Yesterday I mentioned that a key aspect of fighting AIDS is staying on the drug regimen. Charles pointed out that this is more difficult than it might seem: the drugs are constant reminder of your condition, and taking them can revive horrible memories.
But how important is it to maintain adherence to the regimen? A 2008 [...]... Read more »
Bisson, G., Gross, R., Bellamy, S., Chittams, J., Hislop, M., Regensberg, L., Frank, I., Maartens, G., & Nachega, J. (2008) Pharmacy Refill Adherence Compared with CD4 Count Changes for Monitoring HIV-Infected Adults on Antiretroviral Therapy. PLoS Medicine, 5(5). DOI: 10.1371/journal.pmed.0050109
Cells tend to produce unwanted protein aggregates and other molecular refuse slightly faster than they can get rid of it, resulting in a time-dependent accumulation of potentially toxic cellular garbage. This, in turn, can cause an age-dependent loss of cellular viability, which is (in certain contexts) a fair operational definition of aging.
How can cells deal [...]... Read more »
Liu, B., Larsson, L., Caballero, A., Hao, X., Öling, D., Grantham, J., & Nyström, T. (2010) The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates. Cell, 140(2), 257-267. DOI: 10.1016/j.cell.2009.12.031
by amiya in Physiology physics woven fine
Mobile phones have drastically transformed our lives. Also known as cellular phones or cell phones, these gadgets not only incorporate a phone, as the name suggests, but also a lot of other technologically advanced features. They include a camera, a sound recorder cum music system, a Bluetooth device and many more depending on the model and the maker of the phone. They are called mobile phones since they can be used while on the move.A mobile phone maintains a two way (transmit and receive) comm........ Read more »
Gary W. Arendash, Juan Sanchez-Ramos, Takashi Mori, Malgorzata Mamcar, Xiaoyang Lin, Melissa Runfeldt, Li Wang, Guixin Zhang, Vasyl Sava, Jun Tan.... (2010) Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice . Journal of Alzheimer's Disease, 191-210. info:/
There is considerable deliberations on the international policy agreements on each countries’ magnitude of CO2 reductions to avert catastrophic consequences due to climate change. The main indicator for the allocations are based on the percentage reductions in emission rates relative to 1990. This has had a tendency to split international negotiations into developed and developing countries. The difficulty is due to four main factors with respect to each country: population levels, wealth,........ Read more »
Zickfeld, K., Eby, M., Matthews, H., & Weaver, A. (2009) From the Cover: Setting cumulative emissions targets to reduce the risk of dangerous climate change. Proceedings of the National Academy of Sciences, 106(38), 16129-16134. DOI: 10.1073/pnas.0805800106
Yesterday a couple of colleagues were talking about balance in life, and making it plain that they think people who spend a lot of time and energy on their work are sad. Their opinion? Work is the means to pay for your ‘real’ life, to spend more on working means less on what is really [...]... Read more »
MCCRACKEN, L., & VOWLES, K. (2007) Psychological Flexibility and Traditional Pain Management Strategies in Relation to Patient Functioning With Chronic Pain: An Examination of a Revised Instrument. The Journal of Pain, 8(9), 700-707. DOI: 10.1016/j.jpain.2007.04.008
GUTIERREZ, O., LUCIANO, C., RODRIGUEZ, M., & FINK, B. (2004) Comparison between an acceptance-based and a cognitive-control-based protocol for coping with pain*. Behavior Therapy, 35(4), 767-783. DOI: 10.1016/S0005-7894(04)80019-4
Welcome to the third part (of 4) of the current series on navigation. For a review, you can go read about path integration in the desert ant, and also read about navigation in the gerbil.
The question for today is: is path integration innate, or is it learned (even if only minimal experience is required)?
Let us [...]... Read more »
U. von Saint Paul. (1982) Do Geese Use Path Integration for Walking Home?. F. Papi , 296-307. info:/
Altruistic behavior is one of the great unsolved problems of social science research. What I find particularly fascinating is the huge effect that very subtle cues can exhibit on people's giving behavior...or not so subtle cues, like when you're made to feel God might be watching you...... Read more »
Shariff, A., & Norenzayan, A. (2007) God Is Watching You: Priming God Concepts Increases Prosocial Behavior in an Anonymous Economic Game. Psychological Science, 18(9), 803-809. DOI: 10.1111/j.1467-9280.2007.01983.x
HALEY, K., & FESSLER, D. (2005) Nobody's watching?Subtle cues affect generosity in an anonymous economic game. Evolution and Human Behavior, 26(3), 245-256. DOI: 10.1016/j.evolhumbehav.2005.01.002
Last month, a terrible earthquake raised havoc in Port-au-Prince, Haiti. While the Haitians in Port-au-Prince are miles away from us, witnessing media images of their physical and emotional suffering moves us tremendously, and motivates many of us to respond to their distress with monetary and other donations. In a sense, this is an amazing human [...]... Read more »
Rizzolatti, G. (1996) Premotor cortex and the recognition of motor actions. Cognitive Brain Research, 3(2), 131-141. DOI: 10.1016/0926-6410(95)00038-0
Decety, J., & Meyer, M. (2008) From emotion resonance to empathic understanding: A social developmental neuroscience account. Development and Psychopathology, 20(04), 1053. DOI: 10.1017/S0954579408000503
If there is one aspect of "complementary and alternative" medicine (CAM) that can puzzle advocates of science-based medicine, it's why, given how nonsensical much of it is given that some of it actually goes against the laws of physics (think homeopathy or distance healing), CAM is so popular. Obviously one reason is that there are conditions for which SBM does not have any "magic bullet" treatments. Diabetes, heart disease, other chronic illnesses, SBM can manage them quite well, but it can't c........ Read more »
Heiligers, P., de Groot, J., Koster, D., & van Dulmen, S. (2010) Diagnoses and visit length in complementary and mainstream medicine. BMC Complementary and Alternative Medicine, 10(1), 3. DOI: 10.1186/1472-6882-10-3
In order to protect the relative genetic health of jaguar populations and to establish priorities for habitat conservation, researchers use an innovative model to map potential corridors between 90 remaining areas of high jaguar density throughout Central and South America...... Read more »
Rabinowitz, A., & Zeller, K. (2010) A range-wide model of landscape connectivity and conservation for the jaguar, Panthera onca. Biological Conservation. DOI: 10.1016/j.biocon.2010.01.002
The distribution of colour terms on Wikipedia correlates with the human Just Noticable Difference Curve.... Read more »
Long F, Yang Z, & Purves D. (2006) Spectral statistics in natural scenes predict hue, saturation, and brightness. Proceedings of the National Academy of Sciences of the United States of America, 103(15), 6013-8. PMID: 16595630
A fascinating thing about DNA replication is that the actual process lacks the ability to replicate the very ends of chromosomes. That means chromosomes should get shorter with every round of cell division (DNA replication), but they remain more or less the same length, getting gradually shorter with aging. The natural shortening of chromosomes is [...]... Read more »
Shore, D., & Bianchi, A. (2009) Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase. The EMBO Journal, 28(16), 2309-2322. DOI: 10.1038/emboj.2009.195
Codd, V., Mangino, M., van der Harst, P., Braund, P., Kaiser, M., Beveridge, A., Rafelt, S., Moore, J., Nelson, C., Soranzo, N.... (2010) Common variants near TERC are associated with mean telomere length. Nature Genetics. DOI: 10.1038/ng.532
After getting over my little moment of rage there, I decided to go ahead and redo the forams while I could still vaguely remember the phylogeny, sort of. So here comes the Tree of Eukaryotes Expansion Pack: Forams!I hope somebody is happy now, after nagging me about the freaking forams for the past two weeks! I know they deserve more space, and I did them an awful injustice by shrinking the entire group to just 'Forams'. Since I still haven't figured out the space problem (should I just shrink e........ Read more »
HABURA, A., GOLDSTEIN, S., PARFREY, L., & BOWSER, S. (2006) Phylogeny and Ultrastructure of Miliammina fusca: Evidence for Secondary Loss of Calcification in a Miliolid Foraminifer. The Journal of Eukaryotic Microbiology, 53(3), 204-210. DOI: 10.1111/j.1550-7408.2006.00096.x
LONGET, D., & PAWLOWSKI, J. (2007) Higher-level phylogeny of Foraminifera inferred from the RNA polymerase II (RPB1) gene. European Journal of Protistology, 43(3), 171-177. DOI: 10.1016/j.ejop.2007.01.003
The vivid, intrusive visual images that are a hallmark of post-traumatic disorder (PTSD) are based on a separate memory system from intrusive verbal thoughts. That's according to a new study that claims to provide empirical support for psychologist Chris Brewin's dual-representation theory of PTSD.Brewin's theory posits two memory systems, one that's largely sensation-based, inflexible and automatically accessed and another that's more deliberately accessible, containing material that is context........ Read more »
Hagenaars, M., Brewin, C., van Minnen, A., Holmes, E., & Hoogduin, K. (2010) Intrusive images and intrusive thoughts as different phenomena: Two experimental studies. Memory, 18(1), 76-84. DOI: 10.1080/09658210903476522
It is a long-standing argument among religious believers that religiosity were necessary for morality. In a recent Trends in Cognitive Sciences article (requires subscription), Pyysiäinen and Hauser argue that morality can arise and indeed can be found without and before any religious education and thus religion is a by-product of pre-existing cognitive properties of the brain. Indeed, religion is not ubiquitous, as for instance the Hadza's religion has been described as 'minimal', and yet, coo........ Read more »
Ilkka Pyysiäinen, & Marc Hauser. (2010) The origins of religion: evolved adaptation or by-product?. Trends in Cognitive Sciences. info:/10.1016/j.tics.2009.12.007
The strongest evidence exists for Broadman Area 25 in the subcallosal cingulate gyrus (SCG) as target for deep brain stimulation in treatment resistant depression. This area in the brain is depicted in the figure above and is from the most important publication about DBS and depression in Neuron march 2005 by Helen Mayberg. Functional neuroimaging [...]
Related posts:Deep Brain Stimulation for Treatment Resistant depression New data are being published about deep brain stimulation...
New Kin........ Read more »
Hamani, C., Mayberg, H., Snyder, B., Giacobbe, P., Kennedy, S., & Lozano, A. (2009) Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting. Journal of Neurosurgery, 111(6), 1209-1215. DOI: 10.3171/2008.10.JNS08763
by Merry Youle in Small Things Considered
On first inspection the habitat seems as sterile as the surface of autoclaved glassware... but the trained eye, aided by a microscope, sees otherwise.
E.O. Wilson, The Future of Life
For the microbiologist, the next best thing to a trip to Mars might well be an expedition to the McMurdo Dry Valleys of Antarctica. Here, in the Earth's coldest and driest deserts, the conditions approach those on our neighboring planet and are thought to also approach the cold-arid limit for life.... Read more »
Pointing SB, Chan Y, Lacap DC, Lau MC, Jurgens JA, & Farrell RL. (2009) Highly specialized microbial diversity in hyper-arid polar desert. Proceedings of the National Academy of Sciences of the United States of America, 106(47), 19964-9. PMID: 19850879
A 7 year-old girl was brought to hospital with lethargy, irritability and vomiting. A week previously she developed chicken pox, and was treated with regular aspirin and paracetamol for fever and discomfort.... Read more »
Glasgow JF, & Middleton B. (2001) Reye syndrome--insights on causation and prognosis. Archives of disease in childhood, 85(5), 351-3. PMID: 11668090
Schrör K. (2007) Aspirin and Reye syndrome: a review of the evidence. Paediatric drugs, 9(3), 195-204. PMID: 17523700
Cherie Booth was in the news this week for giving a suspended prison sentence to a man who broke another guy's jaw in an assault, apparently on the grounds that he was religious. Here's the offending quote: “I am going to suspend this sentence for the period of two years based on the fact you are a religious person and have not been in trouble before," she told him at Inner London Crown Court. "You caused a mild fracture to the jaw of a member of the public standing in a queue at L........ Read more »
Think of something wonderful - something someone said to you that made your day, or the happiest moment you can remember. Go ahead, take a moment. Now, what are you doing? Odds are, you're smiling.
It takes 12 different muscles in our faces to produce the easily-recognized expression. But smiling is far from a tough feat for our facial muscles. Smiles are so hard-wired into the human condition that babies have been known to smile before birth. Smiling is as instinctual to us as breathing.
Why ........ Read more »
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