Medical bioremediation is the name given to the SENS Foundation approach to removing one class of harmful waste chemicals that accumulate in our cells with advancing age: Cells have a lot of reasons to break down big molecules and structures into their component parts, and a lot of ways to do so. Unfortunately, one of the main reasons to break things down is because they have been chemically modified so that they no longer work, and sometimes these chemical modifications create structures that a........ Read more »
Grubb, J., Vogler, C., & Sly, W. (2010) New Strategies for Enzyme Replacement Therapy for Lysosomal Storage Diseases. Rejuvenation Research, 2147483647. DOI: 10.1089/rej.2009.0920
Non-native species could escape from Spanish zoos
... Read more »
Fàbregas, M.C., Guillén-Salazar, F., & C. Garcés-Narro. (2010) The risk of zoological parks as potential pathways for the introduction of non-indigenous species. Biological Invasions. DOI: 10.1007/s10530-010-9755-2
sourceA report in Popular Science (authored by Jeremy Hsu) points to a recent paper published in Academic Emergency Medicine. In this, Dawes and colleagues report on an investigation on the effects of TASER on sheep intoxicated with methamphetamine (MA). I was alerted to this by Damn Good Technician who wanted a little bit of context for what would seem to be a WTF? kind of study.
The study was conducted in Dorset sheep who were anesthetized, and administered 0, 0.5, 1.0 or 1.5 mg/kg of metha........ Read more »
Dawes DM, Ho JD, Cole JB, Reardon RF, Lundin EJ, Terwey KS, Falvey DG, & Miner JR. (2010) Effect of an electronic control device exposure on a methamphetamine-intoxicated animal model. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(4), 436-43. PMID: 20370784
Recent research may help you decide on the best photo to post. Learn more. ... Read more »
Hancock, J., & Toma, C. (2009) Putting Your Best Face Forward: The Accuracy of Online Dating Photographs. Journal of Communication, 59(2), 367-386. DOI: 10.1111/j.1460-2466.2009.01420.x
The other day while travelling home on a long train journey, I was browsing the NY Times app on my iPhone and came across an interesting story about multiple myeloma in the Health section: "For many patients with cancers like...... Read more »
Kumar, S., Mikhael, J., Buadi, F., Dingli, D., Dispenzieri, A., Fonseca, R., Gertz, M., Greipp, P., Hayman, S., Kyle, R.... (2009) Management of Newly Diagnosed Symptomatic Multiple Myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines. Mayo Clinic Proceedings, 84(12), 1095-1110. DOI: 10.4065/mcp.2009.0603
... Read more »
Matteson, K., & Langellotto, G. (2010) Determinates of inner city butterfly and bee species richness. Urban Ecosystems. DOI: 10.1007/s11252-010-0122-y
The mighty mouse has become an invaluable tool in biomedical research, due to the fact that its genome can readily be manipulated, using genetic engineering techniques in embryonic stem cells. These techniques were first developed to “knock out” or delete any gene in the mouse genome and this approach is so established now that off-the-shelf knockouts for most genes in the genome are already available from several centres. Genetic technologies have become increasingly sophisticated, givi........ Read more »
Mitchell, K., & Porteous, D. (2010) Rethinking the genetic architecture of schizophrenia. Psychological Medicine, 1. DOI: 10.1017/S003329171000070X
Sigurdsson T, Stark KL, Karayiorgou M, Gogos JA, & Gordon JA. (2010) Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature, 464(7289), 763-7. PMID: 20360742
Is active case finding necessary to control tuberculosis in developing countries?
Tuberculosis is one of the world’s leading causes of death and disease. Despite effective treatment, tuberculosis still results in several million deaths each year. Reducing the burden of global TB disease is a part the Millennium Development Goals. Earlier, health authorities thought that DOTS (Direct [...]... Read more »
Datiko, D., & Lindtjørn, B. (2009) Health Extension Workers Improve Tuberculosis Case Detection and Treatment Success in Southern Ethiopia: A Community Randomized Trial. PLoS ONE, 4(5). DOI: 10.1371/journal.pone.0005443
Datiko, D., & Lindtjørn, B. (2010) Cost and Cost-Effectiveness of Treating Smear-Positive Tuberculosis by Health Extension Workers in Ethiopia: An Ancillary Cost-Effectiveness Analysis of Community Randomized Trial. PLoS ONE, 5(2). DOI: 10.1371/journal.pone.0009158
A new study from West Virginia finds a significant relationship between the cancer mortality rates in local communities and the ecological integrity of nearby streams. Evidence suggests that coal mining is the underlying cause of both problems. This shows that measurements of stream ecological integrity can serve as a warning sign of underlying environmental problems that are causing cancer in local populations...... Read more »
Hitt, N., & Hendryx, M. (2010) Ecological Integrity of Streams Related to Human Cancer Mortality Rates. EcoHealth. DOI: 10.1007/s10393-010-0297-y
Sometimes, Sci is simply inundated with weird science opportunities, and such a week is this one. There is SO MUCH WEIRD OUT THERE, you guys. This is great, as it keeps Friday Weird Science in business, but sometimes Sci has to file away so many for later that she loses track. Here's really hoping that she WON'T lose track, because she found some real beauties today. And this was one of the best one.
In response to a question from awesome reader and friend of the blog Pascale: Can I post on........ Read more »
Most research on human-environment interactions focuses on large-scale changes in environmental conditions over long periods of time (by human standards, at least). There are good reasons for this, especially when applied to prehistory, most importantly that there are a lot of potential data sources for environmental conditions that can be correlated with cultural chronologies to [...]... Read more »
T. G. Dobzhansky, a prominant evolutionary biologist once said...
"Nothing in biology makes sense except in the light of evolution"
Recently, I received a request from a Tom Paine's Ghost reader to answer some questions about public perceptions of evolution. The questions, along with my responses follow.
Reader: How is evolution relevant to the lives of everyday people?
TPG: I will here talk about medicine, childhood obesity, and sex.
The first topic that springs to mind when I think ........ Read more »
Miller, J. (2006) SCIENCE COMMUNICATION: Public Acceptance of Evolution. Science, 313(5788), 765-766. DOI: 10.1126/science.1126746
When top predators are removed from ecosystems their prey and/or competitors increase due to decreased predation and competitive release. However, can changes in behaviour, or body size, of the predators also cause this effect?... Read more »
Shackell, N., Frank, K., Fisher, J., Petrie, B., & Leggett, W. (2009) Decline in top predator body size and changing climate alter trophic structure in an oceanic ecosystem. Proceedings of the Royal Society B: Biological Sciences, 277(1686), 1353-1360. DOI: 10.1098/rspb.2009.1020
Recently there’s been a television promotional advertisement that really bugs me. It shows a man watching events appearing before his eyes and has a voice-over that says something to the effect of “When you look back on your life are you going to see a life filled with interesting people and excitement?” and when is [...]... Read more »
Jeremy Freese. (2003) Imaginary imaginary friends? Television viewing and satisfaction with friends. Evolution and Human Behavior, 24(1), 65-69. DOI: 10.1016/S1090-5138(02)00109-5
The article lists and discusses eight risk definitions, and then suggests an alternative and comprehensive definition that captures all aspects of [ ... ]... Read more »
Here is an important study. A couple of Italian Neurologists have investigated people with carpal tunnel syndrome who report that their pain has spread beyond the boundaries of the median nerve. Unfortunately, such reports are often misinterpreted by clinicians as evidence of malingering, or hysteria. Well, these fellows did quantitative sensory testing and came up [...]... Read more »
 Caliandro P, La Torre G, Aprile I, Pazzaglia C, Commodari I, Tonali P, & Padua L. (2006) Distribution of paresthesias in Carpal Tunnel Syndrome reflects the degree of nerve damage at wrist. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 117(1), 228-31. PMID: 16325467
 Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, & Porreca F. (2000) Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain, 86(1-2), 185-94. PMID: 10779675
 Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, & Serra J. (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, 70(18), 1630-5. PMID: 18003941
 Wilder-Smith EP, Ng ES, Chan YH, & Therimadasamy AK. (2008) Sensory distribution indicates severity of median nerve damage in carpal tunnel syndrome. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 119(7), 1619-25. PMID: 18467170
 Zanette G, Marani S, & Tamburin S. (2006) Extra-median spread of sensory symptoms in carpal tunnel syndrome suggests the presence of pain-related mechanisms. Pain, 122(3), 264-70. PMID: 16530966
 Zanette G, Marani S, & Tamburin S. (2007) Proximal pain in patients with carpal tunnel syndrome: a clinical-neurophysiological study. Journal of the peripheral nervous system : JPNS, 12(2), 91-7. PMID: 17565533
 Zanette G, Cacciatori C, & Tamburin S. (2010) Central sensitization in carpal tunnel syndrome with extraterritorial spread of sensory symptoms. Pain, 148(2), 227-36. PMID: 20004060
Last night I received an alert from Medivation announcing that an article would be published in today's online The Lancet regarding their prostate cancer agent, MDV3100. Sure enough, here's the article: Although the trial is an early phase I/II study,...... Read more »
Scher, H., Beer, T., Higano, C., Anand, A., Taplin, M., Efstathiou, E., Rathkopf, D., Shelkey, J., Yu, E., & Alumkal, J. (2010) Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study. The Lancet. DOI: 10.1016/S0140-6736(10)60172-9
Scientists train endangered carnivores to avoid poisonous toads
... Read more »
O’Donnell, S., Webb, J.K., & R. Shine. (2010) Conditioned taste aversion enhances the survival of an endangered predator imperilled by a toxic invader. Journal of Applied Ecology. DOI: 10.1111/j.1365-2664.2010.01802.x
Vertebrate fertilizer is not the only source of nutrients in the soils of East African savannahs, at least according to a study recently published in the journal Ecology. Alison Brody from the University of Vermont and colleagues found that termites actually had more of an effect on the fruiting success of Acacia trees in Kenya than did dung and urine deposition from ungulate herbivores, such as zebras and gazelles.
... Read more »
Brody, A., Palmer, T., Fox-Dobbs, K., & Doak, D. (2010) Termites, vertebrate herbivores, and the fruiting success of Acacia drepanolobium. Ecology, 91(2), 399-407. DOI: 10.1890/09-0004.1
Top of the encrusted surface of a brachiopod shell, showing the "war" between an edrioasteroid (star-shaped organism at center) and a fast-growing bryozoan colony. From Sprinkle and Rodgers 2010.
Back in the early days of paleontology, when the meaning and origin of fossils was still in doubt, some naturalists believed that the shells, shark teeth, and other petrified curiosities were attempts by the rock to imitate life. Fossils were not true vestiges of history, it was believed, but inst........ Read more »
Sprinkle, J., & Rodgers, J. (2010) Competition between a Pennsylvanian (Late Carboniferous) Edrioasteroid and a Bryozoan for Living Space on a Brachiopod. Journal of Paleontology, 84(2), 356-359. DOI: 10.1666/09-089R.1
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.