Epilepsy represents a complex neuropsychiatric condition with significant public health impact. The prevalence estimates of active epilepsy range from about 1 to 4% of the general population. Like other medical conditions, epilepsy appears to increase the risk for a variety of secondary (or cormorbidity problems). Understanding these related risks can aid patients, families and clinicians in understanding symptoms, common presentation conundrums and best treatment approaches. A........ Read more »
Ottman R, Lipton RB, Ettinger AB, Cramer JA, Reed ML, Morrison A, & Wan GJ. (2011) Comorbidities of epilepsy: Results from the Epilepsy Comorbidities and Health (EPIC) Survey. Epilepsia. PMID: 21269285
I would like to start a series of brief posts that will present in detail the ancient Greek household worship and religious practice. One, major, problem that exists when a research is been conducted for the ancient Greek world and especially the ancient Greek religion is generalization. As it has been identified by a great number of scholars for every aspect of ancient Greek religious practice, generalization is in fact an error which has been occurred as soon as omissions and over-simplificati........ Read more »
Nilsson, M., P. (1940) Greek Popular Religion. Lectures on the history of religions. n.s. info:other/608793
Rose, H.J. (1957) The religion of a Greek household. Euphrosyne, 95-116. info:/
Full-blown delusions are thought to be pretty rare. By that I mean the truly bizarre delusions, like Capgras syndrome (when you think that relatives or close friends are sometimes replaced by identical-looking impostors), or Subjective Doubles (a belief that there is another person who looks and acts like you) and Controlled Thoughts (that your thoughts are not fully under your control).
It's actually quite difficult to find out just how common these kinds of delusions are. You can't just ask p........ Read more »
Pechey R, & Halligan P. (2011) The Prevalence of Delusion-Like Beliefs Relative to Sociocultural Beliefs in the General Population. Psychopathology, 44(2), 106-115. PMID: 21196811
Do we think differently with our eyes closed or closed? Apparently we do. And it is not just a simple difference like the brain having more to do when it is processing vision compared to when it is not receiving visual input. There is a difference in how we react to music with our eyes [...]... Read more »
Lerner, Y., Papo, D., Zhdanov, A., Belozersky, L., & Hendler, T. (2009) Eyes Wide Shut: Amygdala Mediates Eyes-Closed Effect on Emotional Experience with Music. PLoS ONE, 4(7). DOI: 10.1371/journal.pone.0006230
Think of DNA and you probably think of a double helix – the spiralling ladder shape made famous by Crick and Watson. But DNA can also exist in a number of other, rarer, forms. Led by Professor Shankar Balasubramanian, scientists at our Cambridge Research Institute embarked on a molecular ‘fishing trip’ inside our cells. They [...]... Read more »
Müller, S., Kumari, S., Rodriguez, R., & Balasubramanian, S. (2010) Small-molecule-mediated G-quadruplex isolation from human cells. Nature Chemistry, 2(12), 1095-1098. DOI: 10.1038/nchem.842
by Rita Handrich in The Jury Room
Despite reports that death penalty use and support continue to decline and stories of freed innocent prisoners, researchers continue to explore the impact of ‘death qualification’ on the makeup of American juries. Recently, a study published in the Journal of Applied Social Psychology, examined whether the ‘death qualification’ process in jury selection systematically excludes jurors based [...]
Related posts:Is racial bias fueling anti-Obama rhetoric?
Propaganda, Dogmatism & B........ Read more »
Summers, A., Hayward, RD, & Miller, MK. (2010) Death qualification as systematic exclusion of jurors with certain religious and other characteristics. Journal of Applied Social Psychology, 40(12). info:/
When many people think of membrane fusion, they often think of endocytosis and vesicle trafficking. Membrane fusion is a fascinating and dynamic process that is involved in so many processes in the cell, including nuclear envelope formation.... Read more »
Fichtman, B., Ramos, C., Rasala, B., Harel, A., & Forbes, D. (2010) Inner/Outer Nuclear Membrane Fusion in Nuclear Pore Assembly: Biochemical Demonstration and Molecular Analysis. Molecular Biology of the Cell, 21(23), 4197-4211. DOI: 10.1091/mbc.E10-04-0309
This barely merits the Research Blogging tag, because all I want to do here is raise a possibility, and a tenuous one at that. I confess that I was attracted in a high-speed scan of headlines, by this one: Leaving home ain’t easy: non-local seed dispersal is only evolutionarily stable in highly unpredictable environments. The [...]... Read more »
Snyder, R. (2010) Leaving home ain't easy: non-local seed dispersal is only evolutionarily stable in highly unpredictable environments. Proceedings of the Royal Society B: Biological Sciences, 278(1706), 739-744. DOI: 10.1098/rspb.2010.1549
Residency training programs are required to have Morbidity and Mortality (M&M) Conferences, as mandated by the Accreditation Council of Graduate Medical Education (ACGME). These conferences were originally designed to look at medical errors and unforeseen complications in patient care.Traditionally, Surgery programs focus on medical error and complications in their conferences. In contrast, Internal Medicine programs tend to focus more on cases because of their intrinsic learning value. Erro........ Read more »
Seigel, T., McGillicuddy, D., Barkin, A., & Rosen, C. (2010) Morbidity and Mortality Conference in Emergency Medicine. The Journal of Emergency Medicine, 38(4), 507-511. DOI: 10.1016/j.jemermed.2008.09.018
We experience emotion more intensely with our eyes closed
The simple act of closing our eyes has a significant effect on our moral judgement and behaviour. Eugene Caruso and Francesca Gino, who made the observation, think the effect has to do with mental simulation, whereby having our eyes closed causes us to simulate scenarios more vividly. In turn this triggers more intense emotion.
Throughout the study, Caruso and Gino concealed the true aim of the research from participants by telling the........ Read more »
Caruso, E., & Gino, F. (2011) Blind ethics: Closing one’s eyes polarizes moral judgments and discourages dishonest behavior. Cognition, 118(2), 280-285. DOI: 10.1016/j.cognition.2010.11.008
Earlier this month at ScienceOnline2011 (a professional meeting of science bloggers and others using the web to communicate about science), Brian Malow – aka. the Science Comedian – gave a wonderful impromptu performance. On the topic of viruses, Brian described a viral infection as “Your cells: Under new management.” It’s a clever but quite apt [...]... Read more »
Fenton, A., Magoolagan, L., Kennedy, Z., & Spencer, K. (2011) Parasite-induced warning coloration: a novel form of host manipulation. Animal Behaviour, 81(2), 417-422. DOI: 10.1016/j.anbehav.2010.11.010
That's the title of my 'Thought Experiment' column in the next issue of 'The Scientist', due to appear on February 1. Sarah Greene from The Scientist approached me in my role as F1000 faculty member at this year's SfN annual meeting in San Diego and asked me if I didn't want to write something for The Scientist.The short article is about visualizing neuronal activity in small brains. I've recently applied for a starting grant at the European Research Council to develop a microscope which can rec........ Read more »
Cheng, A., Gonçalves, J., Golshani, P., Arisaka, K., & Portera-Cailliau, C. (2011) Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing. Nature Methods, 8(2), 139-142. DOI: 10.1038/nmeth.1552
Sci will admit I spent most the time “preparing” for this post by listening to LOTS of music. This is your brain: (Source) Is this your brain on Music? (Source) Well, to be entirely honest…probably not. But music’s still nice. Let’s take a look at why. So, let’s start out with a little bit of [...]... Read more »
Salimpoor VN, Benovoy M, Larcher K, Dagher A, & Zatorre RJ. (2011) Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nature neuroscience, 14(2), 257-262. PMID: 21217764
So, our next Egypt Week feature is a theoretical paper on a topic closely related to the last post. Once again, we are interested in understanding the mechanisms that are responsible for encouraging or enforcing cooperation, thereby facilitating collective action. Last time, we talked about a paper that found that "altruistic" or "third-party" punishment is common in large-scale, complex societies, but is rare in small-scale societies, while "spiteful" punishment is universal.
Many empirical a........ Read more »
In the following post I will enumerate the many ways in which current science repeatedly demonstrates that giant squids are awesomesauce.
Awesome: (adj) amazing, awe-inspiring, awful, awing (inspiring awe or admiration or wonder) “New York is an amazing city”; “the Grand Canyon is an awe-inspiring sight”; “the awesome complexity of the universe”; “this sea, whose gently awful stirrings seem to speak of . . . → Read More: From The Editor’........ Read more »
Lordan, C., Collins, M., & Perales-Raya, C. (2009) Observations on Morphology, Age and Diet of Three Architeuthis Caught Off the West Coast of Ireland in 1995. Journal of the Marine Biological Association of the United Kingdom, 78(03), 903. DOI: 10.1017/S0025315400044866
K. S. BOLSTAD, & S. O’SHEA. (2004) Gut contents of a giant squid Architeuthis dux (Cephalopoda: Oegopsida) from New Zealand waters. Bolstad , 15-21. info:/
Rosa, R., Pereira, J., & Nunes, M. (2004) Biochemical composition of cephalopods with different life strategies, with special reference to a giant squid, Architeuthis sp. Marine Biology, 146(4), 739-751. DOI: 10.1007/s00227-004-1477-5
Aldrich, F., & Aldrich, M. (1968) On regeneration of the tentacular arm of the giant squid Architeuthis dux Steenstrup (Decapoda, Architeuthidae). Canadian Journal of Zoology, 46(5), 845-847. DOI: 10.1139/z68-120
Landman, N., Cochran, J., Cerrato, R., Mak, J., Roper, C., & Lu, C. (2004) Habitat and age of the giant squid ( Architeuthis sanctipauli ) inferred from isotopic analyses. Marine Biology, 144(4), 685-691. DOI: 10.1007/s00227-003-1245-y
Hoving, H., Roeleveld, M., Lipinski, M., & Melo, Y. (2004) Reproductive system of the giant squid Architeuthis in South African waters. Journal of Zoology, 264(2), 153-169. DOI: 10.1017/S0952836904005710
Deagle, B. (2005) Genetic Screening for Prey in the Gut Contents from a Giant Squid (Architeuthis sp.). Journal of Heredity, 96(4), 417-423. DOI: 10.1093/jhered/esi036
Clarke, M., & Pascoe, P. (2009) Cephalopod Species in the Diet of a Sperm Whale (Physeter Catodon) Stranded at Penzance, Cornwall. Journal of the Marine Biological Association of the United Kingdom, 77(04), 1255. DOI: 10.1017/S0025315400038819
And in keeping with the topic of bees… – I’ve just read a very, very cool paper in Ecology Letters about something I’ve wanted to do myself for some time. It’s a fairly specific piece of work, so it could easily be reproduced elsewhere with different species. My point though is that a hell of [...]... Read more »
Carvalheiro, L., Veldtman, R., Shenkute, A., Tesfay, G., Pirk, C., Donaldson, J., & Nicolson, S. (2011) Natural and within-farmland biodiversity enhances crop productivity. Ecology Letters. DOI: 10.1111/j.1461-0248.2010.01579.x
When is the effect of a mutation neutral?
A mutation (by this I mean any change to the genotype/genome of an organism) is neutral when it does not change the fitness of the organism. This can happen in different ways:
1) A mutation (SNP) that changes one nucleotide in the protein coding sequence, but does not change the amino acid. These are known as synonymous substitutions, and (mostly*) do not affect fitness.
2) When the mutation does not change fitness, just because the genomic chang........ Read more »
To Africa and back again.
[Queen Nzinga (smoking a pipe) with Her Entourage, Kingdom of Kongo, 1670s]--------->
In the 17th Century, tobacco, the prototypical New World stimulant, was introduced to Africa by European traders. By 1607, tobacco was being cultivated in Sierra Leone, and in 1611 a Swiss doctor commented on how the soldiers of the “Kingdom of Kongo” fought hunger by grinding up tobacco leaves and setting them on fire, “so that a strong smoke is produced, which they inhale........ Read more »
Handler, J. (2009) The Middle Passage and the Material Culture of Captive Africans. Slavery , 30(1), 1-26. DOI: 10.1080/01440390802673773
No pain no gain: mums told to grit their teeth if they want sons with balls. Djuke Veldhuis examines how expectant mothers use painkillers could affect their son... Read more »
Kristensen, D., Hass, U., Lesne, L., Lottrup, G., Jacobsen, P., Desdoits-Lethimonier, C., Boberg, J., Petersen, J., Toppari, J., Jensen, T.... (2010) Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Human Reproduction, 26(1), 235-244. DOI: 10.1093/humrep/deq323
Ethiopia, with over 80 million people, is heavily affected by tuberculosis, complicated by poverty and HIV infection, limited access to the health service and shortage of health workers. We recently reviewed tuberculosis control programme in South Ethiopia. Although treatment success rates have improved during the last decade, low case notification rate, mainly because of inability [...]... Read more »
Datiko, D., & Lindtjørn, B. (2010) Cost and Cost-Effectiveness of Treating Smear-Positive Tuberculosis by Health Extension Workers in Ethiopia: An Ancillary Cost-Effectiveness Analysis of Community Randomized Trial. PLoS ONE, 5(2). DOI: 10.1371/journal.pone.0009158
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