Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). These epigenetic modifications like DNA methylation are known to frequently affect gene regulation involved in cancer-related processes. Since epigenetic alterations are reversible in nature, these changes have emerged as attractive ta........ Read more »
Tomar T, de Jong S, Alkema NG, Hoekman RL, Meersma GJ, Klip HG, van der Zee AG, & Wisman GB. (2016) Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways. Genome medicine, 8(1), 107. PMID: 27765068
Alkema NG, Wisman GB, van der Zee AG, van Vugt MA, & de Jong S. (2016) Studying platinum sensitivity and resistance in high-grade serous ovarian cancer: Different models for different questions. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 55-69. PMID: 26830315
Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM.... (2014) Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer discovery, 4(9), 998-1013. PMID: 25185190
Alkema NG, Tomar T, Duiker EW, Jan Meersma G, Klip H, van der Zee AG, Wisman GB, & de Jong S. (2015) Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods. Scientific reports, 14495. PMID: 26440065
The findings reported by Maureen Russell and colleagues  provide some blogging fodder today and the observation that: "Biological caregivers of children with ASD [autism spectrum disorder] demonstrated a high prevalence of RLS [Restless Legs Syndrome] symptoms and poorer mental health."OK, I know some people might be asking 'just what is Restless Legs Syndrome'? It is a recognised condition complete with 'disease' title (Willis-Ekbom disease). Symptoms, as the name suggests, centre ........ Read more »
Russell M, Baldwin C, McClain D, Matthews N, Smith C, & Quan SF. (2016) Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. PMID: 27855729
From bacteria to vertebrates, life — as we know it today — relies on complex molecular interactions, the intricacies of which science has not fully untangled. But for all its complexity, life always requires two essential abilities. Organisms need to preserve their genetic information and reproduce. In our own cells, these tasks are assigned to […]... Read more »
Yeates JA, Hilbe C, Zwick M, Nowak MA, & Lehman N. (2016) Dynamics of prebiotic RNA reproduction illuminated by chemical game theory. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5030-5. PMID: 27091972
The financial and ethical implications that emerge from open access publishing through article processing fees in India are analyzed in a study that proposes the creation of a national open access journal platform such as SciELO in order to reduce costs, increase efficiency and facilitate the sharing of metadata among repositories. … Read More →... Read more »
Morrison, H., Salhab, J., Calvé-Genest, A., & Horava, T. (2015) Open Access Article Processing Charges: DOAJ Survey May 2014. Publications, 3(1), 1-16. DOI: 10.3390/publications3010001
Wang, L., Liu, X., & Fang, H. (2015) Investigation of the degree to which articles supported by research grants are published in open access health and life sciences journals. Scientometrics, 104(2), 511-528. DOI: 10.1007/s11192-015-1624-4
William James authored a seminal book titled The Varieties of Religious Experience: A Study in Human Nature that was published in 1902.In this work, James reviewed the nature of religious experiences and noted a lack of scientific inquiry into this human phenomenon.James would have been extremely interested in a recent scientific inquiry into the religious experience from brain researchers at the University of Utah and Harvard University.In this study, functional magnetic resonance imaging (fMRI........ Read more »
Ferguson MA, Nielsen JA, King JB, Dai L, Giangrasso DM, Holman R, Korenberg JR, & Anderson JS. (2016) Reward, Salience, and Attentional Networks are Activated by Religious Experience in Devout Mormons. Social neuroscience. PMID: 27834117
Intermittency is a disruptive characteristic of a process, which can be associated, in many cases, with a sudden energy release. Intermittency is a key characteristic of flares that should become evident in the flux time evolution at many different wavelengths. We investigate the similarities and differences of the intermittency during [...]... Read more »
Giménez de Castro, G., Simões, P., Raulin, J., & Guimarães, O. (2016) Analysis of Intermittency in Submillimeter Radio and Hard X-Ray Data During the Impulsive Phase of a Solar Flare. Solar Physics, 291(7), 2003-2016. DOI: 10.1007/s11207-016-0949-3
The title of the paper by Konstantin Mechler and colleagues - "Defining the hidden evidence in autism research. Forty per cent of rigorously designed clinical trials remain unpublished - a cross-sectional analysis"  - provides some discussion today. Drawing on the ideas that publication bias and/or the so-called 'file-drawer problem' - terms that refer to the non-publication of study results potentially skewing the collected scientific opinion in a particular area - might also exten........ Read more »
Mechler K, Hoffmann GF, Dittmann RW, & Ries M. (2016) Defining the hidden evidence in autism research. Forty per cent of rigorously designed clinical trials remain unpublished - a cross-sectional analysis. International journal of methods in psychiatric research. PMID: 27862603
Increased hip adduction during stance phase of Trendelenburg gait contributes to excessive knee joint loading.... Read more »
Dunphy, C., Casey, S., Lomond, A., & Rutherford, D. (2016) Contralateral pelvic drop during gait increases knee adduction moments of asymptomatic individuals. Human Movement Science, 27-35. DOI: 10.1016/j.humov.2016.05.008
Researchers recently announced the discovery of a frog whose groin flashes orange to scare away predators! The species was discovered in Australia.
When biologist Simon Clulow spotted a frog with an unusual marble pattern on its belly, he knew it could be a new species. If that turned to be true, it would be very surprising as the sighting took place on land close to an airport and not some ... Read more »
CLULOW, S., ANSTIS, M., KEOGH, J., & CATULLO, R. (2016) A new species of Australian frog (Myobatrachidae: Uperoleia) from the New South Wales mid-north coast sandplains. Zootaxa, 4184(2), 285. DOI: 10.11646/zootaxa.4184.2.3
We’ve written about atheists here (and how unpopular they are in North America) a number of times. The first time was in 2010 when we wrote an article in The Jury Expert because we were so taken aback by the level of vitriol we’d seen in a blog post describing a new research article on […]
Everything you ever wanted to know about atheists (the 2016 update)
An update on disrupting suspicion of atheists
Everyone knows you just can’t trust an atheist!
... Read more »
Edgell, P., Hartmann, D., Stewart, E., & Gerteis, J. (2016) Atheists and Other Cultural Outsiders: Moral Boundaries and the Non-Religious in the United States. Social Forces, 95(2), 607-638. DOI: 10.1093/sf/sow063
Airline travel during the holidays is one big headache. But for some people, “airplane headache” is a truly painful experience. The headache occurs during take-off and landing, is unique to plane travel, and is not associated with other conditions. The pain is severe, with a jabbing or stabbing quality, and located on one side of the head (usually around the eye sockets or forehead).
... Read more »
Bui, S., Petersen, T., Poulsen, J., & Gazerani, P. (2016) Headaches attributed to airplane travel: a Danish survey. The Journal of Headache and Pain, 17(1). DOI: 10.1186/s10194-016-0628-7
Headache Classification Committee of the International Headache Society (IHS). (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 33(9), 629-808. DOI: 10.1177/0333102413485658
Sit-to-stand workstations is an effective strategy to decrease sedentary time and increase light activity time during working hours; however, during non-working hours more time was still spent sitting. ... Read more »
Mansoubi M, Pearson N, Biddle SJ, & Clemes SA. (2016) Using Sit-to-Stand Workstations in Offices: Is There a Compensation Effect?. Medicine and science in sports and exercise, 48(4), 720-5. PMID: 26496419
The paper by Nahit Motavalli Mukaddes and colleagues  provides some important, if small-scale, information when it comes to that still controversial term - optimal outcome - with the diagnosis of autism in mind. Optimal outcome basically refers to a particular 'type' of autism whereby following a definite diagnosis of autism or autism spectrum disorder (ASD), a later re-evaluation of signs and symptoms reveals that diagnostic thresholds are subsequently not reached and/or exceeded a........ Read more »
Motavalli Mukaddes, N., Mutluer, T., Ayik, B., & Umut, A. (2016) What Happens to Children Who Move off the Autism Spectrum? A Clinical Follow-Up Study. Pediatrics International. DOI: 10.1111/ped.13202
Note: the “Life in the Lab” series features interviews of interns and visitors. This post is by our second 2016 OMA Visiting Fellow Tunca Doğan, who spent a month with us earlier this year. You can follow Tunca on Twitter at @tuncadogan. —Christophe
Please introduce yourself in a few sentences.
My name is Tunca Doğan. I received my PhD in 2013 with a thesis study in the fields of bioinformatics and computational biology where we developed methods for the clustering........ Read more »
Doğan T, & Karaçalı B. (2013) Automatic identification of highly conserved family regions and relationships in genome wide datasets including remote protein sequences. PloS one, 8(9). PMID: 24069417
Doğan T, MacDougall A, Saidi R, Poggioli D, Bateman A, O'Donovan C, & Martin MJ. (2016) UniProt-DAAC: domain architecture alignment and classification, a new method for automatic functional annotation in UniProtKB. Bioinformatics (Oxford, England), 32(15), 2264-71. PMID: 27153729
The paper by Wenjie Sun and colleagues  (open-access) provides the blogging fodder for today's post and although based on the science of epigenetics, the usual suspect - DNA methylation - gives way to another concept: histone acetylation with autism in mind. Before heading into the paper myself, I'll draw your attention to some other write-ups of the study including a hat-tip to Jeff Craig and his piece on the topic (see here).So histone acetylation... I've covered the subject ........ Read more »
Sun, W., Poschmann, J., Cruz-Herrera del Rosario, R., Parikshak, N., Hajan, H., Kumar, V., Ramasamy, R., Belgard, T., Elanggovan, B., Wong, C.... (2016) Histone Acetylome-wide Association Study of Autism Spectrum Disorder. Cell, 167(5), 1385-2147483647. DOI: 10.1016/j.cell.2016.10.031
Last week I returned from the 6th annual IMO Workshop at the Moffitt Cancer Center in Tampa, Florida. As I’ve sketched in an earlier post, my team worked on understanding ruxolitinib resistance in chronic myelomonocytic leukemia (CMML). We developed a suite of integrated multi-scale models for uncovering how resistance arises in CMML with no apparent […]... Read more »
Merlevede, J., Droin, N., Qin, T., Meldi, K., Yoshida, K., Morabito, M., Chautard, E., Auboeuf, D., Fenaux, P., Braun, T.... (2016) Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents. Nature Communications, 10767. PMID: 26908133
In the forests of West Africa, bands of handsome primates called Diana monkeys roam the tree branches. Each group has just one male and several females with their babies. The tradeoff for his apparently cushy living situation is that the male has to chase off predators. His female companions use specific calls to tell him what kinds of threats are nearby. And he responds to whatever they tell him—even if it goes against his own judgment.
Diana monkeys (Cercopithecus diana) of both sex... Read more »
Stephan, C., & Zuberbühler, K. (2016) Persistent Females and Compliant Males Coordinate Alarm Calling in Diana Monkeys. Current Biology, 26(21), 2907-2912. DOI: 10.1016/j.cub.2016.08.033
Is forefoot varus related to patellofemoral osteoarthritis?... Read more »
Lufler RS, Stefanik JJ, Niu J, Sawyer FK, Hoagland TM, & Gross KD. (2016) The Association of Forefoot Varus Deformity with Patellofemoral Cartilage Damage in Older Adult Cadavers. Anatomical record (Hoboken, N.J. : 2007). PMID: 27884055
Birt–Hogg–Dubé syndrome (BHD) is caused by germline mutations in the FLCN gene and characterized by fibrofolliculomas, lung cysts, spontaneous pneumothorax and renal tumours. The stretch hypothesis for pulmonary cyst formation proposes that cysts in BHD arise from defects in cell–cell adhesion, leading to repeated respiration-induced physical stretch-induced stress and, over time, expansion of alveolar spaces particularly in vulnerable regions of lung (Kennedy et al., 20........ Read more »
Hoshika, Y., Takahashi, F., Togo, S., Hashimoto, M., Nara, T., Kobayashi, T., Nurwidya, F., Kataoka, H., Kurihara, M., Kobayashi, E.... (2016) Haploinsufficiency of the gene leads to impaired functions of lung fibroblasts in patients with Birt–Hogg–Dubé syndrome . Physiological Reports, 4(21). DOI: 10.14814/phy2.13025
by Piter Kehoma Boll A flatworm again, at last! Not a land planarian, but a flatworm nonetheless. If there is a group of flatworms that may put land planarians in second plan regarding beauty, those are the polyclads. Living in … Continue reading →... Read more »
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