You may not have realised that – since most people nowadays have been vaccinated against it and have never seen it – but measles is a very serious illness. Generally an acute disease of children, measles is spread by the measles virus where it infects the body via the respiratory route and establishes a systemic [...]... Read more »
Manning, L., Laman, M., Edoni, H., Mueller, I., Karunajeewa, H., Smith, D., Hwaiwhanje, I., Siba, P., & Davis, T. (2011) Subacute Sclerosing Panencephalitis in Papua New Guinean Children: The Cost of Continuing Inadequate Measles Vaccine Coverage. PLoS Neglected Tropical Diseases, 5(1). DOI: 10.1371/journal.pntd.0000932
What type of person are you?? When tough times come around – whether it is stress at work, a painful injury, or forced participation in Secret Santa – what do you do? Some people, those lone wolf types, find relief in being alone, taking some time to regroup, and dealing with the problem themselves. Others, [...]... Read more »
Sambo CF, Howard M, Kopelman M, Williams S, & Fotopoulou A. (2010) Knowing you care: effects of perceived empathy and attachment style on pain perception. Pain, 151(3), 687-93. PMID: 20869808
Today is the second Monday of the New Year, January 10, 2011 and we are returning to work, school and normal life, you know, the one without endless shopping, cooking and preparing. Hopefully most of your holiday 2010 remembrances are fond ones…the greetings, baked goods, travel, gifts…all good. Hold on. The greetings; was there was [...]... Read more »
Diemand-Yauman, C., Oppenheimer, D., & Vaughan, E. (2011) Fortune favors the (): Effects of disfluency on educational outcomes. Cognition, 118(1), 111-115. DOI: 10.1016/j.cognition.2010.09.012
New advances in technology are allowing scientists to sequence genomes and determine the structures of the proteins they encode at a faster rate and lower cost than ever before. The NIH’s Protein Structure Initiative centers, such as the Joint Center for Structural Genomics (JCSG), have been instrumental in establishing the structures of hundreds of proteins [...]... Read more »
Ellrott K, Zmasek CM, Weekes D, Sri Krishna S, Bakolitsa C, Godzik A, & Wooley J. (2011) TOPSAN: a dynamic web database for structural genomics. Nucleic acids research, 39(Database issue). PMID: 20961957
Krishna SS, Weekes D, Bakolitsa C, Elsliger MA, Wilson IA, Godzik A, & Wooley J. (2010) TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures. Acta crystallographica. Section F, Structural biology and crystallization communications, 66(Pt 10), 1143-7. PMID: 20944203
Weekes D, Krishna SS, Bakolitsa C, Wilson IA, Godzik A, & Wooley J. (2010) TOPSAN: a collaborative annotation environment for structural genomics. BMC bioinformatics, 426. PMID: 20716366
Astrophysics and Gravitation:
Supermassive Black Hole Surprise?
CREDIT: Reines, et al., David Nidever, NRAO/AUI/NSF, NASA
The dwarf galaxy Henize 2-10, seen in visible light by the Hubble Space Telescope. The central, light-pink region shows an area of radio emission, seen with the Very Large Array. This area indicates the presence of a supermassive black hole drawing in material from its surroundings. This also is indicated by strong X-ray emission from this region detected by the Chandra X-Ray........ Read more »
Andreyev, A., Elseviers, J., Huyse, M., Van Duppen, P., Antalic, S., Barzakh, A., Bree, N., Cocolios, T., Comas, V., Diriken, J.... (2010) New Type of Asymmetric Fission in Proton-Rich Nuclei. Physical Review Letters, 105(25). DOI: 10.1103/PhysRevLett.105.252502
Siye Wu. (2010) Projective flatness in the quantisation of bosons and fermions. arXiv. arXiv: 1008.5333v2
By: Dr. Ken Broda-Bahm - When dealing with the number of plaintiffs in a class action, mass tort, or other large scale litigation, is "Super-Size Me" the plaintiff's best choice? At a legal level, the U.S. Supreme Court will get a chance to weigh in, after the decision last week to determine whether as many as 1.5 million female Wal-Mart workers claiming gender discrimination can be certified as a class (Dukes v. Wal-Mart). The common belief is that a large number of plaintiffs serves to maximiz........ Read more »
Loran F. Nordgren and Mary-Hunter Morris McDonnell. (2010) The Scope-Severity Paradox: Why Doing More Harm Is Judged to be Less Harmful. Social Psychological and. info:/
Lepas anatifera from Washington state, USA. Photo credit: David Cowles 1997.
Barnacle evolution was recently rewritten by a large effort of Perez-Losada and colleagues in 2008. Using a combination of genes and morphological traits they rejected some of the ideas that were foundational to barnacle biology and taxonomy, while giving new support for other ideas.
Though . . . → Read More: Barnacle Evolution I: Phylogeny Served Without Plates... Read more »
by Moselio Schaechter in Small Things Considered
by Welkin E. Johnson
Perhaps more than any other biological discipline, the study of animal viruses is confined to the present. Virions are simply not the stuff of which robust fossils are made. Phylogenetic analysis can help by revealing deep relationships between extant viral lineages, yet such reconstructions lack detail (telling us nothing about transitional or extinct viral forms, the movement of viruses between species, or the timing of major events in viral evolution), and molecular cloc........ Read more »
Gilbert C, & Feschotte C. (2010) Genomic fossils calibrate the long-term evolution of hepadnaviruses. PLoS biology, 8(9). PMID: 20927357
Belyi VA, Levine AJ, & Skalka AM. (2010) Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS pathogens, 6(7). PMID: 20686665
A very common chemical conversion (important to pharmaceutical and other syntheses), which in its most gentle application generates much waste, has now been rendered far more environmentally friendly.... Read more »
Dai, C., Narayanam, J. M. R., & Stephenson, C. R. J. (2011) Visible-light-mediated conversion of alcohols to halides. Nature Chemistry. DOI: 10.1038/NCHEM.949
According to a study by the founder of the Tau Zero Foundation, a collective of space enthusiasts focused on the potential for interstellar travel, which last year published a paper on what it might take to reach a nearby star, we won’t be ready to launch anything outside the solar system by 2196 or so. [...]... Read more »
Marc G. Millis. (2010) Energy, incessant obsolescence, and the first interstellar missions. n/a. DOI: arXiv:1101.1066v1
Advocates of volunteer tourism are keen to stress that the relationship between hosts and guests it engenders is one of responsibility, equality and reciprocity. It is a model of tourism that supposedly brings benefits to all parties involved, especially to host communities in developing countries, and which stands in firm opposition to the insensitive and [...]... Read more »
Sin, H.L. (2010) Who are we responsible to? Locals’ tales of volunteer tourism. Geoforum, 983-992. info:/
This study published in the NEJM seems to have tackled the really dicey issue of unearthing a pharmacotherapeutic agent to deal with the rather ubiquitous, though poorly understood, and more often than not, even less poorly managed problem of irritable … Continue reading →... Read more »
Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, Mareya SM, Shaw AL, Bortey E, Forbes WP.... (2011) Rifaximin therapy for patients with irritable bowel syndrome without constipation. The New England journal of medicine, 364(1), 22-32. PMID: 21208106
If Microsoft Word had its way, passive verbs would be excised from the language. That would solve children some problems, because passive verbs are more difficult to learn than one might think, because not all verbs passivize. Consider:
*The bicycle was resembled by John.
*Three bicycles are had by John.
*Many people are escaped by the argument.
The bicycle was resembled by John: A how-to guide.
So children must learn which verbs have passives and which don't. I recently sat down to read........ Read more »
Pinker S, Lebeaux DS, & Frost LA. (1987) Productivity and constraints in the acquisition of the passive. Cognition, 26(3), 195-267. PMID: 3677572
The motor symptoms of Parkinson’s disease - tremor, inability to initiate movement, rigidity - result from the loss of neurons that secrete the neurotransmitter dopamine. It therefore follows that the best way to treat these symptoms is by replacing a person’s lost dopamine, the strategy behind the drug levodopa. For the first few years, levodopa [...]... Read more »
Ding Y, Won L, Britt JP, Lim SA, McGehee DS, & Kang UJ. (2010) Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21187382
Companies offer a smaller or larger range of products serving different markets, depending on their history and primarily the respective business model.
From a supply chain management point of view this poses the question if it is ok just to use the same supply chain strategy for all those products.
Pipelines vs. Supply Chains
Aitken et al. (2005) make a convincing argument against this approach and instead suggest the "pipeline" to describe the specific operational mechanisms and procedu........ Read more »
Aitken, J., Childerhouse, P., Christopher, M.G., & Towill, D.R. (2005) Designing and Managing multiple Pipelines. Journal of Business Logistics, 26(2), 73-95. info:/
What did Velociraptor eat? Despite what the Jurassic Park franchise might suggest, the answer is not “tourists and hapless scientists.” Those were in rather short supply during the Mesozoic. Instead, as reported in Palaeogeography, Palaeoclimatology, Palaeoecology last year, recently found fossils confirm that this famous, sickle-clawed dinosaur fed upon the horned dinosaur Protoceratops. In 1971, [...]... Read more »
Hone, D., Choiniere, J., Sullivan, C., Xu, X., Pittman, M., & Tan, Q. (2010) New evidence for a trophic relationship between the dinosaurs Velociraptor and Protoceratops. Palaeogeography, Palaeoclimatology, Palaeoecology, 291(3-4), 488-492. DOI: 10.1016/j.palaeo.2010.03.028
In honor of Science Online, which begins on Thursday night, I will be writing about lemurs this week. Why lemurs? Because on Friday morning, as a part of Science Online, I will be taking a tour of the Duke Lemur Center.
It is common among animals - especially primates - to orient their gaze preferentially towards other individuals, as well as to follow the gaze of others. Lots of attention has been paid to gaze-following, in part because the ability to recognize and orient to the behavior of ot........ Read more »
Shepherd, S., & Platt, M. (2007) Spontaneous social orienting and gaze following in ringtailed lemurs (Lemur catta). Animal Cognition, 11(1), 13-20. DOI: 10.1007/s10071-007-0083-6
Description of Congresswoman Giffords' neurosurgery... Read more »
Voytek B, Secundo L, Bidet-Caulet A, Scabini D, Stiver SI, Gean AD, Manley GT, & Knight RT. (2010) Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution. Journal of Cognitive Neuroscience, 22(11), 2491-502. PMID: 19925193
Phase 2 study showing the use of gemcitabine and carboplatin plus iniparib, as compared with gemcitabine and carboplatin alone, resulted in a significantly higher rate of response and increased the progression-free survival. Continue reading →... Read more »
O'Shaughnessy, J., Osborne, C., Pippen, J., Yoffe, M., Patt, D., Rocha, C., Koo, I., Sherman, B., & Bradley, C. (2011) Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1011418
Author Rachel Aviv talked at length with a number of young people who had been identified as being ‘prodromal’ for schizophrenia, experiencing periodic delusions and at risk of converting to full-blown schizophrenia, following some of the at-risk individuals for a year. In December’s Harper’s, Aviv offered a sensitive, insightful account of their day-to-day struggles to maintain insight, recognizing which of their experiences are not real: Which way madness lies: Can psychosis be preve........ Read more »
Bauer, S., Schanda, H., Karakula, H., Olajossy-Hilkesberger, L., Rudaleviciene, P., Okribelashvili, N., Chaudhry, H., Idemudia, S., Gscheider, S., & Ritter, K. (2010) Culture and the prevalence of hallucinations in schizophrenia. Comprehensive Psychiatry. DOI: 10.1016/j.comppsych.2010.06.008
Cohen, A., Patel, V., Thara, R., & Gureje, O. (2007) Questioning an Axiom: Better Prognosis for Schizophrenia in the Developing World?. Schizophrenia Bulletin, 34(2), 229-244. DOI: 10.1093/schbul/sbm105
Corcoran, C., Davidson, L., Sills-Shahar, R., Nickou, C., Malaspina, D., Miller, T., & McGlashan, T. (2003) A Qualitative Research Study of the Evolution of Symptoms in Individuals Identified as Prodromal to Psychosis. Psychiatric Quarterly, 74(4), 313-332. DOI: 10.1023/A:1026083309607
Gearing, R., Alonzo, D., Smolak, A., McHugh, K., Harmon, S., & Baldwin, S. (2010) Association of religion with delusions and hallucinations in the context of schizophrenia: Implications for engagement and adherence. Schizophrenia Research. DOI: 10.1016/j.schres.2010.11.005
Huang, C., Shang, C., Shieh, M., Lin, H., & Su, J. (2010) The interactions between religion, religiosity, religious delusion/hallucination, and treatment-seeking behavior among schizophrenic patients in Taiwan. Psychiatry Research. DOI: 10.1016/j.psychres.2010.07.014
Koenig HG. (2009) Research on religion, spirituality, and mental health: a review. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 54(5), 283-91. PMID: 19497160
Lin KM, & Kleinman AM. (1988) Psychopathology and clinical course of schizophrenia: a cross-cultural perspective. Schizophrenia bulletin, 14(4), 555-67. PMID: 3064282
López SR, & Guarnaccia PJ. (2000) Cultural psychopathology: uncovering the social world of mental illness. Annual review of psychology, 571-98. PMID: 10751981
Roth, T., Lubin, F., Sodhi, M., & Kleinman, J. (2009) Epigenetic mechanisms in schizophrenia. Biochimica et Biophysica Acta (BBA) - General Subjects, 1790(9), 869-877. DOI: 10.1016/j.bbagen.2009.06.009
Saha, S., Chant, D., Welham, J., & McGrath, J. (2005) A Systematic Review of the Prevalence of Schizophrenia. PLoS Medicine, 2(5). DOI: 10.1371/journal.pmed.0020141
Saravanan, B., Jacob, K., Johnson, S., Prince, M., Bhugra, D., & David, A. (2010) Outcome of first-episode schizophrenia in India: longitudinal study of effect of insight and psychopathology. The British Journal of Psychiatry, 196(6), 454-459. DOI: 10.1192/bjp.bp.109.068577
Weisman, A. (1997) Understanding Cross-Cultural Prognostic Variability for Schizophrenia. Cultural Diversity , 3(1), 23-35. DOI: 10.1037//1099-9809.3.1.23
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