Post List

  • April 28, 2010
  • 05:26 PM
  • 1,181 views

Silencing human RSV infection

by geekheartsscience in geek!

A new therapy based on RNA interference (RNAi) successfully reduces respiratory syncytial virus (RSV) infection in humans. The study, published free online in PNAS, demonstrates that therapeutic RNAi-based drugs are clinically effective, and suggests that similar ‘silencing’ therapies could be useful against other respiratory pathogens. RSV is an RNA virus that infects the lungs to [...]... Read more »

DeVincenzo, J., Lambkin-Williams, R., Wilkinson, T., Cehelsky, J., Nochur, S., Walsh, E., Meyers, R., Gollob, J., & Vaishnaw, A. (2010) A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0912186107  

  • April 28, 2010
  • 05:13 PM
  • 887 views

Battle of the diets: Mediterranean versus DASH

by Dave in The Daily Monthly

It seems like every few months we hear about some new diet that is supposed to help us melt away the pounds and add years to our lives. But how different are these diets, really? I’ve already discussed studies suggesting that the DASH diet does indeed appear to decrease risk of heart disease and reduce [...]... Read more »

  • April 28, 2010
  • 03:36 PM
  • 641 views

PCBs escape burial in aquatic sediments, infiltrate terrestrial food webs, and put birds at risk

by David Raikow in River Continua

Spiders are key links in the transfer of pollutants from aquatic to terrestrial food webs.... Read more »

  • April 28, 2010
  • 02:50 PM
  • 463 views

How Confusion and Doubt Drive All Behavior

by Cole Bitting in Fable

Anxiety and False Assurances First

Confusion Second

Relief Third, Hopefully

Large rocks hurtle towards our heads. What happens? We duck. The process, however, is complex.

It involves answering two questions: what is that? and how do I behave? This anthropomorphic perspective is backwards and flawed. It suggests searching (for what, that and how) and then behaving.

The whole process (what, that and how) can be instinctive, like ducking the rock: body-as-it-was, object, body-as-it-is.1 Usual........ Read more »

  • April 28, 2010
  • 02:00 PM
  • 781 views

When Vitamin D can’t replace UVB exposure: multiple sclerosis

by Colby in nutsci.org

Vitamin D is a hot topic lately, and many observational studies have linked it positively with a reduction in various disease risks.  However, we should be careful not to tout it as a panacea without large controlled studies and a deeper understanding of how it regulates various endogenous processes.
A recent publication studying UV radiation exposure [...]... Read more »

Becklund BR, Severson KS, Vang SV, & DeLuca HF. (2010) UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proceedings of the National Academy of Sciences of the United States of America, 107(14), 6418-23. PMID: 20308557  

  • April 28, 2010
  • 12:00 PM
  • 989 views

When Cutting Calories Doesn’t Cut It

by Christie Wilcox in Nutrition Wonderland

New research out of the Oregon Health and Science University may explain the discrepancy between the theory and reality of dieting. They found that, at least in some of our closest relatives, cutting calories isn't enough to lose weight because the body compensates for the reduced intake by lowering activity levels. Image credit: iamchenelle, flickr... Read more »

  • April 28, 2010
  • 11:11 AM
  • 2,092 views

Global rates of forest loss – everyone’s a bastard

by CJA Bradshaw in ConservationBytes

I’ve written rather a lot about rates of forest loss around the world, including accumulated estimates of tropical forest loss and increasing fragmentation/loss in the boreal forest (see Bradshaw et al. 2009 Front Ecol Evol & Bradshaw et al. 2009 Trends Ecol Evol). For the tropics in particular, we used the index that an area [...]... Read more »

Hansen, M., Stehman, S., & Potapov, P. (2010) Quantification of global gross forest cover loss. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0912668107  

  • April 28, 2010
  • 10:51 AM
  • 799 views

Mapping the wetting

by Lars Fischer in EuCheMS 2010 Blog

When it comes to chemistry, surfaces are the places to be. Where two phases meet, interesting stuff is bound to happen. One of the phase interactions that received increased attention during the last few years is the peculiar meeting of a liquid and a solid. One rather interesting phenomenon encountered here is the lotus effect, [...]... Read more »

  • April 28, 2010
  • 10:22 AM
  • 1,110 views

The biology of pancreatic cancer

by Sally Church in Pharma Strategy Blog

The cause of pancreatic cancer is still unknown, although there are risk factors involved, such as increased exposure to tobacco smoke and a family history of the disease. It is usually detected late when advanced stage disease has set in...... Read more »

Goicoechea, S., Bednarski, B., Stack, C., Cowan, D., Volmar, K., Thorne, L., Cukierman, E., Rustgi, A., Brentnall, T., Hwang, R.... (2010) Isoform-Specific Upregulation of Palladin in Human and Murine Pancreas Tumors. PLoS ONE, 5(4). DOI: 10.1371/journal.pone.0010347  

  • April 28, 2010
  • 09:39 AM
  • 1,599 views

6X His Protein Pulldowns: An Alternative to GST

by gkobs in Promega Connections

Pull-down assays probe interactions between a protein of interest that is expressed as fusion protein (e.g., (e.g., bait) and the potential interacting partners (prey). In a pull-down assay one protein partner is expressed as a fusion protein (e.g., bait protein) in E. coli and then immobilized using an affinity ligand specific for the fusion tag. [...]... Read more »

Tonhosolo R, D'Alexandri FL, de Rosso VV, Gazarini ML, Matsumura MY, Peres VJ, Merino EF, Carlton JM, Wunderlich G, Mercadante AZ.... (2009) Carotenoid biosynthesis in intraerythrocytic stages of Plasmodium falciparum. The Journal of biological chemistry, 284(15), 9974-85. PMID: 19203994  

  • April 28, 2010
  • 09:17 AM
  • 1,466 views

English, the non-language

by Ingrid Piller in Language on the Move

Installment #2 in the mini-series on multilingual signage
Much of the signage that can be found in contemporary public spaces is commercial. It is a form of advertising, and language choice in commercial signage such as shop names is a good indicator of the values associated with a particular language. The basic idea is that the [...]... Read more »

Ritzer, G. (2007) The globalization of nothing 2. Thousand Oaks, CA, . info:/

  • April 28, 2010
  • 09:10 AM
  • 1,234 views

Tip of the Week: International Cancer Genome Consortium

by Mary in OpenHelix

So, remember that tidal wave of data we were going to get from the human genome project?  Yeah.  That was a puddle compared to what’s coming your way now. For this week’s tip of the week I will introduce the very ambitious big data project from the International Cancer Genome Consortium (ICGC).  In addition, you’ll [...]... Read more »

Hudson (Chairperson), T., Anderson, W., Aretz, A., Barker, A., Bell, C., Bernabé, R., Bhan, M., Calvo, F., Eerola, I., Gerhard, D.... (2010) International network of cancer genome projects. Nature, 464(7291), 993-998. DOI: 10.1038/nature08987  

  • April 28, 2010
  • 09:00 AM
  • 1,612 views

Peer-to-peer data storage

by David Bradley in Sciencetext

Whenever anyone mentions P2P file systems, the first thought that pops into the n00bs head is probably – piracy – and an image of teens downloading free copies of the latest young person’s popular music tracks from teh interwebs using an illicit file sharing system. Of course, Bit Torrent and other related systems can be [...]Post from: David Bradley's Sciencetext Tech TalkPeer-to-peer data storage
... Read more »

Yu-Wei Chan, Tsung-Hsuan Ho, Po-Chi Shih, & Yeh-Ching Chung. (2010) Malugo: A peer-to-peer storage system. Int. J. Ad Hoc and Ubiquitous Computing, 5(4), 209-218. info:/

  • April 28, 2010
  • 09:00 AM
  • 1,121 views

Lifelong learning online is about connecting people

by sciencebase in Sciencebase Science Blog

Individuals now have the autonomy to make their own learning choices and in recent years there has been an emphasis on the “self made learner”, especially in adult education and ongoing professional development. As such, online communities and other so-called web 2.0 tools have come to the fore as potentially useful for educators and students [...]Lifelong learning online is about connecting people is a post from: Sciencebase Science Blog
... Read more »

Cristina Costa. (2010) Lifelong learning in Web 2.0 environments. Int. J. Technology Enhanced Learning, 2(3), 275-284. info:/

  • April 28, 2010
  • 09:00 AM
  • 983 views

Tilting the three-way tango - disease as a loss of diversity

by Alistair Dove in Deep Type Flow

Disease is a funny old thing.  We're taught from very early on that disease agents are "bad" and that, by contrast, the infected are somehow poor and unfortunate victims of nasty evil bugs.  This is clearly a cultural bias, wherein we project our own concerns about getting sick onto all other animals; there's no real reason to think that a bacterium or virus has any less right to be here or any ... Read more »

  • April 28, 2010
  • 08:48 AM
  • 1,423 views

Maternal infection during pregnancy and autism: The “flu hypothesis” revisited.

by Nestor Lopez-Duran PhD in Child-Psych

BRIEFS
The last issue of the Journal of Autism and Developmental Disorders included one of the largest examinations of the association between maternal infection during pregnancy and risk for autism. The study was conducted in the Denmark where researchers examined the maternal infection rates during pregnancy and autism diagnoses for all children born in Denmark between [...]... Read more »

Atladóttir, H., Thorsen, P., Østergaard, L., Schendel, D., Lemcke, S., Abdallah, M., & Parner, E. (2010) Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders. Journal of Autism and Developmental Disorders. DOI: 10.1007/s10803-010-1006-y  

  • April 28, 2010
  • 08:14 AM
  • 1,358 views

Who Moved My Garden? Spatial Learning in the Octopus

by Jason Goldman in The Thoughtful Animal

Say you're visiting Los Angeles and you have a sudden craving for Chinese food. Since you are only visiting, you might not be aware that nothing is open past, like, 10pm (not even coffee houses), but you get in your rental car and go driving around in search of your Chinese feast anyway. You try hitting up Panda Express, but no such luck. Of course they're closed. You try the neighborhood Chinese restaurant: closed as well. You get back in the car, and think to yourself "maybe the OTHER Panda Ex........ Read more »

  • April 28, 2010
  • 08:00 AM
  • 1,298 views

How much are the ecosystems of New Jersey worth to society?

by Rob Goldstein in Conservation Maven

... Read more »

  • April 28, 2010
  • 08:00 AM
  • 540 views

The Brain Rejects Inequality

by Shaheen Lakhan in Brain Blogger

The human brain likes balance. Not simply biological and physiological homeostasis that maintains the proper functioning of the brain, but emotional, social and psychological balance. Notably, the human brain dislikes inequality when it comes to money, and rejects it at all costs, according to new research in the journal Nature.
Behavioral and anthropological evidence show that [...]... Read more »

Guroglu, B., van den Bos, W., Rombouts, S., & Crone, E. (2010) Unfair? It depends: Neural correlates of fairness in social context. Social Cognitive and Affective Neuroscience. DOI: 10.1093/scan/nsq013  

Smith, D., Hayden, B., Truong, T., Song, A., Platt, M., & Huettel, S. (2010) Distinct Value Signals in Anterior and Posterior Ventromedial Prefrontal Cortex. Journal of Neuroscience, 30(7), 2490-2495. DOI: 10.1523/JNEUROSCI.3319-09.2010  

Tricomi, E., Rangel, A., Camerer, C., & O’Doherty, J. (2010) Neural evidence for inequality-averse social preferences. Nature, 463(7284), 1089-1091. DOI: 10.1038/nature08785  

Yamagishi, T., Horita, Y., Takagishi, H., Shinada, M., Tanida, S., & Cook, K. (2009) The private rejection of unfair offers and emotional commitment. Proceedings of the National Academy of Sciences, 106(28), 11520-11523. DOI: 10.1073/pnas.0900636106  

  • April 28, 2010
  • 06:00 AM
  • 1,257 views

Ethnic Variation in Obesity Risk

by Dr. Arya Sharma in Dr. Sharma's Obesity Notes

In this paper, we looked at the relationship between body weight (BMI), adipokines, and insulin resistance in 1,176 South Asian, Chinese, Aboriginal, and European Canadians in the SHARE study (Study of Health Assessment and Risk in Ethnic groups).... Read more »

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