Post List

  • January 2, 2011
  • 11:46 AM

How aspirin might prevent colorectal cancer?

by Debajyoti Datta in Medicine...Life

I must confess that I am fascinated by the potential of aspirin in colorectal carcinoma prevention. It is worthwhile to look into this in some detail. Before we delve into the mechanism of colorectal carcinoma prevention by aspirin we must examine how colorectal carcinoma develops.... Read more »

  • January 2, 2011
  • 09:12 AM

How Gay Men Talk About Depression

by Ultimo167 in Strong Silent Types

40 gay men interviewed about how they 'construct' depression revealed several co-existing tensions, notably between individual agency and medical orthodoxy, hegemonic masculinity. The findings of this study by Korner et al. (2010) were used to inform general practitioners on how to improve their practice with gay men who might be depressed. ... Read more »

  • January 2, 2011
  • 07:00 AM

Strong Bones Equals Weak Heart

by Shaheen Lakhan in Brain Blogger

Adequate calcium intake is an important nutritional factor for skeletal health. Calcium (when taken with adequate Vitamin D) prevents bone loss and decreases the risk of fractures and associated morbidity and mortality. Most adults require 1000 mg of calcium daily. (Children and postmenopausal women require slightly more.) For decades, physicians and pharmacists have been advocating [...]... Read more »

Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, Ames R, Gamble GD, Grey A, & Reid IR. (2008) Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ (Clinical research ed.), 336(7638), 262-6. PMID: 18198394  

Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, Heckbert SR, Johnson KC, Manson JE, Sidney S.... (2007) Calcium/vitamin D supplementation and cardiovascular events. Circulation, 115(7), 846-54. PMID: 17309935  

Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G.... (2010) The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know. The Journal of clinical endocrinology and metabolism. PMID: 21118827  

Shah SM, Carey IM, Harris T, DeWilde S, & Cook DG. (2010) Calcium supplementation, cardiovascular disease and mortality in older women. Pharmacoepidemiology and drug safety, 19(1), 59-64. PMID: 19757413  

  • January 2, 2011
  • 05:00 AM

Light the Way ~ Rnai Diagnostics

by Linda in Oz Blog No. 159 To warm up the mind:
It's possible to actually see the brain light up. In 2007, Harvard researchers stuck fluorescent proteins in neurons. Check out the palette of the 90 different "colours" and how the brain naturally paints itself with them. ... Read more »

McCaffrey, A., Meuse, L., Pham, T., Conklin, D., Hannon, G., & Kay, M. (2002) Gene expression: RNA interference in adult mice. Nature, 418(6893), 38-39. DOI: 10.1038/418038a  

Saleh, M., van Rij, R., Hekele, A., Gillis, A., Foley, E., O'Farrell, P., & Andino, R. (2006) The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nature Cell Biology, 8(8), 793-802. DOI: 10.1038/ncb1439  

Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H.... (2004) An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature, 432(7020), 1036-40. PMID: 15616564  

  • January 2, 2011
  • 12:42 AM

Designing a Lyme disease vaccine to attack the tick vector

by Microbe Fan in Spirochetes Unwound

Conventional vaccines target the surface components or secreted toxins of pathogens.  Erol Fikrig's group at Yale University has been exploring an unconventional approach towards developing a vaccine for Lyme disease, which is caused by a tick-borne pathogen.  Their recent work, published in the November issue of PLoS Pathogens, demonstrated partial success in protecting laboratory mice by immunization with a protein found in the saliva of the Ixodes tick vector.Ixodes ticks spend seve........ Read more »

  • January 2, 2011
  • 12:09 AM

Preparing for unexpected opportunities in Borneo

by Noam Ross in Noam Ross

Source: dinesh_valke on FlickrConservation Letters has an article about a situation in Borneo that illustrates how sudden, unpredictable events in ecology are not always bad.  In the past year, the island's forests have undergone an ecosystem-wide event known as "general flowering," where trees of many species produce seeds and fruit in massive amounts.  These events occur rarely (the last was 12 years ago), and in the years in between few seeds are produced and few new trees........ Read more »

Kettle, C., Ghazoul, J., Ashton, P., Cannon, C., Chong, L., Diway, B., Faridah, E., Harrison, R., Hector, A., Hollingsworth, P.... (2010) Seeing the fruit for the trees in Borneo. Conservation Letters. DOI: 10.1111/j.1755-263X.2010.00161.x  

  • January 1, 2011
  • 10:32 PM

Group Work Promotes Science Learning and Appreciation

by Michael Long in Phased

Upper-division science students learn more when they work in small groups relative to working alone, and they look favorably upon the experience.... Read more »

  • January 1, 2011
  • 08:35 PM

Study: Sugar Pills Heal People Who Believe They Will Work

by David Berreby in Mind Matters

In a technology-based culture, you learn from infancy that truth is what can be counted and measured. That makes it easy to divide any conversation into what you learned (important!) and how you learned it (immaterial). What your medical tests reveal is vital; how your doctor tells you, her "bedside ...Read More
... Read more »

Kaptchuk, T., Friedlander, E., Kelley, J., Sanchez, M., Kokkotou, E., Singer, J., Kowalczykowski, M., Miller, F., Kirsch, I., & Lembo, A. (2010) Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome. PLoS ONE, 5(12). DOI: 10.1371/journal.pone.0015591  

  • January 1, 2011
  • 05:31 PM

01/01/2011: Looking forward and backward, so fast you may barf

by zacharoo in Lawn Chair Anthropology

2010 was a big year for anthropology and lawn-chair-anthropologists. There was laughter and crying, and maybe also some yelling. And smiling. Let's take a look back at some of the big events of the past year.Ancient DNA. What a great year for ancient human DNA! In April, Krause and colleagues (2010) announced the sequencing of mitochondrial DNA from a ~50,000 year old girl from Denisova in Siberia. This sequence was twice as divergent from humans as Neandertal mtDNA, which really shocked a lot o........ Read more »

Berger, L., de Ruiter, D., Churchill, S., Schmid, P., Carlson, K., Dirks, P., & Kibii, J. (2010) Australopithecus sediba: A New Species of Homo-Like Australopith from South Africa. Science, 328(5975), 195-204. DOI: 10.1126/science.1184944  

Cann, R., Stoneking, M., & Wilson, A. (1987) Mitochondrial DNA and human evolution. Nature, 325(6099), 31-36. DOI: 10.1038/325031a0  

Green, R., Krause, J., Briggs, A., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M.... (2010) A Draft Sequence of the Neandertal Genome. Science, 328(5979), 710-722. DOI: 10.1126/science.1188021  

Haile-Selassie, Y., Latimer, B., Alene, M., Deino, A., Gibert, L., Melillo, S., Saylor, B., Scott, G., & Lovejoy, C. (2010) An early Australopithecus afarensis postcranium from Woranso-Mille, Ethiopia. Proceedings of the National Academy of Sciences, 107(27), 12121-12126. DOI: 10.1073/pnas.1004527107  

Krause, J., Fu, Q., Good, J., Viola, B., Shunkov, M., Derevianko, A., & Pääbo, S. (2010) The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature, 464(7290), 894-897. DOI: 10.1038/nature08976  

Liu W, Jin CZ, Zhang YQ, Cai YJ, Xing S, Wu XJ, Cheng H, Edwards RL, Pan WS, Qin DG.... (2010) Human remains from Zhirendong, South China, and modern human emergence in East Asia. Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19201-6. PMID: 20974952  

Reich D, Green RE, Kircher M, Krause J, Patterson N, Durand EY, Viola B, Briggs AW, Stenzel U, Johnson PL.... (2010) Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature, 468(7327), 1053-60. PMID: 21179161  

Zalmout IS, Sanders WJ, Maclatchy LM, Gunnell GF, Al-Mufarreh YA, Ali MA, Nasser AA, Al-Masari AM, Al-Sobhi SA, Nadhra AO.... (2010) New Oligocene primate from Saudi Arabia and the divergence of apes and Old World monkeys. Nature, 466(7304), 360-4. PMID: 20631798  

  • January 1, 2011
  • 03:11 AM

Kitti's Hog-nosed Bat: World's smallest bat

by beredim in Strange Animals

The Kitti's Hog-nosed Bat is a small animal, best known for being the world's smallest bat. Depending on how size is defined, it is also the world's smallest mammal, with a total length of 2.9 to 3.3 cm, roughly the size of a large bumblebee. No wonder why it is also known as the Bumblebee bat.... Read more »

  • December 31, 2010
  • 10:33 PM

Cowboy Wash Is Not an Easy Place to Live

by teofilo in Gambler's House

If you stand at the Four Corners monument and look in the direction of Colorado you will see Sleeping Ute Mountain dominating the view.  From this direction you are looking at the southwest side of the mountain, and in front of it you see the southern piedmont.  On the right side of the piedmont, though [...]... Read more »

  • December 31, 2010
  • 08:07 PM

Naked Mole Rat: World's Strangest Rodent

by beredim in Strange Animals

The naked mole rat (Heterocephalus glaber) is arguably one of the strangest mammals out-there, combining all kinds of crazy adaptations. Some of them are the lack of pain sensation, a remarkably long lifespan, being the only known mammalian thermoconformer and one of the known mammals to form ant-like colonies... Not to mention its scary and alien-like appearance.... Read more »

Park TJ, Lu Y, Jüttner R, Smith ES, Hu J, Brand A, Wetzel C, Milenkovic N, Erdmann B, Heppenstall PA.... (2008) Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). PLoS biology, 6(1). PMID: 18232734  

Azpurua, J., Ke, Z., Chen, I., Zhang, Q., Ermolenko, D., Zhang, Z., Gorbunova, V., & Seluanov, A. (2013) Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proceedings of the National Academy of Sciences, 110(43), 17350-17355. DOI: 10.1073/pnas.1313473110  

Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, & Gorbunova V. (2009) Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proceedings of the National Academy of Sciences of the United States of America, 106(46), 19352-7. PMID: 19858485  

Csiszar A, Labinskyy N, Orosz Z, Xiangmin Z, Buffenstein R, & Ungvari Z. (2007) Vascular aging in the longest-living rodent, the naked mole rat. American journal of physiology. Heart and circulatory physiology, 293(2). PMID: 17468332  

  • December 31, 2010
  • 05:54 PM

Pandemic Influenza: 1510 – 2010

by Michelle Ziegler in Contagions

My first clue on the existence of specific influenza pandemics before 1918 came a few years ago while reading some local newspapers on the Spanish Flu itself. The papers were warning people that this was not an ordinary flu year, it would be like 1893! The papers referred to 1893 in the same way that [...]... Read more »

  • December 31, 2010
  • 05:30 PM

Mapping the “Green Sahara”

by Razib Khan in Gene Expression

Guelta d’Archei, Chad. Credit: Dario Menasce. Everyone who is literate knows that the Sahara desert is the largest of its kind in the world. The chasm in cultural, biological, and physical geography is very noticeable. Northern Africa is part of the Palearctic zone, while the peoples north of the Sahara have long been part of [...]... Read more »

Drake NA, Blench RM, Armitage SJ, Bristow CS, & White KH. (2010) Ancient watercourses and biogeography of the Sahara explain the peopling of the desert. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21187416  

  • December 31, 2010
  • 03:34 PM

What causes cancer?

by Science Exploiter in Science Exploits

A local radio station recently hosted a physician and asked him various questions.  As you'd expect, one of the topics included cancer.  Unfortunately the physician made a blanket statement: everyone has cancer.I don't know about you, but I do not want to receive a diagnosis of cancer from a medical professional.  Certainly the diagnoses of many cancers has changed today when compared to twenty years ago, but that does not make the thought of receiving such a diagnosis a........ Read more »

MCCONNELL, H., WATTS, T., WEIS, R., & BRIAN, A. (1986) Supported planar membranes in studies of cell-cell recognition in the immune system. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 864(1), 95-106. DOI: 10.1016/0304-4157(86)90016-X  

  • December 31, 2010
  • 02:47 PM

The Ink Post – Ink as a conspecific alarm cue in squid

by Mike Mike in Cephalove

Cephalopods have a lot to offer – tentacles, beaks, and big scary (and perhaps cute) eyeballs. Today, though, let’s look at a part of the cephalopod body that doesn’t get paid so much attention to, especially by us neurobiologist types: the ink. Most coleoid cephalopods (that is, all the living cephalopods excluding nautiluses and a [...]... Read more »

W. F. Gilly and Mary T. Lucero. (1992) Behavioral Responses to Chemical Stimulation of the Olfactory Organ of the Squid, Loligo opalescens. Journal of Experimental Biology. info:/

  • December 31, 2010
  • 01:20 PM

Environmental Sustainability of Raising Insects for Protein

by Michael Long in Phased

Insects may be a more environmentally-sustainable source of protein than livestock.... Read more »

  • December 31, 2010
  • 08:42 AM

Is it cancer? Another case study

by Debajyoti Datta in Medicine...Life

As I wrote in my previous post, sometimes other diseases may masquerade as cancer. Tay CW et al. reports another such case published in the International Journal of Surgery Case Reports.They reported a case of a 33 year old female patient who presented with difficulty in swallowing, technically termed as dysphagia. There were no other symptoms. She was a non-smoker and there were no significant previous medical conditions. Chest X-ray and routine blood examination was normal. Physical exami........ Read more »

Tay, C., Deans, D., Khor, J., Seet, J., & So, B. (2010) Suspected oesophageal cancer in a 33 year old lady. International Journal of Surgery Case Reports. DOI: 10.1016/j.ijscr.2010.10.002  

  • December 31, 2010
  • 07:02 AM

2010 in review: Aging brains, money, happiness, and a bris exception

by Doug Keene in The Jury Room

As trial consultants, we are always on the lookout for new nuggets of useful information. Some of them are true wisdom and some… let’s just say ‘not so much’. Generally, we share only the really good stuff with you but sometimes we regress a bit. And this is one of those times. Hang on! Despite [...]

Related posts:The Jury Expert for May 2010 is uploaded
Bummer! Our brains do decline with age…but there is good news
An uncivil union: Being ‘heard’
... Read more »

Gervais, S. J.,, Hillard, A. , & Vescio, T. K. (2010) Confronting sexism: The role of relationship orientation and gender. . Sex Roles, 463-474. info:/

Kraus MW, Côté S, & Keltner D. (2010) Social class, contextualism, and empathic accuracy. Psychological science : a journal of the American Psychological Society / APS, 21(11), 1716-23. PMID: 20974714  

  • December 31, 2010
  • 06:30 AM

Asymptomatic Sustained Ventricular Fibrillation in a Patient With Left Ventricular Assist Device

by Rogue Medic in Rogue Medic

This patient is pulseless. Pulseless patients are not rare. A 911 call for a pulseless patient is usually because the pulseless patient is dead.

Contrariwise, a patient talking to me has a pulse. I have had several patients who were awake and talking, but without any palpable pulses. The absence of palpable pulses is different from the absence of pulses. All of these patients, with no palpable pulses, were significantly symptomatic.... Read more »

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