Post List

  • December 6, 2016
  • 03:05 AM
  • 223 views

Infections treated with anti-infective agents linked to schizophrenia?

by Paul Whiteley in Questioning Answers

Identify everyone born in Denmark between 1985-2002. Identify those treated "in the primary care setting" for an infection. Identify those diagnosed with schizophrenia and affective disorders. Look-see whether there is an overlap between infection or treated infection and schizophrenia / affective disorders. Report results.That's basically the study published by Köhler and colleagues [1] (a name that has appeared on this blog before) who concluded that: "Infections treated with anti-infect........ Read more »

  • December 5, 2016
  • 04:30 AM
  • 214 views

Is Normative Data the New Normal?

by Sam Walton in Sports Medicine Research (SMR): In the Lab & In the Field

Individual differences may be seen in baseline SCAT3 data between sex, history of concussion, and history of comorbidities. Therefore, using the patient’s personal medical history may add value to the SCAT3 sideline screening.... Read more »

  • December 5, 2016
  • 02:58 AM
  • 254 views

Double-blind randomised, placebo-controlled trial of vitamin D in autism

by Paul Whiteley in Questioning Answers

It was inevitable ("it is your destiny") that I would formulate a post about the paper published by Khaled Saad and colleagues [1] reporting results based on "a double-blinded, randomized clinical trial (RCT)" looking at the potential usefulness of a vitamin D supplement on "the core symptoms of autism in children." Inevitable because the peer-reviewed research literature looking at the sunshine vitamin/hormone in relation to autism is getting rather voluminous (see here and see here f........ Read more »

Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, El-Houfey AA, Othman HA, Bjørklund G, Jia F, Urbina MA, Abo-Elela MG.... (2016) Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. Journal of child psychology and psychiatry, and allied disciplines. PMID: 27868194  

  • December 4, 2016
  • 03:34 PM
  • 272 views

Do Synapses Really Store Memories?

by Neuroskeptic in Neuroskeptic_Discover

Most neuroscientists will tell you that long-term memories are stored in the brain in the form of synapses, the connections between neurons. On this view, memory formation occurs when synaptic connections are strengthened, or entirely new synapses are formed.



However, in a new piece in Frontiers in Systems Neuroscience, Austrian researcher Patrick C. Trettenbrein critiques the synapse-memory theory: The Demise of the Synapse As the Locus of Memory.



Trettenbrein acknowledges that "t... Read more »

  • December 3, 2016
  • 06:25 AM
  • 293 views

19th Century DIY Brain Stimulation

by The Neurocritic in The Neurocritic





Fig. 4 (Wexler, 2016). Lindstrom's Electro-Medical Apparatus (ca. 1895), courtesy of the Bakken.



Think the do-it-yourself transcranial direct current stimulation movement (DIY tDCS) is a technologically savvy and hip creation of 21st century neural engineering? MIT graduate student Anna Wexler has an excellent and fun review of late 19th and early 20th century electrical stimulation

... Read more »

  • December 3, 2016
  • 04:23 AM
  • 267 views

Parent-mediated interventions for young children with autism meta-analysed

by Paul Whiteley in Questioning Answers

Do not mess with  Lois.Today I'm posting on the topic of the paper by Rose Nevill and colleagues [1] concluding: "that while most outcome domains of parent-delivered intervention are associated with small effects, the quality of research is improving."Parent-mediated interventions in relation to autism have been covered on this blog quite recently (see here) accompanied by that 'super-parenting' headline fail. Such approaches work on the idea that helping parents to "develop strategies........ Read more »

  • December 2, 2016
  • 08:30 PM
  • 211 views

This Month in Blastocystis Research (NOV 2016)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Lab protocols on Blastocystis culture, cryopreservation, and subtyping are now available in Wiley Online Library.... Read more »

  • December 2, 2016
  • 01:40 PM
  • 259 views

Parkour Athletes Teach Scientists about Swinging Apes

by Elizabeth Preston in Inkfish



"I was at a conference, and a colleague was talking about the locomotion of great apes in the trees," says Lewis Halsey, a physiologist at the University of Roehampton in London. The colleague mentioned that it's tough to measure how these animals use energy. That's when Halsey had an epiphany. "I was working with parkour athletes on another project," he says, studying how much energy the athletes used while jumping and climbing around a city. Why not use these human athletes to stand in........ Read more »

  • December 2, 2016
  • 07:48 AM
  • 246 views

Case studies: BHD syndrome associated with pulmonary malformation and with lung neoplasm

by Joana Guedes in BHD Research Blog

Matsutani et al. (2016) reported for the first time BHD syndrome accompanied by pulmonary arteriovenous malformation. The patient, a young male with no significant medical history, presented with chest pain. Chest X-ray and CT revealed emphysematous changes in both lungs and a tumour with pleural fluid. A thoracoscopy revealed dark red pleural fluid and multiple cysts in the lung. The tumour lesion was resected and identified as a non-malignant intrapulmonary hematoma caused by a significant hae........ Read more »

Matsutani, N., Dejima, H., Takahashi, Y., Uehara, H., Iinuma, H., Tanaka, F., & Kawamura, M. (2016) Birt-Hogg-Dube syndrome accompanied by pulmonary arteriovenous malformation. Journal of Thoracic Disease, 8(10). DOI: 10.21037/jtd.2016.09.68  

Gunji-Niitsu, Y., Kumasaka, T., Kitamura, S., Hoshika, Y., Hayashi, T., Tokuda, H., Morita, R., Kobayashi, E., Mitani, K., Kikkawa, M.... (2016) Benign clear cell “sugar” tumor of the lung in a patient with Birt-Hogg-Dubé syndrome: a case report. BMC Medical Genetics, 17(1). DOI: 10.1186/s12881-016-0350-y  

  • December 2, 2016
  • 07:02 AM
  • 97 views

Should I trust you? Let me see your face… 

by Doug Keene in The Jury Room

If you try to identify what it is that makes someone trustworthy, you might list their forthrightness, values consistent with your own, or even their willingness to embrace unpopular positions. And that is all well and good but it likely is untrue. Instead, researchers tell us, we draw “relatively stable trustworthinesss impressions from facial appearance”. […]

Related posts:
Your face can get you killed… 
Never trust a man with a wide face
You can tell a lot from looking at some........ Read more »

Klapper, A., Dotsch, R., van Rooij, I., & Wigboldus, D. (2016) Do we spontaneously form stable trustworthiness impressions from facial appearance?. Journal of Personality and Social Psychology, 111(5), 655-664. DOI: 10.1037/pspa0000062  

  • December 2, 2016
  • 06:18 AM
  • 216 views

Friday Fellow: Indian shot

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Today’s Friday Fellow may not seem to be such an astonishing plant, but it has its peculiarities, some of them quite interesting. Commonly known as Indian shot, African arrowroot, purple arrowroot, and many other names, it … Continue reading →... Read more »

  • December 2, 2016
  • 03:18 AM
  • 396 views

The prebiotic galactooligosaccharide (B-GOS) and autism: just add to poo(p)

by Paul Whiteley in Questioning Answers

Yes, it is childish but...With all the continued chatter on a possible role for the collected gut microbiota - those wee beasties that inhabit our deepest, darkest recesses - in relation to some autism (see here for example), the paper by Roberta Grimaldi and colleagues [1] (open-access available here) provides yet more potentially important information.So, poo(p) samples were the starring material in the paper - "obtained from three non-autistic children and three autistic child donors"- and sp........ Read more »

  • December 1, 2016
  • 04:30 AM
  • 250 views

Neurological or Mechanical – Cross-over Effects of Foam Rolling on Ankle Dorsiflexion

by Richard Shaw in Sports Medicine Research (SMR): In the Lab & In the Field

Foam rolling may lead to small improvements in dorsiflexion range of motion in the contralateral limb. ... Read more »

  • December 1, 2016
  • 02:57 AM
  • 254 views

Dietary fibre deficiency and gut barrier integrity

by Paul Whiteley in Questioning Answers

"Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium."So said the findings reported by Mahesh Desai and colleagues [1] meriting an editorial in the publishing journal [2] as the sentiments of 'eating your greens' applies to some rather interesting [mouse] findings.Fibre (UK spelling) comes in various different forms typically categorised as soluble and insoluble d........ Read more »

Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A.... (2016) A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility. Cell, 167(5), 1339-2147483647. PMID: 27863247  

  • November 30, 2016
  • 01:41 PM
  • 320 views

Open and Post Peer Review: New Trends in Open Access Publications

by Nesru Koroso in United Academics

Among the academic community, there a growing feeling that traditional peer review is failing at accomplishing its core objective: ensuring scientific quality.... Read more »

  • November 30, 2016
  • 10:30 AM
  • 250 views

Playtime After Training Improves a Dog's Memory

by CAPB in Companion Animal Psychology Blog

Making time for play immediately after a dog training session improves the dog’s memory.New research by Nadja Affenzeller (University of Lincoln) et al investigates whether play following learning leads to better performance the next day. The scientists wanted to know whether this effect, previously found in humans, would also apply to dogs.In people, it is thought that the hormonal response during positive arousal acts on parts of the brain called the hippocampus and amygdala and leads to........ Read more »

  • November 30, 2016
  • 07:00 AM
  • 218 views

A Better Model System for Ovarian Cancer: Patient-derived tumor xenografts (PDXs) are suitable for epigenetic methylome-based cancer research

by Tushar Tomar in EpiBeat

Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). These epigenetic modifications like DNA methylation are known to frequently affect gene regulation involved in cancer-related processes. Since epigenetic alterations are reversible in nature, these changes have emerged as attractive ta........ Read more »

Alkema NG, Wisman GB, van der Zee AG, van Vugt MA, & de Jong S. (2016) Studying platinum sensitivity and resistance in high-grade serous ovarian cancer: Different models for different questions. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 55-69. PMID: 26830315  

Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, Clarke RB, de Jong S, Jonkers J, Mælandsmo GM.... (2014) Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer discovery, 4(9), 998-1013. PMID: 25185190  

  • November 30, 2016
  • 03:10 AM
  • 236 views

Restless leg syndrome in parents of children with autism

by Paul Whiteley in Questioning Answers

The findings reported by Maureen Russell and colleagues [1] provide some blogging fodder today and the observation that: "Biological caregivers of children with ASD [autism spectrum disorder] demonstrated a high prevalence of RLS [Restless Legs Syndrome] symptoms and poorer mental health."OK, I know some people might be asking 'just what is Restless Legs Syndrome'? It is a recognised condition complete with 'disease' title (Willis-Ekbom disease). Symptoms, as the name suggests, centre ........ Read more »

Russell M, Baldwin C, McClain D, Matthews N, Smith C, & Quan SF. (2016) Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. PMID: 27855729  

  • November 30, 2016
  • 02:00 AM
  • 231 views

Chemical games and the origin of life from prebiotic RNA

by Eric Bolo in Evolutionary Games Group

From bacteria to vertebrates, life — as we know it today — relies on complex molecular interactions, the intricacies of which science has not fully untangled. But for all its complexity, life always requires two essential abilities. Organisms need to preserve their genetic information and reproduce. In our own cells, these tasks are assigned to […]... Read more »

Yeates JA, Hilbe C, Zwick M, Nowak MA, & Lehman N. (2016) Dynamics of prebiotic RNA reproduction illuminated by chemical game theory. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5030-5. PMID: 27091972  

  • November 29, 2016
  • 01:36 PM
  • 222 views

Open Access article processing charges: a new serial publication crisis?

by SciELO in SciELO in Perspective

The financial and ethical implications that emerge from open access publishing through article processing fees in India are analyzed in a study that proposes the creation of a national open access journal platform such as SciELO in order to reduce costs, increase efficiency and facilitate the sharing of metadata among repositories. … Read More →... Read more »

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