Post List

  • September 29, 2016
  • 03:06 AM
  • 265 views

On "socially successful elementary school-aged children with autism"

by Paul Whiteley in Questioning Answers

"School-based interventions should address malleable factors such as the number of peer connections and received friendships that predict the best social outcomes for children with ASD [autism spectrum disorder]."So said the study findings reported by Jill Locke and colleagues [1] looking at "the stable (unlikely to change) and malleable (changeable) characteristics of socially successful children with ASD."Mindful that the phrase 'socially successful children' is perhaps not one that I'm p........ Read more »

Locke J, Williams J, Shih W, & Kasari C. (2016) Characteristics of socially successful elementary school-aged children with autism. Journal of child psychology and psychiatry, and allied disciplines. PMID: 27620949  

  • September 29, 2016
  • 01:21 AM
  • 285 views

Urban sociolinguistics in Dubai

by Ingrid Piller in Language on the Move

A couple of years ago, I mused here on Language on the Move what linguistic theory would look like if...... Read more »

Piller, I. (2016) Dubai: Language in the ethnocratic, corporate and mobile city. Smakman, D. and P. Heinrich. Eds. Metrolinguistics: Urban Language Ecologies around the World. info:/

  • September 28, 2016
  • 01:51 PM
  • 256 views

Research team may have observed building blocks of memories in the brain

by Dr. Jekyll in Lunatic Laboratories

A team of researchers has observed what they believe are the building blocks of memories in a mouse brain. In their paper, the researchers describe how they caused certain neurons to become illuminated when they fired, allowing them to watch in real time as memories were made and then later as they were replayed while the mouse was sitting idle.

... Read more »

Malvache, A., Reichinnek, S., Villette, V., Haimerl, C., & Cossart, R. (2016) Awake hippocampal reactivations project onto orthogonal neuronal assemblies. Science, 353(6305), 1280-1283. DOI: 10.1126/science.aaf3319  

  • September 28, 2016
  • 11:10 AM
  • 263 views

Lewy Body Versus Alzheimer's Dementias and Parkinson's

by William Yates, M.D. in Brain Posts

One clinical challenge is making an accurate diagnosis in patients with dementia.Alzheimer's disease is typically the predominant diagnosis in dementia. However a significant number of patients will present with dementia due to Lewy Body disease, Parkinson's dementia,  frontotemporal dementia or vascular dementia.A recent study helps clinicians to distinguish Lewy Body  from Alzheimer's dementia and Parkinson's disease.Douglas Scharre and collegues from Ohio State University conducted ........ Read more »

Scharre, D., Chang, S., Nagaraja, H., Park, A., Adeli, A., Agrawal, P., Kloos, A., Kegelmeyer, D., Linder, S., Fritz, N.... (2016) Paired Studies Comparing Clinical Profiles of Lewy Body Dementia with Alzheimer’s and Parkinson’s Diseases. Journal of Alzheimer's Disease, 1-10. DOI: 10.3233/JAD-160384  

  • September 28, 2016
  • 11:10 AM
  • 231 views

When the writing is wrong: PRMT5 histone arginine methylation promotes invasivity and metastasis in a range of human cancers

by David Schecter in EpiBeat

Cancer metastasis occurs when cancer cells leave a primary tumor and invade other tissues. Generally, this leads to a poor prognosis for patients. Underlying epigenetic mechanisms of tumor progression are poorly understood but are of great interest for developing new approaches of treatment in the clinic. Cancer etiology is highly correlated with alterations in the histone code1-5 and protein methyltransferases are frequently dysregulated in cancer, implicating them as compelling novel targets f........ Read more »

Stopa N, Krebs JE, & Shechter D. (2015) The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cellular and molecular life sciences : CMLS, 72(11), 2041-59. PMID: 25662273  

Sebova K, & Fridrichova I. (2010) Epigenetic tools in potential anticancer therapy. Anti-cancer drugs, 21(6), 565-77. PMID: 20436342  

Yang, Y., & Bedford, M. (2012) Protein arginine methyltransferases and cancer. Nature Reviews Cancer, 13(1), 37-50. DOI: 10.1038/nrc3409  

Greenblatt SM, Liu F, & Nimer SD. (2016) Arginine methyltransferases in normal and malignant hematopoiesis. Experimental hematology, 44(6), 435-41. PMID: 27026282  

Chan-Penebre E, Kuplast KG, Majer CR, Boriack-Sjodin PA, Wigle TJ, Johnston LD, Rioux N, Munchhof MJ, Jin L, Jacques SL.... (2015) A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nature chemical biology, 11(6), 432-7. PMID: 25915199  

Liu F, Cheng G, Hamard PJ, Greenblatt S, Wang L, Man N, Perna F, Xu H, Tadi M, Luciani L.... (2015) Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. The Journal of clinical investigation, 125(9), 3532-44. PMID: 26258414  

Ikushima H, & Miyazono K. (2010) TGFbeta signalling: a complex web in cancer progression. Nature reviews. Cancer, 10(6), 415-24. PMID: 20495575  

Lamouille, S., Xu, J., & Derynck, R. (2014) Molecular mechanisms of epithelial–mesenchymal transition. Nature Reviews Molecular Cell Biology, 15(3), 178-196. DOI: 10.1038/nrm3758  

  • September 28, 2016
  • 10:20 AM
  • 254 views

A New Hope For Alzheimer’s Disease Immunotherapy

by Agnese Mariotti in United Academics

For the first time, an antibody was able to target and disrupt the Aβ plaques in the brain.... Read more »

Sevigny, J., Chiao, P., Bussière, T., Weinreb, P., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y.... (2016) The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature, 537(7618), 50-56. DOI: 10.1038/nature19323  

  • September 28, 2016
  • 04:30 AM
  • 277 views

No Need to Supplement What You Don’t Need

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Dietary intake in young athletes seem to meet most recommendations, therefore supplementing may only be necessary for a few select micronutrients based on age and gender. ... Read more »

  • September 28, 2016
  • 02:55 AM
  • 246 views

Postural tachycardia syndrome and gluten?

by Paul Whiteley in Questioning Answers

Please use your full stops wisely.I believe that this is the first time that I've talked about postural tachycardia syndrome (PoTS) on this blog as I bring to your attention some rather intriguing findings reported by Hugo Penny and colleagues [1] on how PoTS and gluten-related disorders might not be unstrange diagnostic bedfellows.PoTS by the way, describes symptoms where standing upright / sitting down induces dizziness, fainting and other symptoms. As well as being quite prevalent in a c........ Read more »

Penny, H., Aziz, I., Ferrar, M., Atkinson, J., Hoggard, N., Hadjivassiliou, M., West, J., & Sanders, D. (2016) Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology , 1. DOI: 10.1097/MEG.0000000000000740  

  • September 27, 2016
  • 05:50 PM
  • 265 views

The unintended consequences of almond milk on California

by Dr. Jekyll in Lunatic Laboratories

A new study using aerial imagery across the state of California has found that converting land to grow almonds between 2007 and 2014 has led to a 27% annual increase in irrigation demands—despite the state's historic drought. The expansion of almonds has also consumed 16,000 acres of wetlands and will likely put additional pressure on already stressed honeybee populations.

... Read more »

WATKINS, Larissa, WATSON, Kelly, & HUFFMAN, F. Tyler. (2016) MONITORING CHANGE IN AGRICULTURAL LAND AND WATER USAGE IN CALIFORNIA’S CENTRAL VALLEY USING GEOSPATIAL TECHNIQUES. Geological Society of America. info:/10.1130/abs/2016AM-285205

  • September 27, 2016
  • 05:25 PM
  • 211 views

‘Overpronation’ and achilles tendon blood flow

by Craig Payne in Running Research Junkie

‘Overpronation’ and achilles tendon blood flow... Read more »

Karzis, K., Kalogeris, M., Mandalidis, D., Geladas, N., Karteroliotis, K., & Athanasopoulos, S. (2016) The effect of foot overpronation on Achilles tendon blood supply in healthy male subjects. Scandinavian Journal of Medicine . DOI: 10.1111/sms.12722  

  • September 27, 2016
  • 03:09 PM
  • 249 views

Sex changes in nature

by Emily Makowski in Sextraordinary!

We might think of animal mating being as simple as 1 male and 1 female, like on Noah's Ark. But many types of fish undergo sex changes throughout their lives. My goal is to open people's eyes to the diversity among sex in animals.... Read more »

  • September 27, 2016
  • 09:01 AM
  • 133 views

Diagnostics of the acceleration modulation process based on quasi-periodic variations of flare emission by Kupriyanova et al.*

by CESRA in Solar Radio Science

Quasi-periodic pulsations (QPPs) with the characteristic time scales from a few seconds up to tens of minutes are frequently seen in the time profiles of solar and stellar flare emission (Nakariakov et al., 2016 ). Among all the possibilities of QPPs explanation, two reasons are discussed more actively: magnetohydrodynamic (MHD) [...]... Read more »

Kupriyanova et al. (2016) Diagnostics of the acceleration modulation process based on quasi-periodic variations of flare emission. Solar Physics. info:/

  • September 27, 2016
  • 08:32 AM
  • 253 views

Do you really see plants? Humans and their plant blindness

by Alice Breda in la-Plumeria

What do you see in the picture? An elephant, right?
Some will say that they see an African elephant, or perhaps an elephant in the savannah protecting from the sun in the shade of a tree. But who sees an elephant and a majestic flowering baobab surrounded by savannah shrubs in a dry grass meadow?
If your answer is the latter, congratulations, you are a quite unique case. If in the picture you just see “an elephant” then you are just like most of the people around you.

This pheno........ Read more »

Wandersee, J., & Schussler, E. (1999) Preventing Plant Blindness. The American Biology Teacher, 61(2), 82-86. DOI: 10.2307/4450624  

  • September 27, 2016
  • 02:55 AM
  • 235 views

Neurotensin, intestinal inflammation and autism?

by Paul Whiteley in Questioning Answers

"Elevated peripheral pro-NT [neurotensin] levels reflect more severe forms of active celiac disease, indicating a potential role of NT in intestinal inflammation."The suggestion, from Caroline Montén and colleagues [1], that the neuropeptide called neurotensin might play a role in paediatric coeliac disease is an interesting one that caught my eye recently. Interesting not only because of the potential implications for the archetypal 'gluten-causing' autoimmune condition cal........ Read more »

Montén C, Torinsson Naluai Å, & Agardh D. (2016) Role of pro-neurotensin as marker of paediatric celiac disease. Clinical and experimental immunology. PMID: 27612962  

  • September 26, 2016
  • 07:04 PM
  • 228 views

What is behavior? Baby don’t ask me, don’t ask me, no more

by Piter Boll in Earthling Nature

by Piter Kehoma Boll One of the most difficult concepts to explain in biology is certainly life itself. But I am not here today to talk about the definition of life, but rather of another puzzling concept: behavior. Behavior is the … Continue reading →... Read more »

  • September 26, 2016
  • 01:35 PM
  • 266 views

Why do more men than women commit suicide?

by Dr. Jekyll in Lunatic Laboratories

Why do more men die when they attempt suicide than women? The answer could lie in four traits, finds scientists. There are over 6,000 British lives lost to suicide each year, and nearly 75 per cent of those are male. However, research has found women are more likely to suffer from depression, and to attempt to take their own life.

... Read more »

Deshpande, G., Baxi, M., Witte, T., & Robinson, J. (2016) A Neural Basis for the Acquired Capability for Suicide. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2016.00125  

  • September 26, 2016
  • 04:30 AM
  • 331 views

Exergaming Brings Postural Control Rehabilitation Up to a Whole New Level

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Exergaming using the XBOX Kinect system has the potential to enhance postural control compared to standard gym-based exercise.... Read more »

  • September 26, 2016
  • 02:48 AM
  • 250 views

On HERV-H, autism, ADHD and methylphenidate?

by Paul Whiteley in Questioning Answers

Today's post is a bit of a mash-up including two paper: the first from Emanuela  Balestrieri and colleagues [1] (open-access available here) talking about "increased HERV-H [Human Endogenous Retroviruses - H] transcriptional activity in all autistic patients" included in their cohort (author's words not mine) and the second from D'Agati and colleagues [2] (open-access available here) describing "the reduction of HERV-H expression and the significant improvement of ADHD&n........ Read more »

Balestrieri E, Cipriani C, Matteucci C, Capodicasa N, Pilika A, Korca I, Sorrentino R, Argaw-Denboba A, Bucci I, Miele MT.... (2016) Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders. The new microbiologica, 39(3), 228-31. PMID: 27602423  

  • September 25, 2016
  • 09:29 PM
  • 239 views

Big news in iPS cell transplants

by adam phillips in It Ain't Magic

iPS cell-derived retinal cells have been successfully transplanted from one money to another without need of immunosuppressant drugs.... Read more »

  • September 25, 2016
  • 02:57 PM
  • 265 views

Linking perception to action

by Dr. Jekyll in Lunatic Laboratories

Researchers studying how the brain uses perception of the environment to guide action offer a new understanding of the neural circuits responsible for transforming sensation into movement.

... Read more »

join us!

Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.

If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.

Register Now

Research Blogging is powered by SMG Technology.

To learn more, visit seedmediagroup.com.