The future of medicine, we are told time and time again, is genetic and personalized. Someday, physicians will call up the genetic code of a patient and determine their genetic risks and which treatments will work most effectively with the fewest side effects. That information can be organized into individual, unique medical plans for each [...]... Read more »
Greeley SA, John PM, Winn AN, Ornelas J, Lipton RB, Philipson LH, Bell GI, & Huang ES. (2011) The Cost-Effectiveness of Personalized Genetic Medicine: The case of genetic testing in neonatal diabetes. Diabetes care. PMID: 21273495
an exploration into connections between the sensory modalities of a marine predator.
Cephalopods are known as the ‘charismatic megafauna’ of the invertebrate world. We humans are generally fascinated by their stealth, their ability to camouflage, and their massive brains. The physical form of cephalopods is so different from our own that we find them [...]... Read more »
Guibé M, Boal JG, & Dickel L. (2010) Early exposure to odors changes later visual prey preferences in cuttlefish. Developmental psychobiology, 52(8), 833-7. PMID: 21157990
by Persuasion Strategies in Persuasive Litigator
By: Dr. Ken Broda-Bahm - In his recent State of the Union address, President Obama followed the common pattern of giving attention and applause lines to nearly every issue on the national agenda. But there was one issue that received no mention at all: climate change. The absence, noted by many commentators, extended even to areas where it would have been natural to mention the environment. The President's "clean energy" initiative, for example, was touted based on its ability to create jobs and........ Read more »
William R. L. Anderegga, James W. Prallb, Jacob Haroldc, and Stephen H. Schneidera. (2010) Expert credibility in climate change. Proceedings of the National Academy of Sciences of the United States of America. info:/
Masiakasaurus was a weird-looking dinosaur. The paper that first described it was titled “A bizarre predatory dinosaur from the Late Cretaceous of Madagascar.” What made it so strange were its teeth. At the front of its lower jaw, this six-foot theropod had forward-tilted teeth much different from those of its larger cousin Majungasaurus, which lived [...]... Read more »
Sampson, S., Carrano, M., & Forster, C. (2001) A bizarre predatory dinosaur from the Late Cretaceous of Madagascar. Nature, 409(6819), 504-506. DOI: 10.1038/35054046
Carrano, M.T., Loewen, M.A., and Sertich, J.J.W. (2011) New Materials of Masiakasaurus knopfleri Sampson, Carrano, and Forster, 2001, and Implications for the Morphology of the Noasauridae (Theropoda: Ceratosauria). Smithsonian Contributions to Paleobiology, 1-54. info:/
Stress tests are an acknowledged method to test systems under extreme conditions. The method is not only used in engineering (eg. Great picture of a Boing wing stress test (Guardian Eyewitness)), but also in business, most notably and in the banking industry. But can this method also be used to test supply chain designs?
Method / Case Study
There is limited literature on using simulation to evaluate supply chains under stress. The authors took the following approach: Determining the scope ........ Read more »
Jain, Sanjay, & Leong, Swee. (2005) Stress Testing a Supply Chain Using Simulation. Proceedings of the 2005 Winter Simulation Conference, 1650-1657. info:/
The arms race of sequencing has always been about throughput. The big players (Illumina and Life Tech technologies) have engaged in a continual game of one-upmanship over the last few years. As a result, we’ve seen yields skyrocket to from 10 gigabases per run to the current and outrageous 180-200 gb on the HiSeq. Good [...]... Read more »
Over the last couple of years, our knowledge and understanding of non-small cell lung cancer (NSCLC) has improved as mutations and translocations that drive tumour growth and survival have been identified. # Unfortunately, while we have many new targeted agents … Continue reading →
... Read more »
If your client is African American, jurors will demonstrate to you that the answer is much more likely to be yes. And the more stereotypically black (with darker skin and wider nose)—the more likely the death penalty will be assigned. Hard to stomach? Yes. Hard to believe? We didn’t think so. But it is pretty [...]
Related posts:Does ‘death qualification’ systematically bias our juries?
I read the entire newspaper every day
“I can look into his eyes and just tell he is lying”
... Read more »
Eberhardt JL, Davies PG, Purdie-Vaughns VJ, & Johnson SL. (2006) Looking deathworthy: perceived stereotypicality of Black defendants predicts capital-sentencing outcomes. Psychological science : a journal of the American Psychological Society / APS, 17(5), 383-6. PMID: 16683924
Cancer is not a disease…it is many many diseases. Some cancers come about gradually, while others can occur from a single catastrophic cellular event, according to a recent paper.... Read more »
Stephens, P., Greenman, C., Fu, B., Yang, F., Bignell, G., Mudie, L., Pleasance, E., Lau, K., Beare, D., & Stebbings, L. (2011) Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development. Cell, 144(1), 27-40. DOI: 10.1016/j.cell.2010.11.055
Following our call for contributions to BMC Research Notes on data standards, sharing and publication, the journal and this initiative have received considerable attention from the research community. Today we launch this series of educational articles, as we publish the first of the numerous manuscripts we have received since September.
This new article by Tony Mathys and Maged Boulos gives an overview of the geospatial resources available for the health research community and public health s........ Read more »
Mathys T, & Kamel Boulos MN. (2011) Geospatial resources for supporting data standards, guidance and best practice in health informatics. BMC research notes, 4(1), 19. PMID: 21269487
It is 2 a.m. You, the resident, have just spoken to your staff/attending, who told you to do a task. You have seen one, but don't feel comfortable doing one independently.Will you tell your staff/attending about how you feel? What if the patient did poorly after that?This study examines the perception of EM trainees of their competence and adverse events and how they feel about reporting them.MethodsAnonymous web-based survey sent to all trainees from 9 EM programs in Canada outside Quebe........ Read more »
Friedman SM, Sowerby RJ, Guo R, & Bandiera G. (2010) Perceptions of emergency medicine residents and fellows regarding competence, adverse events and reporting to supervisors: a national survey. CJEM : Canadian journal of emergency medical care , 12(6), 491-9. PMID: 21073775
Around two years ago we wrote about research from scientists at the Institute of Cancer Research, partly funded by Cancer Research UK, who discovered that a molecule called LOX (lysyl oxidase) plays an important role in the spread of breast cancer around the body. Now the same team, led by Dr Janine Erler, has shown [...]... Read more »
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, & Erler JT. (2011) The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer. Journal of the National Cancer Institute. PMID: 21282564
Imagine, for a moment, that you are a small planktonic crustacean floating in the tropical ocean. Your world is vast, but its physical geography at your scale is relatively simple. Light and warmth are above, dark and cold are down. … Continue reading →... Read more »
Stephen D. Simpson, Andrew N. Radford, Edward J. Tickle, Mark G. Meekan, Andrew G. Jeffs. (2011) Adaptive Avoidance of Reef Noise. PLoS ONE. info:/doi:10.1371/journal.pone.0016625
Montgomery JC, Jeffs A, Simpson SD, Meekan M, & Tindle C. (2006) Sound as an orientation cue for the pelagic larvae of reef fishes and decapod crustaceans. Advances in marine biology, 143-96. PMID: 16905427
Stanley, J., Radford, C., & Jeffs, A. (2009) Induction of settlement in crab megalopae by ambient underwater reef sound. Behavioral Ecology, 21(1), 113-120. DOI: 10.1093/beheco/arp159
It's been more than 10 years since it was noticed that certain enzymes – the sirtuins – had life-extending properties in organisms like yeast, and later nematodes, fruit flies, and mice. The excitement spread to other compounds, such as resveratrol, that seemed to activate or assist sirtuins. Hopes were high that such things might offer the known longevity benefits of calorie restriction in a pill form. Ever since then the gold rush has been on to figure out how these things work &nd........ Read more »
Someya, S., Yu, W., Hallows, W., Xu, J., Vann, J., Leeuwenburgh, C., Tanokura, M., Denu, J., & Prolla, T. (2010) Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction. Cell, 143(5), 802-812. DOI: 10.1016/j.cell.2010.10.002
Does using online social networking compensate for certain character traits? It’s suggested that participating in online social networks such as Facebook or twitter is mostly done by those who struggle to make social connections in face to face contacts. The use of Facebook to enhance their social relationships online. This is called the social compensation [...]
No related posts.... Read more »
Gosling, S., Augustine, A., Vazire, S., Holtzman, N., & Gaddis, S. (2011) Manifestations of Personality in Online Social Networks: Self-Reported Facebook-Related Behaviors and Observable Profile Information. Cyberpsychology, Behavior, and Social Networking, 2147483647. DOI: 10.1089/cyber.2010.0087
Choosing a set of questionnaires for an assessment battery can be a task fraught with all kinds of traps, because if there is one thing bound to get clinical tongues flapping, it’s the idea that their favourite questionnaire will be left out of the mix! And to complicate matters for us Southern Hemispherians, most of … Read more... Read more »
DWORKIN, R., TURK, D., WYRWICH, K., BEATON, D., CLEELAND, C., FARRAR, J., HAYTHORNTHWAITE, J., JENSEN, M., KERNS, R., & ADER, D. (2008) Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations. The Journal of Pain, 9(2), 105-121. DOI: 10.1016/j.jpain.2007.09.005
The scientific community often discusses the misrepresentation of health news by the media. A less discussed subject is misrepresentation of data in the scientific literature. Gonon, Bezard and Boraud used their knowledge about ADHD to find misrepresentations of data in scientific literature and mass media, and found that the misrepresentation problem often begins in the scientific literature. 1. Internal inconsistenciesThe good news is that only 2 out of about 360 papers (Barbaresi et al and V........ Read more »
Gonon, F., Bezard, E., & Boraud, T. (2011) Misrepresentation of Neuroscience Data Might Give Rise to Misleading Conclusions in the Media: The Case of Attention Deficit Hyperactivity Disorder. PLoS ONE, 6(1). DOI: 10.1371/journal.pone.0014618
I am really loving the new paper by O’Hara et al. The gist is we typically think of the different oceans having unique sets of deep-sea organisms. A Pacific set of animals, an Atlantic set, an Indian set and so on. But O’Hara and colleagues show instead that brittle stars are differentiated along broad latitudinal bands. This is very similar to . . . → Read More: Deep-Sea Creatures Play in the Same Band... Read more »
O'Hara, T., Rowden, A., & Bax, N. (2011) A Southern Hemisphere Bathyal Fauna Is Distributed in Latitudinal Bands. Current Biology. DOI: 10.1016/j.cub.2011.01.002
I admit that I am a skeptic about the effect of diet on ADHD and most mental disorders. No one can argue that a healthy diet should not be routinely advised for all individuals with or without an emotional disorder. However, I am open to looking at research studies and data--I'm willing to change my opinion if the research supports such a change.A group of Dutch researchers recently published a study of diet and ADHD symptoms in a small sample of children with ADHD be........ Read more »
Pelsser, L., Frankena, K., Toorman, J., Savelkoul, H., Dubois, A., Pereira, R., Haagen, T., Rommelse, N., & Buitelaar, J. (2011) Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial. The Lancet, 377(9764), 494-503. DOI: 10.1016/S0140-6736(10)62227-1
Recent high-impact papers have highlighted concerns about the epigenetic differences between reprogrammed pluripotent cells and their embryonic stem cell counterparts. However, when one considers the propagation of DNA methyl marks and the history of this young field, these observations are neither new or surprising. In fact, brand new research released this month indicates that their differences might not be as detrimental to therapeutic potential as once thought.... Read more »
Lister, R., Pelizzola, M., Kida, Y., Hawkins, R., Nery, J., Hon, G., Antosiewicz-Bourget, J., O’Malley, R., Castanon, R., Klugman, S.... (2011) Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. DOI: 10.1038/nature09798
Takahashi K, & Yamanaka S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663-76. PMID: 16904174
Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T.... (2010) Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nature biotechnology, 28(8), 848-55. PMID: 20644536
Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI.... (2010) Epigenetic memory in induced pluripotent stem cells. Nature, 467(7313), 285-90. PMID: 20644535
Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, Chen J, & Ding S. (2011) Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nature cell biology. PMID: 21278734
Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH.... (2011) Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines. Cell, 144(3), 439-52. PMID: 21295703
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.