Here is an important study. A couple of Italian Neurologists have investigated people with carpal tunnel syndrome who report that their pain has spread beyond the boundaries of the median nerve. Unfortunately, such reports are often misinterpreted by clinicians as evidence of malingering, or hysteria. Well, these fellows did quantitative sensory testing and came up [...]... Read more »
 Caliandro P, La Torre G, Aprile I, Pazzaglia C, Commodari I, Tonali P, & Padua L. (2006) Distribution of paresthesias in Carpal Tunnel Syndrome reflects the degree of nerve damage at wrist. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 117(1), 228-31. PMID: 16325467
 Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, & Porreca F. (2000) Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain, 86(1-2), 185-94. PMID: 10779675
 Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, & Serra J. (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology, 70(18), 1630-5. PMID: 18003941
 Wilder-Smith EP, Ng ES, Chan YH, & Therimadasamy AK. (2008) Sensory distribution indicates severity of median nerve damage in carpal tunnel syndrome. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 119(7), 1619-25. PMID: 18467170
 Zanette G, Marani S, & Tamburin S. (2006) Extra-median spread of sensory symptoms in carpal tunnel syndrome suggests the presence of pain-related mechanisms. Pain, 122(3), 264-70. PMID: 16530966
 Zanette G, Marani S, & Tamburin S. (2007) Proximal pain in patients with carpal tunnel syndrome: a clinical-neurophysiological study. Journal of the peripheral nervous system : JPNS, 12(2), 91-7. PMID: 17565533
 Zanette G, Cacciatori C, & Tamburin S. (2010) Central sensitization in carpal tunnel syndrome with extraterritorial spread of sensory symptoms. Pain, 148(2), 227-36. PMID: 20004060
Last night I received an alert from Medivation announcing that an article would be published in today's online The Lancet regarding their prostate cancer agent, MDV3100. Sure enough, here's the article: Although the trial is an early phase I/II study,...... Read more »
Scher, H., Beer, T., Higano, C., Anand, A., Taplin, M., Efstathiou, E., Rathkopf, D., Shelkey, J., Yu, E., & Alumkal, J. (2010) Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study. The Lancet. DOI: 10.1016/S0140-6736(10)60172-9
Scientists train endangered carnivores to avoid poisonous toads
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O’Donnell, S., Webb, J.K., & R. Shine. (2010) Conditioned taste aversion enhances the survival of an endangered predator imperilled by a toxic invader. Journal of Applied Ecology. DOI: 10.1111/j.1365-2664.2010.01802.x
Vertebrate fertilizer is not the only source of nutrients in the soils of East African savannahs, at least according to a study recently published in the journal Ecology. Alison Brody from the University of Vermont and colleagues found that termites actually had more of an effect on the fruiting success of Acacia trees in Kenya than did dung and urine deposition from ungulate herbivores, such as zebras and gazelles.
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Brody, A., Palmer, T., Fox-Dobbs, K., & Doak, D. (2010) Termites, vertebrate herbivores, and the fruiting success of Acacia drepanolobium. Ecology, 91(2), 399-407. DOI: 10.1890/09-0004.1
Top of the encrusted surface of a brachiopod shell, showing the "war" between an edrioasteroid (star-shaped organism at center) and a fast-growing bryozoan colony. From Sprinkle and Rodgers 2010.
Back in the early days of paleontology, when the meaning and origin of fossils was still in doubt, some naturalists believed that the shells, shark teeth, and other petrified curiosities were attempts by the rock to imitate life. Fossils were not true vestiges of history, it was believed, but inst........ Read more »
Sprinkle, J., & Rodgers, J. (2010) Competition between a Pennsylvanian (Late Carboniferous) Edrioasteroid and a Bryozoan for Living Space on a Brachiopod. Journal of Paleontology, 84(2), 356-359. DOI: 10.1666/09-089R.1
Two recent papers have attracted a lot of media attention because they draw direct links between adult neurogenesis and behavioral disorders: Noonan et al. showed that rats lacking adult neurogenesis (stopped with irradiation) are more susceptible to cocaine addiction. Jin et al. showed that mice lacking adult neurogenesis (using a transgenic model) suffer greater infarct [...]... Read more »
Noonan MA, Bulin SE, Fuller DC, & Eisch AJ. (2010) Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(1), 304-15. PMID: 20053911
Jin K, Wang X, Xie L, Mao XO, & Greenberg DA. (2010) Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20385829
Note: Online Universities has included me in their list of top 50 female science bloggers. It’s not actually for this blog, but for my Brain Science and Creative Writing blog. Anyways, check out the list if you get a chance. There are lot of interesting bloggers.
We’ve looked at the neuroscience of dyslexia and how the dyslexic brain processes words.
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Shaywitz BA, Shaywitz SE, Blachman BA, Pugh KR, Fulbright RK, Skudlarski P, Mencl WE, Constable RT, Holahan JM, Marchione KE.... (2004) Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention. Biological psychiatry, 55(9), 926-33. PMID: 15110736
Today I wanted to highlight the basics of supply chain management by talking about "Supply chain migration from lean and functional to agile and customised" by Christopher and Towill (2000).
Agile supply chains are a quite new concept which emphasis a change in the corporate mindset to adjust to the constantly changing customer demand.... Read more »
Christopher, M., & Towill, D. (2000) Supply chain migration from lean and functional to agile and customised. Supply Chain Management: An International Journal, 5(4), 206-213. DOI: 10.1108/13598540010347334
A couple of papers should have captured your attention lately in the realm of fungal genomics.
One is the publication of the genome of the black truffle Tuber melanosporum. This appears as an advanced publication at Nature (OA by virtue of Nature’s agreement on genome papers) along with a NYT writeup and is a tasty exploration [...]... Read more »
Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R.... (2010) Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis. Nature. PMID: 20348908
Skibbe DS, Doehlemann G, Fernandes J, & Walbot V. (2010) Maize tumors caused by Ustilago maydis require organ-specific genes in host and pathogen. Science (New York, N.Y.), 328(5974), 89-92. PMID: 20360107
As many readers here on PSB know, I've not been a big fan of genome-wide molecular profiling, preferring an oncogene addiction approach to drug development and targeted cancer therapies. However, every once in a while something comes along that stops...... Read more »
Friedberg, J., Sharman, J., Sweetenham, J., Johnston, P., Vose, J., LaCasce, A., Schaefer-Cutillo, J., De Vos, S., Sinha, R., Leonard, J.... (2009) Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood, 115(13), 2578-2585. DOI: 10.1182/blood-2009-08-236471
Yesterday I pointed to a new paper, Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. P. vivax is the least virulent of the malaria inducing pathogens, and it is presumably responsible for the fact that the Duffy antigen locus is one of the more ancestrally informative ones in the human genome. In [...]... Read more »
Ménard D, Barnadas C, Bouchier C, Henry-Halldin C, Gray LR, Ratsimbasoa A, Thonier V, Carod JF, Domarle O, Colin Y.... (2010) Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Proceedings of the National Academy of Sciences of the United States of America, 107(13), 5967-71. PMID: 20231434
Published today in the journal Nature is the whole-genome sequencing of a basal-like breast cancer tumor, metastasis, and xenograft. There’s also a News and Views article by Joe Gray of Lawrence Berkeley National Laboratory, as well as a news feature on large-scale cancer projects.
This study is a bit unlike our previous cancer genomes (AML1 and [...]... Read more »
Li Ding, Matthew J. Ellis, Shunqiang Li, David E. Larson, Ken Chen, John W. Wallis, Christopher C. Harris, Michael D. McLellan, Robert S. Fulton, Lucinda L. Fulton, Rachel M. Abbott, Jeremy Hoog, David J. Dooling, Daniel C. Koboldt, Heather Schmidt, Joell. (2010) Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature, 464(15), 999-1005. info:/10.1038/nature08989
Why does the full moon seem bigger when it’s near the horizon than when it’s high in the sky? The moon illusion, which also applies to the perception of the size of the sun in the sky, has intrigued artists and puzzled psychologists for many years.
The moon illusion refers to the fact that the sun [...]Young children see the moon illusion is a post from: Sciencebase Science Blog
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Helen E. Ross, & Adele Cowie. (2010) The moon illusion in children’s drawings. Int. J. Arts and Technology, 3(2/3), 275-287. info:/
On FriendFeed, Open Science is a frequent discussion topic and I also get the impression that the scientific community at large is starting to pay more and more attention to the principles of Open Science, possibly in the wake of the Open Access movement.As a proponent of Open Science, I've always had a bad conscience that my own contribution to the movement was so ridiculously small: I just tell everybody about my results here on my blog. Most of my data is acquired in a proprietary format (ha........ Read more »
Karl Götz. (1980) Visual guidance in Drosophila. Basic Life Sci, 391-407. info:/
Neuser, K., Triphan, T., Mronz, M., Poeck, B., & Strauss, R. (2008) Analysis of a spatial orientation memory in Drosophila. Nature, 453(7199), 1244-1247. DOI: 10.1038/nature07003
Do animals create art? So far, this seems a uniquely human ability.
But do animals have a sense of the aesthetically pleasing? What about the ability to judge and critique art? Can an animal decide if a given work of art is beautiful or ugly? What is beauty in the first place? All good questions.
Shigeru Watanabe of Keio University in Tokyo wanted to investigate the questions, with pigeons. Did he introduce them to the works of Picasso? Or Rembrandt? Romero Britto? No. He used art created by ........ Read more »
Watanabe, S. (2009) Pigeons can discriminate “good” and “bad” paintings by children. Animal Cognition, 13(1), 75-85. DOI: 10.1007/s10071-009-0246-8
T cell receptor (top) interacting with MHC
It would be nice if I could claim that advances in biology are driven by pure intellectual processes, by hermits on mountaintops achieving new theories through mediation and deep, pure thoughts. Of course, that’s not the case. I think its fair to say that many, if not most, of [...]... Read more »
Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, & Ploegh HL. (2010) Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science (New York, N.Y.), 328(5975), 243-8. PMID: 20378817
Kisielow P, Blüthmann H, Staerz UD, Steinmetz M, & von Boehmer H. (1988) Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4 8 thymocytes. Nature, 333(6175), 742-6. PMID: 3260350
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A fossil unearthed from a remote corner of western India reads like an ancient crime scene. The fossil depicts a dinosaur nest containing two unhatched dinosaur eggs and the broken pieces of shell from a third egg. Next to the shattered shell lies the remains of a hatchling dinosaur. The fossil also features the remnants of a rather more sinister creature: an ancient snake lies coiled around the broken egg, as if caught in the act of raiding the nest.
The fossil........ Read more »
Wilson, J., Mohabey, D., Peters, S., & Head, J. (2010) Predation upon Hatchling Dinosaurs by a New Snake from the Late Cretaceous of India. PLoS Biology, 8(3). DOI: 10.1371/journal.pbio.1000322
Douglas and Walsh (2010) paint a not so pretty picture of what child protection workers think about their clients, particularly those battered mothers entangled in what are usually, extraordinarily complicated dynamics. The authors suggest several possible improvements, including better worker supervision, tougher police interventions, and more holistic service delivery for victims and their children.
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Lax security at zoos is putting ecosystems at risk for invasion by exotic species according to a new study by researchers in Spain. Zoos already are the 2nd biggest contributor of exotic species invasions in Europe...... Read more »
Fàbregas, M., Guillén-Salazar, F., & Garcés-Narro, C. (2010) The risk of zoological parks as potential pathways for the introduction of non-indigenous species. Biological Invasions. DOI: 10.1007/s10530-010-9755-2
When groups of people get together to make decisions, they often struggle to fulfil their potential. Part of the reason is that they tend to spend more time talking about information that everyone shares rather than learning fresh insights from each other. In a forthcoming paper, Andreas Mojzisch and Stefan Schulz-Hardt have uncovered a new reason groups so often make sub-optimal decisions. The researchers show that when a group of people begin a discussion by sharing their initial preferences, ........ Read more »
Andreas Mojzisch, & Stefan Schulz-Hardt. (2010) Knowing others' preferences degrades the quality of group decisions. Journal of Personality and Social Psychology. info:/
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