Post List

  • August 17, 2010
  • 07:57 AM

Patterns of expression of DNA repair genes and relapse from melanoma

by Sally Church in Pharma Strategy Blog

Someone kindly sent me this pattern on how gene expression can be used to track insufficient DNA repair can lead to relapse in melanoma, making it potentially useful as both a prognostic and predictive biomarker for the disease. Regular readers...... Read more »

Jewell, R., Conway, C., Mitra, A., Randerson-Moor, J., Lobo, S., Nsengimana, J., Harland, M., Marples, M., Edward, S., Cook, M.... (2010) Patterns of Expression of DNA Repair Genes and Relapse from Melanoma. Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-10-1521  

  • August 17, 2010
  • 06:15 AM

Pigs (and their viruses) fly

by iayork in Mystery Rays from Outer Space

An emerging disease that I just missed directly seeing emerge is PRRS. PRRS is “porcine reproductive and respiratory syndrome”, which pretty much sums up the disease. It’s caused by — you’ll never guess — Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus that emerged in 1987. That was the year I left large animal [...]... Read more »

  • August 17, 2010
  • 05:55 AM

How to apologise

by BPS Research Digest in BPS Research Digest

Whether it's a company like BP apologising for causing environmental catastrophe or a political leader expressing regret for her country's prior misdemeanors, it seems there's barely a day goes by without the media watching hawkishly to find out just how the contrite words will be delivered and what effect they'll have on the aggrieved.

Surprisingly, psychology has, until now, paid little attention to what makes for an effective apology. Past studies have tended to focus instead simply on wheth........ Read more »

  • August 17, 2010
  • 05:08 AM

Genetic Constraints on Colour Terms

by Sean Roberts in A Replicated Typo 2.0

Continuing my series on the Evolution of Colour terms, this post reviews the evidence for genetic constrains on colour perception.... Read more »

Hardy, J., Frederick, C., Kay, P., & Werner, J. (2004) Color naming and lens brunescence. Journal of Vision, 4(8), 56-56. DOI: 10.1167/4.8.56  

Regier T, & Kay P. (2004) Color naming and sunlight: commentary on Lindsey and Brown (2002). Psychological science : a journal of the American Psychological Society / APS, 15(4), 289. PMID: 15043652  

Jameson KA, & Komarova NL. (2009) Evolutionary models of color categorization. II. Realistic observer models and population heterogeneity. Journal of the Optical Society of America. A, Optics, image science, and vision, 26(6), 1424-36. PMID: 19488182  

  • August 17, 2010
  • 01:59 AM

Learning Eldercare in Nongeriatric Clerkship is a Myth

by Dr Shock in Dr Shock MD PhD

I see a lot of elderly patients while treating severe depression. I do. According to recent research during medical clerkship on an internal ward is not the same as a specialized geriatric rotation. A geriatric rotation is more effective than a traditional clerkship for medical students to understand and to care for an aging population.
So [...]

Related posts:Speciality Choice of Medical Students, Impact of Clerkship
Formal, Informal, and Hidden Curricula of a Psychiatry Clerkship
The Effect ........ Read more »

Diachun L, Van Bussel L, Hansen KT, Charise A, & Rieder MJ. (2010) "But I see old people everywhere": dispelling the myth that eldercare is learned in nongeriatric clerkships. Academic medicine : journal of the Association of American Medical Colleges, 85(7), 1221-8. PMID: 20592520  

  • August 17, 2010
  • 12:59 AM

Sex, Stress, and Neurogenesis

by Brian Mossop in The Decision Tree

There’s an article in the latest issue of Wired by Jonah Lehrer explaining just how dangerous stress can be to our health.  It’s a fascinating read — and instead of relying on my poor attempt to paraphrase — I suggest checking out the article in its entirety. The part of the story that struck a [...]... Read more »

  • August 16, 2010
  • 11:13 PM

An Anthropological Genetic View of Berkeley’s Personalized Medicine Project

by Kris in Ge·knit·ics

Recently, UC Berkeley announced their “Bring Your Genes to Cal” Project, offering personalized genetic testing for all incoming freshmen. The program allowed incoming students, on a voluntary and anonymous basis, to submit DNA samples, with the promise that they would receive their personal results of tests for three common genetic variants. The program had IRB [...]... Read more »

  • August 16, 2010
  • 10:01 PM

Chasing the Genes for Cocaine Addiction

by Dirk Hanson in Addiction Inbox

Brain protein MeCP2 in the spotlight.
Dr. Edward Sellers, former director of the psychopharmacological research program at the University of Toronto’s Addiction Research Foundation once said to me: “Every cell, every hormone, every membrane in the body has got genetic underpinnings, and while many of the genetic underpinnings are similar in people, in fact there are also huge differences. So on one level, the fact that there is a genetic component to addiction is not very surprising. What i........ Read more »

  • August 16, 2010
  • 08:19 PM

Combat Veterans Disabled by War

by Ultimo167 in Strong Silent Types

MacLean (2010) confirms that combat veterans can be disabled for life by their battlefield experiences, regardless of whatever 'pre-combat characteristics' they might have possessed.... Read more »

  • August 16, 2010
  • 08:05 PM

Basketmaker Subsistence

by teofilo in Gambler's House

One of the important questions in understanding the spread of agriculture into the Southwest from Mexico is when Southwestern peoples became dependent on it for their subsistence.  It is generally accepted that this dependence was in place by the Pueblo I period, which is defined as starting around AD 750 in most areas, but there [...]... Read more »

  • August 16, 2010
  • 07:50 PM

How mantis shrimp see circularly polarized light

by Michael Bok in Arthropoda

Mantis shrimp have long been regarded as visual super-stars. They can have up to 16 distinct photoreceptor types that are maximally sensitive to at least 12 different wavelengths (colors) of light; from deep in the ultraviolet, across our visual range, and into the infrared. In addition, they are strongly sensitive to linearly polarized light (LPL) [...]... Read more »

Chiou TH, Kleinlogel S, Cronin T, Caldwell R, Loeffler B, Siddiqi A, Goldizen A, & Marshall J. (2008) Circular polarization vision in a stomatopod crustacean. Current biology : CB, 18(6), 429-34. PMID: 18356053  

  • August 16, 2010
  • 05:42 PM

High Carbohydrate Eating Increases Risk of Diabetes

by Steve Parker, M.D. in Diabetic Mediterranean Diet Blog

The American Journal of Clinical Nutrition reported earlier this month that high consumption of carbohydrates, high-glycemic-index eating, and high-glycemic-load eating increases the risk of developing diabetes.  High fiber consumption, on the other hand, seems to protect against diabetes.  The article abstract doesn’t mention type 1 versus type 2 diabetes, but it’s probably type 2, the [...]... Read more »

  • August 16, 2010
  • 05:32 PM

Ape-man the hunter?

by Julien Riel-Salvatore in A Very Remote Period Indeed

Well, at least the butcher, if not the tool-maker... McPherron et al. (2010) report the discovery of four bone fragments bearing marks left by stone tools from the the Dikika-55 locality in Ethiopia (dating to between 3.24-3.42 million years BP), a stone's throw from where the juvenile Australopithecus afarensis dubbed Selam was found. This is a pretty monumental discovery, in that it pushes back the evidence for the use of stone tool technology by about 800,000 years, and associates it fairly c........ Read more »

Semaw S, Renne P, Harris JW, Feibel CS, Bernor RL, Fesseha N, & Mowbray K. (1997) 2.5-million-year-old stone tools from Gona, Ethiopia. Nature, 385(6614), 333-6. PMID: 9002516  

Stout D, Quade J, Semaw S, Rogers MJ, & Levin NE. (2005) Raw material selectivity of the earliest stone toolmakers at Gona, Afar, Ethiopia. Journal of human evolution, 48(4), 365-80. PMID: 15788183  

  • August 16, 2010
  • 05:13 PM

Experiments in communication pt 2: Human Iterated Learning

by Wintz in A Replicated Typo 2.0

In the last post, I discussed some of the literature into experimental communication, with the intention of then following it up by looking at recent experiments done at Edinburgh (and beyond). But as Hannah pipped me to the post, with a great overview of the wide range of experiments into language evolution, I’ll instead limit this . . . → Read More: Experiments in communication pt 2: Human Iterated Learning... Read more »

  • August 16, 2010
  • 02:45 PM

Circulating IGF-I levels and pancreatic cancer risk

by Sally Church in Pharma Strategy Blog

A couple of new papers will be reviewed this week, thanks to everyone who sent in links and suggested topics for discussion. I'll try and cover one a day, although there were so many worthy of consideration! Please do keep...... Read more »

  • August 16, 2010
  • 01:30 PM

Epigenetics of Blood Stem Cell Differentiation

by Michael Long in Phased

Andrew Feinberg (John Hopkins University, United States) and coworkers have investigated the epigenetic basis of blood stem cell differentiation into leukocytes and lymphocytes. This news feature was written on August 16, 2010.... Read more »

Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P., Doi, A., Lindau, P., Lee, H., Aryee, M. J., Irizarry, R. A., Kim, K.... (2010) Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature. info:/10.1038/nature09367

  • August 16, 2010
  • 01:26 PM

This Week in the Universe: August 10th – August 16th

by S.C. Kavassalis in The Language of Bad Physics

What have people been talking about this week in high energy physics, astrophysics, gravitation, general relativity and quantum gravity? ... Read more »

Assef, R., Kochanek, C., Brodwin, M., Cool, R., Forman, W., Gonzalez, A., Hickox, R., Jones, C., Le Floc'h, E., Moustakas, J.... (2010) LOW-RESOLUTION SPECTRAL TEMPLATES FOR ACTIVE GALACTIC NUCLEI AND GALAXIES FROM 0.03 TO 30 μm. The Astrophysical Journal, 713(2), 970-985. DOI: 10.1088/0004-637X/713/2/970  

Albert P. Linnell, Paula Szkody, Richard M. Plotkin, Jon Holtzman, Mark Seibert, Thomas E. Harrison, & Steve B. Howell. (2010) GALEX and Optical Light Curves of WX LMi, SDSSJ103100.5 202832.2 and SDSSJ121209.31 013627.7. The Astrophysical Journal. arXiv: 1003.2564v1

Kjær, K., Leibundgut, B., Fransson, C., Jerkstrand, A., & Spyromilio, J. (2010) The 3-D structure of SN 1987A's inner ejecta. Astronomy and Astrophysics. DOI: 10.1051/0004-6361/201014538  

Knispel, B., Allen, B., Cordes, J., Deneva, J., Anderson, D., Aulbert, C., Bhat, N., Bock, O., Bogdanov, S., Brazier, A.... (2010) Pulsar Discovery by Global Volunteer Computing. Science. DOI: 10.1126/science.1195253  

Hansen, S., Juncher, D., & Sparre, M. (2010) AN ATTRACTOR FOR DARK MATTER STRUCTURES. The Astrophysical Journal, 718(2). DOI: 10.1088/2041-8205/718/2/L68  

V. M. Abazov et al. (D0 Collaboration). (2010) Evidence for an Anomalous Like-Sign Dimuon Charge Asymmetry. Phys. Rev. Lett. , 105(8), 1801. info:/10.1103/PhysRevLett.105.081801

V. M. Abazov et al. (D0 Collaboration). (2010) Evidence for an anomalous like-sign dimuon charge asymmetry. Phys. Rev. D, 82(3), 32001. info:/10.1103/PhysRevD.82.032001

  • August 16, 2010
  • 12:50 PM


by Mike Mike in Cephalove

Let’s take a minute to talk about connectomics.  No, not genomics.  No, not metabolomics.  Not any of the other -omics, but connectomics.  It’s a new-ish field that the computational neuroscience geek in all of us can love. By way of introduction, the “connectome” is the “network of elements and connections forming the human brain” (according [...]... Read more »

Yoonsuck Choe, Louise C Abbott, Giovanna Ponte, John Keyser, Jaerock Kwon, David Mayerich, Daniel Miller, Donghyeop Han, Anna Maria Grimaldi, Graziano Fiorito.... (2010) Charting out the octopus connectome at submicron resolution using the knife-edge scanning microscope. BMC Neuroscience, 11(Supplement 1), 136-137. info:/10.1186/1471-2202-11-S1-P136

White, J., Southgate, E., Thomson, J., & Brenner, S. (1986) The Structure of the Nervous System of the Nematode Caenorhabditis elegans. Philosophical Transactions of the Royal Society B: Biological Sciences, 314(1165), 1-340. DOI: 10.1098/rstb.1986.0056  

  • August 16, 2010
  • 10:26 AM

The Evolution of Colour terms

by Sean Roberts in A Replicated Typo 2.0

In a series of posts, I’ll review the current state of the field of the Evolution of Colour Categories. It has been argued that universals in colour naming across cultures can be traced back to constraints from many domains including genetic, perceptual and environmental. I’ll review these arguments and show that if our perception is affected by our language, then many conflicts can be resolved.... Read more »

Mollon, J. (1999) Color vision: Opsins and options. Proceedings of the National Academy of Sciences, 96(9), 4743-4745. DOI: 10.1073/pnas.96.9.4743  

Regier, T., Kay, P., & Khetarpal, N. (2007) Color naming reflects optimal partitions of color space. Proceedings of the National Academy of Sciences, 104(4), 1436-1441. DOI: 10.1073/pnas.0610341104  

Griffin, L. (2004) Optimality of the Basic Colours Categories. Journal of Vision, 4(8), 309-309. DOI: 10.1167/4.8.309  

Regier T, & Kay P. (2004) Color naming and sunlight: commentary on Lindsey and Brown (2002). Psychological science : a journal of the American Psychological Society / APS, 15(4), 289. PMID: 15043652  

  • August 16, 2010
  • 09:32 AM

Musical Accompaniment

by KWombles in Countering...

I have a soundtrack playing in my head, nearly 24/7. It beats the hell out of my tinnitus, but it can be distracting at times. I wake up in the middle of the night to the music playing in my head. I have conversations while it phantom plays; I type and it's there, playing in the background. Call it the ultimate in multitasking and totally easier than walking around with an MP3 player and earbuds. It's exclusively in my head, though; thankfully it hasn't branched out to musical hallucination........ Read more »

Praharaj, S., Goyal, N., Sarkar, S., Bagati, D., Sinha, P., & Sinha, V. (2009) Musical obsession or pseudohallucination: Electrophysiological standpoint. Psychiatry and Clinical Neurosciences, 63(2), 230-234. DOI: 10.1111/j.1440-1819.2009.01926.x  

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