Post List

  • November 30, 2010
  • 07:17 PM

Driver Mutations and Metastasis

by Daniel Koboldt in Massgenomics

Two recent papers used very different appraoches to shed light on the genetic alterations underlying tumor growth and progression in human cancers. Peter Campbell and colleagues from the Wellcome Trust Sanger Institute employed Illumina paired-end sequencing to survey the landscape of structural variation in metastatic pancreatic cancer. Ivana Bozic and colleagues from Harvard University took [...]... Read more »

Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, Chen S, Karchin R, Kinzler KW, Vogelstein B, & Nowak MA. (2010) Accumulation of driver and passenger mutations during tumor progression. Proceedings of the National Academy of Sciences of the United States of America, 107(43), 18545-50. PMID: 20876136  

Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, Morsberger LA, Latimer C, McLaren S, Lin ML.... (2010) The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature, 467(7319), 1109-13. PMID: 20981101  

  • November 30, 2010
  • 06:33 PM

Using Cadaver Legs to Study ACL Injuries

by Brian Mossop in The Decision Tree

My latest post at Wired Playbook profiles Mark Drakos, an orthopedic surgeon who uses cadaver legs to test the biomechanics of ACL injuries: At times, Drakos seems like a typical orthopedist: seeing patients, prescribing meds, performing surgery. But in the lab, Drakos — always drawing on his previous athletic experience — turns orthopedic research into [...]... Read more »

Drakos MC, Hillstrom H, Voos JE, Miller AN, Kraszewski AP, Wickiewicz TL, Warren RF, Allen AA, & O'Brien SJ. (2010) The effect of the shoe-surface interface in the development of anterior cruciate ligament strain. Journal of biomechanical engineering, 132(1), 11003. PMID: 20524741  

  • November 30, 2010
  • 05:56 PM

A Lego Robot Uncovers Risk Behavior of Foraging Rats

by Michael Long in Phased

Robogator is a realistic mimic of a predator, enabling scientists to study fear of predation in rats, and possibly to study the effect of drugs designed to address human psychological disorders related to risk perception.... Read more »

  • November 30, 2010
  • 05:47 PM

Contagious Cooperation

by Shaheen Lakhan in Brain Blogger

Humans, and other animals, tend to cooperate with each other in a variety of social situations. Without working together toward a common goal, species as a whole would suffer and evolution may have been short-lived. In general, humans tend to be most cooperative and apt to help others when the costs are small to the [...]... Read more »

Dreber A, Rand DG, Fudenberg D, & Nowak MA. (2008) Winners don't punish. Nature, 452(7185), 348-51. PMID: 18354481  

Fowler, J. (2005) Altruistic punishment and the origin of cooperation. Proceedings of the National Academy of Sciences, 102(19), 7047-7049. DOI: 10.1073/pnas.0500938102  

Fowler, J., & Christakis, N. (2010) Cooperative behavior cascades in human social networks. Proceedings of the National Academy of Sciences, 107(12), 5334-5338. DOI: 10.1073/pnas.0913149107  

Rand DG, Dreber A, Ellingsen T, Fudenberg D, & Nowak MA. (2009) Positive interactions promote public cooperation. Science (New York, N.Y.), 325(5945), 1272-5. PMID: 19729661  

  • November 30, 2010
  • 04:59 PM

Kuru – Brain-eating, Nobel-winning and kiddy-fiddling

by thomastu in Disease Prone

As our lifetimes get longer and medical science’s diagnoses get more sophisticated, we end up finding new diseases (e.g cancer, Alzheimer’s, diabetes). More often than not, we are unable to treat them because they’re unlike anything we’ve ever encountered. For … Continue reading →... Read more »

  • November 30, 2010
  • 04:59 PM

Kuru – Brain-eating, Nobel-winning and kiddy-fiddling

by Thomas Tu in Disease of the week!

As our lifetimes get longer and medical science’s diagnoses get more sophisticated, we end up finding new diseases (e.g cancer, Alzheimer’s, diabetes). More often than not, we are unable to treat them because they’re unlike anything we’ve ever encountered. For … Continue reading →... Read more »

  • November 30, 2010
  • 04:49 PM

Evidence into practice: but wait, there’s more!

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

I pondered a bit about writing this post today. Yesterday I discussed some of the challenges of transferring research into daily practice, and maybe I’ve done enough on the topic – then again, there are some issues that can take a long time to explore. One of them for me is how to integrate client-centred … Read more... Read more »

Lin SH, Murphy SL, & Robinson JC. (2010) Facilitating evidence-based practice: process, strategies, and resources. The American journal of occupational therapy. : official publication of the American Occupational Therapy Association, 64(1), 164-71. PMID: 20131576  

  • November 30, 2010
  • 02:22 PM

Voytek Journal of Cognitive Neuroscience paper: "Hemicraniectomy: A new model for human electrophysiology with high spatio-temporal resolution"

by Bradley Voytek in Oscillatory Thoughts

(Note: this is a repost of my original post from 2009 Dec. I'm reposting some old posts to work within the framework.)This paper grew out of an interesting collaboration with some physicians at the University of California, San Francisco and San Francisco General Hospital, initially through a meeting between Dr. Geoffrey Manley, Dr. Robert Knight, and I. Dr. Manley has recently published several papers on the clinical benefits of performing a decompressive hemicraniectomy on........ Read more »

Voytek B, Secundo L, Bidet-Caulet A, Scabini D, Stiver SI, Gean AD, Manley GT, & Knight RT. (2010) Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution. Journal of Cognitive Neuroscience, 22(11), 2491-2502. PMID: 19925193  

  • November 30, 2010
  • 02:15 PM

What you'll reveal to a computer

by Daniel Simons in The Invisible Gorilla

People are affected by reciprocity norms, even when they are interacting with a computer... Read more »

Moon, Y. (2000) Using Computers to Elicit Self-Disclosure from Consumers. The Journal of Consumer Research, 26(4), 232-339. info:/

  • November 30, 2010
  • 01:44 PM

Fresh Recruits at the Immunological Frontlines

by Sanford- Burnham in Beaker

The immune system is always standing by, ready to fight infection. Immune cells called lymphocytes and dendritic cells hang out in lymph nodes, surveying the environment for signs of invaders and attacking infected cells when necessary.
“It’s crucial that lymphocytes meet dendritic cells in the confined space of a lymph node – they’d have a hard [...]... Read more »

Bao X, Moseman EA, Saito H, Petryanik B, Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB.... (2010) Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes . Immunity. info:/10.1016/j.immuni.2010.10.018

  • November 30, 2010
  • 01:26 PM

Exercise and Depression: It's Complicated

by Neuroskeptic in Neuroskeptic

Some ideas seem so nice, so inoffensive and so harmless, that it seems a shame to criticize them.Take the idea that exercise is a useful treatment for depression. It's got something for everyone.For doctors, it's attractive because it means they can recommend exercise - which is free, quick, and easy, at least for them - instead of spending the time and money on drugs or therapy. Governments like it for the same reason, and because it's another way of improving the nation's fitness. For people w........ Read more »

Harvey SB, Hotopf M, Overland S, & Mykletun A. (2010) Physical activity and common mental disorders. The British journal of psychiatry : the journal of mental science, 357-64. PMID: 21037212  

  • November 30, 2010
  • 01:00 PM

Using the immune system to fight cancer

by Kevin Bonham in Food Matters

Cancer sucks. I'm sure I don't have to tell you that - it's one of the leading causes of death in developed countries, and our treatment options are pretty thin. Basically, it amounts to cutting out the tumors that can be seen, and then giving a controlled administration of poison in the hopes that the cancer cells die before you do. Don't get me wrong - advances in oncology have saved many lives, but it's no surprise that there's a lot of research happening to find better options.

One promisin........ Read more »

  • November 30, 2010
  • 12:36 PM

Are You Glad Darvocet Got Pulled by the FDA? Are You Sure?

by Christian Sinclair, MD in Pallimed: a Hospice & Palliative Medicine Blog

I know many palliative care practitioners were cheering the news that the world's least effective opioid propoxyphene (Darvocet (w/ APAP) /Darvon)  (similar efficacy to acetaminophen) is being pulled off the market by the FDA.  Along with meperdine (Demerol) I am not sure if a medicine exists that produces as much disdain as propoxyphene amongst palliative care clinicians.

But let's look a little closer as to why this happened.  The FDA cites the increasing cardiotoxicity ........ Read more »

  • November 30, 2010
  • 11:23 AM

The Moral Mind of Toddlers

by Amy Webb in The Thoughtful Parent

We, as parents, all want to encourage the moral development of our children. From a young age, we teach our children to help other people, share their toys, etc. Of course, for very young children, this is often a challenge because they simply lack the cognitive development to be able to understand events from another person's perspective or understand another's feelings. New research, however, is showing that toddlers as young as 3 years old are quite developed and discriminating in their under........ Read more »

  • November 30, 2010
  • 11:00 AM

Mung! (Or Pylaiella and Macroalgal Blooms)

by Richard Littauer in The B(l)og

A short foray into the seaweed pylaiella littoris and its distribution near Cape Cod during the summer months.... Read more »

  • November 30, 2010
  • 09:53 AM

Insects: slaves in a fungal nation

by davesbrain in Dave Hubble's ecology spot

Imagine you are a Yellow Dung-fly, let’s say a common species like Scathophaga stercoraria. It is a warm summer’s day and you are flying around a grassy meadow peppered with juicy cow-pats. Just the sort of cow-pats frequented by the other flies you prey upon, and where your species’ larvae will develop. Marvellous. Then however, you get a strange urge. The urge is telling you to climb to the top of a tall grass stem. You obey. When you get there, the urge tells you to do the following:Tur........ Read more »

Salwiczek, L.H. . (2009) Parasites as scouts in behaviour research. Ideas in Ecology and Evolution, 1-6. DOI: 10.4033/iee.2009.2.1.c  

  • November 30, 2010
  • 09:39 AM

Aerobic vs Strength Training: Which Improves Diabetes More?

by Steve Parker, M.D. in Diabetic Mediterranean Diet Blog

Judging from improvement in hemoglobin A1c, the combination of aerobic and strength training is needed to improve diabetic blood sugar levels.  Both types of exercise—when considered alone—did not improve diabetes control, according to the latest research in the Journal of … Continue reading →... Read more »

Church, T., Blair, S., Cocreham, S., Johannsen, N., Johnson, W., Kramer, K., Mikus, C., Myers, V., Nauta, M., Rodarte, R.... (2010) Effects of Aerobic and Resistance Training on Hemoglobin A1c Levels in Patients With Type 2 Diabetes: A Randomized Controlled Trial. JAMA: The Journal of the American Medical Association, 304(20), 2253-2262. DOI: 10.1001/jama.2010.1710  

  • November 30, 2010
  • 09:35 AM

Drug Development for Irritable Bowel Syndrome

by William Yates, M.D. in Brain Posts

Irritable bowel syndrome (IBS) is a common and chronic gastrointestinal disorder.  Symptoms include abdominal pain and cramping accompanied by diarrhea and/or constipation.  Estimated to effect 10 to 15% of the population, current drug treatment modalities are fail to relieve symptoms in many patients.  There is considerable interest in novel drugs that might more effectively control symptoms while producing limited side effects.  A recent review of treatments for irritable b........ Read more »

  • November 30, 2010
  • 09:27 AM

50 years of metallic glasses

by Joerg Heber in All That Matters

This week I am attending the 2010 Materials Research Society Fall Meeting in Boston — one of the key meetings in materials science. One of the sessions is on bulk metallic glasses and their applications, which this year is a little special. It is organised in honour of the 50 year anniversary of the first demonstration [...]... Read more »

  • November 30, 2010
  • 09:05 AM

Nibbled to distraction: Gerbils infested with fleas don't watch for foxes

by Jeremy Yoder in Denim and Tweed

In natural communities, each species is embedded in a web of interactions with other species—predators, prey, competitors, mutualists, and parasites. The effects of all these other species combine in complex, unpredictable ways. I recently discussed a study of protozoans living inside pitcher plants that found predators and competitors can cancel out each others' evolutionary effects. Now another study finds that parasites and predators can interact to make desert-living gerbils adopt less eff........ Read more »

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