Post List

  • July 12, 2010
  • 01:00 PM
  • 1,385 views

The Uncultured Bacteria

by Kim Lewis in Small Things Considered

The majority of bacteria will not grow on nutrient medium in the lab. The basic experiment is simple: take a sample from the environment, such as marine sediment or soil, mix with water, vortex, allow it to settle, dilute supernatant and take two droplets. Plate one on a Petri dish...... Read more »

D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, & Lewis K. (2010) Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry , 17(3), 254-64. PMID: 20338517  

  • July 12, 2010
  • 12:25 PM
  • 768 views

Biological Micro Machines II: Inactivation Station

by Rob Mitchum in ScienceLife


Last month, we discussed the garage doors of the body’s ion channels, the millions of microscopic machines that control the heart’s beat and the nervous system’s communication. Benoît Roux and his colleagues employed 25 million computational hours to model the potassium channel voltage sensor, a kind of garage door control box that determines when the [...]... Read more »

Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, & Perozo E. (2010) Structural basis for the coupling between activation and inactivation gates in K( ) channels. Nature, 466(7303), 272-5. PMID: 20613845  

Cuello LG, Jogini V, Cortes DM, & Perozo E. (2010) Structural mechanism of C-type inactivation in K( ) channels. Nature, 466(7303), 203-8. PMID: 20613835  

  • July 12, 2010
  • 12:25 PM
  • 487 views

Why we get cancer.

by Herman in monofilia.org

The short of it...
Creationists often put physicians on a pedestal as the scientists doing the real work in biology, useful work of improving human health and well-being as opposed to the pontificating, abstract work of the evolutionists. But, can we really understand human aliments outside of the light of evolution? Well worn examples of antibiotic resistance vividly illustrate the folly of ignoring evolutionary processes in medicine. Cancer however is another example of evolution in action. T........ Read more »

  • July 12, 2010
  • 12:24 PM
  • 1,031 views

Preschool Eating Problems in Autism Spectrum Disorder

by William Yates, M.D. in Brain Posts

Eating problems are not a diagnostic criteria for autism spectrum disorder (ASD). Anecdotally, many parents of autistic children report difficulty with mealtime and food selection. A recent study from the University of New Mexico describes the type and extent of eating problems in a group of preschool children with ASD.The research team surveyed 24 parents of children with ASD and compared them with a group of 24 parents with a typically developing child. The primary measure was an instrument........ Read more »

  • July 12, 2010
  • 11:32 AM
  • 990 views

Programming bacteria for search and destroy

by Lab Rat in Lab Rat

As iGEM season is now properly underway, I thought I'd have a look at a synthetic biology paper and found this fairly awesome one about programming bacteria to hunt out and destroy atrazine, a chemical herbicide pollutant. One of the most exciting things about this work was that it didn't just involve bacteria with the ability to remove atrazine from the environment but to actively migrate towards the chemical and then destroy it.The chemical structure of atrazineThe bacteria are controlled usin........ Read more »

Sinha J, Reyes SJ, & Gallivan JP. (2010) Reprogramming bacteria to seek and destroy an herbicide. Nature chemical biology, 6(6), 464-70. PMID: 20453864  

  • July 12, 2010
  • 10:05 AM
  • 1,437 views

Computational modeling of GPCRs: What are the challenges?

by The Curious Wavefunction in The Curious Wavefunction

GPCRs are extremely important proteins both for pure and applied science research, but they are also very difficult to crystallize and hence structural information on them has been sparse. Naturally in such a case, computational modeling can be expected to be of great value of providing insight into GPCR structure and function. However, even though progress has been impressive, such modeling still has to overcome many challenges. A recent review lists some of them.Firstly, in the absence of crys........ Read more »

  • July 12, 2010
  • 08:00 AM
  • 528 views

Mind your Immune System

by Shaheen Lakhan in Brain Blogger

Another significant piece in the mind-body puzzle comes from this new study where obsessive-compulsive behavior in mice was cured by a bone marrow transplant. A rare form of a genetic disorder in mice causes a “hair pulling” disorder, very similar to its human counterpart trichotillomania. In their new findings published in Cell, Mario Capecchi and [...]... Read more »

Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, & Capecchi MR. (2010) Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell, 141(5), 775-85. PMID: 20510925  

  • July 12, 2010
  • 08:00 AM
  • 1,020 views

Point-Counterpoint: the use of ‘sex’ and ‘gender’ in physiological studies

by EcoPhysioMichelle in C6-H12-O6 (old)

I recently read a very interesting point/counterpoint on the use of ‘sex’ and ‘gender’ in physiological research from last month’s AJP:RICP. In Point: a call for proper usage of “gender” and “sex” in biomedical publications, King points out that sex and gender are often used interchangeably when the variable involved is very clearly sex and [...]... Read more »

  • July 12, 2010
  • 08:00 AM
  • 1,559 views

Book review: Do Fish Feel Pain?

by Zen Faulkes in NeuroDojo

Victoria Braithwaite’s Do Fish Feel Pain? is not a technical book. The type is large and the prose is easy to understand.

I had to read this book, because many of the issues around fish pain are the same as those raised for invertebrate pain (Puri and Faulkes 2010; this post). Fish researchers are about five years ahead of the invertebrate researchers.

Braithwaite’s answer to the question posed in her title is...

Spoiler alert! Click the heading of the post to read more.




“Yes.”

H........ Read more »

Brathwaite V. (2010) Do fish feel pain?. Oxford University Press, 1-194. info:/978-0-19-955120-0

Tracey Jr., W., Wilson, R., Laurent, G., & Benzer, S. (2003) painless, a Drosophila gene essential for nociception. Cell, 113(2), 261-273. DOI: 10.1016/S0092-8674(03)00272-1  

  • July 12, 2010
  • 06:14 AM
  • 567 views

Short takes: Deep sequencing and HIV drug resistance

by iayork in Mystery Rays from Outer Space

Short comments about what I’ve been reading (besides several hundred influenza articles): Hedskog, C., Mild, M., Jernberg, J., Sherwood, E., Bratt, G., Leitner, T., Lundeberg, J., Andersson, B., & Albert, J. (2010). Dynamics of HIV-1 Quasispecies during Antiviral Treatment Dissected Using Ultra-Deep Pyrosequencing PLoS ONE, 5 (7) DOI: 10.1371/journal.pone.0011345 The whole deep sequencing thing is [...]... Read more »

Hedskog, C., Mild, M., Jernberg, J., Sherwood, E., Bratt, G., Leitner, T., Lundeberg, J., Andersson, B., & Albert, J. (2010) Dynamics of HIV-1 Quasispecies during Antiviral Treatment Dissected Using Ultra-Deep Pyrosequencing. PLoS ONE, 5(7). DOI: 10.1371/journal.pone.0011345  

  • July 12, 2010
  • 06:00 AM
  • 595 views

Article Review: What do EM learners want from teachers?

by Michelle Lin in Academic Life In Emergency Medicine

Evaluations of clinical faculty typically incorporate comments from rotating medical students and residents regarding their teaching ability. In the Emergency Department (ED), how do you balance your pressing clinical responsibilities with teaching?There were 28 Canadian medical students and residents in their focus group interviews in this qualitative study. Learners were asked what qualities made a good EM teacher. Answers were transcribed and coded. There were 14 positive qualities identified........ Read more »

  • July 12, 2010
  • 04:25 AM
  • 908 views

The links between bloggers' personalities and their use of words

by BPS Research Digest in BPS Research Digest

You can tell a person's personality from the words they use. Neurotics have a penchant for negative words; agreeable types for words pertaining to socialising; and so on. We know this from recordings of people's speech and from brief writing tasks. Now Tal Yarkoni has extended this line of research to the blogosphere by analysing the content of 694 blogs - containing an average of 115,000 words written over an average period of about two years - and matching this with the bloggers' (predominantl........ Read more »

  • July 12, 2010
  • 03:12 AM
  • 1,716 views

Genome sequence of mushroom Schizophyllum commune

by stajich in The Hyphal Tip

I am excited to announce the publication of another mushroom genome this week. The mushroom Schizophyllum commune is an important model system for mushroom biology, development of genome was sequenced as part of efforts at the Joint Genome Institute and a collection of international researchers.  The data and analyses from these efforts are presented in a publication [...]... Read more »

Ohm, R., de Jong, J., Lugones, L., Aerts, A., Kothe, E., Stajich, J., de Vries, R., Record, E., Levasseur, A., Baker, S.... (2010) Genome sequence of the model mushroom Schizophyllum commune. Nature Biotechnology. DOI: 10.1038/nbt.1643  

  • July 12, 2010
  • 02:14 AM
  • 1,749 views

Parkinson’s Disease and Depression

by Dr Shock in Dr Shock MD PhD


Depression is common in patients with Parkinson’s disease (mean prevalence 17% in patients with Parkinson’s). It can be the first sign of the disease. It can be treated with antidepressants. There is little evidence that patients with Parkinson’s disease might benefi t more from any
one particular class of antidepressants than any others. The problem with [...]


Related posts:Understanding Depression in Kidney Disease
Psychiatrists don’t Use Scales to Measure Outcome in Dep........ Read more »

  • July 12, 2010
  • 01:35 AM
  • 1,110 views

Global Biodiversity Indicators at-a-glance

by Pablo Astudillo in astu's science blog

I really wanted to talk about this article before. A few weeks ago, it was published in Science a work by an extensive work by a high number of researchers, focused in the review and discussion of indicators of global indicators of biodiversity. Citing the article, in 2002 world leaders committed, through the Convention on [...]... Read more »

Butchart, S., Walpole, M., Collen, B., van Strien, A., Scharlemann, J., Almond, R., Baillie, J., Bomhard, B., Brown, C., Bruno, J.... (2010) Global Biodiversity: Indicators of Recent Declines. Science, 328(5982), 1164-1168. DOI: 10.1126/science.1187512  

Secretariat of the Convention on Biological Diversity (2010) Global Biodiversity Outlook 3., & Montréal, 94 pages. (2010) Global Biodiversity Outlook 3. Convention on Biological Diversity. info:other/

  • July 12, 2010
  • 12:42 AM
  • 359 views

…clouds, who are our genii?

by Rift in Psycasm

I think I’ll keep this one light today. I had a few ideas I was working on, but this seems easy. I’ve recently started a second blog – ilikeclouds. I’ll give some back story before I get to the related science. About a year ago I started to think – what about clouds? Not a [...]... Read more »

  • July 12, 2010
  • 12:09 AM
  • 946 views

For Stress Resiliance, thank DeltaFosB

by Scicurious in Neurotic Physiology

Sci’s not gonna lie, the past several days have been, to say the least, incredibly stressful.  I have no idea when blogging went from something that was fun and interesting to something that took up my entire life, but WHOA DUDES.  The end result is stress, and Sci has been eating junkfood, not sleeping, and [...]... Read more »

Vialou V, Robison AJ, Laplant QC, Covington HE 3rd, Dietz DM, Ohnishi YN, Mouzon E, Rush AJ 3rd, Watts EL, Wallace DL.... (2010) DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nature neuroscience, 13(6), 745-52. PMID: 20473292  

  • July 11, 2010
  • 11:12 PM
  • 1,441 views

Breaking news – new guidelines for treating CRPS

by Lorimer Moseley in BodyInMind

BMC Neurology has just published the findings of a group of Dutch researchers in their quest to develop multidisciplinary guidelines for treatment of CRPS[1].  They looked at literature from 1980 – 2005.  It is a major piece of work and I reckon it deserves publication. It is also a shocker when one produces such a [...]... Read more »

[1] Perez, R., Zollinger, P., Dijkstra, P., Thomassen-Hilgersom, I., Zuurmond, W., Rosenbrand, K., Geertzen, J., & Task force, T. (2010) Evidence based guidelines for complex regional pain syndrome type 1. BMC Neurology, 10(1), 20. DOI: 10.1186/1471-2377-10-20  

  • July 11, 2010
  • 09:32 PM
  • 771 views

cracks in the edifice of visual time?

by Alex Holcombe in ceptional

Below is a draft of a chapter I’m writing for Subjective Time, an upcoming book from MIT Press edited by Valtteri Arstila and Dan Lloyd. In a bowling alley, a professional player launches his ball down the lane. As the ball rolls toward the pins, our visual experience of it is smooth and seamless. The [...]... Read more »

VanRullen R, Reddy L, & Koch C. (2005) Attention-driven discrete sampling of motion perception. Proceedings of the National Academy of Sciences of the United States of America, 102(14), 5291-6. PMID: 15793010  

  • July 11, 2010
  • 07:24 PM
  • 978 views

70’s Porn Staches and the Female Fish Who Love Them

by Dr. M in Deep Sea News

From Schlupp, I., Riesch, R., Tobler, M., Plath, M., Parzefall, J., & Schartl, M. (2010) Behavioral Ecology and Sociobiology
Straight men let’s face it.  We will do anything if we think females will find it attractive.  No matter how ludicrous, expensive, or time-consuming it may be, we will do it.  The rise of mullets and Camaros . . . → Read More: 70’s Porn Staches and the Female Fish Who Love Them... Read more »

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