One goal of integrative systems biology is the accurate representation of metabolite and protein interaction networks. To this end, several groups independently defined the metabolic network of baker’s yeast from available genomic and literature data [1,2]. These models differed considerably, so a “Jamboree” was held in Manchester in April 2007, bringing together experts from various [...]... Read more »
Kuepfer L, Sauer U, & Blank LM. (2005) Metabolic functions of duplicate genes in Saccharomyces cerevisiae. Genome research, 15(10), 1421-30. PMID: 16204195
Mo ML, Palsson BO, & Herrgård MJ. (2009) Connecting extracellular metabolomic measurements to intracellular flux states in yeast. BMC systems biology, 37. PMID: 19321003
Herrgård MJ, Swainston N, Dobson P, Dunn WB, Arga KY, Arvas M, Blüthgen N, Borger S, Costenoble R, Heinemann M.... (2008) A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nature biotechnology, 26(10), 1155-60. PMID: 18846089
Installment #4 in the mini-series on multilingual signage
Toilets as an object of sociolinguistic research?! Not likely?! Think again! Today, I am going to discuss toilet signage as an indicator of how inclusive a society is.
Types of toilets and ways of cleaning yourself after using them are quite diverse internationally – thus, creating the potential for [...]... Read more »
Pavlenko, Aneta. (2005) 'Ask Each Pupil About Her Methods of Cleaning': Ideologies of Language and Gender in Americanisation Instruction (1900-1924). International Journal of Bilingual Education and Bilingualism, 8(4), 275-297. info:/
Wikipedia, Wordpress, Linux…the list of community-driven projects goes on with more and more people getting involved. They do so, it seems, purely for the sake of contributing, bettering themselves and the projects with which they become involved, almost always for no financial reward. This is not crowdsourcing. This is open-source production, collaborative learning, or online [...]Post from: David Bradley's Sciencetext Tech TalkCloud workers: laborers, addicts, or slaves?
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Jonathan R. Corney, Carmen Torres-Sánchez, A. Prasanna Jagadeesan, & William C. Regli. (2009) Outsourcing labour to the cloud. Int. J. Innovation and Sustainable Development, 4(4), 294-313. info:/
What do professionals in the domain of supply chain management think about disruptions? How do they prepare for them, how do they act when a disruption occurs?
Blackhurst et al. (2005) answer these questions in their work about "An empirically derived agenda of critical research issues for managing supply-chain disruptions".... Read more »
Blackhurst, J., Craighead, C., Elkins, D., & Handfield, R. (2005) An empirically derived agenda of critical research issues for managing supply-chain disruptions. International Journal of Production Research, 43(19), 4067-4081. DOI: 10.1080/00207540500151549
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Griffith, E., Sauer, J., & Royle, J. (2010) Traffic Effects on Bird Counts on North American Breeding Bird Survey Routes. The Auk, 127(2), 387-393. DOI: 10.1525/auk.2009.09056
Anyone who has ever taken high doses of cortisone is well aware of the profound effect of glucocorticoids on appearance and body weight.
Not only do patients on high doses of cortisone regularly develop a typical Cushingoid phenotype (with abdominal obesity, moon face and buffalo hump) but patients also develop a ravenous hunger and appetite with [...]... Read more »
Cellini E, Castellini G, Ricca V, Bagnoli S, Tedde A, Rotella CM, Faravelli C, Sorbi S, & Nacmias B. (2010) Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity. Psychiatric genetics. PMID: 20440229
Michael Ash looks at leaky gut with a contemporary approach to investigation, relevance and restoration. It is quite clear that in order to extract nutrients and other sentinel information carrying agents the barrier that divides the contents of the gastric lumen from the host must be permeable. The question that has interested clinicians for many [...]... Read more »
Ménard S, Cerf-Bensussan N, & Heyman M. (2010) Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal immunology, 3(3), 247-59. PMID: 20404811
I've been looking at evolutionary precursors to bilingualism. What does this mean? At the moment, I'm thinking about it in the sense of having two or more signals which correspond to the same action or meaning. Not much before language, you say? How about going all the way back to RNA codes?RNA converts genetic information stored in DNA into proteins which regulate processes within cells. The ‘code’ for translating DNA into proteins is redundant but not ambiguous. There are varieties o........ Read more »
Marquez R, Smit S, & Knight R. (2005) Do universal codon-usage patterns minimize the effects of mutation and translation error?. Genome biology, 6(11). PMID: 16277746
Monica Tamariz, Andrew D. M. Smith. (2008) Quantifying the regularity of the mappings between signals and meanings. Proceedings of the 7th Conference on the Evolution of Language. info:/
The political parties don't agree on much but what they do all agree on is that the more people who exercise their right to vote, the better. Psychology can help. A new study shows that phone calls to encourage people to vote can be made more effective by a simple strategy - that is, by asking the would-be voter to spell out what time they plan to vote, where they will be coming from prior to voting and what they will have been doing beforehand.David Nickerson and Todd Rogers targeted 155,669 vo........ Read more »
Nickerson DW, & Rogers T. (2010) Do you have a voting plan?: implementation intentions, voter turnout, and organic plan making. Psychological science : a journal of the American Psychological Society / APS, 21(2), 194-9. PMID: 20424044
Science-based medicine is, among other things, a tool. Science helps us sequester our biases so that we may better understand reality. Of course, there is no way to avoid being human; our biases and our intuition still betray us, and when they do, we use other tools. Ethics help us think through situations using an [...]... Read more »
Stulberg, D., Lawrence, R., Shattuck, J., & Curlin, F. (2010) Religious Hospitals and Primary Care Physicians: Conflicts over Policies for Patient Care. Journal of General Internal Medicine. DOI: 10.1007/s11606-010-1329-6
by Drew Rosielle MD in Pallimed: a Hospice & Palliative Medicine Blog
As a follow up for today's top-post, some more floundering about prognosis in brain injuries, and yes this one is for the progno-wonks out there.
Neurology also has an article looking at the prognostic importance of bilateral absence of the N20 response of median nerve somatosensory evoked potentials for patients with hypoxic-ischemic encephalopathy (anoxic brain injury) who have undergone therapeutic hypothermia.
Some background (although this NEJM review is the best place to go........ Read more »
Leithner C, Ploner CJ, Hasper D, & Storm C. (2010) Does hypothermia influence the predictive value of bilateral absent N20 after cardiac arrest?. Neurology, 74(12), 965-9. PMID: 20308680
Besides DYING to write something in ALL CAPS and using ultimate twice in the same sentence, I've also really been waiting to write something like this: Science reveals the ultimate secret to happiness, better sex, longer life and ultimate riches...... Read more »
McNulty JK, Neff LA, & Karney BR. (2008) Beyond initial attraction: physical attractiveness in newlywed marriage. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43), 22(1), 135-43. PMID: 18266540
The open access journal PLoS ONE has published a lot of neat paleontology articles over the last few years (see here for a reasonably comprehensive listing). Charismatic, terrestrial vertebrates (whether dinosaurs, Ice Age mammals, or prehistoric humans) seem to dominate. But what about the poor, neglected fish?
Today, PLoS ONE published a nifty article by Anthony (Tony) Martin [pictured at left] and colleagues, discussing a 50 million year old fish feeding and swimming trace fossil from Wyomin........ Read more »
Martin, A., Vazquez-Prokopec, G., & Page, M. (2010) First Known Feeding Trace of the Eocene Bottom-Dwelling Fish Notogoneus osculus and Its Paleontological Significance. PLoS ONE, 5(5). DOI: 10.1371/journal.pone.0010420
Excess visceral fat tissue and other side-effects of the sort of high-calorie, low-exercise lifestyle required to pack on the fat will do you great harm in the long term. Getting fat is a choice is for the vast majority of people, a choice made again and again day after day by deciding to eat more calories and skip exercise in favor of other activities. For 99.9% of the audience here: you're not special, and there's nothing in your genes that's making it noticeably easier to gain weight or harde........ Read more »
African wild dogs (Lycaon pictus), photographed at the Bronx Zoo.
African wild dogs (Lycaon pictus) don't have it easy. Their taste for large mammalian prey puts them in competition with lions and spotted hyenas for both prey and living space, meaning that wild dogs regularly have their kills stolen or are even killed by other predators. In fact, the dogs may even be unintentionally attracting the attention of these other hunters.
Like other social carnivores, African wild dogs communicat........ Read more »
Webster, H., McNutt, J., & McComb, K. (2010) Eavesdropping and Risk Assessment Between Lions, Spotted Hyenas and African Wild Dogs. Ethology, 116(3), 233-239. DOI: 10.1111/j.1439-0310.2009.01729.x
Invasive plants don’t have stronger chemical defenses than natives
... Read more »
Lind, E.M., & J.D. Parker. (2010) Novel Weapons Testing: Are Invasive Plants More Chemically Defended than Native Plants?. PLoS ONE, 5(5). DOI: 10.1371/journal.pone.0010429
The protein Slitrk5—which is specific to neurons—is involved in the pathogenesis of obsessive–compulsive disorder (OCD) and loss of this protein leads to OCD-like behaviour in mice. The study, published in Nature Medicine, demonstrates that Slitrk5-knockout mice can be used as model of OCD and could help elucidate the molecular mechanisms that underlie this condition. OCD [...]... Read more »
Shmelkov, S., Hormigo, A., Jing, D., Proenca, C., Bath, K., Milde, T., Shmelkov, E., Kushner, J., Baljevic, M., Dincheva, I.... (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice. Nature Medicine. DOI: 10.1038/nm.2125
One of the most amazing visual illusions is also one of the simplest. It’s called the Troxler effect for Ignaz Troxler, the scientist who discovered it in 1804. To experience it, just stare at the central dot in this figure for 30 seconds or so, with your head about 12 inches from your computer monitor. [...]... Read more »
HSIEH, P., & TSE, P. (2006) Illusory color mixing upon perceptual fading and filling-in does not result in ‘forbidden colors’. Vision Research, 46(14), 2251-2258. DOI: 10.1016/j.visres.2005.11.030
Repetitive Transcranial Magnetic Stimulation (rTMS) is a treatment for depression that was approved by the FDA in October of 2008 (1). Repetitive TMS involves a device (pictured right), which is noninvasive, that excites the neurons in the brain. When this done over the left dorsolateral prefrontal cortex (an area of the brain supposedly less active in depressed patients), brain activity increases. The major selling point is that it has very few side-effects compared to ........ Read more »
George MS, Lisanby SH, Avery D, McDonald WM, Durkalski V, Pavlicova M, Anderson B, Nahas Z, Bulow P, Zarkowski P.... (2010) Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Archives of general psychiatry, 67(5), 507-16. PMID: 20439832
There’s new paper in Genome Biology (tip: Dienekes) which doesn’t present too much in terms of new results, Characterizing the admixed African ancestry of African Americans, but has really, really, good visualization of the data:
From cluster analysis, we found that all the African Americans are admixed in their African components of ancestry, with the majority [...]... Read more »
Zakharia F, Basu A, Absher D, Assimes TL, Go AS, Hlatky MA, Iribarren C, Knowles JW, Li J, Narasimhan B.... (2009) Characterizing the admixed African ancestry of African Americans. Genome biology, 10(12). PMID: 20025784
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