Post List

  • April 15, 2010
  • 05:00 PM

When the pain of carpal tunnel syndrome spreads, we should be thinking dorsal horn not malingering

by Lorimer Moseley in BodyInMind

Here is an important study.  A couple of Italian Neurologists have investigated people with carpal tunnel syndrome who report that their pain has spread beyond the boundaries of the median nerve.  Unfortunately, such reports are often misinterpreted by clinicians as evidence of malingering, or hysteria.  Well, these fellows did quantitative sensory testing and came up [...]... Read more »

[1] Caliandro P, La Torre G, Aprile I, Pazzaglia C, Commodari I, Tonali P, & Padua L. (2006) Distribution of paresthesias in Carpal Tunnel Syndrome reflects the degree of nerve damage at wrist. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 117(1), 228-31. PMID: 16325467  

[3] Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, & Serra J. (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, 70(18), 1630-5. PMID: 18003941  

[4] Wilder-Smith EP, Ng ES, Chan YH, & Therimadasamy AK. (2008) Sensory distribution indicates severity of median nerve damage in carpal tunnel syndrome. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 119(7), 1619-25. PMID: 18467170  

  • April 15, 2010
  • 04:20 PM

New developments in castration resistant prostate cancer - MDV3100

by Sally Church in Pharma Strategy Blog

Last night I received an alert from Medivation announcing that an article would be published in today's online The Lancet regarding their prostate cancer agent, MDV3100. Sure enough, here's the article: Although the trial is an early phase I/II study,...... Read more »

Scher, H., Beer, T., Higano, C., Anand, A., Taplin, M., Efstathiou, E., Rathkopf, D., Shelkey, J., Yu, E., & Alumkal, J. (2010) Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study. The Lancet. DOI: 10.1016/S0140-6736(10)60172-9  

  • April 15, 2010
  • 04:00 PM

A Lesson Before Dying

by Journal Watch Online in Journal Watch Online

Scientists train endangered carnivores to avoid poisonous toads

... Read more »

  • April 15, 2010
  • 02:14 PM

Field Talk: Termites enrich the soil in East Africa

by Katie Kline in EcoTone

Vertebrate fertilizer is not the only source of nutrients in the soils of East African savannahs, at least according to a study recently published in the journal Ecology. Alison Brody from the University of Vermont and colleagues found that termites actually had more of an effect on the fruiting success of Acacia trees in Kenya than did dung and urine deposition from ungulate herbivores, such as zebras and gazelles.

... Read more »

  • April 15, 2010
  • 01:44 PM

Fossil Shell Preserves Signs of a Prehistoric Tug-of-War

by Laelaps in Laelaps

Top of the encrusted surface of a brachiopod shell, showing the "war" between an edrioasteroid (star-shaped organism at center) and a fast-growing bryozoan colony. From Sprinkle and Rodgers 2010.

Back in the early days of paleontology, when the meaning and origin of fossils was still in doubt, some naturalists believed that the shells, shark teeth, and other petrified curiosities were attempts by the rock to imitate life. Fossils were not true vestiges of history, it was believed, but inst........ Read more »

  • April 15, 2010
  • 01:10 PM

Increased neurogenesis is not (necessarily) the opposite of reduced neurogenesis

by Jason Snyder in Functional Neurogenesis

Two recent papers have attracted a lot of media attention because they draw direct links between adult neurogenesis and behavioral disorders: Noonan et al. showed that rats lacking adult neurogenesis (stopped with irradiation) are more susceptible to cocaine addiction. Jin et al. showed that mice lacking adult neurogenesis (using a transgenic model) suffer greater infarct [...]... Read more »

Noonan MA, Bulin SE, Fuller DC, & Eisch AJ. (2010) Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(1), 304-15. PMID: 20053911  

  • April 15, 2010
  • 12:07 PM

Phonological Training Changes Brain Activation in Dyslexic Children

by Livia in Reading and Word Recognition Research

Note: Online Universities has included me in their list of top 50 female science bloggers. It’s not actually for this blog, but for my Brain Science and Creative Writing blog. Anyways, check out the list if you get a chance. There are lot of interesting bloggers.

 Accessibility:  Intermediate-Advanced

We’ve looked at the neuroscience of dyslexia and how the dyslexic brain processes words.

... Read more »

Shaywitz BA, Shaywitz SE, Blachman BA, Pugh KR, Fulbright RK, Skudlarski P, Mencl WE, Constable RT, Holahan JM, Marchione KE.... (2004) Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention. Biological psychiatry, 55(9), 926-33. PMID: 15110736  

  • April 15, 2010
  • 11:43 AM

Agile Supply Chains

by Daniel Dumke in SCRM Blog - Supply Chain Risk Management

Today I wanted to highlight the basics of supply chain management by talking about "Supply chain migration from lean and functional to agile and customised" by Christopher and Towill (2000).
Agile supply chains are a quite new concept which emphasis a change in the corporate mindset to adjust to the constantly changing customer demand.... Read more »

Christopher, M., & Towill, D. (2000) Supply chain migration from lean and functional to agile and customised. Supply Chain Management: An International Journal, 5(4), 206-213. DOI: 10.1108/13598540010347334  

  • April 15, 2010
  • 11:03 AM

I’ll have the truffles and huitlacoche

by stajich in The Hyphal Tip

A couple of papers should have captured your attention lately in the realm of fungal genomics.
One is the publication of the genome of the black truffle Tuber melanosporum. This appears as an advanced publication at Nature (OA by virtue of Nature’s agreement on genome papers) along with a NYT writeup and is a tasty exploration [...]... Read more »

Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R.... (2010) Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis. Nature. PMID: 20348908  

  • April 15, 2010
  • 11:02 AM

The molecular genetics of aggressive B-cell lymphomas

by Sally Church in Pharma Strategy Blog

As many readers here on PSB know, I've not been a big fan of genome-wide molecular profiling, preferring an oncogene addiction approach to drug development and targeted cancer therapies. However, every once in a while something comes along that stops...... Read more »

Lenz, G., & Staudt, L. (2010) Aggressive Lymphomas. New England Journal of Medicine, 362(15), 1417-1429. DOI: 10.1056/NEJMra0807082  

  • April 15, 2010
  • 11:01 AM

When diversity is good for disease

by Razib Khan in Gene Expression

Yesterday I pointed to a new paper, Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. P. vivax is the least virulent of the malaria inducing pathogens, and it is presumably responsible for the fact that the Duffy antigen locus is one of the more ancestrally informative ones in the human genome. In [...]... Read more »

Ménard D, Barnadas C, Bouchier C, Henry-Halldin C, Gray LR, Ratsimbasoa A, Thonier V, Carod JF, Domarle O, Colin Y.... (2010) Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Proceedings of the National Academy of Sciences of the United States of America, 107(13), 5967-71. PMID: 20231434  

  • April 15, 2010
  • 10:06 AM

The Four Dimensions of a Breast Cancer Genome

by Daniel Koboldt in Massgenomics

Published today in the journal Nature is the whole-genome sequencing of a basal-like breast cancer tumor, metastasis, and xenograft. There’s also a News and Views article by Joe Gray of Lawrence Berkeley National Laboratory, as well as a news feature on large-scale cancer projects.

This study is a bit unlike our previous cancer genomes (AML1 and [...]... Read more »

Li Ding, Matthew J. Ellis, Shunqiang Li, David E. Larson, Ken Chen, John W. Wallis, Christopher C. Harris, Michael D. McLellan, Robert S. Fulton, Lucinda L. Fulton, Rachel M. Abbott, Jeremy Hoog, David J. Dooling, Daniel C. Koboldt, Heather Schmidt, Joell. (2010) Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature, 464(15), 999-1005. info:/10.1038/nature08989

  • April 15, 2010
  • 09:00 AM

Young children see the moon illusion

by sciencebase in Sciencebase Science Blog

Why does the full moon seem bigger when it’s near the horizon than when it’s high in the sky? The moon illusion, which also applies to the perception of the size of the sun in the sky, has intrigued artists and puzzled psychologists for many years.

The moon illusion refers to the fact that the sun [...]Young children see the moon illusion is a post from: Sciencebase Science Blog
... Read more »

Helen E. Ross, & Adele Cowie. (2010) The moon illusion in children’s drawings. Int. J. Arts and Technology, 3(2/3), 275-287. info:/

  • April 15, 2010
  • 07:46 AM

Our own little Open Science project: Buridan's paradigm

by Björn Brembs in

On FriendFeed, Open Science is a frequent discussion topic and I also get the impression that the scientific community at large is starting to pay more and more attention to the principles of Open Science, possibly in the wake of the Open Access movement.As a proponent of Open Science, I've always had a bad conscience that my own contribution to the movement was so ridiculously small: I just tell everybody about my results here on my blog. Most of my data is acquired in a proprietary format (ha........ Read more »

Karl Götz. (1980) Visual guidance in Drosophila. Basic Life Sci, 391-407. info:/

Neuser, K., Triphan, T., Mronz, M., Poeck, B., & Strauss, R. (2008) Analysis of a spatial orientation memory in Drosophila. Nature, 453(7199), 1244-1247. DOI: 10.1038/nature07003  

  • April 15, 2010
  • 07:06 AM

What Is Beauty? Your Kids' Newest Art Critic

by Jason Goldman in The Thoughtful Animal

Do animals create art? So far, this seems a uniquely human ability.

But do animals have a sense of the aesthetically pleasing? What about the ability to judge and critique art? Can an animal decide if a given work of art is beautiful or ugly? What is beauty in the first place? All good questions.

Shigeru Watanabe of Keio University in Tokyo wanted to investigate the questions, with pigeons. Did he introduce them to the works of Picasso? Or Rembrandt? Romero Britto? No. He used art created by ........ Read more »

  • April 15, 2010
  • 06:15 AM

Living in the future: Mouse TcR clones

by iayork in Mystery Rays from Outer Space

T cell receptor (top) interacting with MHC

It would be nice if I could claim that advances in biology are driven by pure intellectual processes, by hermits on mountaintops achieving new theories through mediation and  deep, pure thoughts. Of course, that’s not the case.  I think its fair to say that many, if not most, of [...]... Read more »

  • April 15, 2010
  • 06:07 AM

Ancient Snake Dined on Dinos

by Laura Klappenbach in About Animals / Wildlife

↑ Click to enlarge image

A fossil unearthed from a remote corner of western India reads like an ancient crime scene. The fossil depicts a dinosaur nest containing two unhatched dinosaur eggs and the broken pieces of shell from a third egg. Next to the shattered shell lies the remains of a hatchling dinosaur. The fossil also features the remnants of a rather more sinister creature: an ancient snake lies coiled around the broken egg, as if caught in the act of raiding the nest.

The fossil........ Read more »

  • April 15, 2010
  • 05:36 AM

Harsh Attitudes of Child Protection Workers

by Ultimo167 in Strong Silent Types

Douglas and Walsh (2010) paint a not so pretty picture of what child protection workers think about their clients, particularly those battered mothers entangled in what are usually, extraordinarily complicated dynamics. The authors suggest several possible improvements, including better worker supervision, tougher police interventions, and more holistic service delivery for victims and their children.

... Read more »

Douglas, H., & Walsh, T. (2010) Mothers, Domestic Violence, and Child Protection. Violence Against Women, 16(5), 489-508. DOI: 10.1177/1077801210365887  

  • April 15, 2010
  • 05:00 AM

Breaking out of the zoo: study finds high risk of species escape

by Rob Goldstein in Conservation Maven

Lax security at zoos is putting ecosystems at risk for invasion by exotic species according to a new study by researchers in Spain. Zoos already are the 2nd biggest contributor of exotic species invasions in Europe...... Read more »

  • April 15, 2010
  • 04:52 AM

Don't start group discussions by sharing initial preferences

by BPS Research Digest in BPS Research Digest

When groups of people get together to make decisions, they often struggle to fulfil their potential. Part of the reason is that they tend to spend more time talking about information that everyone shares rather than learning fresh insights from each other. In a forthcoming paper, Andreas Mojzisch and Stefan Schulz-Hardt have uncovered a new reason groups so often make sub-optimal decisions. The researchers show that when a group of people begin a discussion by sharing their initial preferences, ........ Read more »

Andreas Mojzisch, & Stefan Schulz-Hardt. (2010) Knowing others' preferences degrades the quality of group decisions. Journal of Personality and Social Psychology. info:/

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