In the past few years, as addiction researchers have been mapping out the chemical alterations in the brain caused by alcohol, nicotine, methamphetamine, and other drugs, America’s most popular illegal drug has remained largely a scientific mystery. It is a drug that millions of Americans have been using regularly for years, and, from a clinical [...]... Read more »
Budney, A. (2004) Review of the Validity and Significance of Cannabis Withdrawal Syndrome. American Journal of Psychiatry, 161(11), 1967-1977. DOI: 10.1176/appi.ajp.161.11.1967
Kouri, E., & Pope, H. (2000) Abstinence symptoms during withdrawal from chronic marijuana use. Experimental and Clinical Psychopharmacology, 8(4), 483-492. DOI: 10.1037/1064-1222.214.171.1243
Rodriguez de Fonseca, F. (1997) Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal. Science, 276(5321), 2050-2054. DOI: 10.1126/science.276.5321.2050
Tanda, G. (1997) Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ1 Opioid Receptor Mechanism. Science, 276(5321), 2048-2050. DOI: 10.1126/science.276.5321.2048
After skipping a day, you may be expecting something special, and while I do think this is special, it's also a little focused. I make no apologies (and don't think I'm promising a new big post every day, although I'm trying). The subject this time is a very high-energy type of cellular "signaling" molecule: pyrophosphorylated inositols.InositolsLet's start with inositol: a sugar (sort of) that plays an important role in the cell metabolism.Figure 1: Chemical structure of inositol. (From Wik........ Read more »
Shears, S. (2009) Diphosphoinositol Polyphosphates: Metabolic Messengers?. Molecular Pharmacology. DOI: 10.1124/mol.109.055897
Losito, O., Szijgyarto, Z., Resnick, A., & Saiardi, A. (2009) Inositol Pyrophosphates and Their Unique Metabolic Complexity: Analysis by Gel Electrophoresis. PLoS ONE, 4(5). DOI: 10.1371/journal.pone.0005580
For anyone who missed the original bioinformatics seminar I’ll be doing a repeat of the “Defrosting the Digital Library” talk, this time for the staff in the John Rylands University Library (JRUL) . This is the main academic library in Manchester with (quote) “more than 4 million printed books and manuscripts, over 41,000 electronic journals [...]... Read more »
Hull, D., Pettifer, S., & Kell, D. (2008) Defrosting the Digital Library: Bibliographic Tools for the Next Generation Web. PLoS Computational Biology, 4(10). DOI: 10.1371/journal.pcbi.1000204
A PLOS One article, looking at how our current practice of influenza vaccination leaves us vulnerable to an H5N1 pandemic...Let's put aside the (current) H1N1 concern, and go back to the H5N1, or avian, influenza strain, and its potential for a bad pandemic, since its lethality is significantly higher than any other currently circulating strain. We know that our current seasonal influenza vaccine does not protect us against infection with the H1N1 strain currently being passed around the globe. ........ Read more »
Bodewes, R., Kreijtz, J., Baas, C., Geelhoed-Mieras, M., de Mutsert, G., van Amerongen, G., van den Brand, J., Fouchier, R., Osterhaus, A., & Rimmelzwaan, G. (2009) Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus. PLoS ONE, 4(5). DOI: 10.1371/journal.pone.0005538
Franzen et al. announced the discovery of the most complete transitional fossil primate ever found. The fossil, described as Darwinius masillae, shows prosimian characteristics (e.g. a grooming claw...
[[ This is a content summary only. Visit my website for full links, other content, and more! ]]... Read more »
Franzen, J., Gingerich, P., Habersetzer, J., Hurum, J., von Koenigswald, W., & Smith, B. (2009) Complete Primate Skeleton from the Middle Eocene of Messel in Germany: Morphology and Paleobiology. PLoS ONE, 4(5). DOI: 10.1371/journal.pone.0005723
by Nestor Lopez-Duran PhD in Child-Psych
When I was 13 my parents took me to the orthodontist to get braces. At that time, the most effective technique consisted of horse bridle-like machine that I was supposed to wear overnight and for at least 6 hours during the day. This meant I was supposed to go to school wearing the bridle. I [...]... Read more »
Huang, I., Sugden, D., & Beveridge, S. (2009) Assistive devices and cerebral palsy: the use of assistive devices at school by children with cerebral palsy. Child: Care, Health and Development. DOI: 10.1111/j.1365-2214.2009.00968.x
Want to share your umpteen multi-omics data sets and experimental protocols with one common format? Encourage collaboration! Speak a common language! Share your work! How, you might ask? With FuGE!
In 2007, FuGE version 1 was released (website, Nature Biotechnology paper). FuGE allows biologists and bioinformaticians to describe any life science experiment using a single format, making collaboration and repeatability of experiments easier and more efficient. However, if you wanted to start usin........ Read more »
Jones, A., Lister, A.L., Hermida, L., Wilkinson, P., Eisenacher, M., Belhajjame, K., Gibson, F., Lord, P., Pocock, M., Rosenfelder, H.... (2009) Modeling and Managing Experimental Data Using FuGE. OMICS: A Journal of Integrative Biology, 2147483647-13. DOI: 10.1089/omi.2008.0080
While the rapid expansion of human cities have been detrimental for most animals, some have found ways of exploiting these brave new worlds and learned to live with their prolific inhabitants. The Northern mockingbird is one such species. It's very common in cities all over America's east coast, where it frequently spends time around humans. But Douglas Levey from the University of Florida has found that its interactions with us are more complex than anyone would have guessed.
The mocking........ Read more »
Levey, D., Londono, G., Ungvari-Martin, J., Hiersoux, M., Jankowski, J., Poulsen, J., Stracey, C., & Robinson, S. (2009) Urban mockingbirds quickly learn to identify individual humans. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0811422106
I thought it would be fun to do a series on hot new trends in science and medicine based on different mechanisms of action, partly because this is what science is all about and partly because hearing about creative new...... Read more »
Di Fede, G., Catania, M., Morbin, M., Rossi, G., Suardi, S., Mazzoleni, G., Merlin, M., Giovagnoli, A., Prioni, S., Erbetta, A.... (2009) A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis. Science, 323(5920), 1473-1477. DOI: 10.1126/science.1168979
A quite bizarre research paper appears in the inaugural issue of the International Journal of Critical Accounting, coincidentally the month the Metallica Guitar Hero pack is released. The paper is entitled: “Structural change in the music industry: a Marxist critique of public statements made by members of Metallica during the lawsuit against Napster”
The research paper [...]Post from: David Bradley's Sciencetext Tips and Tricks
Metallica, Napster, and Marx... Read more »
Kieran James, & Christopher Tolliday. (2009) Structural change in the music industry: a Marxist critique of public statements made by members of Metallica during the lawsuit against Napster. International Journal of Critical Accounting, 1(1), 144-176.
The use of ultrafast (femtosecond) lasers as a tool to see (image) the eye structures is reviewed. In particular, how multiphoton microscopes can be improved by aberration correction and how impressive images from ocular tissues could help diagnosis and treatment of eye's diseases... ... Read more »
Bueno, J., Vohnsen, B., Roso, L., & Artal, P. (2009) Temporal wavefront stability of an ultrafast high-power laser beam. Applied Optics, 48(4), 770. DOI: 10.1364/AO.48.000770
Four major US national laboratories have worked together to develop a computer model to help airport authorities screen passengers for pandemic influenza. The tool can detect false negatives, people with influenza who slip through the screening process, and so cut the risk of infected passengers unknowingly spreading disease across the nation.
During a confirmed outbreak of [...]... Read more »
Robert T. Brigantic, John D. Malone, George A. Muller, Russell Lee, & Jim Kulesz. (2009) Simulation to assess the efficacy of US airport entry screening of passengers for pandemic influenza. Int. J. Risk Assessment and Management, 12(2/3/4), 290-310.
Recently, some human survival data – together with matching gene expression data from lymphoblastoid cell lines – have become available from a long-range study that began in the early 1980s. In the first aging study to take advantage of this resource, Kerber et al. mine the data to identify gene changes associated with longevity:... Read more »
Kerber, R., O’Brien, E., & Cawthon, R. (2009) Gene expression profiles associated with aging and mortality in humans. Aging Cell, 8(3), 239-250. DOI: 10.1111/j.1474-9726.2009.00467.x
I certainly hope not because if a recent study holds true, if thinking about exercise causes your heart to race you're twice as likely to die of a sudden heart attack.Of course it occurs to me that the folks whose hearts are likeliest to race at the thought of exercise would be those who are the least fit as they'll be worried about the prospect of exercising which in turn might cause their adrenalin to flow and their hearts to race.So perhaps the results aren't so surprising - those who are the........ Read more »
Jouven, X., Schwartz, P., Escolano, S., Straczek, C., Tafflet, M., Desnos, M., Empana, J., & Ducimetiere, P. (2009) Excessive heart rate increase during mild mental stress in preparation for exercise predicts sudden death in the general population. European Heart Journal. DOI: 10.1093/eurheartj/ehp160
Is it possible to reconcile supply chain vulnerability, risk and supply chain management with corporate governance, business continuity, national security and emergency planning? In her 2006 article, Helen Peck attempts to do just that, hence my analogy of looking down at supply chains from Space – in order to really see the big picture. Because, in supply chains, most stakeholders are found far beyond the individual supply chain and Helen Peck explains why.... Read more »
Peck, H. (2006) Reconciling supply chain vulnerability, risk and supply chain management. International Journal of Logistics, 9(2), 127-142. DOI: 10.1080/13675560600673578
Recent gadgets such as the handheld portable Nintendo DS video game console, portable Sony Playstation Portable (PSP), iPhone and iPod touch go with video games. The advantage being obvious that any moment waiting can be used to play a video game.
Screens of these portable media consoles are comparable with television and video monitors in terms [...]... Read more »
Ivory, J., & Magee, R. (2009) You Can't Take It with You? Effects of Handheld Portable Media Consoles on Physiological and Psychological Responses to Video Game and Movie Content. CyberPsychology , 2147483647. DOI: 10.1089/cpb.2008.0279
This is the age of biotechnology, and many believe that one of the crowning triumphs of the age will be the defeat of cancer. If we're going to greatly extend healthy human longevity, then the defeat of cancer certainly has to be achieved one way or another. I think that the one of the most exciting possibilities in modern cancer research is that a cure for cancer is in fact easy, but we don't yet know how to do it. Let me explain what I mean by "easy." This is an era in which we can order cells........ Read more »
Rebecca J. Critchley-Thorne, Diana L. Simons, Ning Yana, Andrea K. Miyahira, Frederick M. Dirbas, Denise L. Johnson, Susan M. Swetter, Robert W. Carlson, George A. Fisher, Albert Koong.... (2009) Impaired interferon signaling is a common immune defect in human cancer. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0901329106
The ability to interpret other peoples' emotions is vital for social interactions. We recognize emotions in others by observing their body language and facial expressions. The voice also betrays one's emotional state: words spoken in anger have a different rhythm, stress and intonation than those uttered with a sense of joy or relief. But how the emotional content of a voice is encoded in the brain was unclear.
Now though, Swiss researchers report that they have decoded the neural activity in t........ Read more »
Ethofer, T., Van De Ville, D., Scherer, K., & Vuilleumier, P. (2009) Decoding of Emotional Information in Voice-Sensitive Cortices. Current Biology. DOI: 10.1016/j.cub.2009.04.054
If, like me, you grew up in the U.S. in the 1970s and 80s, you probably remember the game show Name That Tune, where contestants heard brief snippets from popular songs and had to name them as quickly as possible. Even though I didn't know most of the music, which was primarily American Standards from the 30s, 40s, and 50s, I still found the show fascinating. My favorite part of the game was when the two contestants engaged in a bidding war, where a clue was given and the contestants bet on how ........ Read more »
Peynircioglu, Z., Rabinovitz, B., & Thompson, J. (2007) Memory and metamemory for songs: the relative effectiveness of titles, lyrics, and melodies as cues for each other. Psychology of Music, 36(1), 47-61. DOI: 10.1177/0305735607079722
David Smith (University of York, United Kingdom)
and coworkers have synthesized polymers that form strong
chemical bonds with DNA, yet degrade over time, which enhances
their utility as possible DNA delivery vehicles for gene therapy.
This news feature was written on May 18, 2009.... Read more »
Welsh, D. J., Jones, S. P., & Smith, D. K. (2009) “On-Off” Multivalent Recognition: Degradable Dendrons for Temporary High-Affinity DNA Binding. Angewandte Chemie International Edition, 48(22), 4047-4051. DOI: 10.1002/anie.200900401
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.