain images, babies, and bathwater: critiquing critiques of functional neuroimaging. The Hastings Center report. PMID: 24634081
Moore, C., & Cao, R. (2008) The Hemo-Neural Hypothesis: On The Role of Blood Flow in Information Processing. Journal of Neurophysiology, 99(5), 2035-2047. DOI: 10.1152/jn.01366.2006
…Or does mom do it all?Photo: Samuel Borges Photography / ShutterstockHow should children learn to take some responsibility for family pets? New research by Janine Muldoon et al (University of St Andrews) investigates children’s perspectives of the division of labour in relation to their pets.The exploratory study involved focus groups with children aged 7, 9, 11 and 13. The researchers planned equal numbers of boys and girls, but constraints meant that 30 girls and only 23 boys took part.&n........ Read more »
Muldoon, J., Williams, J., & Lawrence, A. (2014) 'Mum cleaned it and I just played with it': Children's perceptions of their roles and responsibilities in the care of family pets. Childhood. DOI: 10.1177/0907568214524457
Vampire bats sense heat via pit organs in their nose-leaves, but they find their victims by sight, smell and echolocation. New research shows that an alternatively spliced version of the capsaicin receptor TRPV1 is responsible for the heat sensing, but what do they use it for? Their teeth are so short that they must find blood vessels close to the surface – shallow vessels give off more heat than do deep vessels or skin where there is no large vessel.
Vampire bats occasionally feed on ........ Read more »
Vanderelst D, De Mey F, Peremans H, Geipel I, Kalko E, & Firzlaff U. (2010) What noseleaves do for FM bats depends on their degree of sensorial specialization. PloS one, 5(8). PMID: 20808438
Patel R, Ispoglou S, & Apostolakis S. (2014) Desmoteplase as a potential treatment for cerebral ischaemia. Expert opinion on investigational drugs, 23(6), 865-73. PMID: 24766516
Ma D, Mizurini DM, Assumpção TC, Li Y, Qi Y, Kotsyfakis M, Ribeiro JM, Monteiro RQ, & Francischetti IM. (2013) Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo. Blood, 122(25), 4094-106. PMID: 24159172
Gröger U, & Wiegrebe L. (2006) Classification of human breathing sounds by the common vampire bat, Desmodus rotundus. BMC biology, 18. PMID: 16780579
Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, & Julius D. (2011) Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature, 476(7358), 88-91. PMID: 21814281
When men are aggressive towards women, their behaviour is often driven by the feeling that their masculinity has been threatened. Consider these previous findings: men told they'd performed poorly on a strength test gave more painful electric shocks to a woman who criticised them; and men whose masculine identity was threatened subsequently harassed a feminist woman by sending her pornographic photos.Now Kris Mescher and Laurie Rudman have shown that this link is particularly strong for men who ........ Read more »
Mescher K, & Rudman LA. (2014) Men in the Mirror: The Role of Men's Body Shame in Sexual Aggression. Personality . PMID: 24839983
The paper by Yu Wang and colleagues  (open-access here) concluded that: "reduced ENO2 expression may be a biomarker for a subset of autistic children" following their genome-wide methylation study of autism. For those who've picked up the word 'methylation' in that first sentence, this is yet another sign that epigenetics - the science of changes to gene function not entailing structural genomic changes - is starting to impact on autism research.Silentio! @ Wikipedia Based on an ini........ Read more »
Wang Y, Fang Y, Zhang F, Xu M, Zhang J, Yan J, Ju W, Brown WT, & Zhong N. (2014) Hypermethylation of the enolase gene (ENO2) in autism. European journal of pediatrics. PMID: 24737292
A new study has shown that the Irish pygmy shrew is at risk of extinction due to the invasion of another shrew, the greater white-toothed shrew. ... Read more »
McDevitt, A., Montgomery, W., Tosh, D., Lusby, J., Reid, N., White, T., McDevitt, C., O'Halloran, J., Searle, J., & Yearsley, J. (2014) Invading and Expanding: Range Dynamics and Ecological Consequences of the Greater White-Toothed Shrew (Crocidura russula) Invasion in Ireland. PLoS ONE, 9(6). DOI: 10.1371/journal.pone.0100403
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