The tumor suppressor p53 is one of the cell’s very best friends. Just how good a friend it is becomes apparent when, just like in other relationships, this particular relationship turns sour. p53 is the “master guardian angel” of the genome and constitutes the most frequent genetic alteration in cancer. More than 50% of human tumors contain a mutation in the p53 gene. With this kind of glowing track record, p53 would be a prime target for drugs.It turns out that discovering drugs for p53 i........ Read more »
Basse, N., Kaar, J., Settanni, G., Joerger, A., Rutherford, T., & Fersht, A. (2010) Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chemistry , 17(1), 46-56. DOI: 10.1016/j.chembiol.2009.12.011
Objective 1: Develop the least publicly accessible title for a blog post about seadragons, mate selection, and evolution
Objective 1 Status: complete
Objective 2: Draw in whatever readers push passed the unwieldy title with an unconventional narrative structure.
Objective 2 Status: complete
Objective 3: Hook the reader with a fascinating, though brief, background on seahorses, seadragons, and pipefish.
Female [...]... Read more »
Wilson, N., & Rouse, G. (2010) Convergent camouflage and the non-monophyly of ‘seadragons’ (Syngnathidae: Teleostei): suggestions for a revised taxonomy of syngnathids. Zoologica Scripta. DOI: 10.1111/j.1463-6409.2010.00449.x
I found a new paper in my reader this morning from the crew who published the first description and taxonomic statements about Darwinius massillae, Phillip Gingerich and his colleagues. This paper is a reply to Williams et al. (2010), which … Continue reading →... Read more »
Gingerich, P., Franzen, J., Habersetzer, J., Hurum, J., & Smith, B. (2010) Darwinius masillae is a Haplorhine — Reply to Williams et al. (2010). Journal of Human Evolution. DOI: 10.1016/j.jhevol.2010.07.013
Williams, B., Kay, R., Christopher Kirk, E., & Ross, C. (2010) Darwinius masillae is a strepsirrhine—a reply to Franzen et al. (2009). Journal of Human Evolution. DOI: 10.1016/j.jhevol.2010.01.003
Seiffert, E., Perry, J., Simons, E., & Boyer, D. (2009) Convergent evolution of anthropoid-like adaptations in Eocene adapiform primates. Nature, 461(7267), 1118-1121. DOI: 10.1038/nature08429
by Mary in OpenHelix
This week I was working on finishing up some training materials on the ENCODE data. We’ve talked about this before, and we’ve had some materials out already to support the ENCODE project, since we have a contract with the folks at UCSC to do some training on it. (The new materials should be out later [...]... Read more »
Schnoes, A., Brown, S., Dodevski, I., & Babbitt, P. (2009) Annotation Error in Public Databases: Misannotation of Molecular Function in Enzyme Superfamilies. PLoS Computational Biology, 5(12). DOI: 10.1371/journal.pcbi.1000605
Rosenbloom, K., Dreszer, T., Pheasant, M., Barber, G., Meyer, L., Pohl, A., Raney, B., Wang, T., Hinrichs, A., Zweig, A.... (2009) ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Research, 38(Database). DOI: 10.1093/nar/gkp961
Harold Garner (Virginia Bioinformatics Institute, United States) and coworkers have improved upon the eTBLAST tool for uncovering plagiarism in the technical science literature. This news feature was written on September 16, 2010.... Read more »
Sun, Z., Errami, M., Long, T., Renard, C., Choradia, N., & Garner, H. (2010) Systematic Characterizations of Text Similarity in Full Text Biomedical Publications. PLoS ONE, 5(9). DOI: 10.1371/journal.pone.0012704
Storage room, garage, attic, boxes, under the bed, dorm room... Whatever we choose to call it it, we all have our secret stashes of mess. Imagine the last time you were forced to confront your secret mess pile (if you are anything like me, this is still in short-term memory) to find your blue shirt amongst the heaps of cell phone chargers, clothes, and other notebooks. A few days later, you have to re-confront the mass to find a few AA batteries. Do you have any chance?... Read more »
Just before the American Society of Hematology (ASH) meeting last December, I posted an overview of the JAK2 pathway and pipeline inhibitors in development. Things have changed a bit since then, with TargeGen's inhibitor, TG101348, being licensed by sanofi-aventis and...... Read more »
Vannucchi, A. (2010) From Palliation to Targeted Therapy in Myelofibrosis. New England Journal of Medicine, 363(12), 1180-1182. DOI: 10.1056/NEJMe1005856
Verstovsek, S., Kantarjian, H., Mesa, R., Pardanani, A., Cortes-Franco, J., Thomas, D., Estrov, Z., Fridman, J., Bradley, E., Erickson-Viitanen, S.... (2010) Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis. New England Journal of Medicine, 363(12), 1117-1127. DOI: 10.1056/NEJMoa1002028
Anderson (2010) discovers that cheating men crave ‘emotional monogamy’ with their partners and to have their physical desires fulfilled through multiple, additional sexual contacts. Many such men claim to love their partners even more because they cheat on them.
... Read more »
Anderson, E. (2010) 'At Least With Cheating There is an Attempt at Monogamy': Cheating and Monogamism Among Undergraduate Heterosexual Men. Journal of Social and Personal Relationships. info:/
Physical activity is recommended as part of every healthy lifestyle in order to maintain appropriate body weight and composition and to prevent a myriad of diseases. Now, researchers suggest that genetics plays a role in how much voluntary physical activity one is likely to engage in. Predispositions to active, athletic lifestyles are passed on from [...]... Read more »
Garland T Jr, Kelly SA, Malisch JL, Kolb EM, Hannon RM, Keeney BK, Van Cleave SL, & Middleton KM. (2010) How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels. Proceedings. Biological sciences / The Royal Society. PMID: 20810439
Houle-Leroy P, Garland T Jr, Swallow JG, & Guderley H. (2000) Effects of voluntary activity and genetic selection on muscle metabolic capacities in house mice Mus domesticus. Journal of applied physiology (Bethesda, Md. : 1985), 89(4), 1608-16. PMID: 11007602
Knab AM, & Lightfoot JT. (2010) Does the difference between physically active and couch potato lie in the dopamine system?. International journal of biological sciences, 6(2), 133-50. PMID: 20224735
Koteja P, Garland T Jr, Sax JK, Swallow JG, & Carter PA. (1999) Behaviour of house mice artificially selected for high levels of voluntary wheel running. Animal behaviour, 58(6), 1307-1318. PMID: 10600154
Li, S., Zhao, J., Luan, J., Ekelund, U., Luben, R., Khaw, K., Wareham, N., & Loos, R. (2010) Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study. PLoS Medicine, 7(8). DOI: 10.1371/journal.pmed.1000332
Rezende EL, Kelly SA, Gomes FR, Chappell MA, & Garland T Jr. (2006) Effects of size, sex, and voluntary running speeds on costs of locomotion in lines of laboratory mice selectively bred for high wheel-running activity. Physiological and biochemical zoology : PBZ, 79(1), 83-99. PMID: 16380930
Swallow JG, Koteja P, Carter PA, & Garland T Jr. (2001) Food consumption and body composition in mice selected for high wheel-running activity. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 171(8), 651-9. PMID: 11765974
Spurred by questions from readers, I've expanded the coffee series to include two additional posts on this caffeinated drink that will run this week. If this is your first visit to AiP, you can review our coffee discussions here. Monday's post asked, how can we explain the popularity of instant coffee in coffee producing countries? As a follow-up, today we will look at the future of Peruvian coffee among native Peruvian coffee drinkers. As always, thanks for stopping by—and for yo........ Read more »
Castillo, R., & Nigh, R. (1998) Global Processes and Local Identity among Mayan Coffee Growers in Chiapas, Mexico. American Anthropologist, 100(1), 136-147. DOI: 10.1525/aa.19126.96.36.199
I am slowly re-posting some work from my lab blog. This one received quite a bit of traffic. I actually have a follow-up in the works, so watch for it!You have probably seen the buzz about the recent American Journal of Obstetrics and Gynecology article (Wax et al 2010) on home birth safety, and the editorial in the Lancet that took the article’s shaky meta-analysis to crazytown: “Women have the right to choose how and where to give birth, but they do not have the right to put their baby at ........ Read more »
Wax, J., Lucas, F., Lamont, M., Pinette, M., Cartin, A., & Blackstone, J. (2010) Maternal and newborn outcomes in planned home birth vs planned hospital births: a metaanalysis. American Journal of Obstetrics and Gynecology. DOI: 10.1016/j.ajog.2010.05.028
by Peter Janiszewski, Ph.D. in Obesity Panacea
After introducing the concept of the metabolically healthy obese phenotype earlier this week, we have covered the risk of chronic disease as well as mortality among this large proportion of obese individuals who despite their excess weight remain metabolically healthy. Today we look at the effect of weight loss among such individuals.
While countless epidemiological studies have shown that as you move from a normal weight (BMI = 18.5-24.9 kg/m2) towards overweight (BMI = 25-29.9kg/m2) and obesi........ Read more »
Karelis, A., Messier, V., Brochu, M., & Rabasa-Lhoret, R. (2008) Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia, 51(9), 1752-1754. DOI: 10.1007/s00125-008-1038-4
Part 2 of my series examining research evidence for the value of video games. This time: the potential of video games to improve spatial cognition.... Read more »
Today is our last paper on high throughput screening (HTS) techniques. We’re back to discovering drugs on this one but the premise is quite different for this particular screen. Whereas other papers we’ve done so far have involved finding novel … Continue reading →... Read more »
Bachovchin, D., Brown, S., Rosen, H., & Cravatt, B. (2009) Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nature biotechnology, 27(4), 387-394. DOI: 10.1038/nbt.1531
The other day a friend of mine bumped into some news that concerned her. She could have asked a random person about this to find out more information, but there was a bit of information that came with the news indicating that I might know more than the average person about it. So, she asked me, and as it turns out, I did not know anything. But, having heard the news from her, I noticed a different bit of information that came along with it that told me exactly who would know everything about i........ Read more »
Christakis, N., & Fowler, J. (2010) Social Network Sensors for Early Detection of Contagious Outbreaks. PLoS ONE, 5(9). DOI: 10.1371/journal.pone.0012948
Since the early days of paleontology, the posture of dinosaurs and the range of motion they were capable of have been contentious subjects for paleontologists. During the 19th century, especially, the general view of what dinosaurs would have looked like changed no less than three times, and investigations into how these animals moved continue to [...]... Read more »
Mallison, H. (2010) CAD assessment of the posture and range of motion of Kentrosaurus aethiopicus Hennig 1915. Swiss Journal of Geosciences. DOI: 10.1007/s00015-010-0024-2
First, there was plain and simple creationism, a Christian idea that, in an ideal Christian world, would be taught as part of any science dealing with the past, including biology (evolution), geology, and presumably history.
But the constitution stood in the way of implementing basic Christian teachings in public schools in the United States, though that battle took decades. Just as creationists were being driven off he landscape, a sort of Battle of the Bulge occurred, in the form of Intellig........ Read more »
Rosenau, Joshua. (2010) Leap of Faith: Intelligent Design's Trajectory after Dover. UNIV. OF ST. THOMAS JOURNAL OF LAW . info:/
Despite all the overhyped nonsense which surrounded the debut of the 47-million-year-old primate Darwinius masillae (“Ida” to her fans) last year, I have to admit that the first-described specimen was a gorgeous fossil. It was a paleontologist’s dream – a complete, articulated skeleton with traces of hair and even intact gut contents. Never before had [...]... Read more »
Gregory, W.K. (1920) On the structure and relations of Notharctus, an American Eocene primate. Memoirs of the AMNH, 3(2), 49-243. info:/
We have just stumbled across a paper that is very intriguing if you are not up with this tricky little evolutionary twist. Tim Bruckner and colleagues at University of California Irvine and Berkeley, have reported that the odds of a male fetus dying – called the ‘fetal death sex ratio’ – were increased above the [...]... Read more »
Bruckner, T., Catalano, R., & Ahern, J. (2010) Male fetal loss in the U.S. following the terrorist attacks of September 11, 2001. BMC Public Health, 10(1), 273. DOI: 10.1186/1471-2458-10-273
Catalano R, Bruckner T, Gould J, Eskenazi B, & Anderson E. (2005) Sex ratios in California following the terrorist attacks of September 11, 2001. Human reproduction (Oxford, England), 20(5), 1221-7. PMID: 15734763
Catalano R, Bruckner T, Marks AR, & Eskenazi B. (2006) Exogenous shocks to the human sex ratio: the case of September 11, 2001 in New York City. Human reproduction (Oxford, England), 21(12), 3127-31. PMID: 16936298
Whilst endeavouring to keep updated with my research topics I came across the following study on leaving intentions by Simon et al (2010).
The authors have identified three dimensions which they suggest illustrate the different aspects which contribute to Turnover in previous definitions: Voluntariness (collaborative relationship with organisation), Controllability (who has actual control over turnover), and [...]... Read more »
Simon, M., Müller, B., & Hasselhorn, H. (2010) Leaving the organization or the profession - a multilevel analysis of nurses’ intentions. Journal of Advanced Nursing, 66(3), 616-626. DOI: 10.1111/j.1365-2648.2009.05204.x
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.