Post List

  • September 16, 2010
  • 01:55 PM

Drugging the cell's best friend

by The Curious Wavefunction in The Curious Wavefunction

The tumor suppressor p53 is one of the cell’s very best friends. Just how good a friend it is becomes apparent when, just like in other relationships, this particular relationship turns sour. p53 is the “master guardian angel” of the genome and constitutes the most frequent genetic alteration in cancer. More than 50% of human tumors contain a mutation in the p53 gene. With this kind of glowing track record, p53 would be a prime target for drugs.It turns out that discovering drugs for p53 i........ Read more »

  • September 16, 2010
  • 01:00 PM

Non-Monophyly within Syngnathidae

by Southern Fried Scientist in Southern Fried Science

Objective 1: Develop the least publicly accessible title for a blog post about seadragons, mate selection, and evolution
Objective 1 Status: complete
Objective 2: Draw in whatever readers push passed the unwieldy title with an unconventional narrative structure.
Objective 2 Status: complete
Objective 3: Hook the reader with a fascinating, though brief, background on seahorses, seadragons, and pipefish.

Female [...]... Read more »

  • September 16, 2010
  • 12:52 PM

Darwinius massillae, continued…

by zinjanthropus in A Primate of Modern Aspect

I found a new paper in my reader this morning from the crew who published the first description and taxonomic statements about Darwinius massillae, Phillip Gingerich and his colleagues.  This paper is a reply to Williams et al. (2010), which … Continue reading →... Read more »

  • September 16, 2010
  • 12:37 PM

The data isn’t in the papers anymore, you know.

by Mary in OpenHelix

This week I was working on finishing up some training materials on the ENCODE data. We’ve talked about this before, and we’ve had some materials out already to support the ENCODE project, since we have a contract with the folks at UCSC to do some training on it. (The new materials should be out later [...]... Read more »

Rosenbloom, K., Dreszer, T., Pheasant, M., Barber, G., Meyer, L., Pohl, A., Raney, B., Wang, T., Hinrichs, A., Zweig, A.... (2009) ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Research, 38(Database). DOI: 10.1093/nar/gkp961  

Hudson (Chairperson), T., Anderson, W., Aretz, A., Barker, A., Bell, C., Bernabé, R., Bhan, M., Calvo, F., Eerola, I., Gerhard, D.... (2010) International network of cancer genome projects. Nature, 464(7291), 993-998. DOI: 10.1038/nature08987  

  • September 16, 2010
  • 12:05 PM

Uncovering Plagiarism in Biomedical Research

by Michael Long in Phased

Harold Garner (Virginia Bioinformatics Institute, United States) and coworkers have improved upon the eTBLAST tool for uncovering plagiarism in the technical science literature. This news feature was written on September 16, 2010.... Read more »

  • September 16, 2010
  • 11:59 AM

A Blue Shirt and AA Batteries: Sorting Through The Mess

by Psychology 379 bloggers in Cognition & the Arts

Storage room, garage, attic, boxes, under the bed, dorm room... Whatever we choose to call it it, we all have our secret stashes of mess. Imagine the last time you were forced to confront your secret mess pile (if you are anything like me, this is still in short-term memory) to find your blue shirt amongst the heaps of cell phone chargers, clothes, and other notebooks. A few days later, you have to re-confront the mass to find a few AA batteries. Do you have any chance?... Read more »

  • September 16, 2010
  • 11:38 AM

Incyte's INCB018424 looks promising in myelofibrosis

by Sally Church in Pharma Strategy Blog

Just before the American Society of Hematology (ASH) meeting last December, I posted an overview of the JAK2 pathway and pipeline inhibitors in development. Things have changed a bit since then, with TargeGen's inhibitor, TG101348, being licensed by sanofi-aventis and...... Read more »

Vannucchi, A. (2010) From Palliation to Targeted Therapy in Myelofibrosis. New England Journal of Medicine, 363(12), 1180-1182. DOI: 10.1056/NEJMe1005856  

Verstovsek, S., Kantarjian, H., Mesa, R., Pardanani, A., Cortes-Franco, J., Thomas, D., Estrov, Z., Fridman, J., Bradley, E., Erickson-Viitanen, S.... (2010) Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis. New England Journal of Medicine, 363(12), 1117-1127. DOI: 10.1056/NEJMoa1002028  

  • September 16, 2010
  • 11:24 AM

Cheating Men Love Their Girlfriends More

by Ultimo167 in Strong Silent Types

Anderson (2010) discovers that cheating men crave ‘emotional monogamy’ with their partners and to have their physical desires fulfilled through multiple, additional sexual contacts. Many such men claim to love their partners even more because they cheat on them.
... Read more »

Anderson, E. (2010) 'At Least With Cheating There is an Attempt at Monogamy': Cheating and Monogamism Among Undergraduate Heterosexual Men. Journal of Social and Personal Relationships. info:/

  • September 16, 2010
  • 11:12 AM

Born to be Lazy

by Shaheen Lakhan in Brain Blogger

Physical activity is recommended as part of every healthy lifestyle in order to maintain appropriate body weight and composition and to prevent a myriad of diseases. Now, researchers suggest that genetics plays a role in how much voluntary physical activity one is likely to engage in. Predispositions to active, athletic lifestyles are passed on from [...]... Read more »

Garland T Jr, Kelly SA, Malisch JL, Kolb EM, Hannon RM, Keeney BK, Van Cleave SL, & Middleton KM. (2010) How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels. Proceedings. Biological sciences / The Royal Society. PMID: 20810439  

Swallow JG, Koteja P, Carter PA, & Garland T Jr. (2001) Food consumption and body composition in mice selected for high wheel-running activity. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 171(8), 651-9. PMID: 11765974  

  • September 16, 2010
  • 11:11 AM

Can Peruvian Coffee Gain a Foothold at Home?

by Krystal D'Costa in Anthropology in Practice

Spurred by questions from readers, I've expanded the coffee series to include two additional posts on this caffeinated drink that will run this week. If this is your first visit to AiP, you can review our coffee discussions here. Monday's post asked, how can we explain the popularity of instant coffee in coffee producing countries? As a follow-up, today we will look at the future of Peruvian coffee among native Peruvian coffee drinkers. As always, thanks for stopping by—and for yo........ Read more »

  • September 16, 2010
  • 11:05 AM

Repost: Which is more safe: home birth or hospital birth?

by Kate Clancy in Context & Variation

I am slowly re-posting some work from my lab blog. This one received quite a bit of traffic. I actually have a follow-up in the works, so watch for it!You have probably seen the buzz about the recent American Journal of Obstetrics and Gynecology article (Wax et al 2010) on home birth safety, and the editorial in the Lancet that took the article’s shaky meta-analysis to crazytown: “Women have the right to choose how and where to give birth, but they do not have the right to put their baby at ........ Read more »

Editorial staff. (2010) Home birth--proceed with caution. Lancet, 376(9738), 303. PMID: 20674705  

  • September 16, 2010
  • 10:40 AM

Obese, but metabolically healthy: Is weight loss detrimental? (Series Pt 4/5)

by Peter Janiszewski, Ph.D. in Obesity Panacea

After introducing the concept of the metabolically healthy obese phenotype earlier this week, we have covered the risk of chronic disease as well as mortality among this large proportion of obese individuals who despite their excess weight remain metabolically healthy. Today we look at the effect of weight loss among such individuals.
While countless epidemiological studies have shown that as you move from a normal weight (BMI = 18.5-24.9 kg/m2) towards overweight (BMI = 25-29.9kg/m2) and obesi........ Read more »

  • September 16, 2010
  • 10:30 AM

What Does Video Game Research Really Say? (Part 3/10)

by Richard Landers in NeoAcademic

Part 2 of my series examining research evidence for the value of video games. This time: the potential of video games to improve spatial cognition.... Read more »

Spence, I., & Feng, J. (2010) Video games and spatial cognition. Review of General Psychology, 14(2), 92-104. DOI: 10.1037/a0019491  

  • September 16, 2010
  • 10:29 AM

Identifying novel inhibitors for uncharacterized enzymes, Pharm 551A: Bachovchin et al., 2009


Today is our last paper on high throughput screening (HTS) techniques. We’re back to discovering drugs on this one but the premise is quite different for this particular screen. Whereas other papers we’ve done so far have involved finding novel … Continue reading →... Read more »

  • September 16, 2010
  • 10:02 AM

Science proves that your friends are more important than you!

by Greg Laden in Greg Laden's Blog

The other day a friend of mine bumped into some news that concerned her. She could have asked a random person about this to find out more information, but there was a bit of information that came with the news indicating that I might know more than the average person about it. So, she asked me, and as it turns out, I did not know anything. But, having heard the news from her, I noticed a different bit of information that came along with it that told me exactly who would know everything about i........ Read more »

  • September 16, 2010
  • 09:59 AM

Stegosaurus Week: The Many Postures of Kentrosaurus

by Brian Switek in Dinosaur Tracking

Since the early days of paleontology, the posture of dinosaurs and the range of motion they were capable of have been contentious subjects for paleontologists. During the 19th century, especially, the general view of what dinosaurs would have looked like changed no less than three times, and investigations into how these animals moved continue to [...]... Read more »

  • September 16, 2010
  • 08:54 AM

Intelligent Design's Legal Status after Dover

by Greg Laden in Greg Laden's Blog

First, there was plain and simple creationism, a Christian idea that, in an ideal Christian world, would be taught as part of any science dealing with the past, including biology (evolution), geology, and presumably history.

But the constitution stood in the way of implementing basic Christian teachings in public schools in the United States, though that battle took decades. Just as creationists were being driven off he landscape, a sort of Battle of the Bulge occurred, in the form of Intellig........ Read more »

Rosenau, Joshua. (2010) Leap of Faith: Intelligent Design's Trajectory after Dover. UNIV. OF ST. THOMAS JOURNAL OF LAW . info:/

  • September 16, 2010
  • 08:38 AM

Tracking Notharctus, Wyoming’s Prehistoric “Lemur”

by Laelaps in Laelaps

Despite all the overhyped nonsense which surrounded the debut of the 47-million-year-old primate Darwinius masillae (“Ida” to her fans) last year, I have to admit that the first-described specimen was a gorgeous fossil. It was a paleontologist’s dream – a complete, articulated skeleton with traces of hair and even intact gut contents. Never before had [...]... Read more »

Gregory, W.K. (1920) On the structure and relations of Notharctus, an American Eocene primate. Memoirs of the AMNH, 3(2), 49-243. info:/

  • September 16, 2010
  • 08:00 AM

Here is fearfully and wonderfully complex for yer

by Lorimer Moseley in BodyInMind

We have just stumbled across a paper that is very intriguing if you are not up with this tricky little evolutionary twist. Tim Bruckner and colleagues at University of California Irvine and Berkeley, have reported that the odds of a male fetus dying – called the ‘fetal death sex ratio’ – were increased above the [...]... Read more »

  • September 16, 2010
  • 07:43 AM

Leaving the organization or the profession – a multilevel analysis of nurses’ intentions

by Amir Rashid in Pharmacy Commitment PhD


Whilst endeavouring to keep updated with my research topics I came across  the following study on leaving intentions by Simon et al (2010).
The authors have identified three dimensions which they suggest illustrate the different aspects which contribute to Turnover in previous definitions: Voluntariness (collaborative relationship with organisation), Controllability (who has actual control over turnover), and [...]... Read more »

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