With a background in a health profession not known for its love of science, I suppose when I came across evidence based health care I felt a strong sense of relief. Here, at last, was a way to work out what to do when faced with the task of helping people with pain. I was … Read more... Read more »
Ostelo, R., Croft, P., van der Weijden, T., & van Tulder, M. (2010) Challenges in using evidence to inform your clinical practice in low back pain. Best Practice , 24(2), 281-289. DOI: 10.1016/j.berh.2009.12.006
This Science Brevia article is the first published example I’ve seen using smartphone technologies to collect psychological data. It comes from Dan Gilbert’s ever inventive lab. They used an iphone application to run an experience sampling study. The article is so short that I can give you the whole abstract right now.... Read more »
Information technology has a carbon footprint, that’s beyond doubt. Now, writing in a special issue of the Journal of Industrial Ecology, Christopher Weber, Jonathan Koomey and Scott Matthews in the US in work supported by grants from Microsoft Corporation and Intel Corporation have calculated that purchasing music digitally reduces the energy and carbon dioxide emissions [...]Climate change and digital music is a post from: Sciencebase Science Blog
... Read more »
Weber, C., Koomey, J., & Matthews, H. (2010) The Energy and Climate Change Implications of Different Music Delivery Methods. Journal of Industrial Ecology, 14(5), 754-769. DOI: 10.1111/j.1530-9290.2010.00269.x
by Merry Youle in Small Things Considered
Back in 1983, researchers at Yale borrowed a microbiological tactic to study evolution at a "single gene locus" in a multicellular animal—the use of altered growth media to select for nutritional mutants. They confronted populations of Drosophila pseudoobscura with a growth medium containing either maltose or starch as the sole carbohydrate source and observed inherited changes to the α-amylase allozyme frequencies and the enzyme's location within the gut in the "starch flies." Interesting, u........ Read more »
Sharon G, Segal D, Ringo JM, Hefetz A, Zilber-Rosenberg I, & Rosenberg E. (2010) Commensal bacteria play a role in mating preference of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. PMID: 21041648
Bike accidents, C-sections and battlefield wounds can all leave scars. But those are only the scars you can see. Any tissue can scar (not just skin), making scar tissue more than a cosmetic problem. Heart muscle, for example, can scar after a heart attack, and the lungs, kidneys, the liver, and many other tissues can [...]... Read more »
Jarvinen TAH, & Ruoslahti E. (2010) Target-seeking anti-fibrotic compound enhances wound healing and suppresses scar formation in mice. Proceedings of the National Academy of Sciences. info:/
Irritable bowel syndrome (IBS) is a common functional gastrointestinal syndrome characterized by abdominal pain and bowel disturbances (diarrhea and/or constipation). It is estimated to affect 10 to 20% of the population and treatment approaches are often unsatisfactory. Irritable bowel syndrome can be viewed as a neuroscience problem from several perspectives. Abnormal gastrointestinal motility and hypersensitivity has been identified in IBS--these functions are related to gut........ Read more »
Moss-Morris R, McAlpine L, Didsbury LP, & Spence MJ. (2010) A randomized controlled trial of a cognitive behavioural therapy-based self-management intervention for irritable bowel syndrome in primary care. Psychological medicine, 40(1), 85-94. PMID: 19531276
Biosimilars are very much a hot topic of late. They are approved new versions of innovator biopharmaceutical products, following patent expiry. Essentially, this is like a generic version of the biologic product, hence their alternative name, follow-on biologics. Recently, the … Continue reading →... Read more »
Bosques, C., Collins, B., Meador, J., Sarvaiya, H., Murphy, J., DelloRusso, G., Bulik, D., Hsu, I., Washburn, N., Sipsey, S.... (2010) Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins. Nature Biotechnology, 28(11), 1153-1156. DOI: 10.1038/nbt1110-1153
by Michele in Promega Connections
In a recent post, I wrote about White-Nose Syndrome (WNS) in hibernating bats in North America. WNS was first documented on February 2006, by a recreational caver exploring Howes Cave in New York, who photographed a bat with an unusual white growth on its muzzle. In the few years since that picture was snapped, hundreds [...]... Read more »
Cryan, P., Meteyer, C., Boyles, J., & Blehert, D. (2010) Wing pathology of white-nose syndrome in bats suggests life-threatening disruption of physiology. BMC Biology, 8(1), 135. DOI: 10.1186/1741-7007-8-135
by Joe Ballenger in Biofortified
In part 1 of this series, I discussed the history of genetic modification in insects as pest control. We’ve been creating insect GMOs for the purposes of controlling pests for awhile. If you bombard insects with radiation, it can kill rapidly reproducing cells. High doses of radiation can also damage the DNA in quickly reproducing gamete producing cells to the point where it can’t be read, creating severe mutations that stop important proteins from Continue reading...... Read more »
Gong, P., Epton, M., Fu, G., Scaife, S., Hiscox, A., Condon, K., Condon, G., Morrison, N., Kelly, D., Dafa'alla, T.... (2005) A dominant lethal genetic system for autocidal control of the Mediterranean fruitfly. Nature Biotechnology, 23(4), 453-456. DOI: 10.1038/nbt1071
Cheaters can be identified by their scores on the Dark Triad: narcissism, Machiavellianism, and psychopathy. But now that we can profile them, what comes next?... Read more »
Williams, K., Nathanson, C., & Paulhus, D. (2010) Identifying and profiling scholastic cheaters: Their personality, cognitive ability, and motivation. Journal of Experimental Psychology: Applied, 16(3), 293-307. DOI: 10.1037/a0020773
Not only are GPS devices useful, they’re also an ongoing experiment that keeps confirming special relativity’s spot on descriptions of how time flows for fast-moving objects. Without constant adjustments, GPS would be quickly rendered unusable because accurate timing of the signals being sent between the satellites and the moving object they’re supposed to track is [...]... Read more »
Angelo Tartaglia, Matteo Luca Ruggiero, & Emiliano Capolongo. (2010) A null frame for spacetime positioning by means of pulsating sources. Advances in Space Research. arXiv: 1001.1068v3
After the last more general entries on managers perception of risk and measuring SC performance I wanted to make a detour back to the basics.
Simulation is one of the tools, which can be used for analyzing supply chain dynamics, optimization and to support corporate decision making.
One major question when starting a supply chain model has always been what level of detail should you choose? Someone could start with a single worker in an agent based simulation model and continue with the mac........ Read more »
Persson, J. F. (2002) The impact of different levels of detail in manufacturing systems simulation models. Robotics and Computer-Integrated Manufacturing, 18(3-4), 319-325. DOI: 10.1016/S0736-5845(02)00024-8
Regular readers of these pages are probably well aware of the increasing data on the importance of obesity as a risk factor for cancers.
This is particularly true for hormone-sensitive cancers like post-menopausal breast and ovarian cancer, which are significantly more common in women with excess weight. In addition, excess weight appears to negatively affect the [...]... Read more »
Di LJ, Fernandez AG, De Siervi A, Longo DL, & Gardner K. (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nature structural . PMID: 21102443
As you'll know if you have your fingers on the throbbing pulse of dinosaur-related publications, the massive, incredibly pricey volume published by the Geological Society of London, and resulting from the 2008 meeting History of Dinosaurs and Other Fossil Saurians, now exists in dead-tree form. It's titled Dinosaurs and Other Extinct Saurians: A Historical Perspective and (in my totally unbiased opinion) is a definite must-see* for anyone interested in the historical side of Mesozoic reptile........ Read more »
SANCHEZ HERNANDEZ, B., BENTON, M., & NAISH, D. (2007) Dinosaurs and other fossil vertebrates from the Late Jurassic and Early Cretaceous of the Galve area, NE Spain. Palaeogeography, Palaeoclimatology, Palaeoecology, 249(1-2), 180-215. DOI: 10.1016/j.palaeo.2007.01.009
Basic research is fundamental if we want to make strides in understanding disease. Please (politely) shout this from the mountaintops and make sure your lawmakers and funding agencies understand this. Today’s image is from a paper that investigates a key player in cell scattering, which is an event very similar to cancer metastasis. Cell scattering is a term used to describe cell-cell dissociation and migration and occurs in liver development, organ regeneration, and metastasis. Cell sc........ Read more »
Vellón, L., Royo, F., Matthiesen, R., Torres-Fuenzalida, J., Lorenti, A., & Parada, L. (2010) Functional blockade of α5β1 integrin induces scattering and genomic landscape remodeling of hepatic progenitor cells. BMC Cell Biology, 11(1), 81. DOI: 10.1186/1471-2121-11-81
The American Medical Association (AMA) just released a policy on Social Media and Medical Professionalism. It focuses more on the negative aspects of social media, and much can be averted by just by using common sense:Physicians should weigh a number of considerations when maintaining a presence online:Physicians should be cognizant of standards of patient privacy and confidentiality that must be maintained in all environments, including online, and must refrain from posting identifiable patient........ Read more »
Greysen SR, Kind T, & Chretien KC. (2010) Online professionalism and the mirror of social media. Journal of general internal medicine, 25(11), 1227-9. PMID: 20632121
A pair of papers from the lab of Fred Gage has provided new insights into the molecular and cellular processes affected in Rett syndrome. This syndrome is associated with arrested development and autistic features. It affects mainly girls, who typically show normal development until around age two, followed by a sudden and dramatic deterioration of function, regression of language skills and the emergence of autistic symptoms. It is caused mainly by mutations in the gene encoding MeCP2, which........ Read more »
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, & Muotri AR. (2010) A model for neural development and treatment of rett syndrome using human induced pluripotent stem cells. Cell, 143(4), 527-39. PMID: 21074045
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, & Gage FH. (2010) L1 retrotransposition in neurons is modulated by MeCP2. Nature, 468(7322), 443-6. PMID: 21085180
From homeopathy to dodgy nutritional supplements, support for pseudoscience and quackery thrives on people believing falsely that one thing causes another, when in fact it doesn't. Meanwhile, psychologists study belief formation, and specifically illusions of control (see earlier), whereby people wrongly believe that they're controlling something when they're not. In a new paper, three psychologists at Deusto University in Bilbao argue that the psychological literature can be mined for ways........ Read more »
Matute, H., Yarritu, I., & Vadillo, M. (2010) Illusions of causality at the heart of pseudoscience. British Journal of Psychology. DOI: 10.1348/000712610X532210
Social software or the use of Internet (Web 2.0) for generating your own content, to connect with one another and to share and manage content with each other is used by young people. How do first year medical students use this social software? This could be important because these networks could become networks of learners [...]
Related posts:Social Media in Health and Medicine: Medlibs Round 2.7
The Risks of Online Social Networking for Students
Disclosure of substance use on social media we........ Read more »
Sandars, J., Homer, M., Pell, G., & Crocker, T. (2010) Web 2.0 and social software: the medical student way of e-learning. Medical Teacher, 2147483647-5. DOI: 10.3109/01421590701798729
Bacterial lipoproteins are proteins with covalently-attached lipid molecules that anchor the protein to the cytoplasmic or outer membrane. The lipid molecules are attached to the cysteine located at the amino terminus of the lipoprotein. The lipoprotein's protein component, being hydrophilic (water-loving), sticks out from the membrane. Different bacterial lipoproteins participate in a variety of functions, including transport of molecules, stabilization of the cell wall, signal tran........ Read more »
TOKUDA, H. (2009) Biogenesis of outer membranes in Gram-negative bacteria. Bioscience, Biotechnology, and Biochemistry, 73(3), 465-473. DOI: 10.1271/bbb.80778
TOKUDA, H. (2004) Sorting of lipoproteins to the outer membrane in E. coli. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1693(1), 5-13. DOI: 10.1016/j.bbamcr.2004.02.005
Schulze, R., & Zückert, W. (2006) Borrelia burgdorferi lipoproteins are secreted to the outer surface by default. Molecular Microbiology, 59(5), 1473-1484. DOI: 10.1111/j.1365-2958.2006.05039.x
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.