It’s been a while since my last post on this blog about transcranial magnetic stimulation (TMS).
Myself ‘m not impressed by it’s efficacy for treatment resistant depression. Especially in treatment resistant depression, whatever that may be, rTMS is probably best avoided for more evidence based form of treatments with proven efficacy.
The reason for this post about [...]
Related posts:rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression
Again Open ........ Read more »
Yip AG, & Carpenter LL. (2010) Transcranial magnetic stimulation for medication-resistant depression. The Journal of clinical psychiatry, 71(4), 502-3. PMID: 20409447
The Lancet paper, Clinical assessment incorporating a personal genome, has held my fascination this weekend (yes, I read it at the beach). Mary posted Friday and again Saturday on the paper and related NPR segment. It feels to me to be a seminal paper, though I do agree with Daniel at Genetic Future, there are a lot there we still don’t know. A large portion of the variation is in non-coding regions, and thus predictions and propensities are hard to come by with the available analysis. In ........ Read more »
Ashley, E., Butte, A., Wheeler, M., Chen, R., Klein, T., Dewey, F., Dudley, J., Ormond, K., Pavlovic, A., & Morgan, A. (2010) Clinical assessment incorporating a personal genome. The Lancet, 375(9725), 1525-1535. DOI: 10.1016/S0140-6736(10)60452-7
Love for someone is associated with a cascade of activation of a variety of neuromodulatory and hormonal brain systems and with further elucidation on the neurobiology of love, we may possibly facilitate a black market of love drug abuse, though these drugs, I wonder, may help individuals who are asexual and/or autistic.... Read more »
Muise A, Christofides E, & Desmarais S. (2009) More information than you ever wanted: does Facebook bring out the green-eyed monster of jealousy?. Cyberpsychology , 12(4), 441-4. PMID: 19366318
Fragment-based Drug Design (FBDD) has emerged as one of the key strategies in drug design during the past two decades. FBDD hinges on the fact that fragments, as opposed to complete ligands, are easier to optimize and study since they possess lesser molecular complexity and have fewer binding interactions.When fragments are optimized to bind to parts of a protein's active site, they can gain powerful binding affinity by being linked together. Usually fragments are relatively weak binders, and co........ Read more »
Borsi, V., Calderone, V., Fragai, M., Luchinat, C., & Sarti, N. (2010) Entropic Contribution to the Linking Coefficient in Fragment Based Drug Design: A Case Study. Journal of Medicinal Chemistry, 2147483647. DOI: 10.1021/jm901723z
There’s no denying that global warming will impose massive changes on the environment. But a recent paper suggests that the models ecologists typically use to assess the effects of environmental changes may be neglecting a key factor: The ability of organisms to adapt to the environment. What are the implications of incorporating the capacity for [...]... Read more »
Chevin, L., Lande, R., & Mace, G. (2010) Adaptation, Plasticity, and Extinction in a Changing Environment: Towards a Predictive Theory. PLoS Biology, 8(4). DOI: 10.1371/journal.pbio.1000357
If we asked someone "what should i do to build muscle" probably not a lot of people would say "cut off the blood flow to a working limb." Turns out though, that this latter kind of work - called occlusion training, or blood flow restriction (BFR) - has proven a powerful technique for inducing hypertrophy at very low loads (10-30% of a 1RM). While it's mainly been explored as a rehab technique to... Read more »
Wernbom M, Augustsson J, & Raastad T. (2008) Ischemic strength training: a low-load alternative to heavy resistance exercise?. Scandinavian journal of medicine , 18(4), 401-16. PMID: 18466185
Madarame, H., Kurano, M., Takano, H., Iida, H., Sato, Y., Ohshima, H., Abe, T., Ishii, N., Morita, T., & Nakajima, T. (2010) Effects of low-intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects. Clinical Physiology and Functional Imaging, 30(3), 210-213. DOI: 10.1111/j.1475-097X.2010.00927.x
Loenneke, J., & Pujol, T. (2009) The Use of Occlusion Training to Produce Muscle Hypertrophy. Strength and Conditioning Journal, 31(3), 77-84. DOI: 10.1519/SSC.0b013e3181a5a352
Over the years, we’ve had many inquiries about using the EZ-Tn5™ Transposomes on biologically interesting but difficult-to-mutate bacteria--usually Gram-positive bacteria that have poorly understood genetics and are difficult to transform with foreign DNA. As time has progressed, some of the difficulties of using EZ-Tn5 Transposomes have been overcome. An example of such success was recently reported by Vidal et al.* regarding the use of a custom EZ-Tn5 Transposome that confers tetracycline ........ Read more »
Vidal, J. et al. (2009) Use of an EZ-Tn5-Based Random Mutagenesis System to Identify a Novel Toxin Regulatory Locus in Clostridium perfringens Strain 13. PLoS ONE, 4(7). DOI: 10.1371/journal.pone.0006232
Based on my blog title’s silly alliteration, you might think that I enjoy writing that is all flash and no substance. On the contrary, I love articles that are straight to the point. Kudos to the authors that can summarize an entire study’s finding in a key sentence. Double kudos if they can use this [...]... Read more »
Boyd, R., Gintis, H., & Bowles, S. (2010) Coordinated Punishment of Defectors Sustains Cooperation and Can Proliferate When Rare. Science, 328(5978), 617-620. DOI: 10.1126/science.1183665
A recent study (Karremans, et.al. 2010) that compared the preferences of blind and sighted men for the shape of adjustable dress forms with one of two WHRs (.70 and .84) has been getting some coverage in the popular press. Nineteen blind from birth adult males (aged 27-72 with a mean of 45.5) and 38 sighted [...]... Read more »
As many know, I generally do not write a lot about papers in non open access journal because I like readers to be able to access all the papers which I write about. But this is one of the exceptions to my normal rule. An amazing paper was published a few days ago in Science by Nancy Moran and Tyler Jarvik. Lateral Transfer of Genes from Fungi Underlies Carotenoid Production in Aphids -- Moran and Jarvik 328 (5978): 624 -- ScienceI first found out about this from Ed Yong's blog post here (just........ Read more »
Moran, N., & Jarvik, T. (2010) Lateral Transfer of Genes from Fungi Underlies Carotenoid Production in Aphids. Science, 328(5978), 624-627. DOI: 10.1126/science.1187113
, . (2010) Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biology, 8(2). DOI: 10.1371/journal.pbio.1000313
Breaking down a hyena kill. Given competition with other carnivores, prehistoric hyenas (like their living counterparts) would probably have disarticulated and transported parts of horses they killed. From Diedrich 2010.
In Hollywood films, there is nothing like an assemblage of bones strewn about a cave floor to testify to the power and voraciousness of a predator. Every skeleton is a testament to the hunting prowess of the carnivore, which causes even more alarm when the person who has s........ Read more »
Diedrich, C. (2010) Specialized horse killers in Europe: Foetal horse remains in the Late Pleistocene Srbsko Chlum-Komín Cave hyena den in the Bohemian Karst (Czech Republic) and actualistic comparisons to modern African spotted hyenas as zebra hunters. Quaternary International. DOI: 10.1016/j.quaint.2010.01.023
Over the weekend a discussion about relaxation and the how’s and why’s came up in a discussion group I belong to. Several members of the group, including me, contributed our ‘list of do’s and don’ts’, much of it based on years of clinical experience – until I thought (as I do!) what about the literature? … Read more... Read more »
Persson, A. L.,, Veenhuizen, H.,, Zachrison, L.,, & Gard, G. (2008) Relaxation as treatment for chronic musculoskeletal pain a systematic review of randomised controlled studies. Physical Therapy Reviews, 13(5), 355-365. info:/
Rather than yet again writing about lower body fat and why losing it during weight loss may or may not be bad for your health, Travis and I decided to try our hand at the first of what we hope to be many Obesity Panacea Blogcasts. In essense, this blogcast is simply Travis and I talking over Skype about this area of research and specifically about my recently published paper.... Read more »
Janiszewski, P., & Kuk, J. (2010) Does loss of gluteofemoral fat through diet and exercise deteriorate metabolic health?. International Journal of Obesity. DOI: 10.1038/ijo.2010.75
Two moms and a dad could give babies the right combination of DNA to prevent mitochondrial diseases such as blindness, deafness, dementia, and diabetes.... Read more »
Tachibana, M., Sparman, M., Sritanaudomchai, H., Ma, H., Clepper, L., Woodward, J., Li, Y., Ramsey, C., Kolotushkina, O., & Mitalipov, S. (2009) Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature, 461(7262), 367-372. DOI: 10.1038/nature08368
Craven, L., Tuppen, H., Greggains, G., Harbottle, S., Murphy, J., Cree, L., Murdoch, A., Chinnery, P., Taylor, R., Lightowlers, R.... (2010) Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature. DOI: 10.1038/nature08958
TANAKA, A. (2009) Metaphase II karyoplast transfer from human in-vitro matured oocytes to enuclueated mature oocytes. Reproductive BioMedicine Online, 19(4), 514-520. DOI: 10.1016/j.rbmo.2009.06.004
I have been working on updating a lecture on substance-induced psychosis. In the last few years a significant amount of research has been published on methamphetamine psychosis. Methamphetamine can produce a psychotic state characterized by paranoia, agitation and behavioral problems. Not all individuals appear to experience this induced state. This leads to the question of what factors might be related to the risk of psychosis in those using methamphetamine. Certain dose and duration of met........ Read more »
Ujike H, Katsu T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Sora I.... (2009) Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis. Progress in neuro-psychopharmacology , 33(4), 625-9. PMID: 19275926
Tsunoka T, Kishi T, Kitajima T, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Kawashima K, Naitoh H, Inada T.... (2010) Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population. Progress in neuro-psychopharmacology . PMID: 20211215
Living in the northern hemisphere where spring showers bring May flowers and being the first post in said month, I feel it is my duty to discuss an important topic: compost. Compost is the seemingly simple product of a complex mixture of materials. Take a smorgasbord of leaves, grass, kitchen waste, coffee grounds and other [...]... Read more »
Ryckeboer J, Mergaert J, Coosemans J, Deprins K, & Swings J. (2003) Microbiological aspects of biowaste during composting in a monitored compost bin. Journal of applied microbiology, 94(1), 127-37. PMID: 12492933
Bear with me here, dear reader – this one’s a bit of a stretch for conservation relevance at first glance, but it is important. Also, it’s one of my own papers so I have the prerogative :-) As some of you probably know, I dabble quite a bit in population dynamics theory, which basically means [...]... Read more »
Clark, F., Brook, B.W., Delean, S., Reşit Akçakaya, H., & Bradshaw, C.J.A. (2010) The theta-logistic is unreliable for modelling most census data. Methods in Ecology and Evolution. DOI: 10.1111/j.2041-210X.2010.00029.x
Most of you have likely read the recent NYtimes article about the effect of touching on the performance of NBA teams. Here's a study that looks at the effect of physical contact on MBA teams: How physical contact influences financial risk taking...... Read more »
Jonathan Levav, & Jennifer Argo. (2010) Physical Contact and Financial Risk Taking. Psychological Science. info:/10.1177/095679761039493
Recent population surveys show that as many as two out of three women will report trying to lose weight in the past year.
Obviously, this answer does not really tell us much about what women are actually doing, as the types of diets and weight loss strategies seem virtually countless - some perhaps healthier than others.
Now [...]... Read more »
Lanza ST, Savage JS, & Birch LL. (2010) Identification and prediction of latent classes of weight-loss strategies among women. Obesity (Silver Spring, Md.), 18(4), 833-40. PMID: 19696754
The Everything Octopus blog provides, via People for the Ethical Treatment of Animals, an example of the low bar for scientific evidence in discussion around invertebrate pain. To be clear, I am in no way defending the practice described (eating live animals). I want to focus on this statement:
Because octopuses have sophisticated nervous systems and feel pain just as acutely as mammals do...
Octopuses and other cephalopods have sophisticated nervous systems, granted. I’ve written about their........ Read more »
Andrews, P., & Tansey, E. (1981) The effects of some anaesthetic agents in Octopus vulgaris. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 70(2), 241-247. DOI: 10.1016/0306-4492(81)90057-5
Kavaliers, M. (1988) Evolutionary and comparative aspects of nociception. Brain Research Bulletin, 21(6), 923-931. DOI: 10.1016/0361-9230(88)90030-5
Park, T., Lu, Y., Jüttner, R., Smith, E., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P.... (2008) Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber). PLoS Biology, 6(1). DOI: 10.1371/journal.pbio.0060013
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