What are the different types of vaccines and how are they made? There are a number of different types of vaccines and each have been developed for different reasons, to prevent different types of disease and to do specific jobs once inside the body. I’ll talk more about the body’s response next week but for now we can just look at the vaccines.... Read more »
Graves PM, Deeks JJ, Demicheli V, & Jefferson T. (2010) Vaccines for preventing cholera: killed whole cell or other subunit vaccines (injected). Cochrane database of systematic reviews (Online). PMID: 20687062
Dhillon S. (2010) DTPa-HBV-IPV/Hib Vaccine (Infanrix hexa): A Review of its Use as Primary and Booster Vaccination. Drugs, 70(8), 1021-58. PMID: 20481658
Once more, we return to those wonderful, phenomenally successful, charismatic beasts.... the toads. As you'll know if you've read the previous articles in the toads series, it seems that most basal divergences within crown-Bufonidae happened in South America. So far as we can tell right now, crown-toads are ancestrally South American, and all of their early history happened on this continent [Rhaebo blombergi image below from here].
All of the basal toads looked at so far - the relatively s........ Read more »
Van Bocxlaer I, Loader SP, Roelants K, Biju SD, Menegon M, & Bossuyt F. (2010) Gradual adaptation toward a range-expansion phenotype initiated the global radiation of toads. Science (New York, N.Y.), 327(5966), 679-82. PMID: 20133569
Earlier this week, I caught an article in the New York Times covering a rare occurrence: 24 members of a high school football team in Oregon developed rhabdomyolysis (muscle breakdown) from an intense workout with limited water in very hot temperatures. Rhabdomyolysis … Continue reading →... Read more »
Buford TW, Kreider RB, Stout JR, Greenwood M, Campbell B, Spano M, Ziegenfuss T, Lopez H, Landis J, & Antonio J. (2007) International Society of Sports Nutrition position stand: creatine supplementation and exercise. Journal of the International Society of Sports Nutrition, 6. PMID: 17908288
Dalbo VJ, Roberts MD, Stout JR, & Kerksick CM. (2008) Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. British journal of sports medicine, 42(7), 567-73. PMID: 18184753
According to some reports, bariatric surgery is now the second most common abdominal surgical procedure performed in the US.
However, despite the well-documented beneficial outcomes, critics continue to question the safety of this treatment option for severe obesity. There is also oft-cited concern about the quality of treatment provided across centres.
These questions were now addressed in [...]... Read more »
Birkmeyer NJ, Dimick JB, Share D, Hawasli A, English WJ, Genaw J, Finks JF, Carlin AM, Birkmeyer JD, & Michigan Bariatric Surgery Collaborative. (2010) Hospital complication rates with bariatric surgery in Michigan. JAMA : the journal of the American Medical Association, 304(4), 435-42. PMID: 20664044
In the absence of GPS, a compass is the best option to find your way around. However, although the earth’s magnetic field is a great way to find your own position, doing the reverse, measuring magnetic fields with a high accuracy — on an atomic scale — remains a challenge. Sure, there are electron microscopes, which are [...]... Read more »
Park, H., Baskin, J., & Zewail, A. (2010) 4D Lorentz Electron Microscopy Imaging: Magnetic Domain Wall Nucleation, Reversal, and Wave Velocity. Nano Letters, 2147483647. DOI: 10.1021/nl102861e
I’m not normally a fan of research that claims to prove that weight gain is anything other than a result of eating too many, and burning too few, calories; it seems too much like wishful thinking. But I have to say that the story around gut microbiota being involved in obesity has been getting interesting. [...]... Read more »
Muccioli GG, Naslain D, Bäckhed F, Reigstad CS, Lambert DM, Delzenne NM, & Cani PD. (2010) The endocannabinoid system links gut microbiota to adipogenesis. Molecular systems biology, 392. PMID: 20664638
The idea that our genes can affect many of the traits that define us as individuals, including our personality, intelligence, talents and interests is one that some people find hard to accept. That this is the case is very clearly and dramatically demonstrated, however, by a number of genetic conditions, which have characteristic profiles of psychological traits. Genetic effects include influences on perception, sometimes quite profound, and other times remarkably selective. A recent study su........ Read more »
Thornton-Wells, T., Cannistraci, C., Anderson, A., Kim, C., Eapen, M., Gore, J., Blake, R., & Dykens, E. (2010) Auditory Attraction: Activation of Visual Cortex by Music and Sound in Williams Syndrome. American Journal on Intellectual and Developmental Disabilities, 115(2), 172. DOI: 10.1352/1944-7588-115.172
Marenco, S., Siuta, M., Kippenhan, J., Grodofsky, S., Chang, W., Kohn, P., Mervis, C., Morris, C., Weinberger, D., Meyer-Lindenberg, A.... (2007) Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Proceedings of the National Academy of Sciences, 104(38), 15117-15122. DOI: 10.1073/pnas.0704311104
How do you risk-stratify undifferentiated chest pain patients in the Emergency Department? There are a multitude of causes for chest pain. We are always taught to think of the 5 big life-threats: ACS, PE, aortic dissection, tension pneumothorax, and pericardial tamponade.So how do YOU risk-stratify your patients for unstable angina (UA) and non-ST elevation myocardial infarction (NSTEMI)? STEMI's are usually obvious. UA and NSTEMIs -- not so much.Fortunately a 2000 JAMA article and a followup Ac........ Read more »
Antman EM, Cohen M, Bernink PJ, McCabe CH, Horacek T, Papuchis G, Mautner B, Corbalan R, Radley D, & Braunwald E. (2000) The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA : the journal of the American Medical Association, 284(7), 835-42. PMID: 10938172
Imagine you’ve entered a contest to cook the world’s biggest ball of spaghetti. You have to meet the following criteria: the ball has to be made of a single spaghetti strand; the strand has to be entwined in a very exact way; and you have to be able to pick up the ball without the [...]... Read more »
Thorslund, T., McIlwraith, M., Compton, S., Lekomtsev, S., Petronczki, M., Griffith, J., & West, S. (2010) The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nature Structural . DOI: 10.1038/nsmb.1905
Jensen, R., Carreira, A., & Kowalczykowski, S. (2010) Purified human BRCA2 stimulates RAD51-mediated recombination. Nature. DOI: 10.1038/nature09399
Liu, J., Doty, T., Gibson, B., & Heyer, W. (2010) Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nature Structural . DOI: 10.1038/nsmb.1904
Classifying pupils by where they live: how well does this predict variations in their GCSE results? From Urban Studies In the UK, this year’s record GCSE results may offer many young British students a great reason to celebrate, but for others who faced disappointing news there may be some frustration at what is viewed by [...]... Read more »
Webber, R., & Butler, T. (2007) Classifying Pupils by Where They Live: How Well Does This Predict Variations in Their GCSE Results?. Urban Studies, 44(7), 1229-1254. DOI: 10.1080/00420980701302353
Last spring two very thorough papers came out which surveyed the genetic landscape of the Jewish people (my posts, Genetics & the Jews it’s still complicated, Genetics & the Jews). The novelty of the results was due to the fact that the research groups actually looked across the very diverse populations of the Diaspora, from [...]... Read more »
Steven M. Bray, Jennifer G. Mulle, Anne F. Dodd, Ann E. Pulver, Stephen Wooding, & Stephen T. Warren. (2010) Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population. PNAS . info:/10.1073/pnas.1004381107
As the dirt and germs are wiped away, we're left feeling not just bodily but also morally cleansed - a kind of metaphorical virtuosity that leads us to judge others more harshly. That's according to Chen-Bo Zhong's team, who invited 58 undergrads to a lab filled with spotless new equipment. Half the students were asked to clean their hands with an antiseptic wipe so as not to soil the shiny surfaces. Afterwards all the students rated the morality of six societal issues including pornography and ........ Read more »
Climate change has been resulting in quite a many detrimental manifestations which tend to have a domino effect: fluctuations in temperature and precipitation (resulting in climate variability), as well as extreme manifestations such as drought, storms, rise in sea levels, and frequent severe weather events.Consider the research by Grinsted et al (2009) who used a ‘physically plausible four parameter linear response equation’ to relate nearly 2,000 years of global temperatures and sea level......... Read more »
Grinsted, A., Moore, J., & Jevrejeva, S. (2009) Reconstructing sea level from paleo and projected temperatures 200 to 2100 ad. Climate Dynamics, 34(4), 461-472. DOI: 10.1007/s00382-008-0507-2
Yup, you knew it! Let’s go back to basics. Let’s talk about ERECTIONS. Deng et al. “Real-time three-dimensional ultrasound visualization of erection and artificial coitus” International Journal of Andrology, 2006. I would have loved to see the advertisements for this study: “Men needed between ages 18-65 for study of erection and coitus. Must have no [...]... Read more »
DENG, J., HALL-CRAGGS, M., PELLERIN, D., LINNEY, A., LEES, W., RODECK, C., & TODD-POKROPEK, A. (2006) Real-time three-dimensional ultrasound visualization of erection and artificial coitus. International Journal of Andrology, 29(2), 374-379. DOI: 10.1111/j.1365-2605.2005.00617.x
In the past couple of years, I have been a passenger in Sydney taxis driven, inter alia, by an agricultural engineer from India, a civil engineer from Somalia, a surgeon from Vietnam, an MBA graduate from Pakistan, an architect from … Continue reading →... Read more »
Creese, G., & Wiebe, B. (2009) ‘Survival Employment’: Gender and Deskilling among African Immigrants in Canada. International Migration. DOI: 10.1111/j.1468-2435.2009.00531.x
When thinking about the evolution of nervous systems, there is sometimes a tendency to think of a sort of manifest destiny of nervous systems. It’s part of a larger tendency to see everything in evolution as part of a “march of progress,” but somehow, I think there’s a greater tendency to think about neural evolution as a tale of ever increasing complexity.
Examples of simplification are nice examples of exceptions. Vestigial organs have always been seen as powerful exa........ Read more »
Lehmann, G., Berger, S., Strauß, J., Lehmann, A., & Pflüger, H. (2010) The auditory system of non-calling grasshoppers (Melanoplinae: Podismini) and the evolutionary regression of their tympanal ears. Journal of Comparative Physiology A. DOI: 10.1007/s00359-010-0560-2
Tadpoles can leave ripples in a stream – even when they are gone. With a deadly fungus causing catastrophic declines in tropical frogs, many streams are losing their tadpoles. The loss of the wrigglers can subtly but significantly reorder stream ecosystems, find researchers who are studying the ecological aftermath in Panama.
The chytrid fungus has […] Read More »... Read more »
Colón-Gaud, C., Whiles, M., Lips, K., Pringle, C., Kilham, S., Connelly, S., Brenes, R., & Peterson, S. (2010) Stream invertebrate responses to a catastrophic decline in consumer diversity. Journal of the North American Benthological Society, 29(4), 1185-1198. DOI: 10.1899/09-102.1
Neuroimaging and lesion studies suggest that imagining the future (i.e. envision future personal experiences) is strongly connected with retrospective memory (i.e. remembering past experiences). Two recent papers published on Neuropsychologia investigated the relationship of retrospective memory and future imagining, as well as their common neural correlates. Kwan, Carson, Addis, and Rosenbaum (2010) report the case [...]... Read more »
Kwan, D., Carson, N., Addis, D., & Rosenbaum, R. (2010) Deficits in past remembering extend to future imagining in a case of developmental amnesia. Neuropsychologia, 48(11), 3179-3186. DOI: 10.1016/j.neuropsychologia.2010.06.011
Maguire, E., Vargha-Khadem, F., & Hassabis, D. (2010) Imagining fictitious and future experiences: Evidence from developmental amnesia. Neuropsychologia, 48(11), 3187-3192. DOI: 10.1016/j.neuropsychologia.2010.06.037
At the moment, I am taking a (temporary) break from my furious critiquing of peer review, and have begun working busily on a new series about the workings of human languages. Writing about this is for a general audience is hard, particularly because I suspect that many people have unexamined intuitive views about language that [...]... Read more »
Lieven, E., Pine, J., & Baldwin, G. (1997) Lexically-based learning and the development of grammar in early multi-word speech. Journal of Child Language, 24(1), 187-219. info:/
Lieven E, Behrens H, Speares J, & Tomasello M. (2003) Early syntactic creativity: a usage-based approach. Journal of child language, 30(2), 333-70. PMID: 12846301
Part 2 - Furosemide.
This drug shortage could be a good thing.
EMS may be forced to do without drugs that cause more harm than benefit.
Maybe we will be smart enough to realize that we are not helping our patients with these drugs.
Maybe.... Read more »
Mosesso VN Jr, Dunford J, Blackwell T, & Griswell JK. (2003) Prehospital therapy for acute congestive heart failure: state of the art. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, 7(1), 13-23. PMID: 12540139
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.