Scientists have found the neutrinos that are far beyond the known energy of neutrinos expected to be produced in the Earth’s atmosphere.
Neutrinos are the elementary particles that are thought to be produced outside of our solar system. High-energy neutrinos have the ability to pass through normal matter and billions of them pass through Earth every second.
The IceCube neutrino observatory at the South Pole pre........ Read more »
IceCube Collaboration. (2013) Evidence for High-Energy Extraterrestrial Neutrinos at the IceCube Detector. Science. DOI: 10.1126/science.1242856
Healthy individuals appear to be more frequent carriers of the two parasites Blastocystis and Dientamoeba fragilis. We would like to know why and what the public health implications are of this.... Read more »
Krogsgaard LR, Engsbro AL, & Bytzer P. (2013) The epidemiology of irritable bowel syndrome in Denmark. A population-based survey in adults ≤50 years of age. Scandinavian journal of gastroenterology, 48(5), 523-9. PMID: 23506174
Just because girl talk between bees is wordless doesn't mean it lacks for intimate details. When sister honey bees gather around their queen, they can tell from her pheromones whether she's mated—and how much. What they learn may determine whether they let her live.The queen honey bee doesn't do much day-to-day ruling, but she does lay nearly every egg in the hive. Her daughters become worker bees, who keep the colony running. Pheromones that the queen and the workers emit—then spread throug........ Read more »
Niño EL, Malka O, Hefetz A, Tarpy DR, & Grozinger CM. (2013) Chemical Profiles of Two Pheromone Glands Are Differentially Regulated by Distinct Mating Factors in Honey Bee Queens (Apis mellifera L.). PloS one, 8(11). PMID: 24236028
Researchers at the University of Copenhagen have unveiled a profound biological process that explains how DNA can be damaged during genome replication. In addition, the scientists developed a new analytical tool to measure the cell’s response to chemotherapy, which could have an important impact on future cancer therapy. The results are now published in the scientific journal Cell.... Read more »
Luis Ignacio Toledo, Matthias Altmeyer, Maj-Britt Rask, Claudia Lukas, Dorthe Helena Larsen, Lou Klitgaard Povlsen, Simon Bekker-Jensen, Niels Mailand, Jiri Bartek, Jiri Lukas. (2013) ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA. Cell. DOI: 10.1016/j.cell.2013.10.043
Wheel invention: was it because of scarab beetles? Some evidence suggests that humans got inspired by scarab beetles in the use of wheel... Read more »
Scholtz G. (2008) Scrab beetles at the interface of wheel invention in nature and culture? . Contributions to Zoology. info:/
Brown adipose tissue (fat) in a woman shown in a PET/CT examObesity and diabetes have become a global epidemic leading to severe cardiovascular disease. Now, researchers at the University of Utah say that their recent identification of brown fat stem cells in adult humans may lead to new treatments for heart and endocrine disorders.The study was led by Amit N. Patel, M.D. M.S., director of Clinical Regenerative Medicine and Tissue Engineering and associate professor in the Division of Cardiothor........ Read more »
Francisco J Silva1, Dolly J Holt, Vanessa Vargas1, James Yockman, Sihem Boudina, Donald Atkinson, David W Grainger, Monica P Revelo, Warren Sherman, David A Bull1, Amit N Patel. (2013) Metabolically active human brown adipose tissue derived stem cells . STEM CELLS. DOI: 10.1002/stem.1595
Brain of a 4-year-old boy with Alexander disease showing macroencephaly and periventricular demyelinisationAlexander disease (also known as fibrinoid leukodystroph) is a devastating brain disease that very few have actually heard of.Alexander disease strikes young or old, and in children destroys white matter in the front of the brain. Many patients, especially those with early onset, have significant intellectual disabilities.Regardless of the age when it begins, Alexander disease is always fat........ Read more »
Tracy L. Hagemann, Richard Paylor, and Albee Messing. (2013) Deficits in Adult Neurogenesis, Contextual Fear Conditioning, and Spatial Learning in a Gfap Mutant Mouse Model of Alexander Disease. The Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.3693-13.2013
For Pancreatic Cancer:
Regarding pancreatic cancer, researchers are of opinion that mammalian target of rapamycin (mTOR) could be the potential targets to eliminate pancreatic cancer stem cells (Shyuichiro Matsubara et al., 2013).
mTOR is a protein that maintains cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription in the body.
Biological function of mTOR pathway in the regulation of cancer microenvironment has to be investigated.
What i........ Read more »
Shyuichiro Matsubara et al. (2013) mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions. Scientific Reports. DOI: 10.1038/srep03230
Sun-Yong Kim,Toshio Hakoshima, Ken Kitano. (2013) Structure of the RecQ C-terminal Domain of Human Bloom Syndrome Protein. Scientific Reports. DOI: 10.1038/srep03294
by Rita Handrich in The Jury Room
Two weeks ago we did a mock trial with a group of attorneys who were passionate about their case and yet got along very well with each other. It was a high-adrenalin experience that lasted 48 hours. On the morning of the second day, the Plaintiff attorney went into the presentation room a little early […]
When you wear glasses you are less attractive but more smart and trustworthy
Republicans prefer ‘Republican-looking’ political candidates
Should you want guilt-prone l........ Read more »
Chen, FF, Jing, Y., & Lee, JM. (2013) The looks of a leader: Competent and trustworthy, but not dominant. . Journal of Experimental Social Psychology. . DOI: 10.1016/j.jesp.2013.10.008
Health literacy is defined as the ability of an individual to obtain, understand and process health information and services needed to make appropriate health decisions (Institute of Medicine, 2004). Those with poorer health literacy have poorer health, find medication difficult … Continue reading →... Read more »
Berkman ND, Sheridan SL, Donahue KE, Halpern DJ, & Crotty K. (2011) Low health literacy and health outcomes: an updated systematic review. Annals of internal medicine, 155(2), 97-107. PMID: 21768583
Whales learn new tunes at shared Antarctic feeding grounds.... Read more »
Garland EC, Gedamke J, Rekdahl ML, Noad MJ, Garrigue C and Gales N. (2013) Humpback whale song on the Southern Ocean feeding grounds: Implications for cultural transmission. PLoS ONE . DOI: 10.1371/journal.pone.0079422
Evidence for High-Energy Extraterrestrial Neutrinos at the IceCube Detector
We report on results of an all-sky search for high-energy neutrino events interacting within the IceCube neutrino detector conducted between May 2010 and May 2012.
Science | DOI: 10.1126/science.1242856
Further Reading and Links
IceCube pushes neutrinos to the forefront of astronomy
“This is the first indication of very high-energy neutrinos coming from outside our solar system, with en........ Read more »
IceCube Collaboration. (2013) Evidence for High-Energy Extraterrestrial Neutrinos at the IceCube Detector. Science AAAS. DOI: 10.1126/science.1242856
The latest version of the American Psychiatric Association's (APA) controversial diagnostic code - "the DSM-5" - continues the check-list approach used in previous editions. To receive a specific diagnosis, a patient must exhibit a minimum number of symptoms in different categories. One problem - this implies someone either has a mental illness or they don't.To avoid missing people who ought to be diagnosed, over time the criteria for many conditions have expanded, and nowhere is this more appar........ Read more »
Isaac R. Galatzer-Levy, & Richard A. Bryant. (2013) 636,120 Ways to Have Posttraumatic Stress Disorder. Perspectives on Psychological Science. info:/
Research in the last decade has identified some of the main effects of exercise on the brain and has started to unravel the molecular mechanisms by which the physiological changes triggered by exercise modify the activity of neurons in the brain.... Read more »
Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, & Spiegelman BM. (2013) Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway. Cell metabolism, 18(5), 649-59. PMID: 24120943
Mattson MP. (2012) Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell metabolism, 16(6), 706-22. PMID: 23168220
Cotman CW, Berchtold NC, & Christie LA. (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends in neurosciences, 30(9), 464-72. PMID: 17765329
An enormous new species of predatory dinosaur has been discovered in the fossil beds of southeastern Utah, a giant carnivore that was the apex predator of its day — even giving tyrannosaurs a run for their money. ... Read more »
Lindsay Zanno, & Peter Makovicky. (2013) Neovenatorid theropods are apex predators in the Late Cretaceous of North America. Nature Communications. DOI: 10.1038/ncomms3827
The aim of the study was to provide evidence for the direct regulatory role of G6P on glycogen synthesis through the phosphorylation-mediated induction of GYS2 activity in the liver. The authors generated liver-specific glycogen synthase (GYS2) mutants containing Ala substitutions in the glucose-6-phosphate (G6P) phosphorylation regions. Compared to the wild type GYS2, targeted mutagenesis yielded several mutants which were insensitive to the phosphorylation-mediated activation of G6P. Specifi........ Read more »
von Wilamowitz-Moellendorff A., Hunter R. W., Garcia-Rocha M., Kang L., Lopez-Soldado I., Lantier L., Patel K., Peggie M. W., Martinez-Pons C., & Voss M. (2013) Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. Diabetes, 62(12), 4070-4082. DOI: 10.2337/db13-0880
Athletic trainers in different settings may adopt different strategies to assess and manage concussions. Athletic trainers must continue to increase their use of both objective concussion assessment tools and the standard clinical examination to ensure the proper diagnosis and management of concussion.... Read more »
Lynall R, Laudner KG, Mihalik JP, & Stanek JM. (2013) Concussion-Assessment and -Management Techniques Used by Athletic Trainers. Journal of athletic training. PMID: 24143906
Another look at the performance claims by the Airia One running shoe; a theoretical context... Read more »
Bojsen-Møller F. (1979) Calcaneocuboid joint and stability of the longitudinal arch of the foot at high and low gear push off. Journal of anatomy, 129(Pt 1), 165-76. PMID: 511760
Resistance training triggers a hormonal response. If it didn’t your body would not respond by increasing muscle mass, strengthening tendons and reinforcing bones. The hormonal changes that occur following trainingThe post Womens Resistance Training. Is it the same as it is for men? Hormonally speaking? appeared first on WODMasters.... Read more »
Niemann I, Hannemann A, Nauck M, Spielhagen C, Völzke H, Wallaschofski H, & Friedrich N. (2013) The association between insulin-like growth factor I and bone turnover markers in the general adult population. Bone, 56(1), 184-90. PMID: 23792936
Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, & Yakar S. (2013) Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age (Dordrecht, Netherlands), 35(5), 1691-703. PMID: 22976122
What do we know about Class II orthodontic treatment? A new Cochrane Systematic Review This week on the Blog I am joined by Badri Thiruvenkatachari, who has worked with me for several years, and was the lead author on our updated Cochrane Systematic Review, on the treatment of Class II malocclusion, published last week. This […]The post What do we know about Class II orthodontic treatment ? A new Cochrane Systematic Review appeared first on Kevin O'Brien's Orthodontic Blog.... Read more »
Thiruvenkatachari B, Harrison JE, Worthington HV, O'Brien KD. (2013) Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children. Cochrane Database of Systematic Reviews . info:other/CD003452.
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