Not only are GPS devices useful, they’re also an ongoing experiment that keeps confirming special relativity’s spot on descriptions of how time flows for fast-moving objects. Without constant adjustments, GPS would be quickly rendered unusable because accurate timing of the signals being sent between the satellites and the moving object they’re supposed to track is [...]... Read more »
Angelo Tartaglia, Matteo Luca Ruggiero, & Emiliano Capolongo. (2010) A null frame for spacetime positioning by means of pulsating sources. Advances in Space Research. arXiv: 1001.1068v3
After the last more general entries on managers perception of risk and measuring SC performance I wanted to make a detour back to the basics.
Simulation is one of the tools, which can be used for analyzing supply chain dynamics, optimization and to support corporate decision making.
One major question when starting a supply chain model has always been what level of detail should you choose? Someone could start with a single worker in an agent based simulation model and continue with the mac........ Read more »
Persson, J. F. (2002) The impact of different levels of detail in manufacturing systems simulation models. Robotics and Computer-Integrated Manufacturing, 18(3-4), 319-325. DOI: 10.1016/S0736-5845(02)00024-8
Regular readers of these pages are probably well aware of the increasing data on the importance of obesity as a risk factor for cancers.
This is particularly true for hormone-sensitive cancers like post-menopausal breast and ovarian cancer, which are significantly more common in women with excess weight. In addition, excess weight appears to negatively affect the [...]... Read more »
Di LJ, Fernandez AG, De Siervi A, Longo DL, & Gardner K. (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nature structural . PMID: 21102443
As you'll know if you have your fingers on the throbbing pulse of dinosaur-related publications, the massive, incredibly pricey volume published by the Geological Society of London, and resulting from the 2008 meeting History of Dinosaurs and Other Fossil Saurians, now exists in dead-tree form. It's titled Dinosaurs and Other Extinct Saurians: A Historical Perspective and (in my totally unbiased opinion) is a definite must-see* for anyone interested in the historical side of Mesozoic reptile........ Read more »
SANCHEZ HERNANDEZ, B., BENTON, M., & NAISH, D. (2007) Dinosaurs and other fossil vertebrates from the Late Jurassic and Early Cretaceous of the Galve area, NE Spain. Palaeogeography, Palaeoclimatology, Palaeoecology, 249(1-2), 180-215. DOI: 10.1016/j.palaeo.2007.01.009
Basic research is fundamental if we want to make strides in understanding disease. Please (politely) shout this from the mountaintops and make sure your lawmakers and funding agencies understand this. Today’s image is from a paper that investigates a key player in cell scattering, which is an event very similar to cancer metastasis. Cell scattering is a term used to describe cell-cell dissociation and migration and occurs in liver development, organ regeneration, and metastasis. Cell sc........ Read more »
Vellón, L., Royo, F., Matthiesen, R., Torres-Fuenzalida, J., Lorenti, A., & Parada, L. (2010) Functional blockade of α5β1 integrin induces scattering and genomic landscape remodeling of hepatic progenitor cells. BMC Cell Biology, 11(1), 81. DOI: 10.1186/1471-2121-11-81
The American Medical Association (AMA) just released a policy on Social Media and Medical Professionalism. It focuses more on the negative aspects of social media, and much can be averted by just by using common sense:Physicians should weigh a number of considerations when maintaining a presence online:Physicians should be cognizant of standards of patient privacy and confidentiality that must be maintained in all environments, including online, and must refrain from posting identifiable patient........ Read more »
Greysen SR, Kind T, & Chretien KC. (2010) Online professionalism and the mirror of social media. Journal of general internal medicine, 25(11), 1227-9. PMID: 20632121
A pair of papers from the lab of Fred Gage has provided new insights into the molecular and cellular processes affected in Rett syndrome. This syndrome is associated with arrested development and autistic features. It affects mainly girls, who typically show normal development until around age two, followed by a sudden and dramatic deterioration of function, regression of language skills and the emergence of autistic symptoms. It is caused mainly by mutations in the gene encoding MeCP2, which........ Read more »
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, & Muotri AR. (2010) A model for neural development and treatment of rett syndrome using human induced pluripotent stem cells. Cell, 143(4), 527-39. PMID: 21074045
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, & Gage FH. (2010) L1 retrotransposition in neurons is modulated by MeCP2. Nature, 468(7322), 443-6. PMID: 21085180
From homeopathy to dodgy nutritional supplements, support for pseudoscience and quackery thrives on people believing falsely that one thing causes another, when in fact it doesn't. Meanwhile, psychologists study belief formation, and specifically illusions of control (see earlier), whereby people wrongly believe that they're controlling something when they're not. In a new paper, three psychologists at Deusto University in Bilbao argue that the psychological literature can be mined for ways........ Read more »
Matute, H., Yarritu, I., & Vadillo, M. (2010) Illusions of causality at the heart of pseudoscience. British Journal of Psychology. DOI: 10.1348/000712610X532210
Social software or the use of Internet (Web 2.0) for generating your own content, to connect with one another and to share and manage content with each other is used by young people. How do first year medical students use this social software? This could be important because these networks could become networks of learners [...]
Related posts:Social Media in Health and Medicine: Medlibs Round 2.7
The Risks of Online Social Networking for Students
Disclosure of substance use on social media we........ Read more »
Sandars, J., Homer, M., Pell, G., & Crocker, T. (2010) Web 2.0 and social software: the medical student way of e-learning. Medical Teacher, 2147483647-5. DOI: 10.3109/01421590701798729
Bacterial lipoproteins are proteins with covalently-attached lipid molecules that anchor the protein to the cytoplasmic or outer membrane. The lipid molecules are attached to the cysteine located at the amino terminus of the lipoprotein. The lipoprotein's protein component, being hydrophilic (water-loving), sticks out from the membrane. Different bacterial lipoproteins participate in a variety of functions, including transport of molecules, stabilization of the cell wall, signal tran........ Read more »
TOKUDA, H. (2009) Biogenesis of outer membranes in Gram-negative bacteria. Bioscience, Biotechnology, and Biochemistry, 73(3), 465-473. DOI: 10.1271/bbb.80778
TOKUDA, H. (2004) Sorting of lipoproteins to the outer membrane in E. coli. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1693(1), 5-13. DOI: 10.1016/j.bbamcr.2004.02.005
Schulze, R., & Zückert, W. (2006) Borrelia burgdorferi lipoproteins are secreted to the outer surface by default. Molecular Microbiology, 59(5), 1473-1484. DOI: 10.1111/j.1365-2958.2006.05039.x
If you've ever rolled your ankle (as I have many times), you have a visceral knowledge of inflammation. Clinically, inflammation is the redness, swelling, heat and pain that's associated with injury. From an immunologist's perspective, it's the set of molecular events that get the immune system going. All of the clinical systems associated with inflammation are due to increased vascular permeability, which is just a fancy way of saying leaky blood vessels. Actually, "leaky" implies that it's unc........ Read more »
Chen GY, & Nuñez G. (2010) Sterile inflammation: sensing and reacting to damage. Nature reviews. Immunology, 10(12), 826-37. PMID: 21088683
Hossler EW, Maroon MS, & Mowad CM (2010). Gastric bypass surgery improves psoriasis. Journal of the American Academy of Dermatology PMID: 20655127How could I not blog this article? What could possibly be the connection between gastric bypass and a skin disease?The authors - dermatologists - describe two cases of significant long-lasting improvement in psoriasis after weight loss from gastric bypass surgery. They point out that obesity has been thought to be a risk factor for psoriasis, and t........ Read more »
Theory of Mind relates to the development of an ability to understand the thoughts and emotions of others. fMRI has provided significant insight into the brain region (right parietal-temporal junction) associated with this ability. Dr. Rebecca Saxe from MIT has been a leader in this research. Posted above is her TED talk related to her research--it is about 16 minutes. Posted below are my notes on the presentation:As scientist I am interested in how it's so easy to unders........ Read more »
Saxe RR, Whitfield-Gabrieli S, Scholz J, & Pelphrey KA. (2009) Brain regions for perceiving and reasoning about other people in school-aged children. Child development, 80(4), 1197-209. PMID: 19630902
[Wherein our Hero seeks to understand the benefits of both reading and writing blogs]How meta- of me. A blog about blogging. It was sure to happen, as surely as it has happened everywhere else.In my defence at least it’s a researchblogging article about blogging.I have to say that the decision to start a blog was one of unintended consequences, all positive, I assure you.I had two motivations in; (read more)
Source: Rift - Discipline: Psychology... Read more »
Li, J., & Chignell, M. (2010) Birds of a feather: How personality influences blog writing and reading. International Journal of Human-Computer Studies, 68(9), 589-602. DOI: 10.1016/j.ijhcs.2010.04.001
Chong, E. (2010) Using blogging to enhance the initiation of students into academic research. Computers , 55(2), 798-807. DOI: 10.1016/j.compedu.2010.03.012
When I’m working with someone who has chronic pain, from the outset I’m pretty straight-up that the treatments I offer don’t directly affect pain intensity. It’s not my focus, and very often after the first session, I don’t even discuss pain – I’m more interested in what the person is doing! And for this focus, … Read more... Read more »
Glombiewski, J., Sawyer, A., Gutermann, J., Koenig, K., Rief, W., & Hofmann, S. (2010) Psychological treatments for fibromyalgia: A meta-analysis. Pain, 151(2), 280-295. DOI: 10.1016/j.pain.2010.06.011
I haven't worked very much with bacteria that infect humans. Most of my lab work has been done in the fields of either synthetic biology (which works with model organisms) or antibiotic production, which works on soil bacteria that produce the antibiotics. Human bacterial parasites therefore hold the fascination of the slightly exotic, not least because they sometimes do things like this:Figure from"Molecular Biology of the Cell, Fourth Edition"by Alberts et al.I've written before about some of ........ Read more »
Ray K, Marteyn B, Sansonetti PJ, & Tang CM. (2009) Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nature reviews. Microbiology, 7(5), 333-40. PMID: 19369949
Kuo SC, & McGrath JL. (2000) Steps and fluctuations of Listeria monocytogenes during actin-based motility. Nature, 407(6807), 1026-9. PMID: 11069185
Surgery is often the only solution to prevent disabilities and death from conditions resulting from pregnancy related complications, surgical conditions (example acute abdomen), infections, traffic accidents, falls, burns, disasters, domestic violence, and congenital defects. Until recently, surgery was neglected as a developing country public health issue. Health officials, especially in the World Health organization and [...]... Read more »
Funk, L., Weiser, T., Berry, W., Lipsitz, S., Merry, A., Enright, A., Wilson, I., Dziekan, G., & Gawande, A. (2010) Global operating theatre distribution and pulse oximetry supply: an estimation from reported data. The Lancet, 376(9746), 1055-1061. DOI: 10.1016/S0140-6736(10)60392-3
It is important for HIV infected patients to take their drugs regularly. Interruptions in treatment lead to viral strains that are resistant to the cheapest medications, and to higher rates of illness and death. Unfortunately, many AIDS patients do not come for their antiretroviral medications. Such patients are labelled as “lost to follow-up.” During the [...]... Read more »
Mulissa, Z., Jerene, D., & Lindtjørn, B. (2010) Patients Present Earlier and Survival Has Improved, but Pre-ART Attrition Is High in a Six-Year HIV Cohort Data from Ethiopia. PLoS ONE, 5(10). DOI: 10.1371/journal.pone.0013268
Fig 1A (modified from Blauwblomme et al., 2010). Top: coronal and lateral representation of the stereotaxic implantation scheme. Bottom: reflex seizure showing ictal onset in the right insula and secondary spreading in the hippocampus.Reflex epilepsy is a rare neurological condition in which seizures are triggered by a specific type of sensory input (Xue & Ritaccio, 2006). The most common reflex seizures are induced by light, but other reported triggers have included reading, Mah-Jong, mus........ Read more »
Blauwblomme, T., Kahane, P., Minotti, L., Grouiller, F., Krainik, A., Vercueil, L., Chabardes, S., Hoffmann, D., & David, O. (2010) Multimodal imaging reveals the role of activity in eating-reflex seizures. Journal of Neurology, Neurosurgery . DOI: 10.1136/jnnp.2010.212696
[...]... Read more »
Fu H, & Dooner HK. (2002) Intraspecific violation of genetic colinearity and its implications in maize. Proceedings of the National Academy of Sciences of the United States of America, 99(14), 9573-8. PMID: 12060715
Lai J, Li Y, Messing J, & Dooner HK. (2005) Gene movement by Helitron transposons contributes to the haplotype variability of maize. Proceedings of the National Academy of Sciences of the United States of America, 102(25), 9068-73. PMID: 15951422
Swanson-Wagner RA, Eichten SR, Kumari S, Tiffin P, Stein JC, Ware D, & Springer NM. (2010) Pervasive gene content variation and copy number variation in maize and its undomesticated progenitor. Genome research. PMID: 21036921
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.