Case studies have unjustifiably acquired a reputation for being semi-anecdotal investigations of the small details of individual circumstances, research that is incapable of generating significant empirical or theoretical advances in knowledge. It is argued that the case study is, at best, a preliminary step, in that it may generate hypotheses that can later be tested using such “more reliable” methods as standardized questionnaires or statistical data. In the study of politics, however, tha........ Read more »
Leo, C. (2006) Deep Federalism: Respecting Community Difference in National Policy. Canadian Journal of Political Science/Revue canadienne de science politique, 39(03). DOI: 10.1017/S0008423906060240
US scientists today report that they’ve identified ‘personalised’ genetic markers in the blood of two bowel cancer patients using a cutting-edge technique called massively parallel DNA sequencing, and used these markers to monitor the patients’ cancers during treatment.
The team say that their new technique – dubbed PARE (‘personalised analysis of recombined ends’) – is a [...]... Read more »
Less and More? Yes, when talking protein. Have you encountered any of these questions? How much protein can i eat at a sitting? What's the right amount of protein to eat? How much protein can i absorb? These are questions in the fitness world that get asked all the time - especially by folks who want to optimize their muscle growth. The answer seems to be "less than you think, but more often"... Read more »
Bilsborough S, & Mann N. (2006) A review of issues of dietary protein intake in humans. International journal of sport nutrition and exercise metabolism, 16(2), 129-52. PMID: 16779921
Symons, T., Sheffield-Moore, M., Wolfe, R., & Paddon-Jones, D. (2009) A Moderate Serving of High-Quality Protein Maximally Stimulates Skeletal Muscle Protein Synthesis in Young and Elderly Subjects. Journal of the American Dietetic Association, 109(9), 1582-1586. DOI: 10.1016/j.jada.2009.06.369
CARLSON, O., MARTIN, B., STOTE, K., GOLDEN, E., MAUDSLEY, S., NAJJAR, S., FERRUCCI, L., INGRAM, D., LONGO, D., & RUMPLER, W. (2007) Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism, 56(12), 1729-1734. DOI: 10.1016/j.metabol.2007.07.018
Cuthbertson, D. (2004) Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. The FASEB Journal. DOI: 10.1096/fj.04-2640fje
KERKSICK, C., RASMUSSEN, C., LANCASTER, S., STARKS, M., SMITH, P., MELTON, C., GREENWOOD, M., ALMADA, A., & KREIDER, R. (2007) Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training. Nutrition, 23(9), 647-656. DOI: 10.1016/j.nut.2007.06.015
Part of my NatSci course at the moment involves group supervisions, which are made up of around ten people; a mix of students and faculty (all from the Biochemistry department). About halfway through last term we had a supervision about nuclei, and one of the supervisors raised the question, "Is it possible to be multicellular without a nucleus?" (by nucleus he meant chromosomes wrapped up in a membrane, rather than the bacterial arrangement of coiled up DNA loosly attached to the outer cell mem........ Read more »
Flores, E., & Herrero, A. (2009) Compartmentalized function through cell differentiation in filamentous cyanobacteria. Nature Reviews Microbiology, 8(1), 39-50. DOI: 10.1038/nrmicro2242
by James Lloyd in The Y.O.R.F.
I recently had a look through some new papers published on moss (Physcomitrella patens) and found one published in Cell titled ‘Transcriptional control of gene expression by microRNAs’ . This didn’t seem to fit the same pattern of a lot of moss papers I have read (ie in less high impact journals). This paper shows how useful moss is for studying gene expression using reverse genetics (so hopefully my PhD wont be a failure). I think it is important to study important biological problems,........ Read more »
Khraiwesh, B., Arif, M., Seumel, G., Ossowski, S., Weigel, D., Reski, R., & Frank, W. (2010) Transcriptional Control of Gene Expression by MicroRNAs. Cell, 140(1), 111-122. DOI: 10.1016/j.cell.2009.12.023
Baulcombe, D. (2008) Of maize and men, or peas and people: case histories to justify plants and other model systems. Nature Medicine, 14(10), 1046-1049. DOI: 10.1038/nm1008-1046
Researchers have identified the functional significance of developing ependymal cells that line the ventricular system. Disruption of the ciliary beating of these cells perturbs the circulation of cerebral spinal fluid within the ventricles and may lead to fluid retention in the head,which is typically fatal.... Read more »
Don’t panic. Despite this morning’s headlines suggesting that cooking on a gas stove could lead to cancer, it’s not exactly time to abandon your pots and pans or to trade the gas oven in for an electric one.
As we’ll discuss below, this shouldn’t be a problem for anyone with decent ventilation in their kitchen. And [...]... Read more »
Sjaastad, A., Jorgensen, R., & Svendsen, K. (2010) Exposure to polycyclic aromatic hydrocarbons (PAHs), mutagenic aldehydes and particulate matter during pan frying of beefsteak. Occupational and Environmental Medicine. DOI: 10.1136/oem.2009.046144
by Merry Youle in Small Things Considered
Roseovarius nubinhibens recently joined the exclusive club of about a thousand bacteria whose genomes have been sequenced. Why this honor? It’s a member of one of the most ubiquitous and most intensely studied clades of α-Proteobacteria, the marine roseobacters. This populous group participates in important jobs, including the global cycling of sulfur, climate regulation, and even modulation...... Read more »
Zhao Y, Wang K, Ackermann HW, Halden RU, Jiao N, & Chen F. (2010) Searching for a "hidden" prophage in a marine bacterium. Applied and environmental microbiology, 76(2), 589-95. PMID: 19948862
This journal article is a little old. Its from 1997, however as its on adherence and recruits from university student, my present research recruits from university staff, its well worth a read. Ryan et al., examined adherence to exercise classes at an aerobics and a Tae Kwon Do class. They reported that the Tae Kwon Do participants both reported greater enjoyment of the class and had a higher adherence than the aerobics participants. The authors postulated that the aerobics participants would be........ Read more »
Ryan, R., Frederick, C., Lepes, D., Rubio, N., . (1997) Intrinsic motivation and exercise adherence. International Journal of Sport Psychology, 335-354. info:/
WHEN it comes to making decisions, timing can be everything, but it is often beneficial to conceal the decision that has been made. Take a game of poker, for instance: during each round, the player has to decide whether to bet, raise the stakes, or fold, based on the hand they have been dealt. A good player will have perfected his "poker face", the blank expression which conceals the emotions he feels and the decisions he makes from the other players sitting at the table.
Increasing numbers of ........ Read more »
Einhauser, W., et al. (2010) Pupil dilation betrays the timing of decisions. Front. Hum. Neurosci. info:/
It appears that few people consciously intend to make meaning out of trauma or to benefit from it. Posttraumatic Growth is most likely a consequence of attempts at psychological survival.
Tedeschi and Calhoun, Posttraumatic Growth 1
After a traumatic event, what then? The trauma itself causes significant psychological distress and need for psychological adjustment to alleviate the distress. Without adjustment, the posttraumatic distress persists (and if pathological is PTSD).
Trauma i........ Read more »
Tedeschi, R., & Calhoun, L. (2004) TARGET ARTICLE: "Posttraumatic Growth: Conceptual Foundations and Empirical Evidence". Psychological Inquiry, 15(1), 1-18. DOI: 10.1207/s15327965pli1501_01
Dolbier, C., Jaggars, S., & Steinhardt, M. (2009) Stress-related growth: pre-intervention correlates and change following a resilience intervention. Stress and Health. DOI: 10.1002/smi.1275
New results from a phase II clinical trial of the prostate cancer drug abiraterone suggest that it may help men with advanced disease who have tried standard treatments. However, a Cancer Research UK clinician cautioned that there were still questions...... Read more »
Reid, A., Attard, G., Danila, D., Oommen, N., Olmos, D., Fong, P., Molife, L., Hunt, J., Messiou, C., Parker, C.... (2010) Significant and Sustained Antitumor Activity in Post-Docetaxel, Castration-Resistant Prostate Cancer With the CYP17 Inhibitor Abiraterone Acetate. Journal of Clinical Oncology. DOI: 10.1200/JCO.2009.24.6819
Birders know well that birds migrate – the cycle of bird movements keeps birding interesting throughout the year. Many landbird migration routes are well-documented, and even some over-water routes are starting to be determined. What is less understood is how the birds know where they are going. Recent research has focused on how birds might sense, or even see, the Earth's magnetic field for orientation. At least one recent study proposed that some birds use an olfactory sense for guidance. Vi........ Read more »
Falkenberg, G., Fleissner, G., Schuchardt, K., Kuehbacher, M., Thalau, P., Mouritsen, H., Heyers, D., Wellenreuther, G., & Fleissner, G. (2010) Avian Magnetoreception: Elaborate Iron Mineral Containing Dendrites in the Upper Beak Seem to Be a Common Feature of Birds. PLoS ONE, 5(2). DOI: 10.1371/journal.pone.0009231
Marine protected areas (MPAs) can be an effective means to conserve coral reef communities. These areas can provide refuges for larvae, help restore healthy food webs, and help mitigate overgrowth via macroalgae by preventing the overexploitation of grazers in coral reef ecosystems. This last point is an especially important one…for example, in the aftermath of [...]... Read more »
Carilli, J., Norris, R., Black, B., Walsh, S., & McField, M. (2009) Local Stressors Reduce Coral Resilience to Bleaching. PLoS ONE, 4(7). DOI: 10.1371/journal.pone.0006324
Mumby, P., & Harborne, A. (2010) Marine Reserves Enhance the Recovery of Corals on Caribbean Reefs. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008657
Selig, E., & Bruno, J. (2010) A Global Analysis of the Effectiveness of Marine Protected Areas in Preventing Coral Loss. PLoS ONE, 5(2). DOI: 10.1371/journal.pone.0009278
For wildlife like the timber rattlesnsake, trying to cross even light-traffic country roads presents a formidable life-or-death challenge. As a new study in the journal Conservation Biology shows, these roads can also contribute to the genetic decline of the species.... Read more »
CLARK, R., BROWN, W., STECHERT, R., & ZAMUDIO, K. (2010) Roads, Interrupted Dispersal, and Genetic Diversity in Timber Rattlesnakes. Conservation Biology. DOI: 10.1111/j.1523-1739.2009.01439.x
Inhibition has a powerful role shaping the network dynamics of the cortex, but most studies of inhibitory circuitry are done in brain slice or anesthetized animals. In Membrane potential dynamics of GABAergic neurons in barrel cortex of behaving mice, Gentet et al use two-photon imaging to guide dual, whole-cell patch clamp of inhibitory and excitatory neurons in the mouse barrel cortex. ... Read more »
Gentet, L., Avermann, M., Matyas, F., Staiger, J., & Petersen, C. (2010) Membrane Potential Dynamics of GABAergic Neurons in the Barrel Cortex of Behaving Mice. Neuron, 65(3), 422-435. DOI: 10.1016/j.neuron.2010.01.006
The human eye suffers of a very large chromatic aberration. This means that when a red object is in focus, a blue one at the same distance will be clearly out of focus. Why we are not yet routinely correcting this defect to improve vision? You will find here some new experiments, results and explanations...... Read more »
Artal, P., Manzanera, S., Piers, P., & Weeber, H. (2010) Visual effect of the combined correction of spherical and longitudinal chromatic aberrations. Optics Express, 18(2), 1637. DOI: 10.1364/OE.18.001637
A new study in Puget Sound, Washington, suggests that building seawalls and other shoreline structures may reduce the diversity and abundance of some intertidal invertebrates and coastal insects. Because these creatures are food for salmon, shorebirds, and other wildlife, shoreline armoring might indirectly alter the broader ecosystem...... Read more »
Sobocinski, K., Cordell, J., & Simenstad, C. (2010) Effects of Shoreline Modifications on Supratidal Macroinvertebrate Fauna on Puget Sound, Washington Beaches. Estuaries and Coasts. DOI: 10.1007/s12237-009-9262-9
Want to get closer to your supernatural deity of choice? You could spend years memorizing holy books, scrolls purported to contain ancient wisdom, and study dense, esoteric tomes filled with endless ruminations on all kinds of vague topics, like most religious scholars. Or you could just have surgery on your parietal cortex and give it [...]... Read more »
I just came across this little gem of a paper in Molecular Ecology (not, by any stretch, a common forum for biodiversity conservation-related papers). It’s another one of those wonderful little experimental manipulation studies I love so much (see previous examples here and here).
I’ve written a lot before about the loss of genetic diversity as [...]... Read more »
Crawford, K., & Whitney, K. (2010) Population genetic diversity influences colonization success. Molecular Ecology. DOI: 10.1111/j.1365-294X.2010.04550.x
Bradshaw, C., Giam, X., Tan, H., Brook, B., & Sodhi, N. (2008) Threat or invasive status in legumes is related to opposite extremes of the same ecological and life-history attributes. Journal of Ecology, 96(5), 869-883. DOI: 10.1111/j.1365-2745.2008.01408.x
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