We spend a lot time at SBM discussing different elements of the art and science of medicine, and how we believe that practice can be improve. Yet our science-based intentions can be thwarted at the last possible moment – in the form of dosing errors. The workup may have been comprehensive, the diagnosis could be [...]... Read more »
Yin HS, Mendelsohn AL, Wolf MS, Parker RM, Fierman A, van Schaick L, Bazan IS, Kline MD, & Dreyer BP. (2010) Parents' medication administration errors: role of dosing instruments and health literacy. Archives of pediatrics , 164(2), 181-6. PMID: 20124148
Yin HS, Wolf MS, Dreyer BP, Sanders LM, & Parker RM. (2010) Evaluation of Consistency in Dosing Directions and Measuring Devices for Pediatric Nonprescription Liquid Medications. JAMA : the journal of the American Medical Association. PMID: 21119074
by Travis Saunders, MSc, CEP in Obesity Panacea
http://www.flickr.com/photos/phrenzee/ / CC BY 2.0
Welcome to our 5-part series delving into the fascinating research being performed in the emerging field of sedentary physiology. In Part 1 we discussed the basics of sedentary physiology, in Part 2 we discussed the relationship between total sedentary time and negative health outcomes, and in Part 3 we examined how interruptions in sedentary time may be protective health benefits. Today we look at the mechanisms underlying these relat........ Read more »
Zimmerman, F., & Bell, J. (2009) Associations of Television Content Type and Obesity in Children. American Journal of Public Health, 100(2), 334-340. DOI: 10.2105/AJPH.2008.155119
Some of the most striking and informative images aren’t of cells or organisms, but are computer-generated representations of what is going on in cells or organisms. These computer-generated images come from the use of two-photon microscopy, a powerful technique that allows for imaging of tissue that’s buried deep in a living organism.... Read more »
Biswas, S., Emond, M., & Jontes, J. (2010) Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation. Originally published in The Journal of Cell Biology, 191(5), 1029-1041. DOI: 10.1083/jcb.201007008
I don't want to get into why I find the whole paleo diet thing so aggravating. I do find some of the assumptions funny and a little naive, but I think its mainly the hype and messianic tone that make it hard for me to listen too. However, late at night, when I can't sleep, I sometimes look at articles dealing with nutrition and here are two that piqued my curiosity.One is that high protein maternal diets may predispose infants (at least rats anyway) to greater risk of obesity later i........ Read more »
Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, & Hanson MA. (2007) Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatric research, 61(5 Pt 2). PMID: 17413851
Results of a web-experiment. Gomez (2002) shows that increased variation in adjacent dependencies can cause learners to pick up on long-distance dependencies. I hypothesise that the variation in input from multiple speakers gives better cues to more abstract structures than input from one speaker alone.... Read more »
When studying eye movement, it is easy to imagine someone sitting in a darkened room, following a dot around a computer screen. New research suggests that the future of this research may require a shifting of the goal posts. Dr Christina Howard and colleagues from the Department of Experimental Psychology, University of Bristol describe a [...]... Read more »
Howard CJ, Troscianko T, & Gilchrist ID. (2010) Eye-response lags during a continuous monitoring task. Psychonomic bulletin , 17(5), 710-7. PMID: 21037171
I'm not surprised, are you?A study out of the journal Sex Roles took a look at preschoolers' attitudes towards obesity by means of Candy Land and Chutes and Ladders. They took 55 girls aged 3-5 and had them choose which character they wanted to be. 69% chose the thinnest, 20% the average and 11% the largest. Moreover when asked to swap thinnest for largest, 63% refused.One of the study's authors apparently was surprised by the findings and she was quoted in the Montreal Gazette stating, "I was........ Read more »
Harriger, J., Calogero, R., Witherington, D., & Smith, J. (2010) Body Size Stereotyping and Internalization of the Thin Ideal in Preschool Girls. Sex Roles, 63(9-10), 609-620. DOI: 10.1007/s11199-010-9868-1
Barely a day goes by without some political scandal or other splashed across the papers. Critics argue this obsession with tittle-tattle distracts the electorate from more important policy issues. '...a fiercely independent media is the guarantor of democracy,' Will Hutton wrote in 2000, before warning that the British media's obsession with scandal 'paradoxically, may be beginning to endanger it [democracy]'.
A new study by Beth Miller at the University of Missouri-Kansas City challenges the a........ Read more »
Miller, B. (2010) The Effects of Scandalous Information on Recall of Policy-Related Information. Political Psychology, 31(6), 887-914. DOI: 10.1111/j.1467-9221.2010.00786.x
Today, medical journal The Lancet has publicly criticised the Canadian government for its attitude towards asbestos, saying that although Canada will not expose its own citizens to asbestos, it will continue exporting the deadly substance to developing nations [Canada accused of hypocrisy, Lancet]. A few facts about asbestos All forms of asbestos are proven human [...]A few facts about asbestos is a post from: Sciencebase Science Blog
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Collegium Ramazzini. (2010) Asbestos is still with us: repeat call for a universal ban. International Journal of Environment and Health, 4(4), 380-388. info:/
A small RNA (siRNA or miRNA) is the "magic bullet" in biotechnology. It's easy to manufacture, it's on target and has high "kill" rates. According to an Industry rep, it currently takes 2 billion USD to launch a new chemical product and the revenue comes back in negative. So companies actually wind up in a deficit when they put out a newly developed drug. However, the "magic bullet" is going to change all of that around. One company alone invested 1.2 bill........ Read more »
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, & Mello CC. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391(6669), 806-11. PMID: 9486653
Grimm, D., Streetz, K., Jopling, C., Storm, T., Pandey, K., Davis, C., Marion, P., Salazar, F., & Kay, M. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature, 441(7092), 537-541. DOI: 10.1038/nature04791
Castanotto, D., & Rossi, J. (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature, 457(7228), 426-433. DOI: 10.1038/nature07758
Antepartum Bed Rest for Pregnancy Complications: Efficacy and Safety for Preventing Preterm Birth From Biological Research for Nursing This article reveals that bed rest may not be the best option for preventing preterm labor and may even cause harm to the mother and baby. Bed rest is prescribed for up to 1 million women in [...]... Read more »
Maloni, J. (2010) Antepartum Bed Rest for Pregnancy Complications: Efficacy and Safety for Preventing Preterm Birth. Biological Research For Nursing, 12(2), 106-124. DOI: 10.1177/1099800410375978
>> My previous post was more of a summary of what the reporting of the "NASA arsenic-thriving bacteria" story looked like from my perspective in the wake of the massive Internet onslaught of information. In this post I want to talk about how the style of communication that drove this story has lead to the dissemination of falsehoods or misconceptions that hinder a proper understanding of biology in general, regardless of the validity of the actual findings.
Last week I conc........ Read more »
Wolfe-Simon, F., Switzer Blum, J., Kulp, T.R., Gordon, G.W., Hoeft, S.E., Pett-Ridge, J., Stolz, J.F., Webb, S.M., Weber, P.K., Davies, P.C.W., Anbar, A.D., Oremland, R.S. (2010) A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus. Science. info:/10.1126/science.1197258
Aspirin knows how to multitask. It was originally developed more than a century ago as a pain reliever, but it was soon discovered that it also reduces fever and fights inflammation. In the last 30 years it was found that a daily low dose of aspirin reduces the risk of heart attacks and strokes. And now a new study suggests that aspirin taken over an extended time period reduces the risk of death from a variety of solid tumor cancers, including colorectal, lung, esophageal, and gastrointestinal ........ Read more »
Rothwell, P., Fowkes, F., Belch, J., Ogawa, H., Warlow, C., & Meade, T. (2010) Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. The Lancet. DOI: 10.1016/S0140-6736(10)62110-1
by Richard in A Replicated Typo 2.0
In an attempt to write out my thoughts for others instead of continually building them up in saved stickies, folders full of .pdfs, and hastily scribbled lecture notes, as if waiting for the spontaneous incarnation of what looks increasingly like a dissertation, I’m going to give a glimpse today of what I’ve been looking into recently. . . . → Read More: Fungus, -i. 2nd Decl. N. Masculine – or is it?: On Gender... Read more »
Bapteste E, O'Malley MA, Beiko RG, Ereshefsky M, Gogarten JP, Franklin-Hall L, Lapointe FJ, Dupré J, Dagan T, Boucher Y.... (2009) Prokaryotic evolution and the tree of life are two different things. Biology direct, 34. PMID: 19788731
Humans have a tendency to seek out their own kind, preferring others who have the same skin colour, the same culture and, yes, the same religion.
What's more, there seems to be some sort of connection. People who are the most stridently religious also tend to be more racist, and to generally be more cautious about dealing with people from outside their own group.
Does this connection stem from some deep, common mechanism that drives people to be suspicious of non-group members (a "central affi........ Read more »
Lewis GJ, & Bates TC. (2010) Genetic evidence for multiple biological mechanisms underlying in-group favoritism. Psychological science : a journal of the American Psychological Society / APS, 21(11), 1623-8. PMID: 20974715
Ole Magga, Norwegian politician
On this blog I regularly get questions about the Sami (Lapp*). That’s because I often talk about Finnish genetics, have readers such as Clark who are of part-Sami origin, and, the provenance and character of the Sami speak to broader questions about the emergence of the modern European gene pool. More precisely [...]... Read more »
Maki-Torkko, Elina, Aikio, Pekka, Sorri, Martti, Huentelman, Matthew J, & Camp, Guy Van. (2010) A genome-wide analysis of population structure in the Finnish Saami with implications for genetic association studies. European Journal of Human Genetics. info:/10.1038/ejhg.2010.179
Traditionally, psychiatrists saw the paranoia exhibited by patients with schizophrenia as qualitatively different from the feelings of mistrust and suspicion expressed by 'healthy' people. Today that view is changing. New research, much of it by psychologists, is demonstrating that clinical paranoia is on a continuum with the experiences of the general public (see earlier). Much of this has involved use of questionnaires or interviews to gauge rates of paranoid feeling in non-clinical samples. B........ Read more »
Green CE, Freeman D, Kuipers E, Bebbington P, Fowler D, Dunn G, & Garety PA. (2011) Paranoid explanations of experience: a novel experimental study. Behavioural and cognitive psychotherapy, 39(1), 21-34. PMID: 20846468
An interesting study by Lluch & Kanavos (2009) in which they examine the regulation of community pharmacies in two context, the UK and Spain. Lluch & Kanavos contend that in the early part of this century in the EU there appears to have been an increasing move toward deregulation in community pharmacy with the view [...]... Read more »
Lluch M, & Kanavos P. (2010) Impact of regulation of Community Pharmacies on efficiency, access and equity. Evidence from the UK and Spain. Health policy (Amsterdam, Netherlands), 95(2-3), 245-54. PMID: 20056292
We can all articulate the importance of using model organisms to understand biology, but many of us fall short in our understanding of some of the more uncommon model organisms. Thankfully, there are amazing biologists out there that save the day! These researchers use some of the more atypical model organisms to understand how different [...]... Read more »
Vargas-Vila, M., Hannibal, R., Parchem, R., Liu, P., & Patel, N. (2010) A prominent requirement for single-minded and the ventral midline in patterning the dorsoventral axis of the crustacean Parhyale hawaiensis. Development, 137(20), 3469-3476. DOI: 10.1242/dev.055160
Is it possible that a lack of centralisation reflects a predominance of centralisation? Well, the undisputed wrestling champion of physical therapy is wrestling with this very topic, having been motivated by an intruiging paper. Fortunately for BiM, John kindly agreed to write a post on it. Here it is: Here is a riddle for you. [...]... Read more »
Werneke, M., & Hart, D. (2005) Centralization: Association between repeated end-range pain responses and behavioral signs in patients with acute non-specific low back pain. Journal of Rehabilitation Medicine, 37(5), 286-290. DOI: 10.1080/16501970510032901
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