A recent paper in Cancer Cell reveals the power of integrated genomic datasets for understanding cancer origins and treatment. Members of the TCGA Research Network identified and characterized four glioblastoma subtypes using gene expression, somatic mutation, and copy number data.
Genetic Characteristics of GBM Subtypes
Each subtype was classified by gene expression clustering, and showed specific patterns [...]... Read more »
Verhaak, R., Hoadley, K., Purdom, E., Wang, V., Qi, Y., Wilkerson, M., Miller, C., Ding, L., Golub, T., & Mesirov, J. (2010) Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell, 17(1), 98-110. DOI: 10.1016/j.ccr.2009.12.020
tags: evolutionary biology, fossils, feathers, plumage color, color, dinosaurs, theropods, Sinosauropteryx, Sinornithosaurus, birds, Confuciusornis, melanosomes, phaeomelanosomes, eumelanosomes, keratinocytes, SEM, scanning electron microscopy, 10.1038/nature08740, bpr3.org/?p=52, peer-reviewed research, peer-reviewed paper
Reconstruction of two Sinosauropteryx, sporting their orange and white striped tails.
Artwork by Chuang Zhao and Lida Xing [larger view]
........ Read more »
Zhang, F., Kearns, S., Orr, P., Benton, M., Zhou, Z., Johnson, D., Xu, X., & Wang, X. (2010) Fossilized melanosomes and the colour of Cretaceous dinosaurs and birds. Nature. DOI: 10.1038/nature08740
Ten days ago, the Sunday Times - Britain's "newspaper of record" - recorded thatBlonde women born to be warrior princessesWomen with fair hair are more aggressive and determined to get their own way than brunettes or redheads, according to a study by the University of California... “We expected blondes to feel more entitled than other young women — this is southern California, the natural habitat of the privileged blonde,” said Aaron Sell, who led the study...Well who'da thought it. Ot........ Read more »
In their study, Evidence for mirror systems in emotions,1 Bastiaansen et al., examine the relationship between mirror systems and embodied simulation.
This examination highlights and advances the connections between body changes, emotions and the simulation of body changes and emotions. These systems also play a significant role in the creation of consciousness.2 The neuroscientific sense of body-mind connection provides great insight into the development of resilience and cultivation of well-b........ Read more »
A recent article in the journal PLOS One describes a novel finding of abnormal prion proteins (PrPres) in additional non-neuronal tissues of a variant CJD (vCJD) patient. The study comes from the National Prion Disease Pathology Surveillance Center, located at Case Western University in Cleveland, Ohio. Prior to this study, there was evidence that PrPres was present in some non-neuronal tissues as shown below. The present study examined other tissues for the possible presence o........ Read more »
Notari, S., Moleres, F., Hunter, S., Belay, E., Schonberger, L., Cali, I., Parchi, P., Shieh, W., Brown, P., Zaki, S.... (2010) Multiorgan Detection and Characterization of Protease-Resistant Prion Protein in a Case of Variant CJD Examined in the United States. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008765
BMC Biology has recently published a paper (It’s Open Access!) which explores trends in brain size in the Primates. A trend toward a larger brain is usually considered one of the “hallmarks” of the Primates, but Stephen Montgomery and his colleagues have shown that in many lineages, there is a trend towards secondarily “shrunken” brains.
The [...]... Read more »
Montgomery, S., Capellini, I., Barton, R., & Mundy, N. (2010) Reconstructing the ups and downs of primate brain evolution: implications for adaptive hypotheses and Homo floresiensis. BMC Biology, 8(1), 9. DOI: 10.1186/1741-7007-8-9
As I wrote yesterday in my piece for The Huffington Post, the history of Western financial involvement in Haiti has been one of growing the nation's textile industry despite the fact that 70% of Haiti's annual income comes from agriculture. By emphasizing programs such as HOPE and HOPE II, the United States has increased the profits of American companies, but the livelihood of Haitian workers has decreased at nearly the same rate.
[A] 2009 report by the Congressional Research Service found th........ Read more »
DOLISCA, F., MCDANIEL, J., SHANNON, D., & JOLLY, C. (2009) Modeling farm households for estimating the efficiency of policy instruments on sustainable land use in Haiti. Land Use Policy, 26(1), 130-138. DOI: 10.1016/j.landusepol.2008.01.007
Stanfordian scientists have attributed age-related financial risks with differential accumbal activity. Honestly, this begs a philosophical conversation of how we can control financial risks of the elderly without jeopardizing their basic human rights.... Read more »
Samanez-Larkin, G., Kuhnen, C., Yoo, D., & Knutson, B. (2010) Variability in Nucleus Accumbens Activity Mediates Age-Related Suboptimal Financial Risk Taking. Journal of Neuroscience, 30(4), 1426-1434. DOI: 10.1523/JNEUROSCI.4902-09.2010
Bats, as this article in Ecology explains, are particularly sensitive to these changes and, due to their enormous numbers, are integral to food webs as predator and prey. They may be that indicator ecologists are looking for.... Read more »
Adams, R. (2010) BAT REPRODUCTION DECLINES WHEN CONDITIONS MIMIC CLIMATE CHANGE PROJECTIONS FOR WESTERN NORTH AMERICA. Ecology, 2147483647. DOI: 10.1890/09-0091
Last week, many of the leading journals in evolutionary biology - including The American Naturalist, Molecular Ecology, Journal of Evolutionary Biology, Evolution, and a number of others - announced a data archiving policy. In short, this policy states that the data behind the results of a paper should be publicly archived in well-known respositories such as Data Dryad, GenBank, or TreeBASE. Do you notice anything missing in this illustrious list of publications?Not a single one of those journal........ Read more »
Accuracy of physical examination in subacromial impingement syndrome
In this study of 55 patients, the authors studied five findings and concluded, “The cut point of 3 or more positive of 5 tests can confirm the diagnosis…, while less than 3 positive of 5 rules out.” If you look at the accuracies and the predictive values below, [...]... Read more »
Michener LA, Walsworth MK, Doukas WC, & Murphy KP. (2009) Reliability and diagnostic accuracy of 5 physical examination tests and combination of tests for subacromial impingement. Archives of physical medicine and rehabilitation, 90(11), 1898-903. PMID: 19887215
If you ever walked along an empty stretch of beach and flushed away a flock of frightened shore birds, you might have wondered to yourself whether you just committed a horrible ecological sin.
Perhaps you asked yourself, "Where are those birds going? Did they just abandon their nestlings? How long until they come back? Or better yet, will they ever come back?"
A new study tries to answer these types of questions with respect to the impact of recreational boaters on nesting colonies of bla........ Read more »
Burger, J., Gochfeld, M., Jenkins, C., & Lesser, F. (2010) Effect of Approaching Boats on Nesting Black Skimmers: Using Response Distances to Establish Protective Buffer Zones. Journal of Wildlife Management, 74(1), 102-108. DOI: 10.2193/2008-576
There has been quite a buzz circulating about the possibility of therapeutic gene silencing strategies. Today I want to take a first look at what these therapies mean.
One great example where gene silencing could be used is in polyglutamine disorders. This includes several disorders where genes accumulate, by replication errors, a repeat expansion of the [...]... Read more »
Scholefield, J., & Wood, M. (2010) Therapeutic gene silencing strategies for polyglutamine disorders. Trends in Genetics, 26(1), 29-38. DOI: 10.1016/j.tig.2009.11.005
There have been a number of studies of late that have concluded that being overweight (not obese, overweight) and elderly is in fact a good combination.Well, here's another.This study, published today in the Journal of the American Geriatric Society has Leon Flicker and his colleagues discussing the impact of weight on mortality over a 10 year period in 9,240 Australian men and women.Their findings?The minimum mortality risk was found at a BMI of 26.6 and as BMI decreased from there, risk i........ Read more »
Flicker, L., McCaul, K., Hankey, G., Jamrozik, K., Brown, W., Byles, J., & Almeida, O. (2010) Body Mass Index and Survival in Men and Women Aged 70 to 75. Journal of the American Geriatrics Society, 58(2), 234-241. DOI: 10.1111/j.1532-5415.2009.02677.x
Time to unveil what I've been up to for the past several Friday nights. I figured that after nearly a year and a half, and almost 20K page views, it's time for our blog to grow up a bit. What we need is our very own tree.Remember how I often refer to the Keeling et al 2005 tree when pointing out where some obscure organism lies on the 'map'? Well, that tree is 5 years out of date now. In fields like molecular biology and genomics, a lot can change in five years; compounded with how the protistan........ Read more »
CAVALIERSMITH, T. (2003) Phylogeny and Classification of Phylum Cercozoa (Protozoa). Protist, 154(3-4), 341-358. DOI: 10.1078/143446103322454112
Cavalier-Smith, T., & Chao, E. (2006) Phylogeny and Megasystematics of Phagotrophic Heterokonts (Kingdom Chromista). Journal of Molecular Evolution, 62(4), 388-420. DOI: 10.1007/s00239-004-0353-8
James, T., Kauff, F., Schoch, C., Matheny, P., Hofstetter, V., Cox, C., Celio, G., Gueidan, C., Fraker, E., Miadlikowska, J.... (2006) Reconstructing the early evolution of Fungi using a six-gene phylogeny. Nature, 443(7113), 818-822. DOI: 10.1038/nature05110
In a recent article in the journal Environmental Management, conservation biologist George Wilhere argues that the Endangered Species Act and its provision for habitat conservation plans are hampered by three main paradoxes: the Train Wreck Paradox, the Jeopardy Paradox, and the Maximum Mitigation Paradox. We interview George Wilhere and ask him how we can fix the problem...... Read more »
Or at least according to a new paper by a physicist and a geologist who propose that a giant bubble of molten heavy metal was ejected from a young Earth after a nuclear meltdown within its innards and formed the Moon. Forget the notion of a wandering world plowing into our planet and ejecting the [...]... Read more »
R. J. de Meijer, & W. van Westrenen. (2010) An alternative hypothesis for the origin of the Moon. Earth, Moon and Planets. arXiv: 1001.4243v1
by Vincent Racaniello in virology blog
Fragments of an abundant protein produced by the prostate form amyloid fibrils that enhance infection of cells by human immunodeficiency virus type 1. These fibrils, called semen-derived enhancer of virus infection (SEVI), have been found to boost infection of prostate cells by the retrovirus XMRV. Is this evidence that XMRV causes prostate cancer?
Because most HIV-1 [...]... Read more »
Hong, S., Klein, E., Das Gupta, J., Hanke, K., Weight, C., Nguyen, C., Gaughan, C., Kim, K., Bannert, N., Kirchhoff, F.... (2009) Fibrils of Prostatic Acid Phosphatase Fragments Boost Infections with XMRV (Xenotropic Murine Leukemia Virus-Related Virus), a Human Retrovirus Associated with Prostate Cancer. Journal of Virology, 83(14), 6995-7003. DOI: 10.1128/JVI.00268-09
Dominique Mazier (Universite Pierre et Marie Curie-Paris, France) and coworkers have used mass spectrometry to rapidly and unambiguously diagnose a blood-based fungal infection, faster than is possible through conventional diagnostics. This news feature was written on January 27, 2010.... Read more »
Marinach-Patrice, C., Fekkar, A., Atanasova, R., Gomes, J., Djamdjian, L., Brossas, J.-Y., Meyer, I., Buffet, P., Snounou, G., Datry, A.... (2010) Rapid Species Diagnosis for Invasive Candidiasis Using Mass Spectrometry. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008862
Thoreau's records help reveal plants' responses to climate change
... Read more »
Willis, C., Ruhfel, B., Primack, R., Miller-Rushing, A., Losos, J., & Davis, C. (2010) Favorable Climate Change Response Explains Non-Native Species' Success in Thoreau's Woods. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008878
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.