Post List

  • June 9, 2010
  • 12:17 PM

A new target for hepatitis C virus

by Vincent Racaniello in virology blog

When infection with hepatitis C virus goes from acute to chronic, severe liver disease may occur which requires organ transplantation. Nearly 200 million people are chronically infected with HCV, necessitating approaches to preventing and treating infections. No HCV vaccine is available, and current antiviral therapy consists of administration of interferon plus ribavirin, a combination that [...]... Read more »

Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR 2nd.... (2010) Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature, 465(7294), 96-100. PMID: 20410884  

  • June 9, 2010
  • 11:08 AM

Galarraga's Almost Perfect Game and the Flash Lag Illusion

by Brad Walters in Cortical Hemming and Hawing

There's been a big sports story that has been getting a lot of press lately.  Armando Galarraga of the Detroit Tigers was on his way to pitching a perfect game, that is, he had pitched 8 and 2/3 innings and hadn't let a single person get on base (no hits, no walks, just 3 batters up and 3 down, every inning).  Philadelphia Phillies pitcher Roy Halladay recently pitched a perfect game against the Florida Marlins, but don't be fooled... his perfect game was only the 20th in the history o........ Read more »

  • June 9, 2010
  • 10:05 AM

The "Big Four," part IV: Migration

by Jeremy Yoder in Denim and Tweed

This post is the last in a special series about four fundamental forces in evolution: natural selection, mutation, genetic drift, and migration.

It's the little differences. I mean, they got the same shit over there that we got here, but it's just—it's just there it's a little different.
— Vincent, Pulp FictionDifferent places are different from each other. This is a truism bordering on tautology, but it also has real implications for the ways in which life evolves and diversifies. The spec........ Read more »

Good J.M., Hird S., Reid N., Demboski J.R., Steppan S.J., Martin-Nims T.R., & Sullivan J. (2008) Ancient hybridization and mitochondrial capture between two species of chipmunks. Molecular ecology, 17(5), 1313-27. PMID: 18302691  

Wright, S.J. (1943) Isolation by distance. Genetics, 139-56. info:other/PMC1209196

  • June 9, 2010
  • 10:00 AM

The Lies That Data Tell

by Richard Landers in NeoAcademic

Without a clear rationale for doing so, statistical significance testing on sample-level statistics can mislead and confuse. Schmidt (2010) provides a clear explanation of how to avoid this problem through psychometric meta-analysis.... Read more »

Schmidt, F. (2010) Detecting and correcting the lies that data tell. Perspectives on Psychological Science, 233-242. DOI: 10.1177/1745691610369339  

  • June 9, 2010
  • 09:55 AM

When Diplodocus Invaded Europe

by Brian Switek in Dinosaur Tracking

On July 4, 1899, the steel tycoon Andrew Carnegie finally got his Diplodocus. He had set his eye on this fossil prize in the fall of the previous year when the New York Journal ran a fanciful illustration of the giant dinosaur peeping into a 10th story skyscraper window, and after some initial disappointments the [...]... Read more »

  • June 9, 2010
  • 09:52 AM

The Life and TImes of a Cellular Signal

by Nachiket Vartak in Emergent Noise

A high-throughput method uses an broad specificity reagent and a specific optical signal to capture a snapshot of signaling mediated phosphorylation in living cells.... Read more »

Grecco, H., Roda-Navarro, P., Girod, A., Hou, J., Frahm, T., Truxius, D., Pepperkok, R., Squire, A., & Bastiaens, P. (2010) In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays. Nature Methods, 7(6), 467-472. DOI: 10.1038/nmeth.1458  

  • June 9, 2010
  • 09:09 AM

“As Close to a ‘Polluting Plant’ As One Can Find”

by Promega Corporation in Promega Connections

Far Eastern vines Run from the clay banks they are Supposed to keep from eroding. Up telephone poles, Which rear, half out of leafage As though they would shriek, Like things smothered by their own Green, mindless, unkillable ghosts. In Georgia, the legend says That you must close your windows At night to keep it [...]... Read more »

  • June 9, 2010
  • 08:30 AM

Bonobos Share Their Food

by Jason Goldman in The Thoughtful Animal

Bonobo Week continues! I'm donating whatever proceeds I receive from my blogging shenanigans for the entire month of June to help the bonobos at Lola Ya Bonobo.

Primate researchers used to think that only humans voluntarily share their own food with others. At the time, it was a reasonable conclusion to make, since lots of studies indicated that chimps don't. But that was before anyone checked to see if bonobos were willing to share their food with others.
Read the rest of this post... | Read........ Read more »

  • June 9, 2010
  • 08:00 AM

Antidepressants Carry Equal Risks

by Shaheen Lakhan in Brain Blogger

For nearly a decade, the public has heeded warnings of suicidal behavior related to antidepressant use in children and adolescents. However, the use of antidepressants in this population is still increasing. Initially, selective serotonin reuptake inhibitors (SSRIs), the most common class of antidepressants prescribed for children, were the only drugs associated with the increase in [...]... Read more »

Jick H, Kaye JA, & Jick SS. (2004) Antidepressants and the risk of suicidal behaviors. JAMA : the journal of the American Medical Association, 292(3), 338-43. PMID: 15265848  

Schneeweiss S, Patrick AR, Solomon DH, Dormuth CR, Miller M, Mehta J, Lee JC, & Wang PS. (2010) Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts. Pediatrics, 125(5), 876-88. PMID: 20385637  

Simon GE, Savarino J, Operskalski B, & Wang PS. (2006) Suicide risk during antidepressant treatment. The American journal of psychiatry, 163(1), 41-7. PMID: 16390887  

Vitiello B, Silva SG, Rohde P, Kratochvil CJ, Kennard BD, Reinecke MA, Mayes TL, Posner K, May DE, & March JS. (2009) Suicidal events in the Treatment for Adolescents With Depression Study (TADS). The Journal of clinical psychiatry, 70(5), 741-7. PMID: 19552869  

  • June 9, 2010
  • 08:00 AM

Why do butterflies have marginal eyespots?

by Rob Goldstein in Conservation Maven

... Read more »

  • June 9, 2010
  • 05:07 AM

Clearing up eukaryotic life histories

by Psi Wavefunction in Skeptic Wonder

I can still vaguely recall the horrid hell that was my second year "non-vascular 'plant'" course (valid contender for most polyphyletic course in existence...) - amid the poorly explained phylogenetic clusterfuck, we also had to cram life cycle diagrams from hell. Ever thought red algae looked cute? Not quite so much after realising you get three fundamental life cycle phases to plow through...the night before a final, as it always is. In hindsight, it actually makes a lot of sense, once you gra........ Read more »

  • June 9, 2010
  • 05:03 AM

by Lars Fischer in EuCheMS 2010 Blog

With increasing demand for effective separation of small-molecule gases – think of carbon caption and storage – there has been a lot of research recently into strategies and materials suitable for those applications. The traditional way to separate gases like nitrogen, oxygen or carbon dioxide is to freeze them out one by one, which is [...]... Read more »

  • June 9, 2010
  • 05:00 AM

Nature promotes vitality in people, study finds

by Rob Goldstein in Conservation Maven

New research shows that interaction with nature, whether actual or imagined, has a significantly positive effect on self-reported levels of mental and physical energy...... Read more »

Ryan, R., Weinstein, N., Bernstein, J., Brown, K., Mistretta, L., & Gagné, M. (2010) Vitalizing effects of being outdoors and in nature. Journal of Environmental Psychology, 30(2), 159-168. DOI: 10.1016/j.jenvp.2009.10.009  

  • June 9, 2010
  • 04:01 AM

the media finds life on titan. sort of…

by Greg Fish in weird things

Around the web, headlines are buzzing about alleged evidence for life on Saturn’s biggest moon Titan, citing a paper which noted a suspicious lack of hydrogen build-up in the lower atmosphere and listing among many a mundane explanation, the possibility of methane-based life. Now, while on this blog I discussed that it’s not impossible to [...]... Read more »

  • June 9, 2010
  • 12:14 AM

…Just hook it up to my veins!

by Rift in Psycasm

In a previous post I reported that ‘fascinating stimuli’ are potentially better at restoring attention/vigilance than non-fascinating stimuli (Zainaghi and Bettella, 2009) [here]; and that, in my opinion, this was more effective than going and spending time observing natural settings (Berman, Jonides and Kaplan, 2008) [here]. We’ll in looking at that I’ve tried a few [...]... Read more »

  • June 8, 2010
  • 11:34 PM

The neuroscience of birdsong

by NeuroKüz in NeuroKüz

I’ve decided to write a couple of articles on a relatively underappreciated area of neuroscience: the study of birds. I hope to demonstrate that although the term “bird brain” is used as an insult in everyday bicker, the tiny brains of birds are more complex than they are perceived to be. Bird brains may even be able to teach us a thing or two about the brightest of human brains. In this first post, I will describe birdsong – a rare example of music production in nonhumans.You’ve proba........ Read more »

Brenowitz EA, Margoliash D, & Nordeen KW. (1997) An introduction to birdsong and the avian song system. Journal of neurobiology, 33(5), 495-500. PMID: 9369455  

Teramitsu I, Kudo LC, London SE, Geschwind DH, & White SA. (2004) Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(13), 3152-63. PMID: 15056695  

  • June 8, 2010
  • 10:22 PM

Copepod Power

by Kelsey in Mauka to Makai

It’s human nature to think of the big bad animals that eat other animals as powerful and the animals that get eaten as wimpy. Of course, humans are often wrong (see “clusterf**kery”). Copepods get eaten by lots of animals—even by critters like jellyfish and right whales, which are known for their lack of speed—but they’re [...]... Read more »

Kiørboe T, Andersen A, Langlois VJ, & Jakobsen HH. (2010) Unsteady motion: escape jumps in planktonic copepods, their kinematics and energetics. Journal of the Royal Society, Interface / the Royal Society. PMID: 20462876  

  • June 8, 2010
  • 09:39 PM

Shape Shifter

by Journal Watch Online in Journal Watch Online

Fish evolve different body shapes in reservoirs

... Read more »

Haas, T.C., Blum, M.J., & D.C. Heins. (2010) Morphological responses of a stream fish to water impoundment. Biology Letters. info:/10.1098/rsbl.2010.0401

  • June 8, 2010
  • 08:03 PM

Group-based CBT for pain in primary care

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

I briefly discussed yesterday the content of this six-session group-based cognitive behavioural approach for chronic pain, delivered in the community. Today I want to look a little more closely at the way the programme was delivered and how the findings might differ from what happens in New Zealand. To refresh your memory, this is a … Read more... Read more »

  • June 8, 2010
  • 07:02 PM

Wake-Up Call

by Journal Watch Online in Journal Watch Online

Sedentary snake populations are dwindling

... Read more »

Reading, C.J. et al. (2010) Are snake populations in widespread decline?. Biology Letters. info:/10.1098/rsbl.2010.0373

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