Post List

  • September 14, 2010
  • 09:11 AM

Predicting new molecular targets for known drugs, Pharm 551A: Keiser et al., 2009


On the agenda today is a fascinating paper titled: predicting new molecular targets for known drugs, Keiser et al., Nature 2009 [PMC]. This is one of my favorite papers of the past two years. I have to admit that it … Continue reading →... Read more »

Keiser, M., Setola, V., Irwin, J., Laggner, C., Abbas, A., Hufeisen, S., Jensen, N., Kuijer, M., Matos, R., Tran, T.... (2009) Predicting new molecular targets for known drugs. Nature, 462(7270), 175-181. DOI: 10.1038/nature08506  

  • September 14, 2010
  • 09:10 AM

Quantifying biogenic bias in screening libraries, Pharm 551A: Hert et al. 2009


Today’s paper [PMC] is Hert et al., (2009) Quantifying biogenic bias in screening libraries. At issue for todays class is a discussion about one of the first steps in drug discovery, compound library selection and generation. The authors of this … Continue reading →... Read more »

Hert, J., Irwin, J., Laggner, C., Keiser, M., & Shoichet, B. (2009) Quantifying biogenic bias in screening libraries. Nature Chemical Biology, 5(7), 479-483. DOI: 10.1038/nchembio.180  

  • September 14, 2010
  • 09:09 AM

Rapid behavior-based identification of neuroactive small molecules in the zebrafish, Pharm 551A: Kokel et al., 2010


Today’s paper is a continuation of our discussion on screening compounds for drug discovery: Kokel et al, 2010 Rapid behavior-based identification of neuroactive small molecules in the zebrafish, Nature Chemical Biology [PMC]. Having just returned from the IASP meeting in … Continue reading →... Read more »

Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C., Mateus, R., Healey, D., Kim, S., Werdich, A., Haggarty, S.... (2010) Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nature Chemical Biology, 6(3), 231-237. DOI: 10.1038/nchembio.307  

  • September 14, 2010
  • 09:05 AM

What keeps mutualists honest—cake, or death?

by Jeremy Yoder in Denim and Tweed

Somewhat like cooperation between members of the same species, mutually beneficial interactions between different species should be prone to fall apart when one species evolves a way to cheat the other. Biologists who study mutualism (myself included) have long believed that the solution to cheating is to punish cheaters—but a new model suggests that the benefits gained from playing nice might be enough to deter cheating [PDF].

I knew I had to write about this one when I saw that the authors ........ Read more »

  • September 14, 2010
  • 09:00 AM

Metabolically-Healthy Obese: Prospective Risk of Disease (Series Pt 2/5)

by Peter Janiszewski, Ph.D. in Obesity Panacea

Yesterday, we introduced the fascinating and seemingly paradoxical concept of metabolically-healthy obesity. Today is part 2 of our 5-part series, in which we discuss evidence regarding the prospective risk of disease among the so-called metabolically-healthy obese.
The cross-sectional research certainly supports the existence of a sub-population of metabolically-health obese individuals; approximately 1 in 3 obese individuals has a healthy metabolic profile. But what about the chances of devel........ Read more »

  • September 14, 2010
  • 08:22 AM

Moonlight and Mild Temps Inspire Owl Monkeys

by Laura Klappenbach in About Animals / Wildlife

Azara's owl monkeys move to the rhythm of the moon. On nights when a full moon floods the evening sky with light, Azara's owl monkeys cannot sit still. They are so active that by dawn the next morning, they are worn out. But when the lunar cycle wanes and the moonlight fades, Azara's owl monkeys grow less active at night. On mornings after moonless nights, they are more active during the dawn hours.
The owl monkey genus is unique among anthropoids (monkeys, apes and humans) because it is the onl........ Read more »

  • September 14, 2010
  • 08:00 AM

Weight Perception And Weight Management Behaviours Across Ethnic Groups

by Arya M. Sharma in Dr. Sharma's Obesity Notes

The perception of excess weight, both as an aesthetic and a health problem, variesy considerably amongst racial/ethnic groups.
But how does this variation in weight perception affect actual weight management behaviours?
This question was addressed by R Dorsey and colleagues from the Centers for Disease Control and Prevention, Hyattsville, MD, USA, in a paper just published in [...]... Read more »

  • September 14, 2010
  • 08:00 AM

7 rules for social networking

by David Bradley in Sciencetext

Technology is transforming the way we many of us communicate. From those queuing up to join the “privacy aware” social network Diaspora and the half a billion Facebook users to Africans bartering call-time on mobile phones through cellular banking and the countless Brazilian users of Google Orkut. We are all becoming connected. The Internet began [...]Post from: David Bradley's Sciencetext Tech Talk7 rules for social networking
... Read more »

Tanuja Singh, & Joe Cullinane. (2010) Social networks and marketing: potential and pitfalls. Int. J. Electronic Marketing and Retailing, 3(3), 202-220. info:/

  • September 14, 2010
  • 07:48 AM

All quiet on the Alpine Fault?

by Chris Rowan in Highly Allochthonous

The Alpine fault has not ruptured since European settlement in the 1840s. Paleoseismology tells us that this is the longest it has gone in a millenium without generating a magnitude 8+ earthquake. Continue reading →... Read more »

  • September 14, 2010
  • 07:42 AM

Breastfeeding may prevent disease by changing gene expression in the gut flora

by Melinda Moyer in Body Politic

Let’s face it: breast milk is pretty amazing. It contains antibodies that help wee ones establish strong immune systems, and some studies suggest the act of breastfeeding even lowers mom’s breast cancer risk. Now researchers at the Universities of Chicago, Maryland, and Illinois have another potential bonus to add to the mix: according to a study they conducted in pigs, breast milk shapes the expression of bacterial genes in the infant gut, potentially boosting antioxidant activity ........ Read more »

Poroyko V, White JR, Wang M, Donovan S, Alverdy J, Liu DC, & Morowitz MJ. (2010) Gut microbial gene expression in mother-fed and formula-fed piglets. PloS one, 5(8). PMID: 20805981  

AYCICEK, A., EREL, O., KOCYIGIT, A., SELEK, S., & DEMIRKOL, M. (2006) Breast milk provides better antioxidant power than does formula. Nutrition, 22(6), 616-619. DOI: 10.1016/j.nut.2005.12.011  

  • September 14, 2010
  • 07:13 AM

The silver age of altitude adaptation

by Razib Khan in Gene Expression

With all the justified concern about “missing heritability”, the age of human genomics hasn’t been a total bust. As I have observed before in 2005’s excellent book Mutants the evolutionary geneticist Armand M. Leroi asserted that we really didn’t have a good understanding of normal variation of human pigmentation. At the time I think it [...]... Read more »

Bigham A, Bauchet M, Pinto D, Mao X, & Akey JM. (2010) Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data. PLoS Genetics. info:/

  • September 14, 2010
  • 05:49 AM

What are participants really up to when they complete an online questionnaire?

by BPS Research Digest in BPS Research Digest

Internet surveys are an increasingly popular method for collecting data in psychology, for obvious reasons, but they have some serious shortcomings. How do you know if a participant read the instructions properly? What if they clicked through randomly, completed it drunk or maybe their cat walked across the keyboard? Now a possible solution has arrived in the form of a tool, called the UserActionTracer (UAT), developed by Stefan Stieger and Ulf-Dietrich Reips.

The UAT is a piece of code that te........ Read more »

  • September 14, 2010
  • 05:44 AM

conspicuous facultative mimicry in octopuses

by alison in bioblog

Or should that be octopodes? Anyway, this is so much more interesting than so-called psychic octopuses: an octopus whose mimicry can make it more conspicuous, not less.The 'mimic' octopus (Thaumoctopus mimicus - now, there's a name that Terry Pratchett would appreciate)...... Read more »

CL Huffard, N Saarman, H Hamilton . (2010) The evolution of conspicuous facultative mimicry in octopuses: an example of secondary adaptation?. Biological Journal of the Linnaean Society, 68-77. info:/

  • September 14, 2010
  • 05:33 AM

Difficult decisions

by David Winter in Careers - in Theory

With all the various ways in which the decision-making process could go wrong, it's a surprise that anyone ever makes any good decisions. But what exactly could go wrong? Does anyone have a list?... Read more »

Gati, I., Krausz, M., & Osipow, S. (1996) A taxonomy of difficulties in career decision making. Journal of Counseling Psychology, 43(4), 510-526. DOI: 10.1037/0022-0167.43.4.510  

  • September 14, 2010
  • 05:30 AM

British ethical foreign policy may be able to justify the intervention in Afghanistan but can it defend the invasion of Iraq?

by SAGE Insight in SAGE Insight

The politics of ethical foreign policy: A responsibility to protect whom? From European Journal of International Relations With the 9/11 anniversary just a few days ago, plus the recent publication of Tony Blair’s autobiography, once again there is much public debate regarding the justification and achievements of the foreign policy implemented over the last decade [...]... Read more »

  • September 14, 2010
  • 02:45 AM

Here's Why Bush Had Better Luck Than Obama In Fighting Anti-Muslim Bigotry

by David Berreby in Mind Matters

In the White House, can a white conservative do more to restrain anti-Islamic bigotry than an African-American progressive? Writing on the anniversary of 9/11, a couple of writers Saturday argued that this is so. Studies on the psychology of prejudice suggest they're right.
Chicken crusaders—Americans who have nothing to fear from Muslims, yet feel free to attack and insult them—are becoming a global problem, as their hatred provokes mirror-image rhetoric in the Muslim worl........ Read more »

  • September 14, 2010
  • 02:37 AM

Chocolate as Antimalarial Prophylaxis

by Dr Shock in Dr Shock MD PhD

Although the tropical regions produce 75% of the worlds cocoa production only 4% of the cocoa is consumed by these regions. These regions also suffer the most from malaria. Malaria is one of the top three killers among infectious diseases. There are numerous anecdotal reports and personal subjective observations of reduced episodic malaria in [...]

Related posts:How does Chocolate protect the Heart?
Short-term Chocolate Effects on Health
Chocolate and Cardiovascular Health
... Read more »

  • September 13, 2010
  • 11:38 PM

Chemical hazards from swimming pools?

by Ashartus in exposure/effect

Three new “ahead of print” articles in Environmental Health Perspectives look at potential health effects from swimming in pools with chlorinated water. One study (by Richardson et al.)  identified the disinfection by-products present in chlorinated and brominated swimming pool water, and related them to mutagenicity. A pair of related studies looked at biomarkers of genotoxicity/carcinogenicity [...]... Read more »

Kogevinas, M., Villanueva, C., Font-Ribera, L., Liviac, D., Bustamante, M., Espinoza, F., Nieuwenhuijsen, M., Espinosa, A., Fernandez, P., DeMarini, D.... (2010) Genotoxic Effects in Swimmers Exposed to Disinfection By-products in Indoor Swimming Pools. Environmental Health Perspectives. DOI: 10.1289/ehp.1001959  

  • September 13, 2010
  • 10:35 PM

The wandering male versus female brain

by NeuroKüz in NeuroKüz

There has certainly been a good amount of recent controversy over the science of sex differences and the brain. Pop-science books such as The Male Brain and The Female Brain that emphasize (and probably exaggerate) sex differences have drawn major criticism. A couple of new books expose flaws in the stereotypical 'men think about sex every 5 seconds because they are programmed to' theory and related ideologies.The above figure summarizes the well-accepted theory of male versus female brain funct........ Read more »

  • September 13, 2010
  • 10:05 PM

Using eyetracking to investigate language comprehension in autism

by Jon Brock in Cracking the Enigma

In her classic book, Autism: Explaining the Enigma, Uta Frith coined the term 'weak central coherence' to describe the tendency of people with autism to focus on details at the expense of pulling together different sources of information and seeing the big picture. Frith described this as the "red thread" running through many of the symptoms of autism, including both the difficulties with social interaction and the strengths in attention to detail.

Frith argued that the ability to pull togeth........ Read more »

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