Parkinson disease is a chronic progressive disease with significant impairment and distress. A host of pharmacological options are available. Unfortunately, drug treatment often is only partially successful in reducing symptoms and can produce problematic adverse events. Deep brain stimulation (DBS) has emerged as a potential therapeutic option for those with severe Parkinson disease. DBS involves a neurosurgical procedure that places an electrode or electrodes into the brain w........ Read more »
Bronstein, J., Tagliati, M., Alterman, R., Lozano, A., Volkmann, J., Stefani, A., Horak, F., Okun, M., Foote, K., Krack, P.... (2010) Deep Brain Stimulation for Parkinson Disease: An Expert Consensus and Review of Key Issues. Archives of Neurology, 68(2), 165-165. DOI: 10.1001/archneurol.2010.260
“The skull of Wynric Lance, failed claimant to the throne of Eirea, does not make as good a wine goblet as Lord Shryke had imagined, the despot revealed Monday. “This damn thing is practically impossible to drink out of,” said Shryke at a banquet celebrating the defeat of the Army Of Light… Shryke concluded that [...]... Read more »
On this, the eve of the 100th season of Survivor, I have myself contemplating the state of immunity.
Perhaps I’ve also been contemplating it since I’ve spent the last 3.5 weeks dealing with a nasty flu bug that has made its rounds to all members of my family. This month of fitfull sleep, endless vomit and [...]... Read more »
Shutler, D., & Campbell, A. (2007) Experimental addition of greenery reduces flea loads in nests of a non-greenery using species, the tree swallow Tachycineta bicolor. Journal of Avian Biology, 38(1), 7-12. DOI: 10.1111/j.2007.0908-8857.04015.x
Massey, R., Buckling, A., & Peacock, S. (2001) Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus. Current Biology, 11(22), 1810-1814. DOI: 10.1016/S0960-9822(01)00507-3
Prendeville HR, & Stevens L. (2002) Microbe inhibition by Tribolium flour beetles varies with beetle species, strain, sex, and microbe group. Journal of chemical ecology, 28(6), 1183-90. PMID: 12184396
A couple of years ago, a paper by Begall and colleagues made a big splash by claiming that cows could detect, and align to, earth’s magnetic field. This report took on a life of its own. I heard it within the last week on one of the science podcasts I listen (though I can’t remember which one).
This paper got attention not only because this was an unusual claim, but for the way that they determined this. Instead of generating their own data, they looked at pictures of cows in Google Earth.
........ Read more »
Begall S, Cerveny J, Neef J, Vojtech O, & Burda H. (2008) Magnetic alignment in grazing and resting cattle and deer. Proceedings of the National Academy of Sciences, 105(36), 13451-13455. DOI: 10.1073/pnas.0803650105
Hert J, Jelinek L, Pekarek L, & Pavlicek A. (2011) No alignment of cattle along geomagnetic field lines found. Journal of Comparative Physiology A. DOI: 10.1007/s00359-011-0628-7
Nine billion is the number that will define the 21st century. That’s the number of people expected to live on this planet by 2045. But 9 billion mouths are a lot to feed, and each of them will hopefully have more than enough to eat. Achieving both goals—feeding 9 billion and feeding them properly—will be a [...]... Read more »
Lambin, E., & Meyfroidt, P. (2011) Inaugural Article: Global land use change, economic globalization, and the looming land scarcity. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1100480108
by Mike Braverman in ionpsych
Does your best friend put on makeup and eat barbecue (weird right) while driving? Do you shake your head, disbelieving and worried, when she tells you, “But I’m great at multitasking! I’ll be fine!” Could she be right? It’s possible. … Continue reading →... Read more »
Watson JM, & Strayer DL. (2010) Supertaskers: Profiles in extraordinary multitasking ability. Psychonomic Bulletin , 17(4), 479-85. PMID: 20702865
Sometimes things go so wrong that it is just easier to start all over again. Bacteria have these situations too - it's not just us, humans! - and the central dogma of molecular biology (DNA replication, transcription and translation) is no exception.In essence all the three steps of the central dogma share the very same basic topology: there is a message that gets read, there is a tool that reads it and there is a product. It looks like so:Say, in the case of translation mRNA (the mess........ Read more »
Toulmé F, Mosrin-Huaman C, Sparkowski J, Das A, Leng M, & Rahmouni AR. (2000) GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming. The EMBO journal, 19(24), 6853-9. PMID: 11118220
Pedersen K, Zavialov AV, Pavlov MY, Elf J, Gerdes K, & Ehrenberg M. (2003) The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site. Cell, 112(1), 131-40. PMID: 12526800
Orlova M, Newlands J, Das A, Goldfarb A, & Borukhov S. (1995) Intrinsic transcript cleavage activity of RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America, 92(10), 4596-600. PMID: 7538676
Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, & Chrzanowska-Lightowlers ZM. (2010) A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. The EMBO journal, 29(6), 1116-25. PMID: 20186120
Shoemaker CJ, Eyler DE, & Green R. (2010) Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science (New York, N.Y.), 330(6002), 369-72. PMID: 20947765
Atkinson GC, Baldauf SL, & Hauryliuk V. (2008) Evolution of nonstop, no-go and nonsense-mediated mRNA decay and their termination factor-derived components. BMC evolutionary biology, 290. PMID: 18947425
Antonicka H, Ostergaard E, Sasarman F, Weraarpachai W, Wibrand F, Pedersen AM, Rodenburg RJ, van der Knaap MS, Smeitink JA, Chrzanowska-Lightowlers ZM.... (2010) Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect. American journal of human genetics, 87(1), 115-22. PMID: 20598281
Zaher HS, & Green R. (2009) Quality control by the ribosome following peptide bond formation. Nature, 457(7226), 161-6. PMID: 19092806
How does a lens work? Well, as the light arrives at the lens it gets bent towards the focal point of the lens. The denser the lens material is in comparison to the surrounding air, the more it is deflected. The materials property that quantifies this effect is the refractive index. For lenses, the general [...]... Read more »
Choi, M., Lee, S., Kim, Y., Kang, S., Shin, J., Kwak, M., Kang, K., Lee, Y., Park, N., & Min, B. (2011) A terahertz metamaterial with unnaturally high refractive index. Nature, 470(7334), 369-373. DOI: 10.1038/nature09776
(This post amuses me. This is the strangest juxtaposition of research papers and topics I've written about. You'll see.)An ode to Mike, by Bradley VoytekThere once was a farmer from FruitaWhose chicken caused quite a hoopla. For what happened next, Made farmer Olsen quite perplexed!And as for the chicken, no "clucks", just some "ooh-aahs".For that farmer had wanted a snack.So he went and grabbed his old axe. H........ Read more »
Komisaruk, B., Whipple, B., Crawford, A., Grimes, S., Liu, W., Kalnin, A., & Mosier, K. (2004) Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the Vagus nerves. Brain Research, 1024(1-2), 77-88. DOI: 10.1016/j.brainres.2004.07.029
Quite a few years back, so long ago that I can’t really remember much more than the fact that I once visited it, my parents took me to Space Farms Zoo and Museum. Tucked away in northern New Jersey, the roadside attraction is not so much a zoo or a museum as a throwback to [...]... Read more »
FIGUEIRIDO, B., & SOIBELZON, L. (2009) Inferring palaeoecology in extinct tremarctine bears (Carnivora, Ursidae) using geometric morphometrics. Lethaia, 43(2), 209-222. DOI: 10.1111/j.1502-3931.2009.00184.x
Soibelzon, L., Pomi, L., Tonni, E., Rodriguez, S., & Dondas, A. (2009) First report of a South American short-faced bears' den (Arctotherium angustidens): palaeobiological and palaeoecological implications. Alcheringa: An Australasian Journal of Palaeontology, 33(3), 211-222. DOI: 10.1080/03115510902844418
Soibelzon, L., & Schubert, B. (2011) The Largest Known Bear, Arctotherium angustidens, from the Early Pleistocene Pampean Region of Argentina: With a Discussion of Size and Diet Trends in Bears. Journal of Paleontology, 85(1), 69-75. DOI: 10.1666/10-037.1
by B.F. Hebb in ionpsych
For rats, the most alluring substance isn’t alcohol, heroin, or cocaine: it’s not a drug at all, in fact, it’s an artificial sweetener called saccharin. What’s saccharin? Saccharin is a non-caloric sugar substitute that has been used in many low-calorie … Continue reading →... Read more »
Cantin L, Lenoir M, Augier E, Vanhille N, Dubreucq S, Serre F, Vouillac C, & Ahmed SH. (2010) Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction. PloS one, 5(7). PMID: 20676364
Wiring. That’s one answer to this question. We know this from topographic maps in the thalamus and neocortex, where the basic units of sensory information are neatly represented in spatially-arranged populations of neurons – the various body parts are represented in specific locations, as are the different frequencies of sound, the different parts of the retina, and [...]... Read more »
Yassin L, Benedetti BL, Jouhanneau JS, Wen JA, Poulet JF, & Barth AL. (2010) An embedded subnetwork of highly active neurons in the neocortex. Neuron, 68(6), 1043-50. PMID: 21172607
Dragoi G, & Tonegawa S. (2011) Preplay of future place cell sequences by hippocampal cellular assemblies. Nature, 469(7330), 397-401. PMID: 21179088
Has warfare been handed down to us through millions of years of evolution? Is it part of who we are as a species? At the heart of this question is whether humans have a natural capacity to kill other humans. Some social scientists have concluded that evolution has in fact left us with this unfortunate ability.
Primatologist Richard Wrangham, a major proponent of this idea, developed the “Imbalance of Power Hypothesis” to explain how evolution could produce a propensity for warfare........ Read more »
ROSCOE, P. (2007) Intelligence, Coalitional Killing, and the Antecedents of War. American Anthropologist, 109(3), 485-495. DOI: 10.1525/aa.2007.109.3.485
by Mary in OpenHelix
One of the most frequently-asked questions we get when we are out doing workshops is: how do I find motifs in promoters, and what can I do with them to find more information? Just last Friday we were asked this again at the workshops we did at USC. So for this week’s tip of the week I’m going to show one of the tools I recommend for that purpose–Melina II. (I also recommended the MEME Suite and VISTA‘s rVISTA features as well, but for this tip I’ll focus on Melin........ Read more »
Okumura, T., Makiguchi, H., Makita, Y., Yamashita, R., & Nakai, K. (2007) Melina II: a web tool for comparisons among several predictive algorithms to find potential motifs from promoter regions. Nucleic Acids Research, 35(Web Server). DOI: 10.1093/nar/gkm362
Since her office is just down the hall from mine, I couldn’t very well write about Erica Bree Rosenblum’s latest scientific paper without talking to her about it in person. Rosenblum and her coauthor Luke Harmon weave together the stories of three lizard species’ evolutionary responses to the gypsum dunes of White Sands, New Mexico. As Rosenblum told me in our interview, the study both consummates work she began as a doctoral student and suggests new avenues of study at a striking and beau........ Read more »
Rosenblum, E., Rompler, H., Schoneberg, T., & Hoekstra, H. (2009) Molecular and functional basis of phenotypic convergence in white lizards at White Sands. Proc. Nat. Acad. Sci. USA, 107(5), 2113-7. DOI: 10.1073/pnas.0911042107
Rosenblum, E., & Harmon, L. (2010) "Same same but different": Replicated ecological speciation at White Sands. Evolution. DOI: 10.1111/j.1558-5646.2010.01190.x
New research reveals that social people tend to use Facebook more often than asocial people. I guess the Internet is not just for nerds anymore.
Some related articles on Neo-Academic:Faculty Apparently Use Social Media
Inappropriate Work-related Facebook Checkups
Montana Job Applications Required FaceBook Password
... Read more »
Gosling, S., Augustine, A., Vazire, S., Holtzman, N., & Gaddis, S. (2011) Manifestations of Personality in Online Social Networks: Self-Reported Facebook-Related Behaviors and Observable Profile Information. Cyberpsychology, Behavior, and Social Networking, 2147483647. DOI: 10.1089/cyber.2010.0087
Landers, R.N., & Lounsbury, J.W. (2006) An investigation of Big Five and narrow personality traits in relation to Internet usage. Computers in Human Behavior, 22(2), 283-293. DOI: 10.1016/j.chb.2004.06.001
“A glass of red wine for women with breast cancer could boost the success rate of treatment” according to the papers – but the reality is a long way from what the headlines suggest. The stories come from a scientific paper published in the journal Cancer Letters, looking at research on breast cancer cells grown [...]... Read more »
He X, Wang Y, Zhu J, Orloff M, & Eng C. (2011) Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer letters, 301(2), 168-76. PMID: 21168265
Guys, I am sure this post will interest you it is about women vocalizations during sex. Is she faking or not? Whatever she is faking or really enjoys the intercourse, the fact is we are different about vocalizations. Some of us are quiet other scream like or worst than porn movie etc but what that [...]... Read more »
Brewer G, & Hendrie CA. (2010) Evidence to Suggest that Copulatory Vocalizations in Women Are Not a Reflexive Consequence of Orgasm. Archives of sexual behavior. PMID: 20480220
Gastric bypass surgery is often considered the “gold-standard” for bariatric surgery and is now widely recommended for the treatment of severe obesity.
But, as I have often blogged before, no form of bariatric surgery guarantees success and patients are often disappointed with the amount of weight they lose (or that fact that there is some weight [...]... Read more »
Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T.... (2011) High Allelic Burden of Four Obesity SNPs Is Associated With Poorer Weight Loss Outcomes Following Gastric Bypass Surgery. Obesity (Silver Spring, Md.). PMID: 21311511
Research on magic has been getting a lot of attention recently, but most of the focus has been on the psychology of the audience.
But what can we learn by studying the performer?
One of the things you need to be a magician, particularly a close-up magician who works with cards or coins, is dexterity. I tried to learn some basic card tricks once, and failed. It requires some very fine motor control, and I didn’t put in enough work to master it.
Many illusions rely on the magician imitating ........ Read more »
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