Post List

  • November 30, 2010
  • 04:59 PM

Kuru – Brain-eating, Nobel-winning and kiddy-fiddling

by thomastu in Disease Prone

As our lifetimes get longer and medical science’s diagnoses get more sophisticated, we end up finding new diseases (e.g cancer, Alzheimer’s, diabetes). More often than not, we are unable to treat them because they’re unlike anything we’ve ever encountered. For … Continue reading →... Read more »

  • November 30, 2010
  • 04:59 PM

Kuru – Brain-eating, Nobel-winning and kiddy-fiddling

by Thomas Tu in Disease of the week!

As our lifetimes get longer and medical science’s diagnoses get more sophisticated, we end up finding new diseases (e.g cancer, Alzheimer’s, diabetes). More often than not, we are unable to treat them because they’re unlike anything we’ve ever encountered. For … Continue reading →... Read more »

  • November 30, 2010
  • 04:49 PM

Evidence into practice: but wait, there’s more!

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

I pondered a bit about writing this post today. Yesterday I discussed some of the challenges of transferring research into daily practice, and maybe I’ve done enough on the topic – then again, there are some issues that can take a long time to explore. One of them for me is how to integrate client-centred … Read more... Read more »

Lin SH, Murphy SL, & Robinson JC. (2010) Facilitating evidence-based practice: process, strategies, and resources. The American journal of occupational therapy. : official publication of the American Occupational Therapy Association, 64(1), 164-71. PMID: 20131576  

  • November 30, 2010
  • 02:22 PM

Voytek Journal of Cognitive Neuroscience paper: "Hemicraniectomy: A new model for human electrophysiology with high spatio-temporal resolution"

by Bradley Voytek in Oscillatory Thoughts

(Note: this is a repost of my original post from 2009 Dec. I'm reposting some old posts to work within the framework.)This paper grew out of an interesting collaboration with some physicians at the University of California, San Francisco and San Francisco General Hospital, initially through a meeting between Dr. Geoffrey Manley, Dr. Robert Knight, and I. Dr. Manley has recently published several papers on the clinical benefits of performing a decompressive hemicraniectomy on........ Read more »

Voytek B, Secundo L, Bidet-Caulet A, Scabini D, Stiver SI, Gean AD, Manley GT, & Knight RT. (2010) Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution. Journal of Cognitive Neuroscience, 22(11), 2491-2502. PMID: 19925193  

  • November 30, 2010
  • 02:15 PM

What you'll reveal to a computer

by Daniel Simons in The Invisible Gorilla

People are affected by reciprocity norms, even when they are interacting with a computer... Read more »

Moon, Y. (2000) Using Computers to Elicit Self-Disclosure from Consumers. The Journal of Consumer Research, 26(4), 232-339. info:/

  • November 30, 2010
  • 01:44 PM

Fresh Recruits at the Immunological Frontlines

by Sanford- Burnham in Beaker

The immune system is always standing by, ready to fight infection. Immune cells called lymphocytes and dendritic cells hang out in lymph nodes, surveying the environment for signs of invaders and attacking infected cells when necessary.
“It’s crucial that lymphocytes meet dendritic cells in the confined space of a lymph node – they’d have a hard [...]... Read more »

Bao X, Moseman EA, Saito H, Petryanik B, Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB.... (2010) Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes . Immunity. info:/10.1016/j.immuni.2010.10.018

  • November 30, 2010
  • 01:26 PM

Exercise and Depression: It's Complicated

by Neuroskeptic in Neuroskeptic

Some ideas seem so nice, so inoffensive and so harmless, that it seems a shame to criticize them.Take the idea that exercise is a useful treatment for depression. It's got something for everyone.For doctors, it's attractive because it means they can recommend exercise - which is free, quick, and easy, at least for them - instead of spending the time and money on drugs or therapy. Governments like it for the same reason, and because it's another way of improving the nation's fitness. For people w........ Read more »

Harvey SB, Hotopf M, Overland S, & Mykletun A. (2010) Physical activity and common mental disorders. The British journal of psychiatry : the journal of mental science, 357-64. PMID: 21037212  

  • November 30, 2010
  • 01:00 PM

Using the immune system to fight cancer

by Kevin Bonham in Food Matters

Cancer sucks. I'm sure I don't have to tell you that - it's one of the leading causes of death in developed countries, and our treatment options are pretty thin. Basically, it amounts to cutting out the tumors that can be seen, and then giving a controlled administration of poison in the hopes that the cancer cells die before you do. Don't get me wrong - advances in oncology have saved many lives, but it's no surprise that there's a lot of research happening to find better options.

One promisin........ Read more »

  • November 30, 2010
  • 12:36 PM

Are You Glad Darvocet Got Pulled by the FDA? Are You Sure?

by Christian Sinclair, MD in Pallimed: a Hospice & Palliative Medicine Blog

I know many palliative care practitioners were cheering the news that the world's least effective opioid propoxyphene (Darvocet (w/ APAP) /Darvon)  (similar efficacy to acetaminophen) is being pulled off the market by the FDA.  Along with meperdine (Demerol) I am not sure if a medicine exists that produces as much disdain as propoxyphene amongst palliative care clinicians.

But let's look a little closer as to why this happened.  The FDA cites the increasing cardiotoxicity ........ Read more »

  • November 30, 2010
  • 11:23 AM

The Moral Mind of Toddlers

by Amy Webb in The Thoughtful Parent

We, as parents, all want to encourage the moral development of our children. From a young age, we teach our children to help other people, share their toys, etc. Of course, for very young children, this is often a challenge because they simply lack the cognitive development to be able to understand events from another person's perspective or understand another's feelings. New research, however, is showing that toddlers as young as 3 years old are quite developed and discriminating in their under........ Read more »

  • November 30, 2010
  • 11:00 AM

Mung! (Or Pylaiella and Macroalgal Blooms)

by Richard Littauer in The B(l)og

A short foray into the seaweed pylaiella littoris and its distribution near Cape Cod during the summer months.... Read more »

  • November 30, 2010
  • 09:53 AM

Insects: slaves in a fungal nation

by davesbrain in Dave Hubble's ecology spot

Imagine you are a Yellow Dung-fly, let’s say a common species like Scathophaga stercoraria. It is a warm summer’s day and you are flying around a grassy meadow peppered with juicy cow-pats. Just the sort of cow-pats frequented by the other flies you prey upon, and where your species’ larvae will develop. Marvellous. Then however, you get a strange urge. The urge is telling you to climb to the top of a tall grass stem. You obey. When you get there, the urge tells you to do the following:Tur........ Read more »

Salwiczek, L.H. . (2009) Parasites as scouts in behaviour research. Ideas in Ecology and Evolution, 1-6. DOI: 10.4033/iee.2009.2.1.c  

  • November 30, 2010
  • 09:39 AM

Aerobic vs Strength Training: Which Improves Diabetes More?

by Steve Parker, M.D. in Diabetic Mediterranean Diet Blog

Judging from improvement in hemoglobin A1c, the combination of aerobic and strength training is needed to improve diabetic blood sugar levels.  Both types of exercise—when considered alone—did not improve diabetes control, according to the latest research in the Journal of … Continue reading →... Read more »

Church, T., Blair, S., Cocreham, S., Johannsen, N., Johnson, W., Kramer, K., Mikus, C., Myers, V., Nauta, M., Rodarte, R.... (2010) Effects of Aerobic and Resistance Training on Hemoglobin A1c Levels in Patients With Type 2 Diabetes: A Randomized Controlled Trial. JAMA: The Journal of the American Medical Association, 304(20), 2253-2262. DOI: 10.1001/jama.2010.1710  

  • November 30, 2010
  • 09:35 AM

Drug Development for Irritable Bowel Syndrome

by William Yates, M.D. in Brain Posts

Irritable bowel syndrome (IBS) is a common and chronic gastrointestinal disorder.  Symptoms include abdominal pain and cramping accompanied by diarrhea and/or constipation.  Estimated to effect 10 to 15% of the population, current drug treatment modalities are fail to relieve symptoms in many patients.  There is considerable interest in novel drugs that might more effectively control symptoms while producing limited side effects.  A recent review of treatments for irritable b........ Read more »

  • November 30, 2010
  • 09:27 AM

50 years of metallic glasses

by Joerg Heber in All That Matters

This week I am attending the 2010 Materials Research Society Fall Meeting in Boston — one of the key meetings in materials science. One of the sessions is on bulk metallic glasses and their applications, which this year is a little special. It is organised in honour of the 50 year anniversary of the first demonstration [...]... Read more »

  • November 30, 2010
  • 09:05 AM

Nibbled to distraction: Gerbils infested with fleas don't watch for foxes

by Jeremy Yoder in Denim and Tweed

In natural communities, each species is embedded in a web of interactions with other species—predators, prey, competitors, mutualists, and parasites. The effects of all these other species combine in complex, unpredictable ways. I recently discussed a study of protozoans living inside pitcher plants that found predators and competitors can cancel out each others' evolutionary effects. Now another study finds that parasites and predators can interact to make desert-living gerbils adopt less eff........ Read more »

  • November 30, 2010
  • 08:46 AM

Crizotinib and ALK rearrangements in lung cancer: an interview with Dr Ross Camidge

by Sally Church in Pharma Strategy Blog

One of the hot topics in cancer this year has definitely been the impressive clinical trial results from crizotinib (Pfizer) in ALK rearrangements seen in a small proportion of people with non-small cell lung cancer (NSCLC).  We’ve covered the data … Continue reading →... Read more »

Kwak, E., Bang, Y., Camidge, D., Shaw, A., Solomon, B., Maki, R., Ou, S., Dezube, B., Jänne, P., Costa, D.... (2010) Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer. New England Journal of Medicine, 363(18), 1693-1703. DOI: 10.1056/NEJMoa1006448  

  • November 30, 2010
  • 08:00 AM

Obese Teens Grow Into Severely Obese Adults

by Arya M. Sharma in Dr. Sharma's Obesity Notes

One of the most important risk factors for adult obesity is excess weight in children and youth.
But exactly how strong is this relationship?
This question was recently addressed by Natalie The and colleagues from the University of North Carolina, Chapel Hill, NC, in a paper published this month in JAMA.
In order to determine the incidence and [...]... Read more »

The NS, Suchindran C, North KE, Popkin BM, & Gordon-Larsen P. (2010) Association of adolescent obesity with risk of severe obesity in adulthood. JAMA : the journal of the American Medical Association, 304(18), 2042-7. PMID: 21063014  

  • November 30, 2010
  • 06:14 AM

HIV evolution: individual vs. population

by iayork in Mystery Rays from Outer Space

Worldwide HIV/AIDs Epidemic Statistics (We are in the process of selling one home and buying another, while at work I just finished organizing a course on biosecurity for an international group. In the upcoming week I’m traveling to a conference in Washington. To say nothing of the Thanksgiving holiday. All this means short and scarce [...]... Read more »

Fryer, H., Frater, J., Duda, A., Roberts, M., , ., Phillips, R., & McLean, A. (2010) Modelling the Evolution and Spread of HIV Immune Escape Mutants. PLoS Pathogens, 6(11). DOI: 10.1371/journal.ppat.1001196  

  • November 30, 2010
  • 05:30 AM

Is it me you like, or my bacteria?

by Becky in It Takes 30

When two populations of a species evolve in different directions — perhaps because they live on separate islands, with different food sources or different dangers — at some point individuals from the two populations become unwilling to mate with each other.  This can increase the rate at which the two populations diverge, and thus the [...]... Read more »

Sharon G, Segal D, Ringo JM, Hefetz A, Zilber-Rosenberg I, & Rosenberg E. (2010) From the Cover: Commensal bacteria play a role in mating preference of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 107(46), 20051-6. PMID: 21041648  

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