Post List

  • August 4, 2014
  • 07:02 AM
  • 135 views

“Everyday liars” and “Prolific liars”

by Doug Keene in The Jury Room

The American Bar Association is seeking nominations until August 8, 2014 to help it decide on the Top 100 law blogs (“Blawgs”). We have been in the ABA Top 100 for the past 4 years and would like to make it 5! If you like this blog, please nominate us (it’s fast and free) here. THANKS! […]

Related posts:
Do great liars know how to tell if you’re lying to them? (Yes, they do!)
Outsmarting liars (five decades of research)
We know liars when we see ‘em


... Read more »

  • August 4, 2014
  • 06:06 AM
  • 145 views

The iPhone Effect - when mobile devices intrude on our face-to-face encounters

by BPS Research Digest in BPS Research Digest

You've probably experienced this. You're in the middle of telling your friend a story when his eyes flick across to his phone. Perhaps he even picks it up, checks the screen. "Sorry, go on," he says. But your flow is interrupted. And you know his mind is at least half elsewhere.Shalini Misra and her team approached 100 pairs of people (109 women; average age 33) in cafes across Washington DC and neighbouring districts. They asked them to chat for ten minutes at a table in the cafe about a trivia........ Read more »

  • August 4, 2014
  • 04:10 AM
  • 120 views

Stopping gliadin peptides in their tracks?

by Paul Whiteley in Questioning Answers

A micropost if you will, to bring to your attention the paper by Marco Sarno and colleagues [1] and their suggestion of "a novel effect of probiotics in the prevention of undigested gliadin peptides toxic effects".Knitting on't Moors @ Wikipedia The probiotic in question is something called Lactobacillus paracasei CBA L74, which if I'm not mistaken is connected with a certain '57 varieties' company. The authors (which included one Alessio Fasano) indicated that said probiotic appe........ Read more »

Sarno M, Lania G, Cuomo M, Nigro F, Passannanti F, Budelli A, Fasano F, Troncone R, Auricchio S, Barone MV.... (2014) Lactobacillus paracasei CBA L74 interferes with gliadin peptides entrance in Caco-2 cells. International journal of food sciences and nutrition, 1-7. PMID: 25030417  

  • August 4, 2014
  • 12:05 AM
  • 134 views

Concussion Indicators of a Phenomenon Yet to be Defined

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Prevalent and consistent indicators of a concussion include observing disorientation or confusion immediately after the injury, and slower reaction time, poor balance, and impaired verbal learning and memory within 2 days after the injury.... Read more »

Carney N, Ghajar J, Jagoda A, Bedrick S, Davis-OʼReilly C, du Coudray H, Hack D, Helfand N, Huddleston A, Nettleton T.... (2014) Concussion guidelines step 1: systematic review of prevalent indicators. Neurosurgery. PMID: 25006974  

  • August 3, 2014
  • 07:12 PM
  • 181 views

Ebola: Role of the Glycoprotein in viral entry and ER stress

by thelonevirologist in Virology Tidbits

Ebola viruses (EBOV) are the causative agent of severe hemorrhagic fever in humans with a high mortality rate, with a case fatality rate of up to 90%, with Ebola Zaire the most pathogenic.The role of viral Glycoprotein in viral entry and induction of apoptosis are discussed.... Read more »

Ito H, Watanabe S, Sanchez A, Whitt MA, & Kawaoka Y. (1999) Mutational analysis of the putative fusion domain of Ebola virus glycoprotein. Journal of virology, 73(10), 8907-12. PMID: 10482652  

Matsuyama, S., Ujike, M., Morikawa, S., Tashiro, M., & Taguchi, F. (2005) Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection. Proceedings of the National Academy of Sciences, 102(35), 12543-12547. DOI: 10.1073/pnas.0503203102  

Schornberg K, Matsuyama S, Kabsch K, Delos S, Bouton A, & White J. (2006) Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. Journal of virology, 80(8), 4174-8. PMID: 16571833  

Marzi A, Reinheckel T, & Feldmann H. (2012) Cathepsin B . PLoS neglected tropical diseases, 6(12). PMID: 23236527  

Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G.... (2011) Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature, 477(7364), 340-3. PMID: 21866103  

Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI.... (2012) Ebola virus entry requires the host-programmed recognition of an intracellular receptor. The EMBO journal, 31(8), 1947-60. PMID: 22395071  

Aleksandrowicz P, Marzi A, Biedenkopf N, Beimforde N, Becker S, Hoenen T, Feldmann H, & Schnittler HJ. (2011) Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis. The Journal of infectious diseases. PMID: 21987776  

Bröcker C, Kuhlee A, Gatsogiannis C, Balderhaar HJ, Hönscher C, Engelbrecht-Vandré S, Ungermann C, & Raunser S. (2012) Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex. Proceedings of the National Academy of Sciences of the United States of America, 109(6), 1991-6. PMID: 22308417  

Lamb CA, Yoshimori T, & Tooze SA. (2013) The autophagosome: origins unknown, biogenesis complex. Nature reviews. Molecular cell biology, 14(12), 759-74. PMID: 24201109  

Ao X, Zou L, & Wu Y. (2014) Regulation of autophagy by the Rab GTPase network. Cell death and differentiation, 21(3), 348-58. PMID: 24440914  

Takáts S, Pircs K, Nagy P, Varga Á, Kárpáti M, Hegedűs K, Kramer H, Kovács AL, Sass M, & Juhász G. (2014) Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Molecular biology of the cell, 25(8), 1338-54. PMID: 24554766  

Olejnik J, Alonso J, Schmidt KM, Yan Z, Wang W, Marzi A, Ebihara H, Yang J, Patterson JL, Ryabchikova E.... (2013) Ebola virus does not block apoptotic signaling pathways. Journal of virology, 87(10), 5384-96. PMID: 23468487  

McElroy AK, Erickson BR, Flietstra TD, Rollin PE, Nichol ST, Towner JS, & Spiropoulou CF. (2014) Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome. The Journal of infectious diseases, 210(4), 558-66. PMID: 24526742  

  • August 3, 2014
  • 05:12 PM
  • 175 views

Exfoliating Method Makes Water-Splitting Catalysts More Efficient

by dailyfusion in The Daily Fusion

Scientists at the Swiss Federal Institute of Technology in Lausanne (EPFL) have developed a new method for improving the catalysis of water-splitting reactions.... Read more »

  • August 3, 2014
  • 05:00 PM
  • 157 views

Resuscitation characteristics and outcomes in suspected drug overdose-related out-of-hospital cardiac arrest

by Rogue Medic in Rogue Medic

This study is interesting for several reasons.

In a system that claims excellence, the most consistent way to identify the study group is by documentation of a protocol violation - but it is not intended as a study of protocol violations.

This may hint at some benefit from epinephrine (Adrenaline in Commonwealth countries), but that would require some study and we just don't study epinephrine. We only make excuses for not studying epinephrine.

The atropine results suggest that the ........ Read more »

  • August 3, 2014
  • 04:11 PM
  • 163 views

The Alondra Oubré Academic Fraud Exposed

by nooffensebut in The Unsilenced Science

Two respected authors, Alondra Oubré and Massimo Pigliucci, are implicated in the academic fraud of taking false information from Wikipedia and falsely attributing it to a research database in order to fulminate against the conclusions of Nicholas Wade’s book, A Troublesome Inheritance, and the science of the warrior gene, monoamine oxidase A.... Read more »

Alia-Klein N, Goldstein RZ, Tomasi D, Woicik PA, Moeller SJ, Williams B, Craig IW, Telang F, Biegon A, Wang GJ.... (2009) Neural mechanisms of anger regulation as a function of genetic risk for violence. Emotion (Washington, D.C.), 9(3), 385-96. PMID: 19485616  

Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, & Meyer-Lindenberg A. (2008) Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Molecular psychiatry, 13(3), 313-24. PMID: 17519928  

Cerasa A, Cherubini A, Quattrone A, Gioia MC, Magariello A, Muglia M, Manna I, Assogna F, Caltagirone C, & Spalletta G. (2010) Morphological correlates of MAO A VNTR polymorphism: new evidence from cortical thickness measurement. Behavioural brain research, 211(1), 118-24. PMID: 20303364  

Fergusson DM, Boden JM, Horwood LJ, Miller A, & Kennedy MA. (2012) Moderating role of the MAOA genotype in antisocial behaviour. The British journal of psychiatry : the journal of mental science, 200(2), 116-23. PMID: 22297589  

Gilad Y, Rosenberg S, Przeworski M, Lancet D, & Skorecki K. (2002) Evidence for positive selection and population structure at the human MAO-A gene. Proceedings of the National Academy of Sciences of the United States of America, 99(2), 862-7. PMID: 11805333  

Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, & Mann JJ. (2004) An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 29(8), 1498-505. PMID: 15150530  

Koen L, Kinnear C, Corfield V, Emsley R, Jordaan E, Keyter N, Moolman-Smook J, Stein D, & Niehaus D. (2004) Violence in male patients with schizophrenia: risk markers in a South African population. Australian and New Zealand Journal of Psychiatry, 38(4), 254-259. DOI: 10.1111/j.1440-1614.2004.01338.x  

Kunugi H, Ishida S, Kato T, Tatsumi M, Sakai T, Hattori M, Hirose T, & Nanko S. (1999) A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Molecular psychiatry, 4(4), 393-5. PMID: 10483059  

Lei H, Zhang X, Di X, Rao H, Ming Q, Zhang J, Guo X, Jiang Y, Gao Y, Yi J.... (2014) A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed research international, 243280. PMID: 24971323  

Philibert RA, Gunter TD, Beach SR, Brody GH, & Madan A. (2008) MAOA methylation is associated with nicotine and alcohol dependence in women. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B(5), 565-70. PMID: 18454435  

Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M.... (2003) Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28(3), 533-41. PMID: 12629534  

Wong CC, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, & Mill J. (2010) A longitudinal study of epigenetic variation in twins. Epigenetics : official journal of the DNA Methylation Society, 5(6), 516-26. PMID: 20505345  

Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, & Yang CW. (2005) Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 30(9), 1719-23. PMID: 15956990  

  • August 3, 2014
  • 02:37 PM
  • 152 views

Is Fat making you… Fat?

by Gabriel in Lunatic Laboratories

Fast food, let’s face it, it’s not the best for you. Yet Mcdonalds and Pizza hut are known practically world wide [although menu options differ]. With the rise of our […]... Read more »

  • August 3, 2014
  • 11:34 AM
  • 129 views

Ignoring the dangers: fracking development outpacing knowledge of biotic impact

by Jonathan Trinastic in Goodnight Earth

New collaborative research across several institutions indicate a complete lack of knowledge about how fracking spills, accidents, and water contamination affect nearby biospheres.... Read more »

Souther, S., Tingley, M., Popescu, V., Hayman, D., Ryan, M., Graves, T., Hartl, B., & Terrell, K. (2014) Biotic impacts of energy development from shale: research priorities and knowledge gaps. Frontiers in Ecology and the Environment, 12(6), 330-338. DOI: 10.1890/130324  

  • August 3, 2014
  • 09:52 AM
  • 124 views

New Insight Into Hot Carriers May Help Make Better Solar Cells

by dailyfusion in The Daily Fusion

Scientists at the Lawrence Berkeley National Laboratory have developed a method to study the properties of “hot carriers” in semiconductors. This method could hold the key to the design and development of new, more efficient solar cells.... Read more »

  • August 2, 2014
  • 04:51 PM
  • 153 views

Parental Age and the Rise of Autism Spectrum Disorder

by Alexis Delanoir in How to Paint Your Panda

It has been documented that there has been a rise in Autism Spectrum Disorder (ASD) in the United States, and that a large cause of this is due to redefinition of the disorder in the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-V) and an increased familiarization among psychiatrists and psychologists; but there is an unexplained portion of the increase. Studies have shown that parental age, namely maternal age can confer a higher risk for ASD. With the rise of paren........ Read more »

  • August 2, 2014
  • 01:53 PM
  • 169 views

At risk for Cancer? Try Spicy Food!

by Gabriel in Lunatic Laboratories

Like spicy food? Well next time you eat some you should hug that chili pepper, because he might just save your life. This is an interesting find, researchers have found that […]... Read more »

de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J.... (2014) Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. The Journal of clinical investigation. PMID: 25083990  

  • August 2, 2014
  • 09:44 AM
  • 131 views

Metamorphic petrology: under pressure and getting stressed?

by Metageologist in Metageologist

High pressure (HP) terranes are areas containing eclogites and other eclogite-facies rocks found within many mountains belts, including the Himalaya and the Alps. HP rocks were metamorphosed at extreme pressures, up to 3 or even 4 billion Pascals (or GPa. Atmospheric … Continue reading →... Read more »

  • August 1, 2014
  • 02:37 PM
  • 59 views

UCSF Scientist Discovers Key to Immune System Aging

by beredim in Stem Cells Freak

Emmanuelle Passegué, PhDThere's a good reason people over the age of sixty are not donor candidates for bone marrow transplantation. The immune system ages and weakens with time, making the elderly prone to life-threatening infection and other maladies, and a UC San Francisco research team now has discovered a reason why."We have found the cellular mechanism responsible for the inability of blood-forming cells to maintain blood production over time in an old organism, and have identifi........ Read more »

Flach, J., Bakker, S., Mohrin, M., Conroy, P., Pietras, E., Reynaud, D., Alvarez, S., Diolaiti, M., Ugarte, F., Forsberg, E.... (2014) Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. DOI: 10.1038/nature13619  

  • August 1, 2014
  • 01:12 PM
  • 163 views

Possible treatment and Prevention for Parkinson’s

by Gabriel in Lunatic Laboratories

Parkinson’s disease affects neurons in a particular brain region, when it develops brain cells have their mitochondrial activity cease and then the cells die. But now researchers have shown that supplying D-lactate […]... Read more »

  • August 1, 2014
  • 09:35 AM
  • 22 views

Fly Life: Why fruit flies are a good model organism for research

by Bethany Christmann in Fly on the Wall

What makes Drosophila melanogaster (fruit flies) a good model organism for research? A general overview of fruit flies and some important papers demonstrating their relevance to human health.... Read more »

Valente EM, Salvi S, Ialongo T, Marongiu R, Elia AE, Caputo V, Romito L, Albanese A, Dallapiccola B, & Bentivoglio AR. (2004) PINK1 mutations are associated with sporadic early-onset parkinsonism. Annals of neurology, 56(3), 336-41. PMID: 15349860  

Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF.... (2000) The genome sequence of Drosophila melanogaster. Science (New York, N.Y.), 287(5461), 2185-95. PMID: 10731132  

Lloyd TE, & Taylor JP. (2010) Flightless flies: Drosophila models of neuromuscular disease. Annals of the New York Academy of Sciences. PMID: 20329357  

  • August 1, 2014
  • 08:00 AM
  • 170 views

The Friday Five for 8/1/2014

by Bill Sullivan in The 'Scope

Five of the coolest science news stories of the week! Friends & DNA, Alzheimer’s, a satanic gecko, fist bumps, and political brains... Read more »

Christakis, N., & Fowler, J. (2014) Friendship and natural selection. Proceedings of the National Academy of Sciences, 111(Supplement_3), 10796-10801. DOI: 10.1073/pnas.1400825111  

  • August 1, 2014
  • 07:18 AM
  • 204 views

THE HETEROGENEITY OF CANCER AND DNA AS A PROGNOSTIC MARKER: THE TRUTH IS IN OUR BLOOD

by Amy Swanston in Antisense Science

Tumours are incredibly heterogeneic- that is that they have different properties including morphology (how they look), metabolism (the processes they use to generate energy), proliferation (how fast they grow, divide and replicate themselves) and potential to metastasise (where a tumour moves to another part of the body). But why is this so?

Many people are under the assumption that a cancer will arise from a single mutation in the DNA, but this is not actually the case. For a cancer to dev........ Read more »

Lo, Y., Corbetta, N., Chamberlain, P., Rai, V., Sargent, I., Redman, C., & Wainscoat, J. (1997) Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485-487. DOI: 10.1016/S0140-6736(97)02174-0  

De Mattos-Arruda L, Weigelt B, Cortes J, Won HH, Ng CK, Nuciforo P, Bidard FC, Aura C, Saura C, Peg V.... (2014) Capturing Intra-Tumor Genetic Heterogeneity by De Novo Mutation Profiling of Circulating Cell-Free Tumor DNA: A Proof-of-Principle. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. PMID: 25009010  

Pantel K, & Alix-Panabières C. (2013) Real-time liquid biopsy in cancer patients: fact or fiction?. Cancer research, 73(21), 6384-8. PMID: 24145355  

  • August 1, 2014
  • 06:51 AM
  • 222 views

Catalyst Promises Commercially Viable Hydrogen Production

by dailyfusion in The Daily Fusion

Rutgers researchers have developed a new catalyst for commercially viable hydrogen production. It is based on carbon nanotubes and performs almost as well as cost-prohibitive platinum-based catalysts.... Read more »

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