My last post touched on microRNA, but this post's subject is a recent discovery involving something I've never mentioned: microvesicles. The paper is Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles by Alex Yuan, Erica L. Farber, Ana Lia Rapoport, Desiree Tejada, Roman Deniskin, Novrouz B. Akhmedov, Debora B. Farber. Among the important points this paper offers is that RNA, both messenger RNA (mRNA) and microRNA, can be carried between cells by carriers called microvesicles.I can do........ Read more »
Yuan, A., Farber, E., Rapoport, A., Tejada, D., Deniskin, R., Akhmedov, N., & Farber, D. (2009) Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles. PLoS ONE, 4(3). DOI: 10.1371/journal.pone.0004722
Goal setting is an important part of most treatment planning in rehabilitation – and pain management is no exception. It is thought to help to:
strengthen the therapeutic relationship through collaboration;
focus therapy on areas that the patient wants;
help the patient maintain motivation and adhere to treatment; and
ensure specific outcomes are identified and measured – [...]... Read more »
Schoeb, V. (2009) “The goal is to be more flexible” – Detailed analysis of goal setting in physiotherapy using a conversation analytic approach. Manual Therapy. DOI: 10.1016/j.math.2009.02.004
by Vincent Racaniello in virology blog
The influenza H1N1 outbreak in Mexico has been analyzed to provide information on the pandemic potential of the new virus strain. The estimates offer some insight into the transmissibility and severity of the virus but must be tempered with the understanding that there are still uncertainties about all aspects of the outbreak.
Influenza incidence is difficult [...]... Read more »
Fraser, C., Donnelly, C., Cauchemez, S., Hanage, W., Van Kerkhove, M., Hollingsworth, T., Griffin, J., Baggaley, R., Jenkins, H., Lyons, E.... (2009) Pandemic Potential of a Strain of Influenza A (H1N1) : Early Findings. Science. DOI: 10.1126/science.1176062
Friday last week, PLoS Genetics published a paper I've been waiting to read for a few weeks, since I saw a reference to it in a draft of a review paper I got by email (that paper I'll tell you all about when it comes out).
The PLoS Genetics paper is this:
Widespread Genomic Signatures of Natural [...]... Read more »
McVicker, G., Gordon, D., Davis, C., & Green, P. (2009) Widespread Genomic Signatures of Natural Selection in Hominid Evolution. PLoS Genetics, 5(5). DOI: 10.1371/journal.pgen.1000471
In response to the conversation on "Obesity, Evolution and Delayed Gratification" on the main page and Razib's coverage of a fascinating new study on the relationship to the lactase gene and obesity, I thought now would be a good time to write about an important new study that helps define the boundaries of what normal and healthy weights are in humans.
This study, entitled Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies is a who........ Read more »
Prospective Studies Collaboration, . (2009) Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. The Lancet, 373(9669), 1083-1096. DOI: 10.1016/S0140-6736(09)60318-4
Conservation is very important, even something as seemingly insignificant as insects. Most people don’t realize exactly how important bees are to our everyday activities, and most people certainly don’t think twice about those strange black and white bugs they find in their pool. However, a study that came out in the most recent issue of [...]... Read more »
Carlson, John C., Dyer, Lee A., Omlin, Franscois X., & Beier, John C. (2009) Diversity Cascades and Malaria Vectors. Journal of Medical Entomology, 46(3), 460-464.
New movement patterns may be a sign of good news for blue whales.
Blue whales have begun moving around the ocean in ways that strongly resemble their historical patterns before the advent of the whaling trade. A century ago, about 300,000 blue whales existed. But in the early 1900s, humans hunted and killed 99.9 percent [...]... Read more »
Calambokidis, J., Barlow, J., Ford, J., Chandler, T., & Douglas, A. (2009) Insights into the population structure of blue whales in the Eastern North Pacific from recent sightings and photographic identification. Marine Mammal Science. DOI: 10.1111/j.1748-7692.2009.00298.x
According to a study just coming out in the Journal of Sexual Medicine, "variations in emotional intelligence--the ability to identify and manage emotions of one's self and others--are associated with orgasmic frequency during intercourse and masturbation." Read the rest of this post... | Read the comments on this post...... Read more »
by Nestor Lopez-Duran PhD in Child-Psych
In my clinical work, I often see parents struggle when placing their young children on epileptic medications. This hesitation is often in response to a common research finding indicating that some antiepileptic medications are associated with significant side-effects, including reduced cognitive capacity (although in most cases these side effects are not as severe as the [...]... Read more »
Meador, K., Baker, G., Browning, N., Clayton-Smith, J., Combs-Cantrell, D., Cohen, M., Kalayjian, L., Kanner, A., Liporace, J., Pennell, P.... (2009) Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs. New England Journal of Medicine, 360(16), 1597-1605. DOI: 10.1056/NEJMoa0803531
"Low emotional intelligence seems to be a significant risk factor for low orgasmic frequency," say researchers from the King's College in London. They studied over 2000 women to see if there was a link between low orgasm frequency and emotional intelligence ("EQ"). By looking at mental variables, they hoped to find new ways to treat female orgasmic disorder (FOD), which up to 30% of women suffer...
[...]... Read more »
How simply having healthy menu options available makes a person feel they've already fulfilled their goal of eating healthy and sends them to the French fries!... Read more »
Wilcox, K., Vallen, B., Block, L., & Fitzsimons, G. (2009) Vicarious Goal Fulfillment: When the Mere Presence of a Healthy Option Leads to an Ironically Indulgent Decision. Journal of Consumer Research, 2147483647. DOI: 10.1086/599219
According to reports, the death of Jade Goody from cervical cancer has made many more women aware that cervical screening is one of the best ways to reduce the risk of getting the disease. The screening test is designed to detect small changes that happen before cancer develops, and these changes can then be treated.
But [...]... Read more »
Goldsmith, M., Austoker, J., Marsh, G., Kehoe, S., & Bankhead, C. (2008) Cervical screening result communication: a focus-group investigation of English women's experiences and needs. Quality and Safety in Health Care, 17(5), 334-338. DOI: 10.1136/qshc.2007.023275
Depression as a serious debilitating illness and not a weakness. Many patients don’t get adequate treatment for depression. What to do about this?
“the Internet affords the opportunity to make psychosocial interventions available to large segments of the public. Interventions can be delivered programmatically and reliably, greatly extending the numbers and types of people who can [...]... Read more »
Björn Meyer PhD, Thomas Berger DPhil, Franz Caspar, DPhil, Christopher G Beevers, PhD, Gerhard Andersson, PhD, & Mario Weiss, MD, MBA. (2009) Effectiveness of a Novel Integrative Online Treatment for Depression (Deprexis): Randomized Controlled Trial. J Med Internet Res , 11(2).
by Drew Rosielle MD in Pallimed: a Hospice & Palliative Medicine Blog
JCO has a fascinating and frustrating study about physician-patient agreement about treatment goals predicting having a discussion about limiting life-prolonging treatments.The study was a prospective study of ~70 hospitalized patients with cancer (mean age 58 years, the full spectrum of solid and hematologic malignancies was represented, 65% had KPS of 60 or less, and 25% had KPS less than 40) at a single German academic medical center. (They were eligible for enrollment if 'questions about fo........ Read more »
Winkler, E., Reiter-Theil, S., Lange-Riess, D., Schmahl-Menges, N., & Hiddemann, W. (2009) Patient Involvement in Decisions to Limit Treatment: The Crucial Role of Agreement Between Physician and Patient. Journal of Clinical Oncology, 27(13), 2225-2230. DOI: 10.1200/JCO.2008.17.9515
Last week, the FDA announced the approval of a novel second generation antipsychotic drug for use in the acute treatment of schizophrenia (1). I believe that this drug has been in development since 1995 (2) and was suppose to hit the market in 2001 (3, 4). It also has a very similar pharmacological profile to Risperdal, which means that there is nothing novel about this drug. Except for the name; first it was called "Fiapta," and then "Fanapta." Now it's called "Fanapt," which kind of sounds lik........ Read more »
Potkin, S., Litman, R., Torres, R., & Wolfgang, C. (2008) Efficacy of Iloperidone in the Treatment of Schizophrenia. Journal of Clinical Psychopharmacology, 28(Suppl. 1). DOI: 10.1097/JCP.0b013e3181692787
by Vincent Racaniello in virology blog
Until the late 1970s the diversity of viral populations was not widely appreciated. The first study to quantitatively describe viral diversity employed the RNA bacteriophage Q-beta. The authors made a startling conclusion based on their analysis of variation within stocks of the virus:
A Q-beta phage population is in a dynamic equilibrium with viral mutants arising [...]... Read more »
Domingo, E. (1978) Nucleotide sequence heterogeneity of an RNA phage population. Cell, 13(4), 735-744. DOI: 10.1016/0092-8674(78)90223-4
The striking thing about supernatural creatures – gods, demons, goblins and the like – is just how very like humans they are. Very often, they will have only one or two magical features, but their other characteristics are decidedly anthropomorphic.Question is: does this reveal something about the way our minds work? Are there limits to what we can invent?Cognitive psychologist Pascal Boyer, in his classic book Religion Explained, suggested that supernatural beings are just weird enough to b........ Read more »
Shtulman, A. (2008) Variation in the anthropomorphization of supernatural beings and its implications for cognitive theories of religion. Journal of Experimental Psychology: Learning, Memory, and Cognition, 34(5), 1123-1138. DOI: 10.1037/0278-73188.8.131.523
This past week in Coevolvers, we dropped back into the empirical world and ready a paper from Piculell et al (2008) on evidence of selection mosaics. Selection mosaics describe a case where the fitness function of the interacting players varies across space (Gomulkiewicz et al 2007; Thompson 1999, 2005), sometimes described as GxGxE interactions (G: genetic; E: environment). What does this mean more generally? Simply put, the fitness of a plant may change from one population to the next becau........ Read more »
Piculell, B., Hoeksema, J., & Thompson, J. (2008) Interactions of biotic and abiotic environmental factors on an ectomycorrhizal symbiosis, and the potential for selection mosaics. BMC Biology, 6(1), 23. DOI: 10.1186/1741-7007-6-23
There is a recent article in Nature Neuroscience by Philpot et al regarding how experience-dependent synaptic plasticity is downregulated in Angelmans' syndrome and perhaps in Autism too, as the Ube3a gene involved is implicated in both disorders.
First a little history about Angelman- it is a disorder caused by deletion/lack of a maternally imprinted UBE3a gene in chromosomal region 15q11-q13 . It is typically contrasted with Prader-Willi syndr........ Read more »
PORT, R., & SEYBOLD, K. (1995) Hippocampal synaptic plasticity as a biological substrate underlying episodic psychosis. Biological Psychiatry, 37(5), 318-324. DOI: 10.1016/0006-3223(94)00128-P
Koji Yashiro, Thorfinn T Riday, Kathryn H Condon, Adam C Roberts, Danilo R Bernardo, Rohit Prakash, Richard J Weinberg, Michael D Ehlers . (2009) Ube3a is required for experience-dependent maturation of the neocortex. Nature Neuroscience. DOI: http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2327.html
I'll never forget the one and only time my mom made quiche for dinner. I was in fourth grade, and she had proudly followed the recipe in "Joy of Cooking" to create an exciting gourmet treat. Naturally, my sister and I absolutely hated it, but mom made us clean our plates. Choking down that quiche (which I now love) is one of my most vivid childhood memories.
This scene, or some version of it, has been repeated countless in kitchens around the world as parents try to introduce new foods to kids ........ Read more »
Laney, C., Morris, E.K., Bernstein, D.M., Wakefield, B.M., & Loftus, E.F. (2008) Asparagus, a love story: Healthier eating could be just a false memory away. Experimental Psychology, 55(5), 291-300. DOI: http://psycnet.apa.org/journals/zea/55/5/291/
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.