This is a direct jargon-to-English translation of an important scientific paper by Clifford Woolf, a distinguished pain researcher, published in Pain in Oct 2010. Everyone — and I do mean everyone — needs to know this. It’s owners manual stuff.
Pain itself often modifies the way the central nervous system works, so that a patient actually becomes more sensitive and gets more pain with less provocation. That sensitization is called “central sensitization” because it involves change........ Read more »
Woolf CJ. (2010) Central sensitization: Implications for the diagnosis and treatment of pain. Pain. PMID: 20961685
Nearly everyone assumes that back pain increases with age because backs hurt as they start to “degenerate.” In fact, studies of low back pain have contradicted this over and over again. Although certain types of back pain are relatively absent in the young and become increasingly common with age, it doesn’t affect the overall trend: most back pain occurs in middle age, and then either declines or levels off in the last third of life — exactly the opposite of what you’d expect if b........ Read more »
Harkness EF, Macfarlane GJ, Silman AJ, & McBeth J. (2005) Is musculoskeletal pain more common now than 40 years ago?: Two population-based cross-sectional studies. Rheumatology (Oxford, England), 44(7), 890-5. PMID: 15784630
Absenteeism, i. e. not showing up for work, has been the subject of much research to date. In contrast, presenteeism (defined as showing up for work when one is ill), has only received interest in recent years, with research suggesting that it might cause more aggregate productivity loss than absenteeism. Consequences of chronic presenteeism or absenteeism may include effects on downstream health status, job attendance dynamics, and organizational membership.... Read more »
Johns, G. (2009) Presenteeism in the workplace: A review and research agenda. Journal of Organizational Behavior, 31(4), 519-542. DOI: 10.1002/job.630
If you have ever had the pleasure of being in a boisterous Tokyo bar at night, eating and drinking amongst a din that would sear the armour off a tank,you get the feeling that this is what pure, hedonistic joy must be like. And, according to this article by Ikeda et al. (2011), Japanese men love it as well. The downer seems to be that while all that upbeat male bonding is good for lowering stress, the accompanying fat and alcohol brings on health effects of a less favourable kind.... Read more »
Ikeda A, Kawachi I, Iso H, Inoue M, Tsugane S, & JPHC Study Group. (2011) Gender difference in the association between social support and metabolic syndrome in Japan: the 'enkai' effect?. Journal of epidemiology and community health, 65(1), 71-7. PMID: 19933686
At the end of the 1990s, cognitive psychologist Steven Pinker infamously characterized music as “auditory cheesecake”: a delightful dessert but, from an evolutionary perspective, no more than a by-product of language. But Pinker was probably right when he wrote: “I suspect music is auditory cheesecake, an exquisite confection crafted to tickle the sensitive spots of...our mental faculties.” Or, to express his idea less graphically: music affects our brains at specific places, thereby sti........ Read more »
Salimpoor, V., Benovoy, M., Larcher, K., Dagher, A., & Zatorre, R. (2011) Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nature Neuroscience. DOI: 10.1038/nn.2726
Let me start out by saying: I love sea turtles. I can’t explain why, but they fascinate me. I have sweatshirts, bags and artwork with sea turtles on them. I even make jewelry with sea turtle themes. Ask anyone who knows me; I have a thing for sea turtles. So when I came across the [...]... Read more »
Witt MJ, Augowet Bonguno E, Broderick AC, Coyne MS, Formia A, Gibudi A, Mounguengui Mounguengui GA, Moussounda C, Nsafou M, Nougessono S.... (2011) Tracking leatherback turtles from the world's largest rookery: assessing threats across the South Atlantic. Proceedings. Biological sciences / The Royal Society. PMID: 21208949
One of the things that came up in the many comments appended to the article on Bob's painting of extinct Maltese animals was the famous Egyptian tomb painting of the 'pygmy mammoth'. You're likely already familiar with this (now well known) case: here's the image, as it appears on the beautifully decorated tomb wall of Rekhmire, 'Governor of the Town' of Thebes, and vizier of Egypt during the reigns of Tuthmose III and Amenhotep II (c. 1479 to 1401 BCE) during the XVIII dynasty...
Read the r........ Read more »
One of the proposed strategies to nudge consumers to eat fewer calories is the mandatory labeling of menus. While this makes intuitive sense, the actual impact of this strategy is not clear.
This issue was now addressed by Eric Finkelstein and colleagues from Duke-National University of Singapore, in a study just published in the American Journal [...]... Read more »
Finkelstein EA, Strombotne KL, Chan NL, & Krieger J. (2011) Mandatory menu labeling in one fast-food chain in king county, washington. American journal of preventive medicine, 40(2), 122-7. PMID: 21238859
In last weeks article (Hendricks and Singhal, 2005) I described the effects of supply chain glitches on supply chain performance. This week should be viewed an update to that.
Already in 2003 Hendricks and Singhal showed in an article the devastating effects supply chain glitches can have on the shareholder value. Up to that time a strong correlation between excellence in supply chain management and shareholder value has always been presumed. Many have alluded to the compelling bottom-line........ Read more »
Hendricks, K., & Singhal, V.R. (2003) The effect of supply chain glitches on shareholder wealth. Journal of Operations Management, 21(5), 501-522. DOI: 10.1016/j.jom.2003.02.003
Effron & Monin’s work on ambiguous and blatant transgressions has multiple applications for our work. In the past, we’ve blogged about Tiger Woods, Eliot Spitzer, and David Letterman. We want to take some time to discuss Effron & Monin’s work in the context of our prior writing on high profile falls from grace. (See Part [...]
Related posts:Martin Luther King, Jr. & Eliot Spitzer: On letting people off the hook [Part I]
Apology redux: Doing it right (and doing it wrong)
El........ Read more »
Effron DA, & Monin B. (2010) Letting people off the hook: when do good deeds excuse transgressions?. Personality and social psychology bulletin, 36(12), 1618-34. PMID: 20978222
We've all seen it before while working in the ED. A parent brings in their child because they pulled on their arm, and now the child is not using it. Parents are thoroughly convinced that the child's arm is either broken or dislocated. We all recognize this as radial head subluxation or "nursemaid's elbow" and immediately attempt to reduce it. The provider takes the injured arm, supinates at the wrist and flexes at the elbow. Does the child scream? Does the parent scream and threaten to sue? Wha........ Read more »
Bek, D., Yildiz, C., Köse, �., Şehirlioğlu, A., & Başbozkurt, M. (2009) Pronation versus supination maneuvers for the reduction of ‘pulled elbow’: a randomized clinical trial. European Journal of Emergency Medicine, 16(3), 135-138. DOI: 10.1097/MEJ.0b013e32831d796a
In science, like most things, one prefers simple over complex whenever possible. You keep adding variables until the explanatory juice starts hitting diminishing marginal returns. So cystic fibrosis is due to a mutation at one gene, and the disease expresses recessively at that locus. The reality is that one mutation accounts for ~65-70% of cystic [...]... Read more »
Wray NR, Purcell SM, & Visscher PM. (2011) Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results. PLoS Biology. info:/10.1371/journal.pbio.1000579
How does the mind file life's episodes?
Autobiographical or 'episodic' memory describes our ability to recall past experiences and is distinct from semantic memory, which is our factual knowledge about the world. So far so good, but according to Youssef Ezzyat and Lila Davachi, psychology has so far largely neglected to investigate exactly how the brain organises the continuity of lived experience into a filing system of discrete episodes.
Ezzyat and Davachi have made a start. They had 23 par........ Read more »
Two recent large epidemiological studies again suggest a beneficial effect of chocolate consumption on cardiovascular disease. One study was a prospective study in 1216 women with a follow up of 9,5 years. The frequency of chocolate consumption was categorized in three groups”: ... Read more »
Buijsse, B., Weikert, C., Drogan, D., Bergmann, M., & Boeing, H. (2010) Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults. European Heart Journal, 31(13), 1616-1623. DOI: 10.1093/eurheartj/ehq068
Heiss, C., & Kelm, M. (2010) Chocolate consumption, blood pressure, and cardiovascular risk. European Heart Journal, 31(13), 1554-1556. DOI: 10.1093/eurheartj/ehq114
Lewis JR, Prince RL, Zhu K, Devine A, Thompson PL, & Hodgson JM. (2010) Habitual chocolate intake and vascular disease: a prospective study of clinical outcomes in older women. Archives of internal medicine, 170(20), 1857-8. PMID: 21059981
Search engines and the production of academic knowledge From International Journal of Cultural Studies Surveys prove that students performing topic searches for scholarly papers overwhelmingly choose search engines, rather than library-based research discovery networks, as their preferred starting-point. Are they getting the best and most relevant information? This article argues that search engines in general, and [...]... Read more »
van Dijck, J. (2010) Search engines and the production of academic knowledge. International Journal of Cultural Studies, 13(6), 574-592. DOI: 10.1177/1367877910376582
Sci has RETURNED from a bangup AWESOME time at #scio11. Sadly, my trusty netbook was not particularly trusty, and so I wasn’t able to crazy tweet up the conference like other attendees did. But I learned a lot and had a spectacular time meeting and having deep conversations with everyone. It’s like the first week [...]... Read more »
Alves-Neto, W., Guapo, V., Graeff, F., Deakin, J., & Del-Ben, C. (2010) Effect of escitalopram on the processing of emotional faces. Brazilian Journal of Medical and Biological Research. DOI: 10.1590/S0100-879X2010005000007
Plasmodium falciparum is the leading cause of malaria in people, although there are Plasmodium species, spp., that infect virtually all the tetrapods (mammals, birds, reptiles, amphibians). As most people know, malaria is acquired from mosquito bites (Anopheles mosquitoes to be specific), because Plasmodium spp. have complex life cycles that require both an insect (mosquito) and a tetrapod host. Importantly, there is essentially no overlap between the Plasmodium spp. that cause fr........ Read more »
Joergensen, L., Bengtsson, D., Bengtsson, A., Ronander, E., Berger, S., Turner, L., Dalgaard, M., Cham, G., Victor, M., Lavstsen, T.... (2010) Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1. PLoS Pathogens, 6(9). DOI: 10.1371/journal.ppat.1001083
Hey, "all you lovers out there," which is how Marvin Berry introduced "Earth Angel" at the Enchantment Under the Sea dance back in good-olde 1955. And by "lovers" I mean "geneticists."
Poring over the recent Neandertal nuclear genome paper (Green et al. 2010) for seminars, we're struck by two contradictory ideas. On the one hand, the authors demonstrate pretty convincingly that Neandertals and the more 'anatomically modern' humans of Europe and Asia interbred. This doesn't come from genetic com........ Read more »
Feng at al. in NSMB show that Z-RNA (or DNA) binding domain Zα inhibits ribosomal function. Binds to the ribosome and inhibits it! Basically does what ribosome-binding antibiotics do - they bind, freeze the ribosome in some particular conformation and thus inhibit it. Viomycin can be a gerat example of that.Better still, Zα seems to bind ribosomes nondiscriminantly (both bacterial and mammalian), so using a column with immobilized Zα you could purify ribosomes from whatever cel........ Read more »
Feng S, Li H, Zhao J, Pervushin K, Lowenhaupt K, Schwartz TU, & Dröge P. (2011) Alternate rRNA secondary structures as regulators of translation. Nature structural . PMID: 21217697
Ermolenko DN, Spiegel PC, Majumdar ZK, Hickerson RP, Clegg RM, & Noller HF. (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nature structural , 14(6), 493-7. PMID: 17515906
So for a while it's just been talk and ideas floating in the ether. But today Psychobabble goes live!What is Psychobabble? It's a fortnightly podcast on the topic of experimental psychology. If you're interested in the way people think, the why's of behaviour, and the how's of the brain, then this is for you.By and large a search on iTunes for 'Psychology' or; (read more)
Source: Rift - Discipline: Psychology... Read more »
Watkins, C., Fraccaro, P., Smith, F., Vukovic, J., Feinberg, D., DeBruine, L., & Jones, B. (2010) Taller men are less sensitive to cues of dominance in other men. Behavioral Ecology, 21(5), 943-947. DOI: 10.1093/beheco/arq091
Callison, C., Karrh, J., & Zillmann, D. (2002) The Aura of Tobacco Smoke: Cigars and Cigarettes as Image Makers. Journal of Applied Social Psychology, 32(7), 1329-1343. DOI: 10.1111/j.1559-1816.2002.tb01439.x
Surawski, M., & Ossoff, E. (2006) The effects of physical and vocal attractiveness on impression formation of politicians. Current Psychology, 25(1), 15-27. DOI: 10.1007/s12144-006-1013-5
Mast, M., & Hall, J. (2004) Who Is the Boss and Who Is Not? Accuracy of Judging Status. Journal of Nonverbal Behavior, 28(3), 145-165. DOI: 10.1023/B:JONB.0000039647.94190.21
Wyer, N. (2010) You Never Get a Second Chance to Make a First (Implicit) Impression: The Role of Elaboration in the Formation and Revision of Implicit Impressions. Social Cognition, 28(1), 1-19. DOI: 10.1521/soco.2010.28.1.1
Naumann, L., Vazire, S., Rentfrow, P., & Gosling, S. (2009) Personality Judgments Based on Physical Appearance. Personality and Social Psychology Bulletin, 35(12), 1661-1671. DOI: 10.1177/0146167209346309
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