When you go to the doctor for an x-ray, the nurse or doctor briefly disappear behind a screen, presses a button for a brief moment, and you’re all set. It seems an x-ray takes about a second but the actual exposure times is much faster. Milliseconds more likely. Such speeds seem like almost an eternity [...]... Read more »
Seibert, M., Ekeberg, T., Maia, F., Svenda, M., Andreasson, J., Jönsson, O., Odić, D., Iwan, B., Rocker, A., Westphal, D.... (2011) Single mimivirus particles intercepted and imaged with an X-ray laser. Nature, 470(7332), 78-81. DOI: 10.1038/nature09748
Researchers at Cambridge have discovered a non-transcriptional clock in the human red blood cell, raising questions about the precise definition of a circadian clock... Read more »
I didn't want to risk making my previous post too long, and I wanted to keep it focused on "hormonal determinism", so I set aside a whole branch of my commentary on the link between the hormone oxytocin and ethnocentrism for another post. The findings I comment on were presented by De Dreu and co-workers in the latest edition of PNAS (see reference below).
So, today I want to talk briefly about bad evolutionary arguments.Continue after the jump »
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Whether you’re young or post-young, there’s no time like the present to get into an exercise routine. Besides helping with weight loss and improving cardiovascular fitness, more and more evidence suggests that aerobic exercise can delay – and even reverse … Continue reading →... Read more »
Erickson, K., Voss, M., Prakash, R., Basak, C., Szabo, A., Chaddock, L., Kim, J., Heo, S., Alves, H., White, S.... (2011) Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1015950108
Can we predict cancer metastasis and spread using a biomarker? In Loh's research, CPE-ΔN tended to be present and have high levels in tumours that have metastasised. Continue reading →
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Lee, T., Murthy, S., Cawley, N., Dhanvantari, S., Hewitt, S., Lou, H., Lau, T., Ma, S., Huynh, T., Wesley, R.... (2011) An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. Journal of Clinical Investigation. DOI: 10.1172/JCI40433
In today’s tip I will feature the data distribution summaries and their drill down features which you can see from many RCSB PDB searches. We are in the process of updating our full tutorial sponsored by the RCSB PDB team, and as part of that effort I’ve gotten to know and appreciate this new data presentation format. Over the last five years the RCSB PDB has really been working hard at redesigning their resource to be more easily accessed by a wide variety of users. Below you will ........ Read more »
Rose, P., Beran, B., Bi, C., Bluhm, W., Dimitropoulos, D., Goodsell, D., Prlic, A., Quesada, M., Quinn, G., Westbrook, J.... (2010) The RCSB Protein Data Bank: redesigned web site and web services. Nucleic Acids Research, 39(Database). DOI: 10.1093/nar/gkq1021
As anyone who's trying to sell you probiotic yogurt will tell you, what you can eat often depends on what's living in your gut. For many animals, symbiotic bacterial communities help break down foods that would otherwise be indigestible. Perhaps most famously, termites would be unable to eat wood without specialized microbes in their guts [$a], but many other animals host bacteria that break down cellulose, the tough structural sugar of plant tissue, or to supply nutrients lacking in their diet......... Read more »
Kaltenpoth, M. (2011) Honeybees and bumblebees share similar bacterial symbionts. Molecular Ecology, 20(3), 439-40. DOI: 10.1111/j.1365-294X.2010.04960.x
Martinson, V. G., B. N. Danforth, R. L. Minckley, O. Rueppell, S. Tingek, & N. A. Moran. (2011) A simple and distinctive microbiota associated with honey bees and bumble bees. Molecular Ecology, 20(3), 619-28. DOI: 10.1111/j.1365-294X.2010.04959.x
Ikeda-Ohtsubo, W., & A. Brune. (2009) Cospeciation of termite gut flagellates and their bacterial endosymbionts: Trichonympha species and ‘Candidatus Endomicrobium trichonymphae’. Molecular Ecology, 18(2), 332-42. DOI: 10.1111/j.1365-294X.2008.04029.x
Russell, J., Moreau, C., Goldman-Huertas, B., Fujiwara, M., Lohman, D., & Pierce, N. (2009) Bacterial gut symbionts are tightly linked with the evolution of herbivory in ants. Proc. Nat. Acad. Sci. USA, 106(50), 21236-41. DOI: 10.1073/pnas.0907926106
Many companies are struggling with the idea to use modern optimization techniques to support decision making in strategic supply chain management.
But beside mathematical modeling of the supply chain there are other methods as well, such as network based approaches. In their 2005 paper Blackhurst, Wu and O'Grady present a more intuitive decision support method with the goal to improve decisions within the supply chain context.
Figure 1: Example Product Chain Decision Model (Bl........ Read more »
Blackhurst, J., Wu, T., & O'Grady, P. (2005) PCDM: A Decision Support Modeling Methodology for Supply Chain, Product and Process Design Decisions. Journal of Operations Management, 23(3-4), 325-343. DOI: 10.1016/j.jom.2004.05.009
One of my long-running plans on Tet Zoo has been to review passerine phylogeny. After decades of people saying that oscine passerines are (except larks and corvids) far too alike for anyone to construct a sensible phylogeny, a flurry of (mostly molecular) studies have meant that - as I like to say - the passerine tree is finally coming together. Alas, I'm nowhere near able to review current hypotheses of passerine evolution in depth (and didn't I say something recently about not starting any n........ Read more »
Jonsson, K., & Fjeldsa, J. (2006) A phylogenetic supertree of oscine passerine birds (Aves: Passeri). Zoologica Scripta, 35(2), 149-186. DOI: 10.1111/j.1463-6409.2006.00221.x
In my interactions with patients, I always ask them to tell me when their weight problems began and what they believe contributed to their weight gain.
Broadly speaking, there are two categories: people, who were big (or were considered big by others) as long as they can remember and those, who can often clearly pinpoint when [...]... Read more »
Smith LH, & Holm L. (2011) Obesity in a life-course perspective: An exploration of lay explanations of weight gain. Scandinavian journal of public health. PMID: 21270139
You probably intuited this already but age is simply not settling well on our largest generation. From the exuberance of youth (“don’t trust anyone over 30”) to the contemplation of approaching 65—Boomers feel anxious about their futures. They are afraid they will outlive Medicare. But that isn’t all that is vexing the Boomers. A recent [...]
Related posts:Generation Y (aka the Millennials): Just the facts
The Millennials (aka ‘Gen Y’): On tattoos, TMI, tolerance and technology........ Read more »
D’Vera Cohn, & Paul Taylor. (2010) Baby Boomers Approach 65 – Glumly. Pew Research Center. info:/
Generating iPS cells can be an arduous task. Reprogramming differentiated adult cells into iPS cells requires so many steps and so much time that the efficiency rate is very low – you might end up with only a few iPS cells even if you started with a million skin cells. So a team set out to improve the process. In a paper published February 1, 2011 in The EMBO Journal, they uncovered microRNAs (miRNAs) that are important during reprogramming and exploited them to make the transition from skin c........ Read more »
Li, Z., Yang, C., Nakashima, K., & Rana, T. (2011) Small RNA-mediated regulation of iPS cell generation. The EMBO Journal. DOI: 10.1038/emboj.2011.2
Analysing user statistics across websites is an issue that often comes under scrutiny from privacy advocates worried that marketing companies are exploiting their personal data to track their behaviour and target them with advertising. The issue is, of course, a double-edged sword. Many of us would prefer that our online behaviour is not being monitored [...]Post from: David Bradley's Sciencetext Tech TalkUse and abuse on the web
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Dong Li, Anne Laurent, & Pascal Poncelet. (2011) WebUser: mining unexpected web usage. Int. J. Business Intelligence and Data Mining, 6(1), 90-111. info:/
The first step to more willpower is a step away from simple nostrums.... Read more »
Gailliot, M., & Baumeister, R. (2007) The Physiology of Willpower: Linking Blood Glucose to Self-Control. Personality and Social Psychology Review, 11(4), 303-327. DOI: 10.1177/1088868307303030
Job, V., Dweck, C., & Walton, G. (2010) Ego Depletion--Is It All in Your Head?: Implicit Theories About Willpower Affect Self-Regulation. Psychological Science, 21(11), 1686-1693. DOI: 10.1177/0956797610384745
In my last posting about the E word I focused on various models of employability (the fun bit in my geeky world!). In this post I wanted to look at some of the various definitions of employability and what those definitions say about the people who construct them. Employers The CBI defines employability as… …a [...]... Read more »
Try bribing him with a sticker
Some experts have warned that bribing children to eat healthy foods can be counter-productive, undermining their intrinsic motivation and actually increasing disliking. Lucy Cooke and colleagues have found no evidence for this in their new large-scale investigation of the issue. They conclude that rewards could be an effective way for parents to improve their children's diet. '...rewarding children for tasting an initially disliked food produced sustained increas........ Read more »
Cooke, L., Chambers, L., Anez, E., Croker, H., Boniface, D., Yeomans, M., & Wardle, J. (2010) Eating for Pleasure or Profit: The Effect of Incentives on Children's Enjoyment of Vegetables. Psychological Science. DOI: 10.1177/0956797610394662
With the technical advances in gene sequencing, the possibilities of their use are growing rapidly. Totally new scientific disciplines evolve – eg the paleogenetics. Gene sequences are produced from bones thousands of years old, and these are compared with each … Continue reading →... Read more »
Reich D, Green RE, Kircher M, Krause J, Patterson N, Durand EY, Viola B, Briggs AW, Stenzel U, Johnson PL.... (2010) Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature, 468(7327), 1053-60. PMID: 21179161
Does place of death from cancer vary between ethnic groups in South East England? From Palliative Medicine There is growing evidence that the end-of-life care needs of many are not being met. Studies have found that 49% to 90% of terminally ill patients would prefer to die at home. However, in reality only around 26% [...]... Read more »
Coupland, V., Madden, P., Jack, R., Moller, H., & Davies, E. (2011) Does place of death from cancer vary between ethnic groups in South East England?. Palliative Medicine. DOI: 10.1177/0269216310395986
Perfect matches aren't always desirable in nature. despite what eharmony & plenty of fish tells you. And you shouldn't hanker for it either. Imperfections are what make matches harmonious..for gene silencing by miRNAs. macroscopic relationships are other people's problems, like...... Read more »
Himber, C. (2003) Transitivity-dependent and -independent cell-to-cell movement of RNA silencing. The EMBO Journal, 22(17), 4523-4533. DOI: 10.1093/emboj/cdg431
Schwab, R., & Voinnet, O. (2010) RNA silencing amplification in plants: Size matters. Proceedings of the National Academy of Sciences, 107(34), 14945-14946. DOI: 10.1073/pnas.1009416107
Park, W., Zhai, J., & Lee, J. (2008) Highly efficient gene silencing using perfect complementary artificial miRNA targeting AP1 or heteromeric artificial miRNA targeting AP1 and CAL genes. Plant Cell Reports, 28(3), 469-480. DOI: 10.1007/s00299-008-0651-5
Schwab, R. (2006) Highly Specific Gene Silencing by Artificial MicroRNAs in Arabidopsis. THE PLANT CELL ONLINE, 18(5), 1121-1133. DOI: 10.1105/tpc.105.039834
Voinnet, O. (2005) Induction and suppression of RNA silencing: insights from viral infections. Nature Reviews Genetics, 6(3), 206-220. DOI: 10.1038/nrg1555
Allen, E., Xie, Z., Gustafson, A., & Carrington, J. (2005) microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants. Cell, 121(2), 207-221. DOI: 10.1016/j.cell.2005.04.004
by Janus in ionpsych
Most people believe that adult language learning is slow and effortful, in stark contrast to how children “automatically” learn languages. Recent research flies in the face of this conventional wisdom by showing that adults, too, have a fast and flexible … Continue reading →... Read more »
McClelland JL, Fiez JA, & McCandliss BD. (2002) Teaching the /r/-/l/ discrimination to Japanese adults: behavioral and neural aspects. Physiology , 77(4-5), 657-62. PMID: 12527015
Warker, J., & Dell, G. (2006) Speech Errors Reflect Newly Learned Phonotactic Constraints. Journal of Experimental Psychology: Learning, Memory, and Cognition, 32(2), 387-398. DOI: 10.1037/0278-73126.96.36.1997
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