by Moselio Schaechter in Small Things Considered
by S. Marvin Friedman
How can thermophilic bacteria not only survive, but actually proliferate, at elevated temperatures that would be lethal to all other forms of life? After extensive research during the past five decades, this question has been answered in a general way, but the molecular basis for this unusual capability has not been clearly resolved. Thermophiles [I use this term to include both thermophiles (optimal growth temperatures of 50-70 °C) and hyperthermophiles (optimal gro........ Read more »
Botting CH, Talbot P, Paytubi S, & White MF. (2010) Extensive lysine methylation in hyperthermophilic crenarchaea: potential implications for protein stability and recombinant enzymes. Archaea (Vancouver, B.C.). PMID: 20811616
Kelp forests provide important habitat for numerous invertebrates, fish, birds and marine mammals. The ecological consequences of industrial harvest of this habitat has not been fully evaluated. Now a recent study has demonstrated that there is justified cause for concern. The study revealed that the removal of these habitats has multi-trophic effects...... Read more »
At many levels of medicine, it’s important for physicians to make predictions about their patient’s future. Will their disease or condition worsen? Will this treatment or that treatment be more effective in curing them? How much longer does a patient have to live? Such decisions are especially important for pediatricians in the NICU, the neonatal [...]... Read more »
Meadow, W., Meadow, X., Tanz, R., Lagatta, J., & Lantos, J. (2011) The value of a trial of therapy - football as a ‘proof-of-concept’. Acta Paediatrica, 100(2), 167-169. DOI: 10.1111/j.1651-2227.2010.02113.x
Meadow W, Lagatta J, Andrews B, Caldarelli L, Keiser A, Laporte J, Plesha-Troyke S, Subramanian M, Wong S, Hron J.... (2008) Just, in time: ethical implications of serial predictions of death and morbidity for ventilated premature infants. Pediatrics, 121(4), 732-40. PMID: 18381538
by Persuasion Strategies in Persuasive Litigator
By: Dr. Ken Broda-Bahm - Watching the Wizard of Oz recently with my three (and a half!)-year-old daughter, we came to the familiar scene of the fearless Toto interrupting the Wizard’s speech by pulling back the curtain on a man furiously working levers and wheels. When Dorothy and company ignore the instruction to “pay no attention to the man behind the curtain,” it becomes clear that what we see of the ‘wizard’ is an elaborate façade. There is a similar façade at work during jury se........ Read more »
Chang, L, . (2010) Comparing oral interviewing with self-administered computerized questionnaires. Public Opinion Quarterly, 1-14. info:/
Crowne, D., & Marlowe, D. (1960) A new scale of social desirability independent of psychopathology. Journal of Consulting Psychology, 24(4), 349-354. DOI: 10.1037/h0047358
That was the question from a reader that greeted me in my inbox recently, it’s a good point. Sorafenib has received FDA approval in this indication, while Pfizer terminated their phase III trial of sunitinib in HCC for futility … Continue reading →... Read more »
Nagai, T., Arao, T., Furuta, K., Sakai, K., Kudo, K., Kaneda, H., Tamura, D., Aomatsu, K., Kimura, H., Fujita, Y.... (2011) Sorafenib Inhibits the Hepatocyte Growth Factor-Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma. Molecular Cancer Therapeutics, 10(1), 169-177. DOI: 10.1158/1535-7163.MCT-10-0544
Supply Chain Risk Management started from the need to better control the risks within Supply and Demand Networks. The processes in (Corporate) Risk Management have been developed and convene in the classic, cyclic processes:Risk IdentificationRisk AssessmentMeasures (Development and Implementation)Risk Monitoring
Hallikas et al. (2004) tried to transfer this process into the supply chain setting.Figure 1: Risk Diagramm (Hallikas et al. 2004) Continue reading "Process oriented Approach to S........ Read more »
As usual, also for this year there has been the Festival delle Scienze (Festival of the Sciences) in Rome. This lasted for all the last week and ended this sunday. This is the chance to hear from leading scientists the status of forefront research. This year’s theme was “The End of the World – Instructions [...]... Read more »
Yesterday I came across this article, proclaiming to the world that "Saturn’s icy moon Rhea has an oxygen and carbon dioxide atmosphere that is very similar to Earth’s. Even better, the carbon dioxide suggests there’s life – and that possibly humans could breathe the air."
Say what? Ok. There's so much badness packed into those two lede sentences that I feel dirty just reprinting them here.... Read more »
Teolis BD, Jones GH, Miles PF, Tokar RL, Magee BA, Waite JH, Roussos E, Young DT, Crary FJ, Coates AJ.... (2010) Cassini finds an oxygen-carbon dioxide atmosphere at Saturn's icy moon Rhea. Science (New York, N.Y.), 330(6012), 1813-5. PMID: 21109635
In The Mass Extinction of Scientists Who Study Species, Dr. Craig McClain argues that we are loosing a fundamental unit of biological science – the Taxonomist. He’s right, of course. Taxonomy is a shrinking field. Entire phyla sit, unstudied, as the expertise necessary to understand them retires and expires. With few to train the [...]... Read more »
Jody Hey. (2001) The mind of the species problem. TRENDS in Ecology and Evolution, 16(7), 326-329. info:/
As in most countries, the population levels of obesity in Canada vary considerably from province to province (as they do within provinces). Although there are many “theories” on why this may be the case there has been little work done on trying to unravel the “explained” and “unexplained” regional variation based on a comparison of [...]... Read more »
Dutton DJ, & McLaren L. (2011) Explained and Unexplained Regional Variation in Canadian Obesity Prevalence. Obesity (Silver Spring, Md.). PMID: 21253004
Anthropogenic climate change has been hypothesized for centuries (discussed in Le Treut 2007) before the careful measurements of scientists in the mid-20th century. From 1833 to 1997, Stanhill (2001) calculated that the climate change science doubled every 11 years. The impact of carbon dioxide concentrations in the ocean was recognized early on with measurements and . . . → Read More: From the Editor’s Desk: The Grand Challenge of Ocean Acidification and Fisheries... Read more »
Carpenter KE, Abrar M, Aeby G, Aronson RB, Banks S, Bruckner A, Chiriboga A, Cortés J, Delbeek JC, Devantier L.... (2008) One-third of reef-building corals face elevated extinction risk from climate change and local impacts. Science (New York, N.Y.), 321(5888), 560-3. PMID: 18653892
Hall-Spencer J, Allain V, & Fosså JH. (2002) Trawling damage to Northeast Atlantic ancient coral reefs. Proceedings. Biological sciences / The Royal Society, 269(1490), 507-11. PMID: 11886643
Melzner F, Göbel S, Langenbuch M, Gutowska MA, Pörtner HO, & Lucassen M. (2009) Swimming performance in Atlantic Cod (Gadus morhua) following long-term (4-12 months) acclimation to elevated seawater P(CO2). Aquatic toxicology, 92(1), 30-7. PMID: 19223084
You could be forgiven for thinking that there’s no way you could get a useful brain scan of a fish.
First all, if you pay attention to brain scanning, you have probably heard a story about fish in fMRI machines that has become the stuff of scientific legend. The salmon in question being scanned for brain activity was deceased. Pushing up daisies. Size feet under. Joined the choir invisible. In a word, dead.
Yet a brain scan revealed statistically significant brain activity.
Bennett and col........ Read more »
Bandoh H, Kida I, & Ueda H. (2011) Olfactory responses to natal stream water in sockeye salmon by BOLD fMRI. PLoS ONE, 6(1). info:/10.1371/ journal.pone.0016051
As the post on existentialism has been one of my most popular, I thought I would do something more on the subject of meaningfulness. And when it comes to meaning, it seems that three is a magic number. But first a short story (involving three workers)… A traveller comes across a group of three men [...]... Read more »
Chalofsky, N., & Krishna, V. (2009) Meaningfulness, Commitment, and Engagement:The Intersection of a Deeper Level of Intrinsic Motivation. Advances in Developing Human Resources, 11(2), 189-203. DOI: 10.1177/1523422309333147
by Rita Handrich in The Jury Room
New research touts findings that conservatives have bigger amygdalas while liberals have bigger cingulate cortices. The bigger amygdala means conservatives could be driven by fear while the bigger cingulated cortex means liberals have more decision-making power. Hmmm. Is it possible that our politics are fixed at birth? Probably not. Neuroskeptic takes a look at the [...]
Related posts:Church attendance, dirt and politics (what we don’t know about ourselves)
“Reactions vary along tradi........ Read more »
Michael D. Dodd, John R. Hibbing, & Kevin B. Smith. (2010) The politics of attention: gaze-cuing effects are moderated by political temperament. Attention, Perception and Psychophysics. info:/
Oscar Wilde once claimed, “It is better to be beautiful than good, but it is better to be good than ugly.” This may be most true when meeting new people. Researchers in British Columbia suggest that beautiful people make better first impressions. In the study, people more accurately described and had a more positive impression [...]... Read more »
Biesanz JC, & Human LJ. (2010) The cost of forming more accurate impressions: accuracy-motivated perceivers see the personality of others more distinctively but less normatively than perceivers without an explicit goal. Psychological science : a journal of the American Psychological Society / APS, 21(4), 589-94. PMID: 20424106
Chan, M., Rogers, K., Parisotto, K., & Biesanz, J. (2010) Forming first impressions: The role of gender and normative accuracy in personality perception. Journal of Research in Personality. DOI: 10.1016/j.jrp.2010.11.001
Lemay EP Jr, Clark MS, & Greenberg A. (2010) What is beautiful is good because what is beautiful is desired: physical attractiveness stereotyping as projection of interpersonal goals. Personality and social psychology bulletin, 36(3), 339-53. PMID: 20179314
Lorenzo GL, Biesanz JC, & Human LJ. (2010) What is beautiful is good and more accurately understood: physical attractiveness and accuracy in first impressions of personality. Psychological science : a journal of the American Psychological Society / APS, 21(12), 1777-82. PMID: 21051521
When we first learned about the cell cycle in high school, we learned about the stunning simplicity of certain proteins that cycle in order to promote progression through the cell cycle. In reality, that picture is quite complex, with many layers of regulation that affect those cycling proteins. A recent paper from the Nurse lab pares down all of that complexity to show us that the simplicity really has been there all along. The cell cycle is the sequence of events that leads to a cell&rsq........ Read more »
Wagner, W., Brenowitz, S., & Hammer, J. (2010) Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons. Nature Cell Biology, 13(1), 40-48. DOI: 10.1038/ncb2132
Coudreuse, D., & Nurse, P. (2010) Driving the cell cycle with a minimal CDK control network. Nature, 468(7327), 1074-1079. DOI: 10.1038/nature09543
In many academic Emergency Departments, there are "off-service" or non-EM residents rotating in the department. They are sometimes invited to the EM residency conference series for the month. Often times though, they have too many departmental didactic events and obligations of their own that they don't have time to attend formal EM didactics.This is the perfect opportunity for an online didactic curriculum, which can be viewed at the residents' own time. The faculty at Northwestern designed suc........ Read more »
Branzetti JB, Aldeen AZ, Foster AW, & Mark Courtney D. (2010) A Novel Online Didactic Curriculum Helps Improve Knowledge Acquisition Among Non-Emergency Medicine Rotating Residents. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. PMID: 21175925
In the morning when I get into lab, around 10 in the morning, I have a set routine. Make a cup of coffee or tea, update my research wiki with a new entry corresponding to the day’s tasks, write/reply to work related emails, admin phygg.com (spam management etc.), scan/vote on papers of interest. Finally I [...]... Read more »
C. Y. Hui, K. S. Cheng, Y. Wang, P. H. T. Tam, A. K. H. Kong, D. O. Chernyshov, & V. A. Dogiel. (2011) The Fundamental Plane of Gamma-ray Globular Clusters. Astrophysical Journal, Volume 726, Page 100 (2011). arXiv: 1101.4107v1
R. van de Weygaert, K. Kreckel, E. Platen, B. Beygu, J. H. van Gorkom, J. M. van der Hulst, M. A. Aragon-Calvo, P. J. E. Peebles, T. Jarrett, G. Rhee.... (2011) The Void Galaxy Survey. "Environment and the Formation of Galaxies: 30 years later", Proceedings of Symposium 2 of JENAM 2010,. arXiv: 1101.4187v1
You are not alone ...
Have you ever had the feeling that everyone else seems so sorted, so at ease? You look about you and see friends chatting over lunch, people laughing on their mobiles, others escaping contentedly through novels or newspapers. According to Alexander Jordan and colleagues, most of us have such a tendency to underestimate other people's experience of negative emotion. In turn the researchers think this skewed perception perpetuates a collective delusion in which we all striv........ Read more »
Jordan, A., Monin, B., Dweck, C., Lovett, B., John, O., & Gross, J. (2010) Misery Has More Company Than People Think: Underestimating the Prevalence of Others' Negative Emotions. Personality and Social Psychology Bulletin, 37(1), 120-135. DOI: 10.1177/0146167210390822
Curious Social Behavior in Trypanosomes ... Read more »
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