Insomnia is something all of us struggle with from time to time. Not being able to get off to sleep is perhaps one of the most frustrating and loathsome things in the world (second only to an itchy back).
Many of us resort to herbal or medical remedies. If you had to choose one, which would you go for? Did you realise though that the colour of your remedy has an effect!? Read on to find out why blue is best…... Read more »
Moerman DE, & Jonas WB. (2002) Deconstructing the placebo effect and finding the meaning response. Annals of internal medicine, 136(6), 471-6. PMID: 11900500
Today, we’re going back to my old frienemy, the arXiv blog. Even though I tend to beat up on it quite a bit, the preprint archive does have some interesting papers, even if the only interesting part about them is shredding them for a skeptical post. Then again, this sort of constant criticism of scientific [...]... Read more »
reposted from: http://info.cancerresearchuk.org/news/archive/cancernews/2011-01-19-Smoking-to-blame-for-majority-of-gender-gap-in-deaths-?rss=truecrabsallover highlights, key points, comments / links.Wednesday 19 January 2011Smoking accounts for up to 60 per cent of the gender gap in death rates across Europe, according to a new study by scientists at the MRC/CSO Social and Public Health Sciences Unit in Glasgow.The study authors set out to investigate death ra........ Read more »
McCartney, G., Mahmood, L., Leyland, A., Batty, G., & Hunt, K. (2011) Contribution of smoking-related and alcohol-related deaths to the gender gap in mortality: evidence from 30 European countries. Tobacco Control. DOI: 10.1136/tc.2010.037929
The shadow of symmetry haunts physics. Symmetry is invoked to understand nature concisely, but broken symmetry is invoked to understand nature completely. Physics is filled with examples of shattered symmetries: there is more matter than antimatter, neutrinos only come in the left handed spin flavor, and quantum processes break symmetries constantly, but nature also violates symmetry in chemistry and biology in a very clever manner. Chemistry and biology are subjects I do no normally touch ........ Read more »
Robert N. Compton, Richard M. Pagni, & Volume 48, 2002, Pages 219-261. (2002) The chirality of biomolecules. Advances In Atomic, Molecular, and Optical Physics, 219-261. info:/
So, in the previous installment, we introduced the "Loudest Voice Prevails" principle, which describes the evolutionarily stable pattern of gene expression at an imprinted locus where there is an intragenomic conflict over the total level of gene expression. Basically, the allele that favors lower expression becomes transcriptionally silenced. Expression from the other allele (the "louder" voice) evolves to the level that maximizes its inclusive fitness. In this sense, the active allele at an im........ Read more »
Kondoh, M., & Higashi, M. (2000) Reproductive Isolation Mechanism Resulting from Resolution of Intragenomic Conflict. The American Naturalist, 156(5), 511-518. DOI: 10.1086/303409
by Kambiz Kamrani in Anthropology.net
I got some archaeobotany for you to start your weekend off right with — a new open access study in PNAS announces a genome wide association of 8,000 years of grape domestication, spanning the Eastern Caucasus to Western Europe. Lead … Continue reading →... Read more »
Myles, S., Boyko, A., Owens, C., Brown, P., Grassi, F., Aradhya, M., Prins, B., Reynolds, A., Chia, J., Ware, D.... (2011) Genetic structure and domestication history of the grape. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1009363108
Sometimes I'm going to write about rare cancers or blood diseases and sometimes I’m going to write about bad breath. That’s just the way I roll.
Halitosis literally means “condition of the breath” and has many causes and just as many home remedies. Original therapies (and by original I mean 1550 BC) like heavily herb infused wines didn’t remove the bad breath but like mints and other modern treatments they just attempted to cover the bad smell with something more pleasant.
Halitos........ Read more »
Suarez FL, Furne JK, Springfield J, & Levitt MD. (2000) Morning breath odor: influence of treatments on sulfur gases. Journal of dental research, 79(10), 1773-7. PMID: 11077993
Wow, the new year is off to a great start in GPCR structural biology: Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, & Kobilka BK (2011). Structure of a [...]... Read more »
Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS.... (2011) Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature, 469(7329), 175-80. PMID: 21228869
Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK.... (2011) Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature, 469(7329), 236-40. PMID: 21228876
Warne T, Moukhametzianov R, Baker JG, Nehmé R, Edwards PC, Leslie AG, Schertler GF, & Tate CG. (2011) The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor. Nature, 469(7329), 241-4. PMID: 21228877
Gene variants make anti-craving drugs a hit-or-miss affair.
Rather than taking on another broad hunt for the genes controlling the expression of alcoholism, noted addiction researcher Dr. Bankole Johnson and co-workers at the Department of Psychiatry and Neurobehavioral Sciences at the University of Virginia took a different tack. The researchers focused, instead, on investigating whether genetic variations among alcoholics might affect their responses to a specific anti-craving medication.
T........ Read more »
Johnson, B., Ait-Daoud, N., Seneviratne, C., Roache, J., Javors, M., Wang, X., Liu, L., Penberthy, J., DiClemente, C., & Li, M. (2011) Pharmacogenetic Approach at the Serotonin Transporter Gene as a Method of Reducing the Severity of Alcohol Drinking. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2010.10050755
dbSNP is NCBI’s catalog of DNA variation. While the SNP in the name implies a focus on Single Nucleotide Polymorphisms, dbSNP is far more comprehensive and includes length variants, mutations, and a plethora of annotations that characterize over 75...
[[ This is a content summary only. Visit my website for full links, other content, and more! ]]... Read more »
Sherry ST, Ward M, & Sirotkin K. (1999) dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation. Genome research, 9(8), 677-9. PMID: 10447503
As I approach my third trimester, I’m becoming a bit of an omega-3 fiend. The unsaturated fatty acids have not only been tied to lower heart disease risk in adults, but they have also been shown to boost fetal brain development, especially when consumed in the final few months of pregnancy. Given that I’m not much of a cold water fish fan—the thought of chewing a mouthful of sardines makes me want to gag—I’ve been looking into how else to get them, and what I’ve uncov........ Read more »
PSOTA, T., GEBAUER, S., & KRISETHERTON, P. (2006) Dietary Omega-3 Fatty Acid Intake and Cardiovascular Risk. The American Journal of Cardiology, 98(4), 3-18. DOI: 10.1016/j.amjcard.2005.12.022
JACOBSON, J., JACOBSON, S., MUCKLE, G., KAPLANESTRIN, M., AYOTTE, P., & DEWAILLY, E. (2008) Beneficial Effects of a Polyunsaturated Fatty Acid on Infant Development: Evidence from the Inuit of Arctic Quebec. The Journal of Pediatrics, 152(3), 356-3640. DOI: 10.1016/j.jpeds.2007.07.008
The Government announced this week the list... Read more »
As a preface to a post about 2011 research by many of the same scientists, this post discusses previous work on music and the emotion that led to the recently published dopamine study.... Read more »
Salimpoor, V., Benovoy, M., Longo, G., Cooperstock, J., & Zatorre, R. (2009) The Rewarding Aspects of Music Listening Are Related to Degree of Emotional Arousal. PLoS ONE, 4(10). DOI: 10.1371/journal.pone.0007487
by Richard in A Replicated Typo 2.0
A recent NPR radio show covered the research of the biosemiotician Con Slobodchikoff of the Univeristy of Arizone on prairie dog calls. The piece is very public-orientated, but still might be worth listening to.
We’ve all (I hope) heard of the vervet monkeys, which have different alarm calls for different predators, such as for leopard (Panthera pardus), martial . . . → Read More: Prairie Dog Communication... Read more »
Schleich, C., Vielma, A., Glösmann, M., Palacios, A., & Peichl, L. (2010) Retinal photoreceptors of two subterranean tuco-tuco species (Rodentia, Ctenomys): Morphology, topography, and spectral sensitivity. The Journal of Comparative Neurology, 518(19), 4001-4015. DOI: 10.1002/cne.22440
Seyfarth, R., Cheney, D., & Marler, P. (1980) Monkey responses to three different alarm calls: evidence of predator classification and semantic communication. Science, 210(4471), 801-803. DOI: 10.1126/science.7433999
Slobodchikoff CN, Paseka A, & Verdolin JL. (2009) Prairie dog alarm calls encode labels about predator colors. Animal cognition, 12(3), 435-9. PMID: 19116730
When I am in situations where there is lack of semantic clarity, where two or more speakers have a different set of “pictures” that describe one or a set of propositions, I am reminded of Wittgenstein. Science has specific operational definitions whose purpose it to get rid of lack of semantic clarity and achieve congruity in the perceived meaning of language signs between two or more individuals.... Read more »
Hare, R., Hart, S., & Harpur, T. (1991) Psychopathy and the DSM-IV criteria for antisocial personality disorder. Journal of Abnormal Psychology, 100(3), 391-398. DOI: 10.1037/0021-843X.100.3.391
Ogloff, J. (2006) Psychopathy/antisocial personality disorder conundrum. Australian and New Zealand Journal of Psychiatry, 40(6-7), 519-528. DOI: 10.1111/j.1440-1614.2006.01834.x
Morten Hesse. (2010) What should be done with antisocial personality disorder in the new edition of the diagnostic and statistical manual of mental disorders (DSM-V)?. BMC Medicine. info:/10.1186/1741-7015-8-66
Image via Wikipedia It has been this blog’s thesis that autism and its milder form autism spectrum disorders (ASD) are diametrically opposed to psychosis and its milder form schizotypy. In no area is this more apparent than in the perception or attribution of minds to others. It thus gave me immense pleasure to read thisRating: 0.0/10 (0 votes cast)... Read more »
Doxepin is a tricyclic antidepressant drug with significant sedative effect recently studied for use as a hypnotic in the treatment of insomnia. Doxepin has strong antagonistic effects on several neurotransmitter receptors including the histamine (one and two), serotonin (two), alpha one adrenergic and muscarinic acetylcholinergic receptors.Juliane Weber and colleagues recently reviewed clinical trial research related to doxepin and insomnia treatment. For depression, doxepin typical........ Read more »
Krystal AD, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, & Roth T. (2010) Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. Sleep, 33(11), 1553-61. PMID: 21102997
Mice ... Read more »
The FDA has conditionally approved the novel contrast agent, Florbetapir, to help in the diagnosis of amyloid beta plaque build up in the brains of Alzheimer’s (or, for that purpose, any damn dementia) patients. Now there are several reasons why … Continue reading →... Read more »
Wong, D., Rosenberg, P., Zhou, Y., Kumar, A., Raymont, V., Ravert, H., Dannals, R., Nandi, A., Brasic, J., Ye, W.... (2010) In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Flobetapir F 18). Journal of Nuclear Medicine, 51(6), 913-920. DOI: 10.2967/jnumed.109.069088
Clark, C., Schneider, J., Bedell, B., Beach, T., Bilker, W., Mintun, M., Pontecorvo, M., Hefti, F., Carpenter, A., Flitter, M.... (2011) Use of Florbetapir-PET for Imaging -Amyloid Pathology. JAMA: The Journal of the American Medical Association, 305(3), 275-283. DOI: 10.1001/jama.2010.2008
Higher altitude has been found to increase the risk of suicide and consequently the west with its higher altitudes carry an increased risk of suicide. Perry Renshaw of the University of Utah School of Medicine believes from his analysis that the risk increases by nearly one third at an altitude of 2,000m (6,500ft above sea level). Renshaw analyzed data from CDC and found that altitude is an independent risk factor for suicide. He believes "...this association may have arisen from the effect........ Read more »
Kim N, Mickelson JB, Brenner BE, Haws CA, Yurgelun-Todd DA, & Renshaw PF. (2011) Altitude, gun ownership, rural areas, and suicide. The American journal of psychiatry, 168(1), 49-54. PMID: 20843869
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