I am red-green colour blind and I’m well aware of my general inability to distinguish red particularly well. In particular, I often miss subtler shades of pink. Apart from a tendency to wear inappropriate shirt and tie combinations it’s hardly life threatening. However, it is perhaps rather more than an inconvenience that blood is red. [...]... Read more »
Katmawi-Sabbagh, S., Haq, A., Jain, S., Subhas, G., & Turnham, H. (2009) Impact of Colour Blindness on Recognition of Haematuria in Bladder Cancer Patients. Urologia Internationalis, 83(3), 289-290. DOI: 10.1159/000241669
Here is a review that, if you are interested in how the brain controls muscles, and you are prepared to put in some hard yards, you should read. Simon Gandevia works down the corridor from me, so do Janet Taylor and Jane Butler. Nicholas Peterson doesn’t but I once had a cup of tea from [...]... Read more »
Petersen NC, Butler JE, Taylor JL, & Gandevia SC. (2010) Probing the corticospinal link between the motor cortex and motoneurones: some neglected aspects of human motor cortical function. Acta physiologica (Oxford, England), 198(4), 403-16. PMID: 20003100
Moseley GL, Nicholas MK, & Hodges PW. (2004) Does anticipation of back pain predispose to back trouble?. Brain : a journal of neurology, 127(Pt 10), 2339-47. PMID: 15282214
Moseley GL, & Hodges PW. (2006) Reduced variability of postural strategy prevents normalization of motor changes induced by back pain: a risk factor for chronic trouble?. Behavioral neuroscience, 120(2), 474-6. PMID: 16719709
Last year I commented that the following image, while funny, was a 'fail' in scientific terms:A recent commenter asked, so is this image scientifically correct or incorrect? (My first thought was that teh lolcat at the end should be a clue...) ...... Read more »
Johnson, W. (2006) The Late Miocene Radiation of Modern Felidae: A Genetic Assessment. Science, 311(5757), 73-77. DOI: 10.1126/science.1122277
Our immune systems are highly trained to recognise and destroy foreign invaders such as bacteria and viruses. But cancer starts from our own cells, so it’s difficult for the immune system to recognise and fight tumours. However, our immune defences do have some powerful weapons at their disposal, including a molecule called tumour necrosis factor, [...]... Read more »
Cordero, J., Macagno, J., Stefanatos, R., Strathdee, K., Cagan, R., & Vidal, M. (2010) Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter. Developmental Cell, 18(6), 999-1011. DOI: 10.1016/j.devcel.2010.05.014
Apple’s Steve Jobs has a reputation for responding personally to some of the presumably millions of emails he receives. (Apparently, he does it on a weekly basis, which smacks of controlled PR campaign, if you ask me). One from “Derick” published on Wired and elsewhere purportedly asked about the chemistry of the iPhone 4. Derick [...]... Read more »
Rosman, K., Chisholm, W., Hong, S., Candelone, J., & Boutron, C. (1997) Lead from Carthaginian and Roman Spanish Mines Isotopically Identified in Greenland Ice Dated from 600 B.C. to 300 A.D. . Environmental Science , 31(12), 3413-3416. DOI: 10.1021/es970038k
Good gravy! In an early release from the New England Journal of Medicine, researchers documented the effects of a 3 year, 21 school, 4,600 student, multi-pronged, intervention that spanned Grades 6 through 8 covering nutrition, physical activity, behavioural knowledge, communications and social marketing on the children's body mass indices, waist circumferences, fasting glucoses and fasting insulins.The nutritional component targeted quantity, quality and energy of foods. The physical activity........ Read more »
The Healthy Study Group. (2010) A School-Based Intervention for Diabetes Risk Reduction. New England Journal of Medicine. DOI: 10.1056/NEJMoa1001933
I recently came across a paper discussing the evaluation of user interface systems. In it the author proposes that complex user interface systems and architectures do not readily yield to the research methods we currently use. It was at this point I started to bristle with derision in a very defensive...... Read more »
Olsen,Jr., Dan R. (2007) Evaluating user interface systems research. UIST '07: Proceedings of the 20th annual ACM symposium on User interface software and technology, 1(1), 251-258. info:/10.1145/1294211.1294256
Greenberg, Saul and Buxton, Bill. (2008) Usability evaluation considered harmful (some of the time). CHI '08: Proceeding of the twenty-sixth annual SIGCHI conference on Human factors in computing systems, 1(1), 111-120. info:/http://dx.doi.org/10.1145/1357054.1357074
Dillon, Andrew. (2010) As we may have thought, and may (still) think. HT '10: Proceedings of the 21st ACM conference on Hypertext and hypermedia, 1(1), 1-2. info:/http://dx.doi.org/10.1145/1810617.1810619
Scott O. Lilienfeld, Steven Jay Lynn, Jeffrey M. Lohr, Carol Tavris. (2003) Science and pseudoscience in clinical psychology: Initial thoughts, reflections and considerations. Science and pseudoscience in clinical psychology. info:other/1-57230-828-1
Over a quarter century ago, a young woman was admitted to a New York hospital with fever and agitation. She never walked out. Libby Zion died while under the care of he primary care doctor and two medical residents. The exact cause of death was never identified, but the case led to a forced examination of medical residents' work hours. This was driven largely by Zion's father who felt that his daughter had been killed by inexperienced, poorly supervised, and overworked resident physicians.
........ Read more »
Fisman, D., Harris, A., Rubin, M., Sorock, G., & Mittleman, M. (2007) Fatigue Increases the Risk of Injury From Sharp Devices in Medical Trainees: Results From a Case‐Crossover Study • . Infection Control and Hospital Epidemiology, 28(1), 10-17. DOI: 10.1086/510569
Trinkoff, A., Le, R., Geiger‐Brown, J., & Lipscomb, J. (2007) Work Schedule, Needle Use, and Needlestick Injuries Among Registered Nurses • . Infection Control and Hospital Epidemiology, 28(2), 156-164. DOI: 10.1086/510785
Steele, M., Ma, O., Watson, W., Thomas, H., & Muelleman, R. (1999) The Occupational Risk of Motor Vehicle Collisions for Emergency Medicine Residents. Academic Emergency Medicine, 6(10), 1050-1053. DOI: 10.1111/j.1553-2712.1999.tb01191.x
Barger LK, Cade BE, Ayas NT, Cronin JW, Rosner B, Speizer FE, Czeisler CA, & Harvard Work Hours, Health, and Safety Group. (2005) Extended work shifts and the risk of motor vehicle crashes among interns. The New England journal of medicine, 352(2), 125-34. PMID: 15647575
Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW.... (2004) Effect of reducing interns' work hours on serious medical errors in intensive care units. The New England journal of medicine, 351(18), 1838-48. PMID: 15509817
Gaba DM, & Howard SK. (2002) Patient safety: fatigue among clinicians and the safety of patients. The New England journal of medicine, 347(16), 1249-55. PMID: 12393823
Nuckols TK, Bhattacharya J, Wolman DM, Ulmer C, & Escarce JJ. (2009) Cost implications of reduced work hours and workloads for resident physicians. The New England journal of medicine, 360(21), 2202-15. PMID: 19458365
About 13 to 19% of new mothers experience depression in the first year after birth. Most of them are never identified nor diagnosed. New mothers often read about pregnancy, giving birth and raising their children in popular magazines. It’s eminent that adequate information in these magazines about postpartum depression is of importance. A recent study [...]
Related posts:A Portrait of Depression in the Mass Media, Gender Influences.
Mass Media and notions about women’s depressive ........ Read more »
Schanie, C., Pinto-Foltz, M., & Logsdon, M. (2008) Analysis of Popular Press Articles Concerning Postpartum Depression: 1998–2006. Issues in Mental Health Nursing, 29(11), 1200-1216. DOI: 10.1080/01612840802370509
Dental researchers are forging ahead with their branch of tissue engineering and regenerative medicine. It hasn't been long since engineered growth in situ of replacement teeth was demonstrated in rats, and now a research group has shown they can regenerate tooth enamel in mice, thereby healing cavities: A new peptide, embedded in a soft gel or a thin, flexible film and placed next to a cavity, encourages cells inside teeth to regenerate in about a month ... The gel or thin film contains a pepti........ Read more »
We all know that linear polymers of amino acids (proteins) adopt complex three-dimensional structures when they are dissolved in water. The process of forming these structures is called folding, and it is understood to occur because proteins are amphiphilic. Some parts of a protein chain like to interact with water (hydrophilic), while others are oily and want to get out of water (hydrophobic). Folding of the chain sticks all the oily parts together on the inside of the structure while the parts........ Read more »
The skeleton of the Hundsheim rhinoceros, Stephanorhinus hundsheimensis. From Kahlke and Kaiser, 2010.
In any given environment, it might be expected that a generalized or unspecialized species might be less prone to extinction than one which depends upon a narrow temperature range, a peculiar kind of food, or other aspect of natural history which is key to its survival. An herbivorous mammal which can subsist on a variety of grasses, leaves, and other plant foods, for example, may be more l........ Read more »
Kahlke, R., & Kaiser, T. (2010) Generalism as a subsistence strategy: advantages and limitations of the highly flexible feeding traits of Pleistocene Stephanorhinus hundsheimensis (Rhinocerotidae, Mammalia)☆. Quaternary Science Reviews. DOI: 10.1016/j.quascirev.2009.12.012
What have people been talking about this week in high energy physics, astrophysics, gravitation, general relativity and quantum gravity, and a little bit of quantum mechanics?... Read more »
Lyne, A., Hobbs, G., Kramer, M., Stairs, I., & Stappers, B. (2010) Switched Magnetospheric Regulation of Pulsar Spin-Down. Science. DOI: 10.1126/science.1186683
H. Rampadarath, M. A. Garrett, G. I. G. Józsa, T. Muxlow, T. A. Oosterloo, Z. Paragi1, R. Beswick, H. van Arkel, W. C. Keel, & K. Schawinski. (2010) Hanny's Voorwerp: Evidence of AGN activity and a nuclear starburst in the central regions of IC 2497. arXiv. arXiv: 1006.4096v1
Norbert Przybilla, Alfred Tillich, Ulrich Heber, & Ralf-Dieter Scholz. (2010) Weighing the Galactic dark matter halo: a lower mass limit from the fastest halo star known. arXiv. arXiv: 1005.5026v1
Andresen, G., Bertsche, W., Bowe, P., Bray, C., Butler, E., Cesar, C., Chapman, S., Charlton, M., Fajans, J., & Fujiwara, M. (2010) Antihydrogen formation dynamics in a multipolar neutral anti-atom trap. Physics Letters B, 685(2-3), 141-145. DOI: 10.1016/j.physletb.2010.01.066
Shaun A. Thomas, Filipe B. Abdalla, & Ofer Lahav. (2010) Upper bound of 0.28 eV on neutrino masses from the largest photometric redshift survey. |Physical Review Letters. info:/
The CDMS II Collaboration. (2010) Dark Matter Search Results from the CDMS II Experiment. Science, 327(5973), 1619-1621. DOI: 10.1126/science.1186112
Tarun Biswas. (2010) Through the Black Hole -- On Not Breaking Time Reversal Symmetry. arXiv. arXiv: 1006.4185v1
A. Garrett Lisi. (2010) An Explicit Embedding of Gravity and the Standard Model in E8. arXiv. arXiv: 1006.4908v1
Ian D. Leroux, Monika H. Schleier-Smith, & Vladan Vuletić. (2010) Orientation-Dependent Entanglement Lifetime in a Squeezed Atomic Clock. Physical Review Letters. info:/10.1103/PhysRevLett.104.250801
Last week, Dmitry Budker's group at Berkeley published a paper in Physical Review Letters (also free on the arxiv) with the somewhat drab title "Spectroscopic Test of Bose-Einsten Statistics for Photons." Honestly, I probably wouldn't've noticed it, even though this is the sort of precision AMO test of physics that I love, had it not been for the awesome press release Berkeley put together, and this image in particular (grabbed with its caption):
This is a nifty paper, and deserves a little e........ Read more »
English, D., Yashchuk, V., & Budker, D. (2010) Spectroscopic Test of Bose-Einstein Statistics for Photons. Physical Review Letters, 104(25). DOI: 10.1103/PhysRevLett.104.253604
A recent paper of mine illustrates the deleterious effects of alcohol on circadian physiology, indicating that disruptions of circadian systems may be an underlying neurobehavioral etiology of alcoholism.... Read more »
Brager AJ, Ruby CL, Prosser RA, & Glass JD. (2010) Chronic Ethanol Disrupts Circadian Photic Entrainment and Daily Locomotor Activity in the Mouse. Alcoholism, clinical and experimental research. PMID: 20477766
A million years ago (truly, ask my daughter if I’m that old!) I completed several papers in postgraduate ergonomics, primarily physical and organisational ergonomics rather than cognitive, and for a while there I could recall the NIOSH lifting equation and even discuss biomechanics with some confidence. Sad to say, over the years, my familiarity with … Read more... Read more »
Driessen, M., Proper, K., van Tulder, M., Anema, J., Bongers, P., & van der Beek, A. (2010) The effectiveness of physical and organisational ergonomic interventions on low back pain and neck pain: a systematic review. Occupational and Environmental Medicine, 67(4), 277-285. DOI: 10.1136/oem.2009.047548
Circadian clocks control a large number of daily processes in most organisms. These endogenous cellular timekeepers regulate rhythms in gene expression, physiology and behaviour and enable organisms to anticipate predictable environmental variations.
Circadian clocks are composed of a central oscillator and two signaling pathways: input pathways convey external signals to the oscillator, so ... Read more »
Vitalini MW, Morgan LW, March IJ, & Bell-Pedersen D. (2004) A genetic selection for circadian output pathway mutations in Neurospora crassa. Genetics, 167(1), 119-29. PMID: 15166141
The preening oil that wild waterbirds spread over their feathers may be acting as a magnet for avian flu viruses, according to a PLoS ONE study.
Researchers studied 345 mallards (Anas platyrhynchos) in Italy and found that 27 percent of the birds tested positive for avian flu virus on their feathers. When feather tufts or […] Read More »... Read more »
Delogu, M. et al. (2010) Can Preening Contribute to Influenza A Virus Infection in Wild Waterbirds?. PLoS ONE, 5(6). DOI: 10.1371/journal.pone.0011315
by Michael Yarmolinsky in Small Things Considered
by Michael Yarmolinsky
Patrons of upscale seafood restaurants are given the opportunity to see that the unfortunate creatures destined for the lobster pot are waving their antennae about. Savvy customers at downscale seafood markets evaluate questionable claims of freshness by smell. A fastidious bacteriophage would welcome the opportunity to gauge the quality of a potential meal, if only it could make that assessment. I was recently reminded, in the course of disposing of old reprints, that ........ Read more »
Samuel AD, Pitta TP, Ryu WS, Danese PN, Leung EC, & Berg HC. (1999) Flagellar determinants of bacterial sensitivity to chi-phage. Proceedings of the National Academy of Sciences of the United States of America, 96(17), 9863-6. PMID: 10449785
AstraZeneca's Gefitinib (Iressa) has had a bit of a chequered history since it's fast track approval by the the Japanese Health Authority in 2002 and the FDA in 2003 for non-small cell lung cancer (NSCLC). However, since the phase III...... Read more »
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I.... (2010) Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. The New England journal of medicine, 362(25), 2380-8. PMID: 20573926
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