What’s grosser than gross? How ‘bout a 100-mile long wad of E. Coli-infested mucus?
(Oh, sorry, did that make you gag? We said it was grosser than gross…)
Mucus wads—also known as mucilages—have been reported in the Mediterranean Sea since at least 1729, but recent research found that the loogies are getting bigger, lasting longer and harboring [...]... Read more »
Danovaro, R., Fonda Umani, S., & Pusceddu, A. (2009) Climate Change and the Potential Spreading of Marine Mucilage and Microbial Pathogens in the Mediterranean Sea. PLoS ONE, 4(9). DOI: 10.1371/journal.pone.0007006
Meralgia Paresthetica like most other neuropathies can purpose a dilemma in diagnosing. Nerves often project arbitrary findings in the examination process. This article discusses a new valid test manual therapist can finally use to help in their diagnosis.... Read more »
A recent paper in PLoS One finds hundreds of new putative transcription start sites (TSS): PLoS ONE: Genome-Wide Identification of Transcription Start Sites, Promoters and Transcription Factor Binding Sites in E. coli. I found the paper interesting, and a good example of how high-throughput studies and genomics can advance our understanding of biology and work in concert with experimental biology, while at the same time dumping a whole lot of new data in our laps.
I’d like to point out so........ Read more »
Mendoza-Vargas, A., Olvera, L., Olvera, M., Grande, R., Vega-Alvarado, L., Taboada, B., Jimenez-Jacinto, V., Salgado, H., Juárez, K., Contreras-Moreira, B.... (2009) Genome-Wide Identification of Transcription Start Sites, Promoters and Transcription Factor Binding Sites in E. coli. PLoS ONE, 4(10). DOI: 10.1371/journal.pone.0007526
THE humble fruit fly (Drosophila melanogaster) has the ability to learn and remember, and to make predictions about the outcome of its behaviours on the basis of past experience. Compared to a human brain, that of the fruit fly is relatively simple, containing approximately 250,000 cells. Even so, little is known about the anatomical basis of memory formation. The neural circuitry underlying memories in these insects has now been dissected. In an elegant new study published in the journal ........ Read more »
Claridge-Chang, A., Roorda, R., Vrontou, E., Sjulson, L., Li, H., Hirsh, J., & Miesenböck, G. (2009) Writing Memories with Light-Addressable Reinforcement Circuitry. Cell, 139(2), 405-415. DOI: 10.1016/j.cell.2009.08.034
Ecosystems can provide nuisances as well as benefits
... Read more »
Lyytimäki, J., & Sipilä, M. (2009) Hopping on one leg – The challenge of ecosystem disservices for urban green management. Urban Forestry . DOI: 10.1016/j.ufug.2009.09.003
Just as I was in the process of finishing my doctorate in August, I found out that my first first-author paper had been accepted for publication by The EMBO Journal. This was good news, because we were reporting some pretty fundamental findings in a relatively saturated field, and one of our competitors had managed to successfully stall the acceptance of this paper since March. Up until that point, witnessing this happen firsthand had been a somewhat frustrating and disillusioning experience for........ Read more »
Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH.... (2009) The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. The EMBO journal. PMID: 19798053
Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC.... (2009) The Structure of the N-Terminus of Kindlin-1: A Domain Important for alphaIIbbeta3 Integrin Activation. Journal of molecular biology. PMID: 19804783
Some invasive plants only become a big problem when they reach a certain abundance. Scientists search for that magic threshold...read more... Read more »
Gooden, B., French, K., Turner, P., & Downey, P. (2009) Impact threshold for an alien plant invader, Lantana camara L., on native plant communities. Biological Conservation, 142(11), 2631-2641. DOI: 10.1016/j.biocon.2009.06.012
You can never accuse cosmologists of thinking small. To them even galaxies are like tiny little molecules and complex formulas govern the behavior of manifolds measuring hundreds of millions of light years. And if you thought that one universe was complicated and difficult enough, some cosmologists are actually tackling the idea of multiple universes branching [...]... Read more »
In a recent online publication about another form of brain stimulation in treatment resistant depression showed promising results. The electrodes are placed on the brain instead of in the brain as with Deep Brain Stimulation (DBS):
A new neurosurgical procedure may prove helpful for patients with treatment-resistant depression. Bilateral epidural prefrontal cortical stimulation (EpCS) was found [...]
Related posts:Deep Brain Stimulation for Treatment Resistant depression New data are being p........ Read more »
Nahas, Z., Anderson, B., Borckardt, J., Arana, A., George, M., Reeves, S., & Takacs, I. (2009) Bilateral Epidural Prefrontal Cortical Stimulation for Treatment-Resistant Depression. Biological Psychiatry. DOI: 10.1016/j.biopsych.2009.08.021
Late last week, I received emails from two journals (The Journal of Biological Chemistry (JBC) and PLoS ONE) indicating that they are now incorporating interactive 3D images of molecular structures in their papers. The atomic coordinates of all published biomolecular structures have been available for some time at the Protein Data Bank. However, making sense of something as complex as a protein structure can require quite a bit of analysis. So, scientists go through great pains to represent impo........ Read more »
Kumar, P., Vahedi-Faridi, A., Saenger, W., Merino, E., Lopez de Castro, J., Uchanska-Ziegler, B., & Ziegler, A. (2009) Structural Basis for T Cell Alloreactivity among Three HLA-B14 and HLA-B27 Antigens. Journal of Biological Chemistry, 284(43), 29784-29797. DOI: 10.1074/jbc.M109.038497
Raush, E., Totrov, M., Marsden, B., & Abagyan, R. (2009) A New Method for Publishing Three-Dimensional Content. PLoS ONE, 4(10). DOI: 10.1371/journal.pone.0007394
Scientists love to group things. We also like to name things. We also like to plot data on bivariate graphs. On really crazy nights, we let our hair down, well not me per se but other scientists with hair, and do all three. 90% of science is grouping, naming, and plotting.
If you don’t know already [...]... Read more »
Tyler, P., Marsh, L., Baco-Taylor, A., & Smith, C. (2009) Protandric hermaphroditism in the whale-fall bivalve mollusc Idas washingtonia. Deep Sea Research Part II: Topical Studies in Oceanography, 56(19-20), 1689-1699. DOI: 10.1016/j.dsr2.2009.05.014
Cytomegalovirus (CMV) is one of the herpesvirus group, viruses that are extremely hard or impossible for the body to clear. They lurk and return time after time. CMV doesn't cause immediate issues in healthy people, but over time it becomes one of the principle causes of the characteristic failure of the immune system with aging: Your immune system is capped in its use of resources; it can only have a set number of T cells in operation at one time. ... chronic infections by the likes of cytomega........ Read more »
Duan QJ, Tao R, Hu MF, & Shang SQ. (2009) Efficient inhibition of human cytomegalovirus UL122 gene expression in cell by small interfering RNAs. Journal of basic microbiology. PMID: 19810036
Crudely speaking, our actions can be divided into those that are automatic and driven by the environment and those that are initiated volitionally, as an act of will. In an intriguing new study, Todd Horowitz and colleagues claim to have recorded the relatively sluggish time taken for free will to be enacted. Their finding could help explain our natural tendency to search visual scenes via apparently random, haphazard attentional shifts, rather than using our conscious will to search more strat........ Read more »
by Rita Tojeiro in we are all in the gutter
In our first post exploring galaxy evolution, we saw how observing galaxies at different distances from us is crucial for our understanding of how galaxies form and evolve. It also naturally follows that the larger the range of distances we can study, the better we can constrain our theories. So it’s only natural that astronomers [...]... Read more »
M. Bradač, T. Treu, D. Applegate, A. H. Gonzalez, D. Clowe, W. Forman, C. Jones, P. Marshall, P. Schneider, & D. Zaritsky. (2009) Focusing Cosmic Telescopes: Exploring Redshift z~5-6 Galaxies with the Bullet Cluster 1E0657-56. Accepted for publication in ApJL. arXiv: 0910.2708v1
P. A. Oesch, R. J. Bouwens, G. D. Illingworth, C. M. Carollo, M. Franx, I. Labbe, D. Magee, M. Stiavelli, M. Trenti, & P. G. van Dokkum. (2009) z~7 Galaxies in the HUDF: First Epoch WFC3/IR Results. submitted to ApJL. arXiv: 0909.1806v1
Andrew Bunker, Stephen Wilkins, Richard Ellis, Daniel Stark, Silvio Lorenzoni, Kuenley Chiu, Mark Lacy, Matt Jarvis, & Samantha Hickey. (2009) The Contribution of High Redshift Galaxies to Cosmic Reionization: New Results from Deep WFC3 Imaging of the Hubble Ultra Deep Field. Submitted to MNRAS. arXiv: 0909.2255v2
Sexual activities at work have become a modern taboo. Everything from sexual jokes and innuendo to overt touching and sex acts have become absolutely forbidden in the workplace. Some sexual behaviors (jokes, banter, flirting) might be seen as innocent and a natural part of being human, but the current trend is one of zero tolerance [...]... Read more »
Dysphagia among stroke patients is suggested by the following test:
First check the patient for “swallowing complaints, abnormalities of voice quality, facial asymmetry, or either expressive or receptive aphasia.” If none is detected then go to step 2.
Have the patient drink 10 mL of water from a cup without a straw while seated upright [...]... Read more »
Turner-Lawrence DE, Peebles M, Price MF, Singh SJ, & Asimos AW. (2009) A feasibility study of the sensitivity of emergency physician Dysphagia screening in acute stroke patients. Annals of emergency medicine, 54(3), 344. PMID: 19362752
Everyday in the news we see stories decrying the use of cell phones while driving. Research reports aplenty have been released estimating the percentage of one’s attention siphoned by mobile jabber and how little is left to focus on the highway.
This is great and I’m glad the discussion is happening, but it might be useful to ask whether cell phone use in other (non-driving) venues has a similar effect on attention. What better way to make the point that cell phone use is danger........ Read more »
Hyman, I., Boss, S., Wise, B., McKenzie, K., & Caggiano, J. (2009) Did you see the unicycling clown? Inattentional blindness while walking and talking on a cell phone. Applied Cognitive Psychology. DOI: 10.1002/acp.1638
The preferred locations for testing according to this systematic review are filled green in the image. As the independent addition of the monofilament to visually inspecting for deformities, pressure marks, cracked skin, infected nails, evidence of prior ulcers, and other findings is not clear in the major trial of screening (http://pubmed.gov/8498761), it seems we [...]... Read more »
Feng Y, Schlösser FJ, & Sumpio BE. (2009) The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter, 50(3), 675. PMID: 19595541
I am not a philosopher. Neither am I very conversant in the arguments around consciousness. But working in pain management means the mind-body debate is something I run into now and again. Is pain all about the body? Is pain all about the mind? Or is it both? Which influences the other?
This debate can often [...]... Read more »
Rebecca Skloot, journalist, University of Memphis writing professor, and author of the upcoming book, The Immortal Life of Henrietta Lacks (pre-order here), just brought to my attention this commentary by Dr Pieter Cohen in the New England Journal of Medicine entitled, "American Roulette -- Contaminated Dietary Supplements."
In the commentary, Dr Cohen remarks upon the epidemic of adulteration of herbal and non-herbal dietary supplements with undeclared prescription drugs or unapproved drugs:
I........ Read more »
Cohen, P. (2009) American Roulette -- Contaminated Dietary Supplements. New England Journal of Medicine, 361(16), 1523-1525. DOI: 10.1056/NEJMp0904768
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