I was lucky in graduate school and my postdoctoral research—I was a microscopist working on a transparent organism (C. elegans). Some microscopists don’t have that luxury, but have developed amazing techniques in order to visualize development in organisms such as mice. In the November 1 issue of Development, Yokomizo and Dzierzak use a technique that [...]... Read more »
Yokomizo, T., & Dzierzak, E. (2010) Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development, 137(21), 3651-3661. DOI: 10.1242/dev.051094
All microbiologists end up writing about gut bacteria at some point. It is the way of things. Disease of the Week is currently doing a whole series on it, and a few weeks ago I covered the interaction of the immune system with gut bacteria (here). However a recent paper came out in Microbiology Today concerning the affect of antibiotics on gut bacteria, which is a topic that I both find interesting and have had some actual experience with.I've taken antibiotics a few times, and each time I've fo........ Read more »
Jernberg C, Löfmark S, Edlund C, & Jansson JK. (2010) Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology (Reading, England), 156(Pt 11), 3216-23. PMID: 20705661
by Paula Welander in Small Things Considered
by Paula Welander
First Evolved! Last Extinct! This prokaryotic pride motto was coined by my undergraduate advisor (and good friend) Prof. Mark Martin. As a microbiologist, I love this motto for many reasons, but especially because it alludes to one of the underlying principles of my current research. Microbes were indeed the first to evolve and the metabolic inventions of ancient microbes greatly influenced the ancient Earth’s environment and the evolution of life. The interaction between ........ Read more »
Welander PV, Coleman ML, Sessions AL, Summons RE, & Newman DK. (2010) Identification of a methylase required for 2-methylhopanoid production and implications for the interpretation of sedimentary hopanes. Proceedings of the National Academy of Sciences of the United States of America, 107(19), 8537-42. PMID: 20421508
Tuesday’s midterm election results appeared to deliver a strong message of discontent to the young Obama administration. With Republicans gaining control of the House of Representatives and closing the gap in the Senate, many analysts saw the election as a rebuke of the Democratic agenda of the last two years. Perhaps the highest-profile of those [...]... Read more »
by Isobel in Promega Connections
If man has no tea in him, he is incapable of understanding truth and beauty. ~Japanese Proverb There is nothing like a good cup of tea. On that there is little dispute. Growing up in Britain, I was introduced to tea at an early age. It was impossible to avoid it. We had tea after [...]... Read more »
van Duynhoven, J., Vaughan, E., M. Jacobs, D., A. Kemperman, R., van Velzen, E., Gross, G., Roger, L., Possemiers, S., Smilde, A., Dore, J.... (2010) Microbes and Health Sackler Colloquium: Metabolic fate of polyphenols in the human superorganism. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1000098107
Gross G, Jacobs DM, Peters S, Possemiers S, van Duynhoven J, Vaughan EE, & van de Wiele T. (2010) In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability. Journal of agricultural and food chemistry, 58(18), 10236-46. PMID: 20726519
A couple of years ago, two researchers at the Technion tested whether or not funnier scientific article titles yielded higher citations. Their article, Amusing titles in scientific journals and article citation, takes the titles of over 1000 articles and has them rated on two scales, pleasantness and how amusing they are. They then checked to [...]... Read more »
Sagi, I., & Yechiam, E. (2008) Amusing titles in scientific journals and article citation. Journal of Information Science, 34(5), 680-687. DOI: 10.1177/0165551507086261
According to the United States Alzheimer’s Association, over 5.3 million people in the US are currently suffering from Alzheimer’s disease. Alzheimer’s is a chronic and progressive form of dementia in which symptoms begin as mild memory impairment and progress into loss of conversational ability, motor function, speech, and the ability to eat. As shown in the illustration below, the disease “eats” neurons in the brain, causing the symptoms discussed above.... Read more »
Simmons-Stern NR, Budson AE, & Ally BA. (2010) Music as a memory enhancer in patients with Alzheimer's disease. Neuropsychologia, 48(10), 3164-7. PMID: 20452365
In 20051, the Liu lab described a new central element in the Neurospora circadian clock. They found that an RNA helicase with similarity to the yeast exosome cofactor Dob1p/Mtr4p, associated with FRQ, a core clock component essential for circadian clock function in this fungus (it was termed FRH, for "FRQ-interacting RNA helicase"). Their evidence suggested that FRH played an important role in ... Read more »
Cheng P, He Q, He Q, Wang L, & Liu Y. (2005) Regulation of the Neurospora circadian clock by an RNA helicase. Genes , 19(2), 234-41. PMID: 15625191
How does one become a fan? Choose an allegiance? Decide that you’re going to wear bright green, or purple and gold, or paint your face orange and black? In many cases, these allegiances are decided for us—handed down via familial loyalties or decided by geographic boundaries. I raised this question on Twitter a few weeks ago, and the results all indicated that team alliance is linked to one’s point-of-entry into fandom: if you begin watching Team A and learning about the sport via Team A,........ Read more »
Miller, Michael. (1997) American Football: The Rationalization of the Irrational. International Journal of Politics, Culture, and Society, 11(1), 101-127. info:/
For some, planting a tree is an act of love. In many parts of the world, however, tree planting has become a source of often violent conflict. The rapid expansion of industrial plantations for wood, palm oil and rubber is sparking protest around the globe, a new analysis finds. The unrest suggests that pro-plantation policies […] Read More »... Read more »
Gerber, J. (2010) Conflicts over industrial tree plantations in the South: Who, how and why?. Global Environmental Change. DOI: 10.1016/j.gloenvcha.2010.09.005
Imagine if instead of having sensor lights to illuminate a garden path, you could line it with light-emitting plants. You could stroll along bio-luminescent flower beds, dancing in dappled moonlight and delighting in eerily lit peace, free from the shackles of electricity. It could be possible with sea urchin shaped gold nanoparticles. Seriously, every time [...]... Read more »
Su, Y., Tu, S., Tseng, S., Chang, Y., Chang, S., & Zhang, W. (2010) Influence of surface plasmon resonance on the emission intermittency of photoluminescence from gold nano-sea-urchins. Nanoscale. DOI: 10.1039/C0NR00330A
I have previously blogged about some of the diagnostic challenges in obese patients.
A paper published a few years ago by Simon Gabriel and colleagues from the Drexel University College of Medicine, Philadelphia, PA, published in the American Journal of Clinical Pathology, further documents the impact of increased BMI levels on missed diagnoses.
Gabriel and colleagues re-examined [...]... Read more »
Gabriel S, Gracely EJ, & Fyfe BS. (2006) Impact of BMI on clinically significant unsuspected findings as determined at postmortem examination. American journal of clinical pathology, 125(1), 127-31. PMID: 16483001
It is well-documented that those who are better educated have better physical health than those who are less educated. This is true throughout the world despite differences in healthcare systems. But why is this the case? Dr Wendy Johnson, from the University of Edinburgh, and colleagues including Wellcome Trust research fellow Dr David Batty, studied [...]... Read more »
Johnson W, Kyvik KO, Mortensen EL, Skytthe A, Batty GD, & Deary IJ. (2010) Education reduces the effects of genetic susceptibilities to poor physical health. International journal of epidemiology, 39(2), 406-14. PMID: 19861402
'Tis the season. Residency interview season, that is.Faculty are trying to sort out the piles of ERAS applications, trying not to zone-out while reading their 50th personal statement over the past 4 hours. Does it seem that medical students are getting more and more amazing every year?! I'm glad I got in when I did.Student forums are abuzz with residency program and interview etiquette questions.Students are second-guessing themselves about why they haven't heard from their first-choice pro........ Read more »
"God is really an artist, like me ... I am God, I am God, I am God." Pablo PicassoSome experts have suggested there's a link between narcissism and creativity. They've wondered if the self-obsession and self-belief create the necessary time and space for originality to flourish. On the contrary, Jack Goncalo at Cornell University has just published results from three experiments which show that narcissists on their own aren't any more creative than usual, even though they think they are. However........ Read more »
Goncalo JA, Flynn FJ, & Kim SH. (2010) Are Two Narcissists Better Than One? The Link Between Narcissism, Perceived Creativity, and Creative Performance. Personality and social psychology bulletin. PMID: 20947771
Falling in love is so romantic, so blissful, so cherished in our lives. Most people will fall in love more than once, first with the 'wait until we're married' sterilizer, then with the 'jealous defender' and finally you hit an age where want to settle down and find the 'practical answer'. And then, after imminent divorce you find yourself with some gold digger who just can't wait for you to die and leave him or her everything.
That darling of a fairy tale also applies to trees. ........ Read more »
Palmer TM, Doak DF, Stanton ML, Bronstein JL, Kiers ET, Young TP, Goheen JR, & Pringle RM. (2010) Synergy of multiple partners, including freeloaders, increases host fitness in a multispecies mutualism. Proceedings of the National Academy of Sciences of the United States of America, 107(40), 17234-9. PMID: 20855614
Bruno Bettelheim is both a controversial and fascinating individual. Below is a Horizon documentary about Bettelheim from 1986. It gives an excellent overview of his life and work. Bettelheim is well-known for his work at the The Orthogenic School. However, Bettelheim is also known as a controversial character. Some suggest his treatment of children in his care was questionable, others maintain he lied about aspects of his past. As well as this, his death by suicide, although sad, seems to ........ Read more »
In New Zealand reports of whales stranding on the beaches make headlines, such as the recent stranding of pilot whales at Spirits Bay. They’re mammals like us and New Zealanders have grown up with news stories of whales and their inquisitive cousins, dolphins. It’s pitiful to see these creatures sprawled helpless on the sand.
Frequent readers will know [...]... Read more »
Mann, D., Hill-Cook, M., Manire, C., Greenhow, D., Montie, E., Powell, J., Wells, R., Bauer, G., Cunningham-Smith, P., Lingenfelser, R.... (2010) Hearing Loss in Stranded Odontocete Dolphins and Whales. PLoS ONE, 5(11). DOI: 10.1371/journal.pone.0013824
First off, I hope that everyone is enjoying the extra hr of today. I spent it at a Cleveland Browns game watching them upset Brady Douche and the Patriots. The best part about daylight savings time is that the sun rises at a more normal time (~7 AM) instead of around 8 AM, which for [...]... Read more »
Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortés A, Casadó V, Canela EI, Ortiz J.... (2010) Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America, 107(43), 18676-81. PMID: 20956312
As a lifelong shark lover whose thesis research happens to be on the subject of predation, I’m a little obsessed with the ecology of predation. Earlier I posted on trophic cascades and debate over whether they are a strong enough … Continue reading →... Read more »
Dill, L., Heithaus, M., & Walters, C. (2003) BEHAVIORALLY MEDIATED INDIRECT INTERACTIONS IN MARINE COMMUNITIES AND THEIR CONSERVATION IMPLICATIONS. Ecology, 84(5), 1151-1157. DOI: 10.1890/0012-9658(2003)084[1151:BMIIIM]2.0.CO;2
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