Research in the last decade has identified some of the main effects of exercise on the brain and has started to unravel the molecular mechanisms by which the physiological changes triggered by exercise modify the activity of neurons in the brain.... Read more »
Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, & Spiegelman BM. (2013) Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Cell metabolism, 18(5), 649-59. PMID: 24120943
Mattson MP. (2012) Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell metabolism, 16(6), 706-22. PMID: 23168220
Cotman CW, Berchtold NC, & Christie LA. (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends in neurosciences, 30(9), 464-72. PMID: 17765329
An enormous new species of predatory dinosaur has been discovered in the fossil beds of southeastern Utah, a giant carnivore that was the apex predator of its day — even giving tyrannosaurs a run for their money. ... Read more »
Lindsay Zanno, & Peter Makovicky. (2013) Neovenatorid theropods are apex predators in the Late Cretaceous of North America. Nature Communications. DOI: 10.1038/ncomms3827
The aim of the study was to provide evidence for the direct regulatory role of G6P on glycogen synthesis through the phosphorylation-mediated induction of GYS2 activity in the liver. The authors generated liver-specific glycogen synthase (GYS2) mutants containing Ala substitutions in the glucose-6-phosphate (G6P) phosphorylation regions. Compared to the wild type GYS2, targeted mutagenesis yielded several mutants which were insensitive to the phosphorylation-mediated activation of G6P. Specifi........ Read more »
von Wilamowitz-Moellendorff A., Hunter R. W., Garcia-Rocha M., Kang L., Lopez-Soldado I., Lantier L., Patel K., Peggie M. W., Martinez-Pons C., & Voss M. (2013) Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. Diabetes, 62(12), 4070-4082. DOI: 10.2337/db13-0880
Athletic trainers in different settings may adopt different strategies to assess and manage concussions. Athletic trainers must continue to increase their use of both objective concussion assessment tools and the standard clinical examination to ensure the proper diagnosis and management of concussion.... Read more »
Lynall R, Laudner KG, Mihalik JP, & Stanek JM. (2013) Concussion-Assessment and -Management Techniques Used by Athletic Trainers. Journal of athletic training. PMID: 24143906
Another look at the performance claims by the Airia One running shoe; a theoretical context... Read more »
Bojsen-Møller F. (1979) Calcaneocuboid joint and stability of the longitudinal arch of the foot at high and low gear push off. Journal of anatomy, 129(Pt 1), 165-76. PMID: 511760
Resistance training triggers a hormonal response. If it didn’t your body would not respond by increasing muscle mass, strengthening tendons and reinforcing bones. The hormonal changes that occur following trainingThe post Womens Resistance Training. Is it the same as it is for men? Hormonally speaking? appeared first on WODMasters.... Read more »
Niemann I, Hannemann A, Nauck M, Spielhagen C, Völzke H, Wallaschofski H, & Friedrich N. (2013) The association between insulin-like growth factor I and bone turnover markers in the general adult population. Bone, 56(1), 184-90. PMID: 23792936
Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, & Yakar S. (2013) Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age (Dordrecht, Netherlands), 35(5), 1691-703. PMID: 22976122
What do we know about Class II orthodontic treatment? A new Cochrane Systematic Review This week on the Blog I am joined by Badri Thiruvenkatachari, who has worked with me for several years, and was the lead author on our updated Cochrane Systematic Review, on the treatment of Class II malocclusion, published last week. This […]The post What do we know about Class II orthodontic treatment ? A new Cochrane Systematic Review appeared first on Kevin O'Brien's Orthodontic Blog.... Read more »
Thiruvenkatachari B, Harrison JE, Worthington HV, O'Brien KD. (2013) Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children. Cochrane Database of Systematic Reviews . info:other/CD003452.
Researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have created a new lithium-sulfur battery prototype that outperforms other lithium-sulfur cells by more than two times in terms of energy capacity.... Read more »
Song M.K., Zhang Y., & Cairns E.J. (2013) A Long-Life, High-Rate Lithium/Sulfur Cell: A Multifaceted Approach to Enhancing Cell Performance. Nano Letters. PMID: 24219588
If you want me to prepare a list of top five healthiest diets based on the clinical study results, no doubt I must include the traditional Mediterranean diet. It's a diet worth chasing; this particular diet is not just a simple diet plan but a lifestyle choice, a path to a healthier and longer life. .......... Read more »
Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, Stampfer M, & Grodstein F. (2013) The association between dietary patterns at midlife and health in aging: an observational study. Annals of internal medicine, 159(9), 584-91. PMID: 24189593
Tsivgoulis G, Judd S, Letter AJ, Alexandrov AV, Howard G, Nahab F, Unverzagt FW, Moy C, Howard VJ, Kissela B.... (2013) Adherence to a Mediterranean diet and risk of incident cognitive impairment. Neurology, 80(18), 1684-92. PMID: 23628929
Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J.... (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. The New England journal of medicine, 368(14), 1279-90. PMID: 23432189
Underwater “tree rings” show 650 years of sea ice change
Calcite crusts of arctic algae help reconstruct climate and improve modelling of climate change to come…
___ Lanna Crucefix | November 19, 2013 | Original online publication University of Toronto Mississauga
Arctic sea-ice decline archived by multicentury annual-resolution record from crustose coralline algal proxy
Northern Hemisphere sea ice has been declining sharply over th........ Read more »
Halfar J, Adey WH, Kronz A, Hetzinger S, Edinger E, & Fitzhugh WW. (2013) Arctic sea-ice decline archived by multicentury annual-resolution record from crustose coralline algal proxy. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24248344
A new study published in top biomedical journal PNAS (Proceedings of the National Academy of Science) this week by scientists at the University of Toronto’s Institute of Biomaterials & Biomedical Engineering (IBBME) and the McEwen Centre for Regenerative Medicine has identified the optimal structure and cell ratio associated with proper heart function. Furthermore, the discovery has already led the team to another research first: the engineering of the first-ever living, three-dimensional ........ Read more »
Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K.... (2013) Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24255110
by amikulak in Daily Observations
We are continuously flooded with sensory information from our physical environment – the sights, sounds, smells, feel of everything around us. We’re flooded with so much information, in fact, that […]... Read more »
Gayet, S., Paffen, C.L.E., & Van der Stigchel, S. (2013) Information Matching the Content of Visual Working Memory Is Prioritized for Conscious Access. Psychological Science. DOI: 10.1177/0956797613495882
Plant transformation is insertion of new genetic material to the plant’s body. This used to be difficult because many economically important plants are recalcitrant to it as they lack certain gene elements. But according to a recent report published in Science, researchers now have successfully transformed a model plant, Arabidopsis, through agrobacterium-mediated transformation process.... Read more »
Sardesai N, Lee LY, Chen H, Yi H, Olbricht GR, Stirnberg A, Jeffries J, Xiong K, Doerge RW, & Gelvin SB. (2013) Cytokinins Secreted by Agrobacterium Promote Transformation by Repressing a Plant Myb Transcription Factor. Science signaling, 6(302). PMID: 24255177
Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) Patient Module printed circuit board & sterilizable case. (Fig. 1, Kimble et al. 2009). Last month, the New York Times reported that the Defense Advanced Research Projects Agency (DARPA) will spend $70 million to further the development of technologies that use deep brain stimulation (DBS), which has been highly successful in treating Parkinson's Disease (PD). The SUBNETS program (Systems-Based Neurotechnology........ Read more »
Chang SY, Kimble CJ, Kim I, Paek SB, Kressin KR, Boesche JB, Whitlock SV, Eaker DR, Kasasbeh A, Horne AE.... (2013) Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback system for deep brain stimulation. Journal of Neurosurgery. PMID: 24116724
Kimble CJ, Johnson DM, Winter BA, Whitlock SV, Kressin KR, Horne AE, Robinson JC, Bledsoe JM, Tye SJ, Chang SY.... (2009) Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society., 4856-9. PMID: 19963865
A bicep tenodesis has minimal influence on passive shoulder instability.... Read more »
Strauss EJ, Salata MJ, Sershon RA, Garbis N, Provencher MT, Wang VM, McGill KC, Bush-Joseph CA, Nicholson GP, Cole BJ.... (2013) Role of the superior labrum after biceps tenodesis in glenohumeral stability. Journal of Shoulder and Elbow Surgery. PMID: 24090980
Scientists have found that asteroid and comet impact craters must be our priorities in finding the evidences of life on other planets.
In the present study, scientists have found complex organic material enclosed in glassy ejecta, produced during a meteor impact in western Tasmania about 800,000 years ago. The impact crated the 1.2-kilometre wide Darwin Crater, near Queenstown, Tasmania.
"When large meteors strike ........ Read more »
NASA’s astronomers have finally found the evidence of jet of high-energy particles coming out from Sagittarius A* (Sgr A*).
The Astrophysical Journal
Sagittarius A* (Sgr A*):
Sgr A* is the supermassive black hole at the center of the Milky Way. It is about 4 million times more massive than our Sun and is present about 26,000 light years away from us.
Jets of high-energy particles:
These jets are usually produced by young star........ Read more »
Zhiyuan Li, Mark R. Morris, & Frederick K. Baganoff. (2013) Evidence for A Parsec-scale Jet from The Galactic Center Black Hole: Interaction with Local Gas. arXiv. arXiv: 1310.0146v1
When is the right time to begin TH (Therapeutic Hypothermia) to produce the best outcomes?
In the ICU (Intensive Care Unit)?
In the ED (Emergency Department)?
In the ambulance?
While the patient is still pulseless?
This question was asked in 2010.... Read more »
Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, Kelly AM, Silvester W, & Rapid Infusion of Cold Hartmanns (RICH) Investigators. (2010) Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: a randomized controlled trial. Circulation, 122(7), 737-42. PMID: 20679551
The BBC headline 'Study links synaesthesia to autism' recently caught my eye (and nose!) discussing the paper by Baron-Cohen and colleagues* (open-access) who suggested that: "The rate of synaesthesia in adults with autism was 18.9% (31 out of 164), almost three times greater than in controls".Colour and sensation @ Wikipedia Synaesthesia according to the UK Synaesthesia Association is best described as a "union of the senses" whereby "two or more of the five senses that are norma........ Read more »
“If you keep running like that, you’ll ruin your knees by the time you’re 40!” If you’re a runner, chances are you’ve heard such cautionary advice one too many times. For the 42% of runners who suffer from knee injuries each year 1, chronic, and potentially debilitating knee pain may be a legitimate concern. For … Continue reading »... Read more »
Kulmala JP, Avela J, Pasanen K, & Parkkari J. (2013) Forefoot strikers exhibit lower running-induced knee loading than rearfoot strikers. Medicine and science in sports and exercise, 23-28. PMID: 23748735
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