Turning on the hypoxic response in worms increases longevity!... Read more »
Mehta, R., Steinkraus, K., Sutphin, G., Ramos, F., Shamieh, L., Huh, A., Davis, C., Chandler-Brown, D., & Kaeberlein, M. (2009) Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans. Science, 324(5931), 1196-1198. DOI: 10.1126/science.1173507
The rewarding side of being a psychopath
What goes on in the brains of psychopaths? They can seem outwardly normal and even charming, but tthese people typically show a lack of empathy, immoral behaviour and an impulsive streak. Joshua Buckholtz found that the last of these traits - impulsivity - may stem from a hyperactive reward system in the brain and unusually high levels of the signalling chemical dopamine.
When given small doses of amphetamines, people who come out as more impulsive on ........ Read more »
Godfrey, S., & Smith, J. (2010) Shark-bitten vertebrate coprolites from the Miocene of Maryland. Naturwissenschaften. DOI: 10.1007/s00114-010-0659-x
Entry 6 March 11, 2010 (from One Reader’s Journey through The Immortal Life of Henrietta Lacks)
Then, in 1953, a geneticist in Texas accidentally mixed the wrong liquid with HeLa and a few other cells, and it turned out to be a fortunate mistake. The chromosomes inside the cells swelled and spread out, and for the [...]... Read more »
BAIKIE AG, COURT-BROWN WM, BUCKTON KE, HARNDEN DG, JACOBS PA, & TOUGH IM. (1960) A possible specific chromosome abnormality in human chronic myeloid leukaemia. Nature, 1165-6. PMID: 13685929
FORD CE. (1960) Human cytogenetics: its present place and future possibilities. American journal of human genetics, 104-17. PMID: 13823894
Hsu, T.C.,. (1952) Mammalian Chromosomes In Vitro: I The Karyotype of Man. J. Heredity, 167-172. info:/
Kottler MJ. (1974) From 48 to 46: cytological technique, preconception, and the counting of human chromosomes. Bulletin of the history of medicine, 48(4), 465-502. PMID: 4618149
Another week has gone by and some very interesting molbio blog posts have been aggregated to Researchblogging.org. Every week [see my opening post on the matter], I'll select some blog posts I consider particularly interesting in the field of molecular biology [see here to get a sense of the criteria that will be used], briefly describe them and list them here for you to check out.Note that I'm ... Read more »
Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., Yamada, T.... (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464(7285), 59-65. DOI: 10.1038/nature08821
Vijay-Kumar, M., Aitken, J., Carvalho, F., Cullender, T., Mwangi, S., Srinivasan, S., Sitaraman, S., Knight, R., Ley, R., & Gewirtz, A. (2010) Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5. Science. DOI: 10.1126/science.1179721
Zhao, D., McBride, D., Nandi, S., McQueen, H., McGrew, M., Hocking, P., Lewis, P., Sang, H., & Clinton, M. (2010) Somatic sex identity is cell autonomous in the chicken. Nature, 464(7286), 237-242. DOI: 10.1038/nature08852
I thought today for some light relief I would post my undergrad dissertation. As I can actually read it and feel OK about it, i reckon its not too bad, it also got quite a good grade It can be downloaded in full here. Don't submit it as your own! That's cheating! Any questions email me!The study was based on the using TARGET framework to influence motivational climate in children coaching sessions, the abstract is below;Grounded in Achievement Goal Theory (Maehr & Nicholls, 1980: Nicho........ Read more »
Ames, C. (1992) Classrooms: Goals, structures, and student motivation. Journal of Educational Psychology, 84(3), 261-271. DOI: 10.1037//0022-06184.108.40.2061
Ecosystems can influence regional climate through biophysical regulation. Researchers test a method to help resource mangers quantify this ecosystem service and predict how land cover changes will affect climate...... Read more »
West, P., Narisma, G., Barford, C., Kucharik, C., & Foley, J. (2010) An alternative approach for quantifying climate regulation by ecosystems. Frontiers in Ecology and the Environment, 2147483647. DOI: 10.1890/090015
The cliché scientist is often portrayed as the laborious worker slogging away days and nights in the lab. In contrast, the cliché for musicians or artists often comprises a bohemian lifestyle, full of parties, drugs and the occasional spurts of genius and frantic artistic expression. Reality, as always, is somewhere in-between. Artists need to work hard and laboriously to get something finished before the concert, recording or exhibition and scientists need to be creative and invest a lot of ........ Read more »
Liston, C., McEwen, B., & Casey, B. (2009) Psychosocial stress reversibly disrupts prefrontal processing and attentional control. Proceedings of the National Academy of Sciences, 106(3), 912-917. DOI: 10.1073/pnas.0807041106
Radley, J. (2005) Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex. Cerebral Cortex, 16(3), 313-320. DOI: 10.1093/cercor/bhi104
Zhong Kui, a Chinese god, punishing two gods of measles (1862)
I’ve talked before about measles incidence and the effect of vaccination. Now I’m going to spend this whole week talking about measles deaths, because I ended up with more than I could cover in one or two posts. So this is Part I of a [...]... Read more »
Armstrong, G. (1999) Trends in Infectious Disease Mortality in the United States During the 20th Century. JAMA: The Journal of the American Medical Association, 281(1), 61-66. DOI: 10.1001/jama.281.1.61
1. Don't smoke.2. See 1.This is essentially what Simon Chapman and Ross MacKenzie suggest in a provocative PloS Medicine paper, The Global Research Neglect of Unassisted Smoking Cessation: Causes and Consequences.Their point is deceptively simple: there is lots of research looking at drugs and other treatments to help people quit smoking tobacco, but little attention is paid to people who quit without any help, despite the fact that the majority (up to 75%) of quitters do just that. This is good........ Read more »
Chapman S, & MacKenzie R. (2010) The global research neglect of unassisted smoking cessation: causes and consequences. PLoS medicine, 7(2). PMID: 20161722
If a mother has a negative perception of her baby when it's just one month old, there's a strong possibility that same baby will have attachment problems as an adult, thirty or forty years later. That's the claim of a longitudinal study that recommends screening new mothers to see if they have a negative perception of their child, so that any necessary action can be taken to stop the transmission of attachment problems from mother to child.Elsie Broussard and Jude Cassidy recruited twenty-six ad........ Read more »
Broussard, E., & Cassidy, J. (2010) Maternal perception of newborns predicts attachment organization in middle adulthood. Attachment , 12(1), 159-172. DOI: 10.1080/14616730903282464
One of the most striking features of those suffering from anorexia nervosa is their perception of their bodies. You can put them in front of a mirror and they will still tell you they’re to fat when in fact they’re skinny. A recent publication in Nature Proceedings has an explanation.
This explanation is based on the [...]
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Riva, Guiseppe. (2010) Neuroscience and Eating Disorders: The role of the medial-temporal lobe. Nature Proceedings. info:/
This week a couple of my Sciblings have been abuzz about an article published in some journal I'd never heard of... a minor impact journal...the Journal of Who Gives a Fuck Science Communication. Bora has a great break down of some of the major criticisms. Drugmonkey, one of the subjects of the "analysis" in this article, is also displeased and critical of the author's conclusions.I've
since read the offending article and can only tell you this - I have no
idea what the balls the aut........ Read more »
Inna Kouper. (2010) Science blogs and public engagement with science: practices, challenges, and opportunities. Journal of Science Communication, 9(1). info:/
thanks to www.savebay.info
The Cove has recently collected a long list of awards including most notably an Oscar for best documentary. These well-deserved accolades reward the filmmakers for risky and groundbreaking filming in a highly protected cove in Japan where a dolphin fishery thrives, both to feed the aquarium trade and citizens wishing to enjoy [...]... Read more »
Akagi H, Grandjean P, Takizawa Y, & Weihe P. (1998) Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. Environmental research, 77(2), 98-103. PMID: 9600802
In 1986, Pat Wall and Steve McMahon commented on the folly of talking about nociception as though it is pain -
‘the labelling of nociceptors as pain fibres was not an admirable simplification but an unfortunate trivialization’ and
‘…pain is an integrated package of analysed results related to meaning, significance and imperative action’ 
Almost 25 years have [...]... Read more »
 Wall, P., & McMahon, S. (1986) The relationship of perceived pain to afferent nerve impulses. Trends in Neurosciences, 254-255. DOI: 10.1016/0166-2236(86)90070-6
 Reimann, F., Cox, J., Belfer, I., Diatchenko, L., Zaykin, D., McHale, D., Drenth, J., Dai, F., Wheeler, J., Sanders, F.... (2010) Pain perception is altered by a nucleotide polymorphism in SCN9A. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0913181107
Take a whiff of mustard or wasabi and you'll be hit with a familiar burning sensation. That's the result of chemicals in these pungent foods hitting a protein called TRPA1, a molecular alarm that warns us about irritating substances. The same protein does a similar job in other animals, but rattlesnakes and vipers have put their version of TRPA1 to a more impressive and murderous purpose. They use it to sense the body heat of their prey.
Pit vipers are famed for their ability to detect the infr........ Read more »
Effective treatment remains elusive.
For addiction to cocaine, amphetamine, and other stimulants, the treatment picture has been complicated by the lack of any truly significant anti-craving medications. (See post, “No Pill for Stimulant Addiction"). The National Institute on Drug Abuse (NIDA) has yet to approve any medications for the treatment of either cocaine or amphetamine addiction.
Take the case of cocaine. Partly the problem stems from the direct effect cocaine has on dopamine transm........ Read more »
Hiranita, T., Soto, P., Newman, A., & Katz, J. (2009) Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors. Journal of Pharmacology and Experimental Therapeutics, 329(2), 677-686. DOI: 10.1124/jpet.108.145813
I’m sure we’ve all seen it. The person comes into a pain management programme, gets excited, does really well during each session, enjoys the company and makes huge gains – then the programme ends and — FIZZLE! It all stops.
Some critics suggest that any change obtained during a short-term programme (such as a three-week [...]... Read more »
Christiansen, S., Oettingen, G., Dahme, B., & Klinger, R. (2010) A short goal-pursuit intervention to improve physical capacity: A randomized clinical trial in chronic back pain patients. Pain. DOI: 10.1016/j.pain.2009.12.015
At Medical and Technology of Joseph Kim, the upcoming Grand Rounds host, I saw the blog post “Need your help on Facebook to get Diet Coke to Donate $50,000 to the Foundation for NIH”.
National Heart Lung and Blood Institute has started a national campaign in the US, The Heart Truth®. They issued a challenge in [...]... Read more »
Litsa K Lambrakos, Pamela Coxson, Lee Goldman, Kirsten Bibbins-Domingo. (2010) Sugar-Sweetened Beverage Consumption and the Attributable Burden to Diabetes and Coronary Heart Disease. Circulation. info:other/
Malik VS, Schulze MB, & Hu FB. (2006) Intake of sugar-sweetened beverages and weight gain: a systematic review. The American journal of clinical nutrition, 84(2), 274-88. PMID: 16895873
Wolff E, & Dansinger ML. (2008) Soft drinks and weight gain: how strong is the link?. Medscape journal of medicine, 10(8), 189. PMID: 18924641
Forshee RA, Anderson PA, & Storey ML. (2008) Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. The American journal of clinical nutrition, 87(6), 1662-71. PMID: 18541554
Gibson S. (2008) Sugar-sweetened soft drinks and obesity: a systematic review of the evidence from observational studies and interventions. Nutrition research reviews, 21(2), 134-47. PMID: 19087367
Janssen I, Katzmarzyk PT, Boyce WF, Vereecken C, Mulvihill C, Roberts C, Currie C, Pickett W, & Health Behaviour in School-Aged Children Obesity Working Group. (2005) Comparison of overweight and obesity prevalence in school-aged youth from 34 countries and their relationships with physical activity and dietary patterns. Obesity reviews : an official journal of the International Association for the Study of Obesity, 6(2), 123-32. PMID: 15836463
What looks like a worm, is completely symmetrical in cross-section, and in the words of Dr. Peter Holland:
“It has no mouth, no gut, no brain and no nerve cord. It doesn’t have a left or right side or a top or bottom – we can’t even tell which end is the front!” (quoted from Physorg)
Its [...]... Read more »
FORMATION of a memory is widely believed to leave a 'trace' in the brain - a fleeting pattern of electrical activity which strengthens the connections within a widely distributed network of neurons, and which re-emerges when the memory is recalled. The concept of the memory trace was first proposed nearly a century ago, but the nature of the trace, its precise location in the brain and the underlying neural mechanisms all remain elusive. A new study by researchers from University College London ........ Read more »
Chadwick, M. J., et al. (2010) Decoding Individual Episodic Memory Traces in the Human Hippocampus. Curr. Biol. info:/
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