Post List

  • January 6, 2011
  • 09:57 AM

How to swap a gearbox for a new model right on the highway

by Vasili Hauryliuk in stringent response

Protein biosyntheses is central a hub for cellular physiology: proteins are essencial for all the cellular processes. Therefore changing something really important in translational machinery is really hard: you still need producing proteins! Swapping an important translational factor for another one? That sounds impossible, but this is exactly what happend with eEF1A - eukaryotic factor that brings aminoacylated tRNA to the ribosome. Moreover, it happened several times!It was indeed swapped for ........ Read more »

  • January 6, 2011
  • 09:50 AM


by Eva Amsen in the Node

The modENCODE project (model organism encyclopedia of DNA elements) is a collaborative effort to identify all sequence-based functional elements of Drosophila and C. elegans. The project has now produced almost a thousand data sets with information about transcription, epigenetics, replication and gene regulation across different developmental stages and multiple cell lines.

Just before the holidays, [...]... Read more »

The modENCODE Consortium, ., Roy, S., Ernst, J., Kharchenko, P., Kheradpour, P., Negre, N., Eaton, M., Landolin, J., Bristow, C., Ma, L.... (2010) Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE. Science, 330(6012), 1787-1797. DOI: 10.1126/science.1198374  

  • January 6, 2011
  • 08:11 AM

Why pregnant women deserve drug trials

by Melinda Moyer in Body Politic

It’s easy to gloss over health care disparities until they start really affecting you or your loved ones. When I became pregnant this summer, I discovered that there is a dearth of information available about drug safety during pregnancy. (I wrote a little about it in this Slate article published in July.) Women who rely on medication get pregnant—for instance, one in eight pregnant women takes antidepressants—and pregnant women develop complications that require medicine. Yet the only........ Read more »

Zaman, K., Roy, E., Arifeen, S., Rahman, M., Raqib, R., Wilson, E., Omer, S., Shahid, N., Breiman, R., & Steinhoff, M. (2008) Effectiveness of Maternal Influenza Immunization in Mothers and Infants. New England Journal of Medicine, 359(15), 1555-1564. DOI: 10.1056/NEJMoa0708630  

  • January 6, 2011
  • 08:00 AM

Energy Drinks

by Scott in Science-Based Pharmacy

My stimulant of choice is coffee. I started drinking it in first-year university, and never looked back. A tiny four-cup coffee maker became my reliable companion right through graduate school. But since I stopped needing to drink a pot at a time, an entirely new category of products has appeared — the energy drink. Targeting [...]... Read more »

  • January 6, 2011
  • 07:52 AM

by beredim in Strange Animals

The Japanese spider crab (Macrocheira kaempferi)is one of the world's largest arthropods. It is the second heaviest and comes first in regards to leg span size. As implied by its name, its mainly found in the waters surrounding Japan. Post contains images, videos and extensive information about this weird aquatic animal.... Read more »

  • January 6, 2011
  • 07:47 AM

Spectroscopic madness

by sarah in One Small Step

The BBC is currently running a 3-part series called BBC Stargazing, hosted by Brian Cox and Dara O Briain. The last episode aired last night, sadly I didn’t have access from here in Germany. There’s lots of discussion and enthusiasm on twitter with the #BBCstargazing hashtag, and not just from the regular crowd of astronomers [...]

... Read more »

Thomas Eversberg. (2011) Spectroscopic madness--A golden age for amateurs. Proc. of "Stellar winds in Interaction", editors T. Eversberg and J.H. Knapen. arXiv: 1101.0680v1

  • January 6, 2011
  • 07:33 AM

More Friends on Facebook Does NOT Equal a Larger Amygdala

by The Neurocritic in The Neurocritic

Bottom image adapted from Fig. 2 of Schumann et al. (2010). Neuroanatomy of the human amygdala postmortem. Nissl-stained section of amygdala nuclei.The amygdala is a subcortical structure located within the medial temporal lobes. It consists of a number of different nuclei, or collections of neurons delineated by commonalities in morphology and connectivity. The amygdala is best known for major roles in fear conditioning (Paré et al., 2004) and responding to emotional stimuli more generally (Ph........ Read more »

Bickart, K., Wright, C., Dautoff, R., Dickerson, B., & Barrett, L. (2010) Amygdala volume and social network size in humans. Nature Neuroscience. DOI: 10.1038/nn.2724  

  • January 6, 2011
  • 07:00 AM

January 6, 2011

by Erin Campbell in HighMag Blog

Our immune system has many different types of specialized cells, and macrophages have to be my favorite. One look at our image today, and you’ll see why they are such amazing little workers.... Read more »

Flannagan, R., Harrison, R., Yip, C., Jaqaman, K., & Grinstein, S. (2010) Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets. originally published in The Journal of Cell Biology, 191(6), 1205-1218. DOI: 10.1083/jcb.201007056  

  • January 6, 2011
  • 06:19 AM

Bridging the gap between nerve repair and cancer spread

by Cancer Research UK in Cancer Research UK - Science Update

Imagine you’re in an army convoy, carrying vital information and heading along the road towards a bridge across a deep gorge. But the bridge has been blown out by enemy fire.  So the engineers are called in. They get to work, clearing the debris and slinging ropes across the gorge to act as a ‘guide [...]... Read more »

Parrinello, S., Napoli, I., Ribeiro, S., Digby, P., Fedorova, M., Parkinson, D., Doddrell, R., Nakayama, M., Adams, R., & Lloyd, A. (2010) EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting. Cell, 143(1), 145-155. DOI: 10.1016/j.cell.2010.08.039  

  • January 6, 2011
  • 06:00 AM

Energy Drinks

by Scott Gavura in Science-Based Medicine

My stimulant of choice is coffee. I started drinking it in first-year university, and never looked back. A tiny four-cup coffee maker became my reliable companion right through graduate school. But since I stopped needing to drink a pot at a time, an entirely new category of products has appeared — the energy drink. Targeting [...]... Read more »

  • January 6, 2011
  • 05:30 AM

Sources sinks = swarmers stalks: a signaling activity gradient within a bacterial cell

by Becky in It Takes 30

You’re probably familiar with the idea that gradients of signaling molecules determine cell fate in early animal embryos.  Now, a recent paper from the Laub lab (Chen et al. 2010.  Spatial gradient of protein phosphorylation underlies replicative asymmetry in a bacterium, PNAS doi:10.1073/pnas.1015397108) has discovered gradients of active signaling molecules within a single bacterial cell.  [...]... Read more »

Chen YE, Tropini C, Jonas K, Tsokos CG, Huang KC, & Laub MT. (2010) Spatial gradient of protein phosphorylation underlies replicative asymmetry in a bacterium. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21191097  

  • January 6, 2011
  • 02:00 AM

Branding in a new light: conveying identities through altered lighting

by SAGE Insight in SAGE Insight

Light and corporate identity: Using lighting for corporate communication From Lighting Research and Technology This study explores how lighting design can alter the perceived brand identity of a room. Today’s shop lighting doesn’t just need to show off the goods in their best light, but also convey the brand image strategically in a chain of [...]... Read more »

  • January 5, 2011
  • 09:45 PM

Genetically Damaged Bacteria Grow via Synthetic Proteins

by Michael Long in Phased

Bacteria which possess genetic damage that normally prevents reproduction in a nutrient-deficient medium can be saved by expression of artificial proteins, an important step towards constructing artificial life.... Read more »

  • January 5, 2011
  • 09:01 PM

Another worry for breast cancer patients?

by PalMD in White Coat Underground

Breast cancer is the most common (non-skin) cancer in women, and despite advances in treatment, it is still deeply feared, and with good reason.  But breast cancer is really several different diseases.  Breast cancers can arise from several different cell types, they can occur during the pre- or post-menopausal period, and they can have various [...]... Read more »

  • January 5, 2011
  • 08:01 PM

The Fightin’ Ibis: Xenicibis and Evolution’s Arrow

by Laelaps in Laelaps

What comes next for evolution? This seems like a simple question. Every day we are learning more about the history of life on earth, and we would expect that, over 150 years since Charles Darwin published On the Origin of Species, the life of the past could be used to extrapolate the trajectory of evolution’s [...]... Read more »

Nicholas R. Longrich, and Storrs L. Olson. (2010) The bizarre wing of the Jamaican flightless ibis Xenicibis xympithecus: a unique vertebrate adaptation. Proceedings of the Royal Society B. info:/10.1098/rspb.2010.2117

Osborn, Henry Fairfield; Brown, Barnum. (1906) Tyrannosaurus, Upper Cretaceous carnivorous dinosaur. Bulletin of the American Museum of Natural History, 22(16), 281-296. info:/

  • January 5, 2011
  • 07:21 PM

Rheology within the concept of aether

by Andrew Sun in On The Road

N/A (1886). Dilatancy Nature, 33 (853), 429-430 DOI: 10.1038/033429b0 I encountered the word “ether” which apparently did not mean the organic reagent when I was reading a short comment on O. Reynolds’s lecture on dilatancy published on Nature in 1886. … Continue reading →... Read more »

N/A. (1886) Dilatancy. Nature, 33(853), 429-430. DOI: 10.1038/033429b0  

  • January 5, 2011
  • 06:52 PM

Recursion: what is it, who has it, and how did it evolve?

by Hannah Little in A Replicated Typo 2.0

Hello Hello and Happy New Year,
So a new article appeared on the internet late last year by Coolidge, Overmann and Wynn (2010) (hereafter referred to as COW because it makes me smile). It’s a really short sweet little paper and you should read it as recursion is perhaps one of the hottest topics around language evolution. . . . → Read More: Recursion: what is it, who has it, and how did it evolve?... Read more »

Coolidge, F., Overmann, K., & Wynn, T. (2010) Recursion: what is it, who has it, and how did it evolve?. Wiley Interdisciplinary Reviews: Cognitive Science. DOI: 10.1002/wcs.131  

  • January 5, 2011
  • 06:37 PM

Slipping into psychosis: living in the prodrome (part 1)

by gregdowney in Neuroanthropology

How might it feel to sense your own sanity eroding? Would you realize it? How might you sift the phantoms from physical reality, daydream from delusion, the irrefutable from the implausible? Or, as author Rachel Aviv puts it,
When does a strong idea take on a pathological flavor? How does a metaphysical crisis morph into a medical one? At what point does our interpretation of the world become so fixed that it no longer matters “what almost everyone else believes” [part of the definition o........ Read more »

Addington, J., Cadenhead, K., Cannon, T., Cornblatt, B., McGlashan, T., Perkins, D., Seidman, L., Tsuang, M., Walker, E., Woods, S.... (2007) North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research. Schizophrenia Bulletin, 33(3), 665-672. DOI: 10.1093/schbul/sbl075  

Corcoran, C., Davidson, L., Sills-Shahar, R., Nickou, C., Malaspina, D., Miller, T., & McGlashan, T. (2003) A Qualitative Research Study of the Evolution of Symptoms in Individuals Identified as Prodromal to Psychosis. Psychiatric Quarterly, 74(4), 313-332. DOI: 10.1023/A:1026083309607  

  • January 5, 2011
  • 04:12 PM

Beautiful People Get More Attention

by APS Daily Observations in Daily Observations

Beautiful people get all of the breaks. They are generally seen more positively than others. Are they seen more accurately? A new study published in Psychological Science finds that people ... Read more »

  • January 5, 2011
  • 03:00 PM

The elusive x-factor

by Lorimer Moseley in BodyInMind

What is it about some clinicians? They just seem to get great results by doing almost nothing! Could that be true? What is that elusive x-factor? Well, fortunately for us, Laura von Bertouch has agreed to tell us about a paper she does read that covers exactly that. Here is what Laura had to say: [...]... Read more »

Dole JA, Sinatra GM. (1998) Reconceptualising change in the cognitive construction of knowledge. Educational Psychologist, 109-128. info:/

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