Post List

  • August 13, 2014
  • 07:02 AM
  • 70 views

“I see my patients as less than fully human”

by Doug Keene in The Jury Room

Here’s an intriguing article on how some nurses cope with stress. If you think, based on the title of this post, they do it by dehumanizing their patients, you would be correct. Somehow we think this is not a good thing to admit on the witness stand, but it is an understandable and human reaction […]

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... Read more »

Trifiletti, E, Di Bernardo, GA, Falvo, R, & Capozza, D. (2014) Patients are not fully human: a nurse’s coping response to stress. . Journal of Applied Social Psychology. . info:/

  • August 13, 2014
  • 04:49 AM
  • 44 views

The stability of your personality peaks in mid-life (then grows increasingly wobbly again)

by BPS Research Digest in BPS Research Digest

As we continue to settle into ourselves, you might think that personality would be something that becomes ever more cemented through life.  Not so, according to a survey of nearly 4000 New Zealanders aged from 20 to 80 years (including 2409 women). Petar Milojev and Chris Sibley report that the stability of personality increases through youth, peaks in mid-life and then gradually reduces again into old age, presumably in response to the variations in social and biological pressures we exper........ Read more »

  • August 13, 2014
  • 04:11 AM
  • 88 views

Neonatal intensive care unit (NICU) survivors and greater risk of autism?

by Paul Whiteley in Questioning Answers

"In term NICU [neonatal intensive care unit] survivors, ASD [autism spectrum disorder] occurs with a greater frequency than in the general population and often develops alongside comorbid conditions". That was the conclusion from the study by Alexander Winkler-Schwartz and colleagues [1] looking at term at-risk infants who survived NICU."You were only meant to blow the bloody doors off"'Surviving' their earliest days spent in NICU brings a bit of lump to my throat. As a paren........ Read more »

  • August 13, 2014
  • 12:05 AM
  • 70 views

Make Sure You Charge That Phone Before Measuring Anterior Tibial Translation

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

A mobile phone arthrometer application may be a reliable alternative to the KT-1000 when measuring anterior tibial translation following an anterior cruciate ligament injury.... Read more »

Andrea, F., Luigi, V., Daniele, M., Luca, M., Paolo, I., Giovanni, G., Fabio, C., & Raffaele, I. (2014) Smartphone versus knee ligament arthrometer when size does not matter. International Orthopaedics. DOI: 10.1007/s00264-014-2432-9  

  • August 12, 2014
  • 08:12 PM
  • 100 views

3 Ways to Improve Your Cultural Intelligence

by Louise Rasmussen in Head Smart

Picture this – you’re introduced to the CEO of a French start-up that your company is in the process of acquiring. The CEO grabs your hand and leans in for some repeated lip action on your cheeks. His breath has a hint of garlic and something else you can’t identify. His grip on your hand […]
This article, 3 Ways to Improve Your Cultural Intelligence, first appeared on Global Cognition.
... Read more »

Earley PC, & Mosakowski E. (2004) Cultural intelligence. Harvard business review, 82(10), 139-146. PMID: 15559582  

  • August 12, 2014
  • 05:15 PM
  • 89 views

Coxsackievirus B3: autophagy, p62, ER stress, and apoptosis

by thelonevirologist in Virology Tidbits

The induction of autophagy by cells infected with viruses can play an important strategy to prevent viral replication - or alternatively, can be subverted by viral proteins to allow the formation of viral particles as it is the case for many positive strand RNA viruses and discussed previously for Corona- and Arteriviruses. Enteroviruses are no different, and indeed the modulation of autophagy by Poliovirus has been studied extensively. Recent data suggest that the viral proteases cleave the cel........ Read more »

Wong J, Zhang J, Si X, Gao G, Mao I, McManus BM, & Luo H. (2008) Autophagosome supports coxsackievirus B3 replication in host cells. Journal of virology, 82(18), 9143-53. PMID: 18596087  

Robinson SM, Tsueng G, Sin J, Mangale V, Rahawi S, McIntyre LL, Williams W, Kha N, Cruz C, Hancock BM.... (2014) Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers. PLoS pathogens, 10(4). PMID: 24722773  

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, & Johansen T. (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. The Journal of biological chemistry, 282(33), 24131-45. PMID: 17580304  

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P.... (2009) A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Molecular cell, 33(4), 505-16. PMID: 19250911  

Moscat J, Diaz-Meco MT, Albert A, & Campuzano S. (2006) Cell signaling and function organized by PB1 domain interactions. Molecular cell, 23(5), 631-40. PMID: 16949360  

Saura, M., Lizarbe, T., Rama-Pacheco, C., Lowenstein, C., & Zaragoza, C. (2007) Inhibitor of NFκB Alpha is a Host Sensor of Coxsackievirus Infection. Cell Cycle, 6(5), 503-506. DOI: 10.4161/cc.6.5.3918  

Durán A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP, Moscat J, & Diaz-Meco MT. (2004) The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Developmental cell, 6(2), 303-9. PMID: 14960283  

Komatsu M, Kageyama S, & Ichimura Y. (2012) p62/SQSTM1/A170: physiology and pathology. Pharmacological research : the official journal of the Italian Pharmacological Society, 66(6), 457-62. PMID: 22841931  

Amitava Mukherjee,, Stefanie A. Morosky,, Elizabeth Delorme-Axford,, Naomi Dybdahl-Sissoko,, M. Steven Oberste,, Tianyi Wang,, & Carolyn B. Coyne. (2011) The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling. PLOS pathogens. info:/

Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, & Diaz-Meco MT. (2011) p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell, 44(1), 134-46. PMID: 21981924  

Xi X, Zhang X, Wang B, Wang T, Wang J, Huang H, Wang J, Jin Q, & Zhao Z. (2013) The interplays between autophagy and apoptosis induced by enterovirus 71. PloS one, 8(2). PMID: 23437282  

  • August 12, 2014
  • 03:18 PM
  • 91 views

Responsibility of demand: air travel projected to create net increase in greenhouse gas emissions

by Jonathan Trinastic in Goodnight Earth

A literature review has revealed that our demand for air travel will lead to a net increase in greenhouse gas emissions despite improvements in energy efficiency. The authors predict behavior change and less flights to be the only way to reduce emissions.... Read more »

Matt Grote, Ian Williams, John Preston. (2014) Direct carbon dioxide emissions from civil aircraft. Atmospheric Environment. info:/

  • August 12, 2014
  • 02:07 PM
  • 103 views

Treatment and Prevention of PTSD

by Gabriel in Lunatic Laboratories

It’s no secret for anyone who follows me that I am a Marine veteran. It’s also no secret for anyone who follows me that I’ve had my own ups and downs in life because of my experiences. PTSD is a nightmare, one that you can’t quite shake no matter how hard you try. Then again, not everyone reacts the same way to the trauma that typically causes PTSD, not everyone walks away from war with it. The big question that scientists set out to answer was, why? And now they might just have an answe........ Read more »

Nikolaos P. Daskalakis, Hagit Cohen, Guiqing Caia, Joseph D. Buxbaum, & Rachel Yehuda. (2014) Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proceedings of the National Academy of Sciences of the United States of America, 111(32). info:/10.1073/pnas.1401660111

  • August 12, 2014
  • 10:47 AM
  • 87 views

Even Kindergarteners Can Rate Their Own Confidence

by Elizabeth Preston in Inkfish

Do you remember on Who Wants to Be a Millionaire—apparently this show is still on, but I’ll assume no one else has seen it this decade—how after contestants picked an answer, Regis Philbin sometimes asked, “How sure are you?” They’d pull a number seemingly out of the air: “Oh, eighty-five percent.” This trick of estimating our […]The post Even Kindergarteners Can Rate Their Own Confidence appeared first on Inkfish.... Read more »

  • August 12, 2014
  • 08:59 AM
  • 90 views

Why are the elderly invisible in archaeological contexts?

by Katy Meyers in Bones Don't Lie

For the past two months, I have been busy preparing my dissertation data for analysis. This means that I am taking the paper versions of my data from books, monographs, […]... Read more »

C. Cave, & M. Oxenham. (2014) Identification of the Archaeological ‘Invisible Elderly’: An Approach Illustrated with an Anglo-Saxon Example. International Journal of Osteoarchaeology. info:/

  • August 12, 2014
  • 04:45 AM
  • 110 views

Remembering and imagining both engage the same key brain region, but they depend on distinct neural processes

by BPS Research Digest in BPS Research Digest

credit: Gray's Anatomy/WikipediaRemembering and imagining appear to be very different functions, one recovering true information from the past, the other considering the unreal or exploring the future. And yet many patients with damage to the hippocampus (a structure in the temporal lobes) - and resultant memory impairment - struggle in imagining the future. Moreover, neuroimaging data show the hippocampus is involved in both tasks. Taken together, this evidence suggests that memory for the past........ Read more »

  • August 12, 2014
  • 04:04 AM
  • 82 views

Neonatal jaundice and increased risk of ADHD

by Paul Whiteley in Questioning Answers

The findings from Chang-Ching Wei and colleagues [1] suggesting an over-representation of the diagnosis of attention-deficit hyperactivity disorder (ADHD) following a history of neonatal jaundice provides fodder for today's brief post. Based in Taiwan, one of the most impressive countries when it comes to the use and analysis of 'big data' (see here), researchers were able to identify some 25,000 participants diagnosed with neonatal jaundice and compare them with almost 70,000 non-jaundiced........ Read more »

  • August 11, 2014
  • 01:30 PM
  • 152 views

New Hope for Autoimmune Diseases

by Gabriel in Lunatic Laboratories

Autoimmune diseases are on the rise. Since I have a history of over sharing, my Uncle suffered from a form of lupus. It caused him intense and — in my opinion — unbearable pain although he shouldered it like the incredible man he was and never complained. My sister unfortunately is suffering from a rare disease that has yet to be diagnosed, which in my opinion has autoimmune dysfunction as the root cause. If you or anyone you know suffers in a similar fashion then you know that the treatment........ Read more »

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK.... (2014) Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 24891519  

  • August 11, 2014
  • 12:00 PM
  • 46 views

IT’S NEVER LUPUS? THINK AGAIN…

by Robb Hollis in Antisense Science

Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?
... Read more »

  • August 11, 2014
  • 11:42 AM
  • 105 views

Clinical Drug Trials for Pathological Gambling

by William Yates, M.D. in Brain Posts

Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269  

  • August 11, 2014
  • 11:05 AM
  • 103 views

Earth’s energy imbalance

by Ed Hawkins in Climate Lab Book

Global surface air temperatures have risen less rapidly over the past 15 years than the previous few decades. The causes of this ‘hiatus’ have been much debated. However, just considering surface temperatures does not tell the whole story – a … Continue reading →... Read more »

Allan, R., Liu, C., Loeb, N., Palmer, M., Roberts, M., Smith, D., & Vidale, P. (2014) Changes in global net radiative imbalance 1985-2012. Geophysical Research Letters. DOI: 10.1002/2014GL060962  

  • August 11, 2014
  • 10:42 AM
  • 102 views

Attraction in the World of Bats

by Denise O'Meara in Denise O'Meara

We spend much of our lives attempting to figure out the opposite sex in the hopes that it will lead to increased opportunities to attract a mate. But even when in a relationship, looking back to see how it all kicked off can still leave you scratching your head for answers. Understanding attraction and the rules (or lack of them) that govern it are complicated, but there is no shortage of purported help out there to be found in books, cinema and online. Midst the cloud of confusion, we sometime........ Read more »

  • August 11, 2014
  • 09:38 AM
  • 105 views

Lithium For Aging Brain

by Vivek Misra in The UberBrain

Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment inc........ Read more »

Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, & Manji HK. (2000) Enhancement of hippocampal neurogenesis by lithium. Journal of neurochemistry, 75(4), 1729-34. PMID: 10987856  

O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, & Klein PS. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(30), 6791-8. PMID: 15282284  

Berggren U, Tallstedt L, Ahlenius S, & Engel J. (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology, 59(1), 41-5. PMID: 100811  

Agam G, Bersudsky Y, Berry GT, Moechars D, Lavi-Avnon Y, & Belmaker RH. (2009) Knockout mice in understanding the mechanism of action of lithium. Biochemical Society transactions, 37(Pt 5), 1121-5. PMID: 19754464  

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS.... (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature, 507(7493), 448-54. PMID: 24670762  

  • August 11, 2014
  • 08:00 AM
  • 114 views

Weather Vs. Climate In Global Warming

by Mark E. Lasbury in The 'Scope

Last winter was horrible, and this summer has been mild – so global warming must not be real. This is the thought process for many people, but it points out the confusion between climate and weather. Climate is the average weather for a place over a given period, while weather is what you get day to day. New research is showing that climate change is causing more intense hurricanes - but is the number changing? Recent studies land on both sides of the issue.... Read more »

  • August 11, 2014
  • 07:14 AM
  • 87 views

A Wrinkly Purpose

by Bernadeta Dadonaite in The Question Gene

On what makes our fingers wrinkle in water... Read more »

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