A new therapy based on RNA interference (RNAi) successfully reduces respiratory syncytial virus (RSV) infection in humans. The study, published free online in PNAS, demonstrates that therapeutic RNAi-based drugs are clinically effective, and suggests that similar ‘silencing’ therapies could be useful against other respiratory pathogens. RSV is an RNA virus that infects the lungs to [...]... Read more »
DeVincenzo, J., Lambkin-Williams, R., Wilkinson, T., Cehelsky, J., Nochur, S., Walsh, E., Meyers, R., Gollob, J., & Vaishnaw, A. (2010) A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0912186107
It seems like every few months we hear about some new diet that is supposed to help us melt away the pounds and add years to our lives. But how different are these diets, really? I’ve already discussed studies suggesting that the DASH diet does indeed appear to decrease risk of heart disease and reduce [...]... Read more »
Trichopoulou, A. (2003) Adherence to a Mediterranean Diet and Survival in a Greek Population. New England Journal of Medicine, 348(26), 2599-2608. DOI: 10.1056/NEJMoa025039
Sofi, F., Cesari, F., Abbate, R., Gensini, G., & Casini, A. (2008) Adherence to Mediterranean diet and health status: meta-analysis. BMJ, 337(sep11 2). DOI: 10.1136/bmj.a1344
Spiders are key links in the transfer of pollutants from aquatic to terrestrial food webs.... Read more »
Walters, D., Mills, M., Fritz, K., & Raikow, D. (2009) Spider-Mediated Flux of PCBs from Contaminated Sediments to Terrestrial Ecosystems and Potential Risks to Arachnivorous Birds . Environmental Science , 2147483647. DOI: 10.1021/es9023139
Anxiety and False Assurances First
Relief Third, Hopefully
Large rocks hurtle towards our heads. What happens? We duck. The process, however, is complex.
It involves answering two questions: what is that? and how do I behave? This anthropomorphic perspective is backwards and flawed. It suggests searching (for what, that and how) and then behaving.
The whole process (what, that and how) can be instinctive, like ducking the rock: body-as-it-was, object, body-as-it-is.1 Usual........ Read more »
Brewin, C., Gregory, J., Lipton, M., & Burgess, N. (2010) Intrusive images in psychological disorders: Characteristics, neural mechanisms, and treatment implications. Psychological Review, 117(1), 210-232. DOI: 10.1037/a0018113
Tedeschi, R., & Calhoun, L. (2004) TARGET ARTICLE: "Posttraumatic Growth: Conceptual Foundations and Empirical Evidence". Psychological Inquiry, 15(1), 1-18. DOI: 10.1207/s15327965pli1501_01
Brewin, C., Dalgleish, T., & Joseph, S. (1996) A dual representation theory of posttraumatic stress disorder. Psychological Review, 103(4), 670-686. DOI: 10.1037//0033-295X.103.4.670
Vitamin D is a hot topic lately, and many observational studies have linked it positively with a reduction in various disease risks. However, we should be careful not to tout it as a panacea without large controlled studies and a deeper understanding of how it regulates various endogenous processes.
A recent publication studying UV radiation exposure [...]... Read more »
Becklund BR, Severson KS, Vang SV, & DeLuca HF. (2010) UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proceedings of the National Academy of Sciences of the United States of America, 107(14), 6418-23. PMID: 20308557
New research out of the Oregon Health and Science University may explain the discrepancy between the theory and reality of dieting. They found that, at least in some of our closest relatives, cutting calories isn't enough to lose weight because the body compensates for the reduced intake by lowering activity levels. Image credit: iamchenelle, flickr... Read more »
Sullivan, E., & Cameron, J. (2010) A rapidly occurring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys. AJP: Regulatory, Integrative and Comparative Physiology, 298(4). DOI: 10.1152/ajpregu.00617.2009
I’ve written rather a lot about rates of forest loss around the world, including accumulated estimates of tropical forest loss and increasing fragmentation/loss in the boreal forest (see Bradshaw et al. 2009 Front Ecol Evol & Bradshaw et al. 2009 Trends Ecol Evol). For the tropics in particular, we used the index that an area [...]... Read more »
When it comes to chemistry, surfaces are the places to be. Where two phases meet, interesting stuff is bound to happen. One of the phase interactions that received increased attention during the last few years is the peculiar meeting of a liquid and a solid. One rather interesting phenomenon encountered here is the lotus effect, [...]... Read more »
Voïtchovsky, K., Kuna, J., Contera, S., Tosatti, E., & Stellacci, F. (2010) Direct mapping of the solid–liquid adhesion energy with subnanometre resolution. Nature Nanotechnology. DOI: 10.1038/NNANO.2010.67
The cause of pancreatic cancer is still unknown, although there are risk factors involved, such as increased exposure to tobacco smoke and a family history of the disease. It is usually detected late when advanced stage disease has set in...... Read more »
Goicoechea, S., Bednarski, B., Stack, C., Cowan, D., Volmar, K., Thorne, L., Cukierman, E., Rustgi, A., Brentnall, T., Hwang, R.... (2010) Isoform-Specific Upregulation of Palladin in Human and Murine Pancreas Tumors. PLoS ONE, 5(4). DOI: 10.1371/journal.pone.0010347
by gkobs in Promega Connections
Pull-down assays probe interactions between a protein of interest that is expressed as fusion protein (e.g., (e.g., bait) and the potential interacting partners (prey). In a pull-down assay one protein partner is expressed as a fusion protein (e.g., bait protein) in E. coli and then immobilized using an affinity ligand specific for the fusion tag. [...]... Read more »
Tonhosolo R, D'Alexandri FL, de Rosso VV, Gazarini ML, Matsumura MY, Peres VJ, Merino EF, Carlton JM, Wunderlich G, Mercadante AZ.... (2009) Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium falciparum. The Journal of biological chemistry, 284(15), 9974-85. PMID: 19203994
Dennis MD, Person MD, & Browning KS. (2009) Phosphorylation of plant translation initiation factors by CK2 enhances the in vitro interaction of multifactor complex components. The Journal of biological chemistry, 284(31), 20615-28. PMID: 19509420
Ahmed NT, Gao C, Lucker BF, Cole DG, & Mitchell DR. (2008) ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery. The Journal of cell biology, 183(2), 313-22. PMID: 18852297
Gembka A, Toueille M, Smirnova E, Poltz R, Ferrari E, Villani G, & Hübscher U. (2007) The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair. Nucleic acids research, 35(8), 2596-608. PMID: 17426133
Installment #2 in the mini-series on multilingual signage
Much of the signage that can be found in contemporary public spaces is commercial. It is a form of advertising, and language choice in commercial signage such as shop names is a good indicator of the values associated with a particular language. The basic idea is that the [...]... Read more »
by Mary in OpenHelix
So, remember that tidal wave of data we were going to get from the human genome project? Yeah. That was a puddle compared to what’s coming your way now. For this week’s tip of the week I will introduce the very ambitious big data project from the International Cancer Genome Consortium (ICGC). In addition, you’ll [...]... Read more »
Whenever anyone mentions P2P file systems, the first thought that pops into the n00bs head is probably – piracy – and an image of teens downloading free copies of the latest young person’s popular music tracks from teh interwebs using an illicit file sharing system. Of course, Bit Torrent and other related systems can be [...]Post from: David Bradley's Sciencetext Tech TalkPeer-to-peer data storage
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Yu-Wei Chan, Tsung-Hsuan Ho, Po-Chi Shih, & Yeh-Ching Chung. (2010) Malugo: A peer-to-peer storage system. Int. J. Ad Hoc and Ubiquitous Computing, 5(4), 209-218. info:/
Individuals now have the autonomy to make their own learning choices and in recent years there has been an emphasis on the “self made learner”, especially in adult education and ongoing professional development. As such, online communities and other so-called web 2.0 tools have come to the fore as potentially useful for educators and students [...]Lifelong learning online is about connecting people is a post from: Sciencebase Science Blog
... Read more »
Cristina Costa. (2010) Lifelong learning in Web 2.0 environments. Int. J. Technology Enhanced Learning, 2(3), 275-284. info:/
Disease is a funny old thing. We're taught from very early on that disease agents are "bad" and that, by contrast, the infected are somehow poor and unfortunate victims of nasty evil bugs. This is clearly a cultural bias, wherein we project our own concerns about getting sick onto all other animals; there's no real reason to think that a bacterium or virus has any less right to be here or any ... Read more »
Mao-Jones, J., Ritchie, K., Jones, L., & Ellner, S. (2010) How Microbial Community Composition Regulates Coral Disease Development. PLoS Biology, 8(3). DOI: 10.1371/journal.pbio.1000345
by Nestor Lopez-Duran PhD in Child-Psych
The last issue of the Journal of Autism and Developmental Disorders included one of the largest examinations of the association between maternal infection during pregnancy and risk for autism. The study was conducted in the Denmark where researchers examined the maternal infection rates during pregnancy and autism diagnoses for all children born in Denmark between [...]... Read more »
Atladóttir, H., Thorsen, P., Østergaard, L., Schendel, D., Lemcke, S., Abdallah, M., & Parner, E. (2010) Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders. Journal of Autism and Developmental Disorders. DOI: 10.1007/s10803-010-1006-y
Say you're visiting Los Angeles and you have a sudden craving for Chinese food. Since you are only visiting, you might not be aware that nothing is open past, like, 10pm (not even coffee houses), but you get in your rental car and go driving around in search of your Chinese feast anyway. You try hitting up Panda Express, but no such luck. Of course they're closed. You try the neighborhood Chinese restaurant: closed as well. You get back in the car, and think to yourself "maybe the OTHER Panda Ex........ Read more »
Mather, J. (1991) Navigation by spatial memory and use of visual landmarks in octopuses. Journal of Comparative Physiology A, 168(4), 491-497. DOI: 10.1007/BF00199609
... Read more »
Liu, S., Costanza, R., Troy, A., D’Aagostino, J., & Mates, W. (2010) Valuing New Jersey’s Ecosystem Services and Natural Capital: A Spatially Explicit Benefit Transfer Approach. Environmental Management. DOI: 10.1007/s00267-010-9483-5
The human brain likes balance. Not simply biological and physiological homeostasis that maintains the proper functioning of the brain, but emotional, social and psychological balance. Notably, the human brain dislikes inequality when it comes to money, and rejects it at all costs, according to new research in the journal Nature.
Behavioral and anthropological evidence show that [...]... Read more »
Guroglu, B., van den Bos, W., Rombouts, S., & Crone, E. (2010) Unfair? It depends: Neural correlates of fairness in social context. Social Cognitive and Affective Neuroscience. DOI: 10.1093/scan/nsq013
Hare, T., Camerer, C., Knoepfle, D., O'Doherty, J., & Rangel, A. (2010) Value Computations in Ventral Medial Prefrontal Cortex during Charitable Decision Making Incorporate Input from Regions Involved in Social Cognition. Journal of Neuroscience, 30(2), 583-590. DOI: 10.1523/JNEUROSCI.4089-09.2010
Smith, D., Hayden, B., Truong, T., Song, A., Platt, M., & Huettel, S. (2010) Distinct Value Signals in Anterior and Posterior Ventromedial Prefrontal Cortex. Journal of Neuroscience, 30(7), 2490-2495. DOI: 10.1523/JNEUROSCI.3319-09.2010
Tricomi, E., Rangel, A., Camerer, C., & O’Doherty, J. (2010) Neural evidence for inequality-averse social preferences. Nature, 463(7284), 1089-1091. DOI: 10.1038/nature08785
Yamagishi, T., Horita, Y., Takagishi, H., Shinada, M., Tanida, S., & Cook, K. (2009) The private rejection of unfair offers and emotional commitment. Proceedings of the National Academy of Sciences, 106(28), 11520-11523. DOI: 10.1073/pnas.0900636106
In this paper, we looked at the relationship between body weight (BMI), adipokines, and insulin resistance in 1,176 South Asian, Chinese, Aboriginal, and European Canadians in the SHARE study (Study of Health Assessment and Risk in Ethnic groups).... Read more »
Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R, Teo K, Gerstein H, Sharma AM, Yusuf S.... (2010) Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes care. PMID: 20413520
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