As somebody training in both critical care and infectious diseases, I'm often left trying to explain what I hope to do with my career, struggling with coherent answers to both laypeople and other doctors. People get sick because of infections. Also, sick people end up getting infections. That's how I look at it, and hence my training.This study, published by some of my bosses, helps validate all of this. Looking at one day in ICUs across the planet, they captured a point-in-time, just to see wha........ Read more »
Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y.... (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA : the journal of the American Medical Association, 302(21), 2323-9. PMID: 19952319
December’s entity of the month at ChEBI is Adrenaline, for all the adrenaline junkies out there. This accompanies ChEBI release 63, containing 536,978 total entities, of which 19,501 are annotated entities and 678 were submitted via the ChEBI submission tool. Text reproduced below from the ChEBI website:
Adrenaline (CHEBI:33568), also known as epinephrine, is a catecholamine [...]... Read more »
Rainer TH, & Robertson CE. (1996) Adrenaline, cardiac arrest, and evidence based medicine. Journal of accident , 13(4), 234-7. PMID: 8832338
Current research on creativity has brought forth such fascinating studies as to the effect of eye movement exercises on creativity, and the degree to which thoughts of love make us more creative (while thoughts of lust do not), but the degree to which foreign country experiences influence creativity has until now remained the domain of folk psychology, according to which traveling broadens our horizon, and is more or less a necessary prerequisite for sophisticated artisitry and other creativity........ Read more »
Maddux, W., & Galinsky, A. (2009) Cultural borders and mental barriers: The relationship between living abroad and creativity. Journal of Personality and Social Psychology, 96(5), 1047-1061. DOI: 10.1037/a0014861
Earlier this week, I saw one of the best treatments of a misinterpreted story that has me thinking about how all news outlets should report in vitro laboratory studies.
Only thing is that it didn't come from a news outlet.
It came a brainwashing site run by those medical socialist types - I am, of course, speaking of the UK National Health Service and their excellent patient education website, NHS Choices.
You may recall reading in the popular dead-tree or online press that investigators from........ Read more »
Louie, B., Rajamahanty, S., Won, J., Choudhury, M., & Konno, S. (2009) Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells. BJU International. DOI: 10.1111/j.1464-410X.2009.08870.x
Is your doctor happy? This is something that may have never crossed your mind: the idea that your personal physician may not be pleased with the current state of his or her life. Even if it has, perhaps you were of the opinion that it was not of minor importance if it did not affect [...]... Read more »
Sargent MC, Sotile W, Sotile MO, Rubash H, & Barrack RL. (2009) Quality of life during orthopaedic training and academic practice. Part 1: orthopaedic surgery residents and faculty. The Journal of bone and joint surgery. American volume, 91(10), 2395-405. PMID: 19797575
Ricci WM, Gallagher B, Brandt A, Schwappach J, Tucker M, & Leighton R. (2009) Is after-hours orthopaedic surgery associated with adverse outcomes? A prospective comparative study. The Journal of bone and joint surgery. American volume, 91(9), 2067-72. PMID: 19723981
by Vincent Racaniello in virology blog
When will the 2009 swine-origin influenza virus become a seasonal strain? While prediction is very hard, especially of the future (at least according to Yogi Berra), examining past pandemics can be informative.
The 1968 pandemic began with the emergence of a novel H3N2 influenza virus in Hong Kong in July 1968. First isolates (stars) were obtained [...]... Read more »
Viboud, C., Grais, R., Lafont, B., Miller, M., Simonsen, L., & , . (2005) Multinational Impact of the 1968 Hong Kong Influenza Pandemic: Evidence for a Smoldering Pandemic. The Journal of Infectious Diseases, 192(2), 233-248. DOI: 10.1086/431150
Here's a Friday evening paradox for you. For most atheists, the abundance of suffering in the world is a pretty clinching argument against the existence of a moral god. Yet religion seems to thrive in places where suffering is greatest (the graphic shows the correlation across US states between a basket of 'suffering' measures and belief in God).What gives? Kurt Gray, a psychologist at Harvard, has some novel ideas about why this should be.First off, he points out that we have a tendency to find........ Read more »
Gray K, & Wegner DM. (2009) Blaming God for Our Pain: Human Suffering and the Divine Mind. Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc. PMID: 19926831
It’s not a new topic and in fact it is one that I recently discussed in “A Silent Mass Extinction”. I also doubt that I’m treading on novel ground by incorporating spiders, centipedes, insects, invertebrates, bugs, or whatever you prefer to use as an everyday descriptive term, in my definition of wildlife. I guess to [...]... Read more »
Snaddon, J., Turner, E., & Foster, W. (2008) Children's Perceptions of Rainforest Biodiversity: Which Animals Have the Lion's Share of Environmental Awareness?. PLoS ONE, 3(7). DOI: 10.1371/journal.pone.0002579
If you don't have the tools to answer a scientific question, invent them.... Read more »
Raikow, D., Atkinson, J., & Croley II, T. (2009) Development of Resource Shed Delineation in Aquatic Ecosystems. Environmental Science , 2147483647. DOI: 10.1021/es900562t
A study recently published by the Proceedings of the National Academy of Sciences describes how modern day representatives of the Phiomorpha and Caviomorpha groups diverged approximately 37 million years ago.
The phylogeny detailed in the article was derived through combination of biogeographical, genetic and fossil evidence... Read more »
Sallam, H., Seiffert, E., Steiper, M., & Simons, E. (2009) Fossil and molecular evidence constrain scenarios for the early evolutionary and biogeographic history of hystricognathous rodents. Proceedings of the National Academy of Sciences, 106(39), 16722-16727. DOI: 10.1073/pnas.0908702106
A new study indicates that mitigation programs may actually alter the overall distribution of streams and wetlands across the landscape and consequently modify their function with both negative and positive consequences...... Read more »
BenDor, T., Sholtes, J., & Doyle, M. (2009) Landscape characteristics of a stream and wetland mitigation banking program. Ecological Applications, 19(8), 2078-2092. DOI: 10.1890/08-1803.1
Oh, you all thought oxytocin posts were DONE!? BY NO MEANS. For oxytocin lends itself to the truly weird science, and this one simply could not be ignored. In addition, Sci is compelled to blog this paper out of sympathy and understanding for the poor little grad student (or possibly the tech) who WITNESSED this entire experiment, on a weekly basis, for I don't know how long. Oh you devoted servant of science, Sci takes her hat off to you this day.
...moment of silence...
Pattij, et al......... Read more »
Pattij T, de Jong TR, Uitterdijk A, Waldinger MD, Veening JG, Cools AR, van der Graaf PH, & Olivier B. (2005) Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. The European journal of neuroscience, 22(3), 724-34. PMID: 16101754
Galaxy Zoo is the worlds largest astronomy collaboration with over a hundred thousand collaborators. I discuss the impetus, implementation and some of the results of the project.... Read more »
Anze Slosar, Kate Land, Steven Bamford, Chris Lintott, Dan Andreescu, Phil Murray, Robert Nichol, M. Jordan Raddick, Kevin Schawinski, Alex Szalay.... (2008) Galaxy Zoo: Chiral correlation function of galaxy spins. MNRAS, 392(1225). arXiv: 0809.0717v2
Way back in 1989, Jared Diamond defined the ‘evil quartet’ of habitat destruction, over-exploitation, introduced species and extinction cascades as the principal drivers of modern extinctions. I think we could easily update this to the ‘evil quintet’ that includes climate change, and I would even go so far as to add extinction synergies as a [...]... Read more »
Sutherland, W., Clout, M., Côté, I., Daszak, P., Depledge, M., Fellman, L., Fleishman, E., Garthwaite, R., Gibbons, D., & De Lurio, J. (2009) A horizon scan of global conservation issues for 2010. Trends in Ecology . DOI: 10.1016/j.tree.2009.10.003
Regular exercise is good for you, and a great weight of scientific studies back up that statement. Insofar as the degenerations of aging go, the present consensus appears to be that exercise in humans slows aging to around the same degree as calorie restriction in humans. Where else could you go to find a fairly cost-effective way of extending your healthy life span by a decade or so? The multiple mechanisms involved in producing the benefits of calorie restriction and exercise are incompletely ........ Read more »
Werner, C., Furster, T., Widmann, T., Poss, J., Roggia, C., Hanhoun, M., Scharhag, J., Buchner, N., Meyer, T., Kindermann, W.... (2009) Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall. Circulation. DOI: 10.1161/CIRCULATIONAHA.109.861005
Something dramatic happened to a lot of very big animals between 20,000 and 10,000 years ago. During this time period, 34 major groups of large animals died-out. Among those that disappeared, were ten species that weighted more than a ton. Giant sloths, mammoths, mastodons, giant kangaroos, and moa were just a few of the fast-vanishing fauna.
It has long been clear that these large animals, also known as "megafauna", perished in a short period of time. But scientists disagree about what caused t........ Read more »
Gill, J., Williams, J., Jackson, S., Lininger, K., & Robinson, G. (2009) Pleistocene Megafaunal Collapse, Novel Plant Communities, and Enhanced Fire Regimes in North America. Science, 326(5956), 1100-1103. DOI: 10.1126/science.1179504
Written 12 years ago, but still holds true. Supply chains are increasingly becoming complex systems of webs and networks and the system thinking that already pervaded Einarsson and Rausand (1997) An Approach to Vulnerability Analysis of Complex Industrial Systems is today still applicable to toady's supply chains. In fact, there is little difference between vulnerability in supply chains and vulnerability in complex industrial systems.... Read more »
Einarsson, S., & Rausand, M. (1998) An Approach to Vulnerability Analysis of Complex Industrial Systems. Risk Analysis, 18(5), 535-546. DOI: 10.1111/j.1539-6924.1998.tb00367.x
The human race has been enslaved by evolutionarily superior organisms.
In the beginning there was but inorganic matter. From these lifeless substances came the organics which later gave rise to legion-minded protobionts. The protobionts in time beget prokaryotic cells, and with this pivotal step the guiding hand of evolution took charge and asserted the symbiotic conception of the eukaryotes. Since the self-proclaimed commencement of evolution’s command, the human ancestral line ha........ Read more »
Brodribb, T., & Feild, T. (2009) Leaf hydraulic evolution led a surge in leaf photosynthetic capacity during early angiosperm diversification. Ecology Letters. DOI: 10.1111/j.1461-0248.2009.01410.x
Still working on the Sunday Protist; it's the last week of classes, finals start next week, and I have to sort out some last minute stuff for the seminar we're running next term (finally got it officially up and running in terms of registration!). As you can see, I'm rather swamped here. Also, staying up till 4am working on the Sunday Protist last night was definitely not a splendid idea. I blame TC-S for distracting me with his elaborate hypotheses...Speaking of which, I've started my very own ........ Read more »
Cavalier-Smith, T. (2006) Cell evolution and Earth history: stasis and revolution. Philosophical Transactions of the Royal Society B: Biological Sciences, 361(1470), 969-1006. DOI: 10.1098/rstb.2006.1842
CAVALIER-SMITH, T. (2005) Economy, Speed and Size Matter: Evolutionary Forces Driving Nuclear Genome Miniaturization and Expansion. Annals of Botany, 95(1), 147-175. DOI: 10.1093/aob/mci010
He looked sick---really sick. He was sitting on a stretcher in an ER bay, flushed, breathing a bit quickly, but his youth seemed to compensate for the acuity of his illness, and he didn't feel nearly as bad has he looked. His fever was 104, his systolic blood pressure was in the 90s, his heart was racing. He'd had a sore throat recently, and rather than getting better started to feel weak, tired, and feverish. His mom finally dragged him in when he wouldn't stop shivering. His blood work wa........ Read more »
Centor RM. (2009) Expand the pharyngitis paradigm for adolescents and young adults. Annals of internal medicine, 151(11), 812-5. PMID: 19949147
Centor RM, Witherspoon JM, Dalton HP, Brody CE, & Link K. (1981) The diagnosis of strep throat in adults in the emergency room. Medical decision making : an international journal of the Society for Medical Decision Making, 1(3), 239-46. PMID: 6763125
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