Could it be that becoming more psychologically flexible could effectively heal much psychopathology? Kashdan and Rottenberg (2010) seem to think so.... Read more »
Kashdan, T., & Rottenberg, J. (2010) Psychological Flexibility as a Fundamental Aspect of Health. Clinical Psychology Review. DOI: 10.1016/j.cpr.2010.03.001
by thomastu in Disease Prone
Some people have commented to me in person (and online) that I was a little brash in calling those violently opposed vaccinations as evil or ignorant. Also, that I might be completely shutting off dialogue and having people immediately list me as one of those pro-vaccination whores. I thought about this for a long time [...]... Read more »
Greenberg SB. (2000) 'Bacilli and bullets': William Osler and the antivaccination movement. Southern medical journal, 93(8), 763-7. PMID: 10963505
Last week, the American Society for Microbiology posted a story that caught my eye which highlighted the most recent work of Kim Lewis and his collaborators published in Chemistry and Biology in March (see citation below). It caught my eye due to the term “siderophores” in the title. You may be wondering why a strange [...]... Read more »
D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, & Lewis K. (2010) Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry , 17(3), 254-64. PMID: 20338517
Episode 2 of series 2 of Inside Nature's Giants was devoted to pythons (for an article reviewing ep 1, go here). Specifically, to Burmese pythons Python molurus. And, quite right too. Snakes are among the weirdest and most phenomenally modified of tetrapods: in contrast to we boring tetrapodal tetrapods with our big limb girdles, long limbs and less than 100 vertebrae, we're talking about tubular reptiles with a few hundred vertebrae, stretched organs, distensible jaws and total or virtual a........ Read more »
Cohn MJ, & Tickle C. (1999) Developmental basis of limblessness and axial patterning in snakes. Nature, 399(6735), 474-9. PMID: 10365960
Research published in Cell, July 9, 2010, provides compelling evidence for an environmental component for cancer survival, that is a macro environmental component. While other studies have examined the effects of diet and exercise and even toxicological components on cancer susceptibility, Cao et al. studied mice living in an “enriched housing environment” that included more [...]... Read more »
Cao L, Liu X, Lin EJ, Wang C, Choi EY, Riban V, Lin B, & During MJ. (2010) Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell, 142(1), 52-64. PMID: 20603014
This is the question asked by Tilman Steinert & Martin Jandl in a letter to the journal Psychopharmacology.They point out that in the past 20 years, the word "antipsychotic" has exploded in popularity. Less than 100 academic papers were published with that word in the title in 1990, but now it's over 600.The older term for the same drugs was "neuroleptics". This terminology, however, has slowly but surely fallen into disuse over the same time period.To illustrate this they have a nice graph ........ Read more »
The photos that accompanied news releases about quadrupedal people living in Turkey, members of a family that allegedly could not walk except on hands and feet, looked staged when I first saw them. Three women and one man scrambling across rocky ground, the women in brightly coloured clothing, the sky radiant blue behind them, their eyes forward and backsides high in the air – like children engaged in some sort of awkward race at a field day or sporting carnival.
Members of a Turkish family ........ Read more »
Hall, Brian K. (1984) Developmental mechanisms underlying the formation of atavisms. . Biological Reviews, 89-124. DOI: 10.1111/j.1469-185X.1984.tb00402.x
Lovejoy CO, Suwa G, Simpson SW, Matternes JH, & White TD. (2009) The great divides: Ardipithecus ramidus reveals the postcrania of our last common ancestors with African apes. Science (New York, N.Y.), 326(5949), 100-6. PMID: 19810199
Tayfun Ozcelik, Nurten Akarsu, Elif Uz, Safak Caglayan, Suleyman Gulsuner, Onur Emre Onat, Meliha Tan, & Uner Tan. (2008) Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. . Proceedings of the National Academy of Sciences, 105(11), 4232-4236. DOI: 10.1073/pnas.0710010105
Ozcelik, Tayfun,, Nurten Akarsu,, Elif Uz,, Safak Caglayan,, Suleyman Gulsuner,, Onur Emre Onat,, Meliha Tan,, & Uner Tan. (2008) Reply to Herz et al. and Humphrey et al.: Genetic heterogeneity of cerebellar hypoplasia with quadrupedal locomotion. . Proceedings of the National Academy of Sciences, 105(23). DOI: 10.1073 pnas.0804078105
Stanford CB. (2006) Arboreal bipedalism in wild chimpanzees: implications for the evolution of hominid posture and locomotion. American journal of physical anthropology, 129(2), 225-31. PMID: 16288480
Tan, Meliha, Sibel Karaca, and Uner Tan. (2010) A New Case of Uner Tan Syndrome—with Late Childhood Quadrupedalism. Movement Disorders, 25(5), 652-653. DOI: 10.1002/mds.22951
Tan, Uner. (2007) A Wrist-Walker Exhibiting No “Uner Tan Sydnrome”: A Theory for Possible Mechanisms of Human Devolution Toward the Atavistic Walking Patterns. International Journal of Neuroscience , 117(1), 147-156. DOI: 10.1080/00207450600936866
Uner Tan, Sadrettin Penccedile, Mustafa Yilmaz, Ayhan Oumlzkur, Sibel Karaca, Meliha Tan, & Mehmet Karatascedil. (2008) “Unertan Syndrome” in two Turkish Families in Relation to Devolution and Emergence of Homo Erectus: Neurological Examination, MRI, and pet Scans. International Journal of Neuroscience, 313-336. DOI: 10.1080/00207450701667766
Tan, Uner, & Meliha Tan. (2009) Unertan Syndrome: A New Variant of Unertan Syndrome: Running on All Fours in Two Upright-Walking Children. International Journal of Neuroscience, 119(7), 909-918. DOI: 10.1080/00207450902828050
Thelen, E.,, & Ulrich, B. D. (1991) Hidden skills: A dynamic systems analysis of treadmill stepping during the first year. Monographs of the Society for Research in Child Development, 56(1), 1-98. DOI: 10.2307/1166099
Thorpe, S. K. S.,, R. L. Holder,, & R. H. Crompton. (2007) Origin of Human Bipedalism As an Adaptation for Locomotion on Flexible Branches. Science, 316(5829), 1328. DOI: 10.1126/science.1140799
Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, Hammer RE, Richardson JA, & Herz J. (1999) Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell, 97(6), 689-701. PMID: 10380922
S Türkmen,, K Hoffmann,, Osman Demirhan,, Defne Aruoba,, N Humphrey,, & S Mundlos. (2008) Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene. European Journal of Human Genetics, 1070-1074. DOI: 10.1038/ejhg.2008.73
Would an anti-indole work?Antibiotic resistance is one of the best examples of evolution in real-time and it’s also one of the most serious medical problems of our time. Emerging resistance in bacteria like MRSA threatens to bring on a wave of epidemics that may remind us of past, more unseemly times.Given the threat that antibiotic resistance poses, it is paramount to understand the mechanisms behind this process. While considerable progress has been made in understanding the genetic basis of........ Read more »
Lee HH, Molla MN, Cantor CR, & Collins JJ. (2010) Bacterial charity work leads to population-wide resistance. Nature, 467(7311), 82-5. PMID: 20811456
When Charles H. Sternberg and his sons excavated one of the first hadrosaur mummies ever found, in the summer of 1908, it was a major discovery. For nearly a century naturalists and paleontologists could only imagine what a dinosaur’s skin was like, but the Edmontosaurus the Sternbergs collected gave scientists an unprecedented look at the [...]... Read more »
Lucia Herrero . (2010) HADROSAURID DINOSAUR SKIN IMPRESSIONS FROM THE UPPER CRETACEOUS KAIPAROWITS FORMATION OF SOUTHERN UTAH, USA. PalArch’s Journal of Vertebrate Palaeontology, 7(2), 1-7. info:/
This is the second post of my SGM conference series and the topic is Microbial Death. I was very interested in this one as a topic, because the mechanisms that lead to bacterial death aren't something I've covered so much. It's generally assumed that antibiotics screw up whatever they target such that the bacteria can no longer survive, and when they aren't around the bacteria just keep dividing.There were two talks concerning antibiotics in bacterial death, the first addressing a theory that's ........ Read more »
Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, & Collins JJ. (2007) A common mechanism of cellular death induced by bactericidal antibiotics. Cell, 130(5), 797-810. PMID: 17803904
Even with the young politician Jefferson Davis behind their adoption by the military, camels were a hard sell to the U.S. government. Along with other military men, Davis was convinced that camels could replace horses as the standard beasts of burden used by cavalry on the ever-expanding western frontier, but most congressmen and senators balked [...]... Read more »
Gina M. Semprebon and Florent Rivals. (2010) Trends in the paleodietary habits of fossil camels from the Tertiary and Quaternary of North America. Palaeogeography, Palaeoclimatology, Palaeoecology, 131-145. DOI: 10.1016/j.palaeo.2010.05.033
A management strategy developed by electronics giant Motorola in the 1980s could help Coca Cola reduce the amount of water it uses to make its products, cut overall energy demands and trim its carbon footprint, according to a study published in the International Journal of Six Sigma and Competitive Advantage. Numerous companies, including Volvo, Nokia [...]... Read more »
Tarek Sadraoui, Ayadi Afef, & Jallouli Fayza. (2010) Six Sigma: a new practice for reducing water consumption within Coca Cola industry. International Journal of Six Sigma and Competitive Advantage, 6(1/2), 53-76. DOI: 10.1504/IJSSCA.2010.034856
Sometimes in applied fields artistic license is constrained by the necessity of function to particular creative channels. Architecture comes to mind, at least before innovative technologies produced lighter and stronger materials, freeing up form from its straight-jacket (whether this was a positive development is a matter of taste). But there’s only so much you can [...]... Read more »
Myres NM, Rootsi S, Lin AA, Järve M, King RJ, Kutuev I, Cabrera VM, Khusnutdinova EK, Pshenichnov A, Yunusbayev B.... (2010) A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe. European journal of human genetics : EJHG. PMID: 20736979
One of the fundamental problems in systems biology is that many important decisions get made at the level of individual cells, but most of the measurement techniques we have (mass spectroscopy, Western blots…) report data on the behavior of populations. And much of the time it’s hard to relate what you see on the single-cell [...]... Read more »
Pfeifer AC, Kaschek D, Bachmann J, Klingmüller U, & Timmer J. (2010) Model-based extension of high-throughput to high-content data. BMC systems biology, 4(1), 106. PMID: 20687942
Freakonomics and its successor Superfreakonomics are two books by the economist Steven Levitt and his partner in crime Stephen Dubner that have a common theme running through them (quote): “People respond to incentives, although not necessarily in ways that are predictable and manifest. Therefore, one of the most powerful laws in the universe is the [...]... Read more »
Bordetella pertussisIs your Emergency Department administering Tdap immunization boosters instead of dT boosters? Patients with wounds are getting updated not only for tetanus and diphtheria, but also now for pertussis. Apparently there has been sharp rise in the national incidence of pertussis in 2010. The infection has been documented in both infants (underimmunized less than 3 months old) and adolescents/adults (loss of immunity after 10 years). In fact, the CDC has issued an epidemic warning........ Read more »
Cornia PB, Hersh AL, Lipsky BA, Newman TB, & Gonzales R. (2010) Does this coughing adolescent or adult patient have pertussis?. JAMA : the journal of the American Medical Association, 304(8), 890-6. PMID: 20736473
David Woods was looking at the early Irish chronicles and he noticed something very odd. There are clusters of entries recording large mast crops. Mast? In Ireland, that would be mostly acorns.. In these sparse annals that normally only record battles, deaths, and other major events, why record large acorn falls? The only typical use [...]... Read more »
David Woods. (2003) Acorns, the Plague, and the 'Iona Chronicle'. Peritia, 495-502. info:/
I have seen many interesting sciencey things this week. Which makes sense, given that a large part of my job is to track new research. Sadly, and for the sake of brevity, I’ve had to pick but two for this post.
Starving to stay awake?
Another interesting factoid related to, well, taking in less calories than one [...]
[Click on the hyperlinked headline for more of the goodness]... Read more »
Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw. (2010) The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis and Prevents Learning Impairments Following Sleep Loss. PLoS Biology. info:/10.1371/journal.pbio.1000466
Notter DA, Gauch M, Widmer R, Wäger P, Stamp A, Zah R, & Althaus HJ. (2010) Contribution of li-ion batteries to the environmental impact of electric vehicles. Environmental science , 44(17), 6550-6. PMID: 20695466
First off, Sci is sorry for two things: 1) Comments on this post are still disabled due to server issues. If you email me with something particularly witty and clever, perhaps I can tweet it. Or edit it on to the post. Or something. 2) Sci has a migraine of rather titanic proportions right now [...]... Read more »
(...) Although these adult sea squirts, or tunicates, don't consist of much more than translucent sacks with intestines, their larval "tadpole" stage exhibits all characteristics of the chordates. This means that they are actually more closely related to us chordate humans than this crab is!
In fact, transparent sea squirts are so similar to us that they may prove to be important for the development of more effective treatments for Alzheimer's disease.... Read more »
Michael J. Virata, & Robert W. Zeller. (2010) Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis. Disease Models , 377-385. DOI: 10.1242/dmm.003434
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