There have been two research studies done, looking at thousand of people to work out how many people with a certain symptom are likely to have cancer. If you are couching up blood, then you should make an appointment and mention this to your GP. The chances are it’s not cancer, but you need to [...]... Read more »
Jones, R., Charlton, J., Latinovic, R., & Gulliford, M. (2009) Alarm symptoms and identification of non-cancer diagnoses in primary care: cohort study. BMJ, 339(aug13 2). DOI: 10.1136/bmj.b3094
[W]e have estimated that natural selection drives twice as much change in immune-related proteins as in proteins with no immune function. Interestingly, the rate of adaptation is also more variable among immunity genes than among other genes in the genome, with a small subset of immunity genes evolving under intense natural selection. We suggest that [...]... Read more »
Obbard, D., Welch, J., Kim, K., & Jiggins, F. (2009) Quantifying Adaptive Evolution in the Drosophila Immune System. PLoS Genetics, 5(10). DOI: 10.1371/journal.pgen.1000698
Last year, the psychologists Lawrence Williams and John Bargh gave participants a cup of coffee to hold and showed that the temperature of the coffee affected the way those participants rated a stranger's character. A hot coffee led them to rate him as more good natured and generous, whilst holding an iced coffee had the opposite effect. The finding was touted as an example of embodied cognition - the idea that the way we think about the world is grounded in, and affected by, physical metaphors......... Read more »
Ijzerman H, & Semin GR. (2009) The Thermometer of Social Relations: Mapping Social Proximity on Temperature. Psychological science : a journal of the American Psychological Society / APS. PMID: 19732385
So, I’ve just started a new job and moved home. There is loads to blog about but little time to do it. Before it’s too late, here are some first week impressions from a newbie starter at the European Bioinformatics Institute (EBI) on the Wellcome Trust Genome Campus.
The Genome Campus owes its existence to the [...]... Read more »
Degtyarenko, K., de Matos, P., Ennis, M., Hastings, J., Zbinden, M., McNaught, A., Alcantara, R., Darsow, M., Guedj, M., & Ashburner, M. (2007) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Research, 36(Database). DOI: 10.1093/nar/gkm791
GNP is Gross National Product, more or less the sum value of all services and products produced in a year by the inhabitants of a given nation. The value is staggeringly large for the US, somewhere north of $11 trillion. Many wars and worse upheavals have been instigated by politicians - and supported by a populace - in reaction to or anticipation of change of a few percentage points of GNP. All the more reason to dislike forms of society and culture that result in this sort of thing, if you ask........ Read more »
A simple 'yes', I believe.I do an attempt to explain this in a book that is about to be published in Dutch (English, and other languages, are planned for 2010/11).The evidence comes from researchers from all over the globe (England, France, Germany, Belgium, North-America, Canada, South America, etc.) .... standing on the shoulders of giants... it turned out to be a great view...H. Honing (2009). Iedereen is muzikaal: Wat we weten over het luisteren naar muziek. Nieuw Amsterdam Uitgevers. ISBN: ........ Read more »
H. Honing. (2009) Iedereen is muzikaal: Wat we weten over het luisteren naar muziek. Nieuw Amsterdam Uitgevers. info:/
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Strayhorn JM, & Strayhorn JC. (2009) Religiosity and teen birth rate in the United States. Reproductive health, 14. PMID: 19761588
When Jim and Nora were in elementary school, both Greta and I worked challenging jobs, so we did whatever we could to save time. Instead of bringing lunches made by their parents, the kids bought hot meals at school. The school was proud of its cafeteria. Kids had credit accounts, which meant they didn't have to carry lunch money to school (thus making them less of a target for bullies). The children were encouraged to make "healthy choices" instead of just getting a ladleful of mystery meat plo........ Read more »
HENDY, H., WILLIAMS, K., & CAMISE, T. (2005) “Kids Choice” School lunch program increases children's fruit and vegetable acceptance. Appetite, 45(3), 250-263. DOI: 10.1016/j.appet.2005.07.006
Fungus kills frogs by hindering skin function
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Voyles, J., Young, S., Berger, L., Campbell, C., Voyles, W., Dinudom, A., Cook, D., Webb, R., Alford, R., Skerratt, L.... (2009) Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian Declines. Science. info:/10.1126/science.1176765
A mountain lake in Glacier National Park, Montana.
Organic pollutants have been on the decline in most natural areas in recent years, due to stricter regulations and improvements to products including the contaminants, such as certain pesticides. But a new study in the journal Environmental Science and Technology shows that these pollutants are showing a [...]
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Bogdal, C., Schmid, P., Zennegg, M., Anselmetti, F., Scheringer, M., & Hungerbühler, K. (2009) Blast from the Past: Melting Glaciers as a Relevant Source for Persistent Organic Pollutants. Environmental Science , 2147483647. DOI: 10.1021/es901628x
By: Rosemary Stephen, Elements: Environmental Health Intelligence
In Part I we saw that we are in the midst of a global, human displacement crisis. Tension is already building in countries which are facing an increasing number of immigrants. Poverty, population growth and environmental issues such as drought and desertification, are the root causes of why [...]... Read more »
Rosemary Stephen. (2009) Climate Change and Environmental Refugees Part II: Can we Decrease the Number of Environmental Refugees ?. Elements: Environmental Health Intelligence. info:/
Cognitive enhancers, also known as nootropics, are a category of drugs with the ability to increase mental performance. Many rave about such “smart drugs” helping them to study, take tests, or increase work performance. Ginkgo biloba, piracetam, and vinpocetine are some popular cognitive enhancers, all with varying mechanisms of action in the human brain. For [...]... Read more »
Hubel DH, Wiesel TN, & LeVay S. (1977) Plasticity of ocular dominance columns in monkey striate cortex. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 278(961), 377-409. PMID: 19791
Medina AE, Krahe TE, & Ramoa AS. (2006) Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(3), 1057-60. PMID: 16421325
Molnár P, & Gaál L. (1992) Effect of different subtypes of cognition enhancers on long-term potentiation in the rat dentate gyrus in vivo. European journal of pharmacology, 215(1), 17-22. PMID: 1516646
Szatmari SZ, & Whitehouse PJ. (2003) Vinpocetine for cognitive impairment and dementia. Cochrane database of systematic reviews (Online). PMID: 12535455
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Marks, J., Haden, G., O’Neill, M., & Pace, C. (2009) Effects of Flow Restoration and Exotic Species Removal on Recovery of Native Fish: Lessons from a Dam Decommissioning. Restoration Ecology. DOI: 10.1111/j.1526-100X.2009.00574.x
So yesterday I detailed the results of the Ipsos Reid based milk advertisement that concluded, surprise, that Canadians should be drinking more milk, but buried in the story is the fact that the survey determined that Canadians were not eating enough of any food group according to Canada's Food Guide.Let me repeat that. According to the survey, Canadians don't eat as much food as the Food Guide recommends.But wait, aren't 65% of Canadians overweight? And they're not eating as much as the Food ........ Read more »
St John M, Durant M, Campagna PD, Rehman LA, Thompson AM, Wadsworth LA, & Murphy RJ. (2008) Overweight Nova Scotia children and youth: the roles of household income and adherence to Canada's Food Guide to Healthy Eating. Canadian journal of public health. Revue canadienne de sante publique, 99(4), 301-6. PMID: 18767276
Young girls are far more prone than boys to getting stuck in the role of bullying victim. That's according to a new investigation by psychologists who studied hundreds of children at 17 primary schools in Hertfordshire and North London.Dieter Wolke and his colleagues interviewed the children when they were aged between six and nine years and then surveyed them again two or four years later once the children had reached year six. The researchers were interested in the individual and situational f........ Read more »
Wolke, D., Woods, S., & Samara, M. (2009) Who escapes or remains a victim of bullying in primary school?. British Journal of Developmental Psychology, 27(4), 835-851. DOI: 10.1348/026151008X383003
Many people claim heel spurs to be an abnormal finding. However, research dating from the early 60’s to late 90’s have reported anywhere from 11-16% of the general population to have some type of heel spur. It’s debatable if heel spurs are strongly correlated to older age, gender and osteoarthritis. However, the debate linking heel spurs and pain has progressed to treatment involving shock wave therapy, surgical incision and even radiation therapy The Debate: Traditionally the pathophysiol........ Read more »
Li, J., & Muehleman, C. (2007) Anatomic relationship of heel spur to surrounding soft tissues: Greater variability than previously reported. Clinical Anatomy, 20(8), 950-955. DOI: 10.1002/ca.20548
Two studies, which are available online as early release articles and will be published in the November edition of the Journal of the American Medical Association (JAMA), detail the characteristics, treatment and outcomes of critically ill patients with H1N1 in Mexico and Canada [1-2].
Although the death rate in each of the studies is quite different, it nonetheless is as high or higher than that of seasonal flu. Furthermore, although [...]... Read more »
Domínguez-Cherit G, Lapinsky SE, Macias AE, Pinto R, Espinosa-Perez L, de la Torre A, Poblano-Morales M, Baltazar-Torres JA, Bautista E, Martinez A.... (2009) Critically Ill Patients With 2009 Influenza A(H1N1) in Mexico. JAMA : the journal of the American Medical Association. PMID: 19822626
Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F.... (2009) Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada. JAMA : the journal of the American Medical Association. PMID: 19822627
Female chimpanzee with her infant requests meat after a successful hunt.
Image: David Bygott / Tree of Life Web Project
Owen Lovejoy's recent paper about Ardipithecus ramidus and human origins (see my detailed critique here) bases its argument on the male provisioning observed in chimpanzees. However, what went unacknowledged in his theory was the inherent gender bias it represented. A perfect example of this was observed in April with the release of the very study on provisioning behavior th........ Read more »
Gomes, C., & Boesch, C. (2009) Wild Chimpanzees Exchange Meat for Sex on a Long-Term Basis. PLoS ONE, 4(4). DOI: 10.1371/journal.pone.0005116
From adamantine therapeutics failures, interest in developing new drugs against the flu virus had come up. Hence, appeared oseltamivir and zanamivir, neuraminidase inhibitors, the first class of planned drugs against Influenza. Here, the path taken for their production was reverse of that of amantadine. Instead of testing the drug and finding out later how [...]... Read more »
von Itzstein, M., Wu, W., Kok, G., Pegg, M., Dyason, J., Jin, B., Phan, T., Smythe, M., White, H., Oliver, S.... (1993) Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature, 363(6428), 418-423. DOI: 10.1038/363418a0
Hata, K., Koseki, K., Yamaguchi, K., Moriya, S., Suzuki, Y., Yingsakmongkon, S., Hirai, G., Sodeoka, M., von Itzstein, M., & Miyagi, T. (2008) Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases. Antimicrobial Agents and Chemotherapy, 52(10), 3484-3491. DOI: 10.1128/AAC.00344-08
De Clercq, E. (2006) Antiviral agents active against influenza A viruses. Nature Reviews Drug Discovery, 5(12), 1015-1025. DOI: 10.1038/nrd2175
Collins, P., Haire, L., Lin, Y., Liu, J., Russell, R., Walker, P., Skehel, J., Martin, S., Hay, A., & Gamblin, S. (2008) Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature, 453(7199), 1258-1261. DOI: 10.1038/nature06956
Hurt, A., Holien, J., Parker, M., Kelso, A., & Barr, I. (2009) Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation. Journal of Virology, 83(20), 10366-10373. DOI: 10.1128/JVI.01200-09
, . (2009) Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans. New England Journal of Medicine, 360(25), 2605-2615. DOI: 10.1056/NEJMoa0903810
Soundararajan, V., Tharakaraman, K., Raman, R., Raguram, S., Shriver, Z., Sasisekharan, V., & Sasisekharan, R. (2009) Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus. Nature Biotechnology, 27(6), 510-513. DOI: 10.1038/nbt0609-510
We know full well that teachers bring their personal opinions into the classroom even though they’re not really supposed to do that. In some cases, that doesn’t matter. Your beliefs about today’s politics in the Middle East won’t suddenly change the rules of math. However, when it comes to important events in history or disciplines [...]... Read more »
Moore, R., & Cotner, S. (2009) The Creationist Down the Hall: Does It Matter When Teachers Teach Creationism?. BioScience, 59(5), 429-435. DOI: 10.1525/bio.2009.59.5.10
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