Post List

  • September 17, 2014
  • 08:28 AM
  • 99 views

Builders and Blocks – Engineering Blood Vessels with Stem Cells

by Jalees Rehman in The Next Regeneration

Back in 2001, when we first began studying how regenerative cells (stem cells or more mature progenitor cells) enhance blood vessel growth, our group as well as many of our colleagues focused on one specific type of blood vessel: arteries. Arteries are responsible for supplying oxygen to all organs and tissues of the body and arteries are more likely to develop gradual plaque build-up (atherosclerosis) than veins or networks of smaller blood vessels (capillaries). Once the amount of plaque in an........ Read more »

Paul JD, Coulombe KL, Toth PT, Zhang Y, Marsboom G, Bindokas VP, Smith DW, Murry CE, & Rehman J. (2013) SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. Journal of molecular and cellular cardiology, 124-31. PMID: 24090675  

  • September 17, 2014
  • 08:05 AM
  • 127 views

Should I Stay Or Should I Go

by Mark Lasbury in As Many Exceptions As Rules

Bacteria can swarm to conquer new territory or settle into structured biofilms, not unlike tribes that are nomadic versus those that build cities. New research indicates has shed light on the mechanics of swarming and biofilm production, including the function of extracellular DNA and secreted polysaccharides. Both biofilms and swarming depend on quorum sensing, and several new papers have identified chemicals that can interrupt quorum sensing in pathogenic bacteria and therefore prevent disease........ Read more »

Gloag ES, Turnbull L, Huang A, Vallotton P, Wang H, Nolan LM, Mililli L, Hunt C, Lu J, Osvath SR.... (2013) Self-organization of bacterial biofilms is facilitated by extracellular DNA. Proceedings of the National Academy of Sciences of the United States of America, 110(28), 11541-6. PMID: 23798445  

Alteri CJ, Himpsl SD, Pickens SR, Lindner JR, Zora JS, Miller JE, Arno PD, Straight SW, & Mobley HL. (2013) Multicellular bacteria deploy the type VI secretion system to preemptively strike neighboring cells. PLoS pathogens, 9(9). PMID: 24039579  

  • September 17, 2014
  • 07:02 AM
  • 44 views

The Disgust Scale: How have we missed this all this time?

by Rita Handrich in The Jury Room

We’ve covered a lot of the disgust research so it is curious to us that somehow we missed sharing the actual Disgust Scale with you earlier. The Disgust Scale was developed by the infamous Jonathan Haidt (his surname is pronounced “height”) back in 1994 before disgust was considered cool. In brief, the Disgust Scale was […]

Related posts:
Disgust and lost confidence in our institutions
Simple Jury Persuasion: Anger + Disgust = Moral Outrage
Choosing to either disgust your jurors o........ Read more »

Olatunji, B. O., Haidt, J., McKay, D., David, B. (2008) Core, animal reminder, and contamination disgust: Three kinds of disgust with distinct personality, behavioral, physiological, and clinical correlates. Journal of Research in Personality, 1243-1259. info:/

  • September 17, 2014
  • 06:29 AM
  • 104 views

Autoimmune disease risk and eating disorders

by Paul Whiteley in Questioning Answers

"We were set up. The cops were waiting for us.""We observed an association between eating disorders and several autoimmune diseases with different genetic backgrounds. Our findings support the link between immune-mediated mechanisms and development of eating disorders".So said the paper by Anu Raevuori and colleagues [1] (open-access) based on an analysis of over 2300 people "treated at the Eating Disorder Unit of Helsinki University Central Hospital between 1995 and 2010" compared with nea........ Read more »

Raevuori A, Haukka J, Vaarala O, Suvisaari JM, Gissler M, Grainger M, Linna MS, & Suokas JT. (2014) The increased risk for autoimmune diseases in patients with eating disorders. PloS one, 9(8). PMID: 25147950  

  • September 17, 2014
  • 06:09 AM
  • 89 views

Unwelcome colonisers: biofilm formation on voice prostheses

by socgenmicro in Microbe Post

A human being’s voice is one of their most distinguishing and individual features. Most of us have experienced the frustration of temporarily losing our voices – but for many survivors of laryngeal cancer (cancer of the voice box), this loss … Continue reading →... Read more »

Talpaert, M., Balfour, A., Stevens, S., Baker, M., Muhlschlegel, F., & Gourlay, C. (2014) Candida Biofilm Formation on Voice Prostheses. Journal of Medical Microbiology. DOI: 10.1099/jmm.0.078717-0  

  • September 17, 2014
  • 04:36 AM
  • 85 views

A talking powered smartphone? The chin strap that makes electricity from chewing

by Stuart Farrimond in Guru: Science Blog

Mouths – where would we be without them? We use our jaws for so many essential tasks: eating food, chewing gum, yawning when we are tired from a hard day’s work and, oh let’s not forget, talking. Most of us […]The post A talking powered smartphone? The chin strap that makes electricity from chewing appeared first on Guru Magazine.... Read more »

  • September 17, 2014
  • 12:05 AM
  • 77 views

Not So Competitive Return Rates to Activity Following ACL Reconstruction

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Only 55% of athletes returned to competitive sport following anterior cruciate ligament (ACL) reconstruction. The debate continues as to whether hamstring or patellar tendon autograft is better. However, factors that may favor return to competitive sport include younger age, male gender, elite sport, and a positive psychological response. ... Read more »

  • September 16, 2014
  • 10:15 PM
  • 89 views

Colon cancer, mathematical time travel, and questioning the sequential mutation model.

by Artem Kaznatcheev in Evolutionary Games Group

On Saturday, I arrived in Columbus, Ohio for the the MBI Workshop on the Ecology and Evolution of Cancer. Today, our second day started. The meeting is an exciting combination of biology-minded mathematicians and computer scientists, and math-friendly biologist and clinicians. As is typical of workshops, the speakers of the first day had an agenda […]... Read more »

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SA, Wright NA.... (2014) Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell reports, 8(4), 940-7. PMID: 25127143  

  • September 16, 2014
  • 07:11 PM
  • 98 views

Breaking battery convention: new study indicates fast charging not necessarily detrimental to cycle lifetimes

by Jonathan Trinastic in Goodnight Earth

New battery research examining the structure of LiFePO4 electrodes during charging indicate that fast charging rates are possible due to a relationship between rate and active intercalation sites.... Read more »

  • September 16, 2014
  • 01:20 PM
  • 105 views

GM plants with modified 'eskimo1' gene have increased 'drought tolerance'

by This Science is Crazy! in This Science Is Crazy!

New study uses siRNA and 35S promoter to regulate multiple genes including ESK1 to improve drought tolerance in Arabidopsis... Read more »

  • September 16, 2014
  • 01:20 PM
  • 113 views

New Cocktail Turns Adult Cells into Stem Cells

by Gabriel in Lunatic Laboratories

For those of us who were following stem cell news, recently the field had a huge setback when a paper, that offered a cheap and novel way to create stem cells, was retracted from publication. Regenerative medicine aims to replace lost or damaged cells, tissues or organs through cellular transplantation, but the promise to a better life has been hampered. Because stem cells derived from human embryos can trigger ethical concerns, a good solution is reprogramming adult cells back to an embryo-like........ Read more »

Buganim Y, Markoulaki S, van Wietmarschen N, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham BJ, Porubsky D.... (2014) The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection. Cell stem cell, 15(3), 295-309. PMID: 25192464  

  • September 16, 2014
  • 11:01 AM
  • 113 views

Cannabis-induced Paranoia: Cognitive Mechanisms

by William Yates, M.D. in Brain Posts

Some individuals appear vulnerable to paranoia induced by exposure to tetrahydrocannabinol (THC) in cannabis.The mechanism for this effect is poorly understood.Daniel Freeman from University of Oxford along with colleagues in England and Switzerland recently conducted an interventional research study on this issue.In this study, 121 subjects were recruited to receive injections of THC in a laboratory setting.These subjects were required to have taken cannabis at least once before participation i........ Read more »

  • September 16, 2014
  • 06:36 AM
  • 80 views

Should Policy Makers and Financial Institutions Have Access to Billions of Brain Scans?

by The Neurocritic in The Neurocritic

"Individual risk attitudes are correlated with the grey matter volume in the posterior parietal cortex suggesting existence of an anatomical biomarker for financial risk-attitude," said Dr Tymula.This means tolerance of risk "could potentially be measured in billions of existing medical brain scans." 1 -Gray matter matters when measuring risk toleranceLet's pretend that scientists have discovered a neural biomarker that could accurately predict a person's propensity to take financial risks in ........ Read more »

Gilaie-Dotan, S., Tymula, A., Cooper, N., Kable, J., Glimcher, P., & Levy, I. (2014) Neuroanatomy Predicts Individual Risk Attitudes. Journal of Neuroscience, 34(37), 12394-12401. DOI: 10.1523/JNEUROSCI.1600-14.2014  

  • September 16, 2014
  • 03:00 AM
  • 47 views

Forgive yourself for relaxing in front of the TV and the couch time might actually do you some good

by BPS Research Digest in BPS Research Digest

There's a snobbishness about relaxation time. Tell someone your hobby is watching TV and chances are they'll look at you with derision. Mention meditation, reading or yoga and you're far more likely to attract nods of approval.And yet there is substantial evidence that time watching TV or playing video games can have a powerful restorative effect - just what many of us need after a hard day. This benefit isn't found for everyone, and in new paper Leonard Reinecke and his collaborators propose th........ Read more »

  • September 16, 2014
  • 02:50 AM
  • 114 views

The schizophrenias (plural)

by Paul Whiteley in Questioning Answers

A micropost if you will, to draw your attention to the paper by Javier Arnedo and colleagues [1] mentioning the concept of 'the schizophrenias' (plural). Some media coverage of this paper can be found here and here. The crux of the paper is that although currently unified by a diagnostic label, schizophrenia seems to be comprised of various conditions: "caused by a moderate number of separate genotypic networks associated with several distinct clinical syndromes"."... dogs and cats living t........ Read more »

Javier Arnedo, Dragan M. Svrakic, Coral del Val, Rocío Romero-Zaliz, Helena Hernández-Cuervo, Molecular Genetics of Schizophrenia Consortium, Ayman H. Fanous, Michele T. Pato, Carlos N. Pato, Gabriel A. de Erausquin.... (2014) Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies. The American Journal of Psychiatry. info:/doi:10.1176/appi.ajp.2014.14040435

  • September 15, 2014
  • 04:50 PM
  • 135 views

Religion And Morality: Belief Isn't Better

by Alexis Delanoir in How to Paint Your Panda

It's no secret that when it comes to what the public thinks, atheists are usually at the bottom of the "nice" list. A survey in 2006 found that atheists were the least trusted minority group in America. Similar studies find that atheists are mistrusted and are seen as more immoral than their religious counterparts. But are these views justified? A new study by Hofmann et al. (2014) suggests they aren't, and this conclusion is consistent with other available data.... Read more »

Gervais WM, Shariff AF, & Norenzayan A. (2011) Do you believe in atheists? Distrust is central to anti-atheist prejudice. Journal of personality and social psychology, 101(6), 1189-206. PMID: 22059841  

Hofmann W, Wisneski DC, Brandt MJ, & Skitka LJ. (2014) Morality in everyday life. Science (New York, N.Y.), 345(6202), 1340-3. PMID: 25214626  

  • September 15, 2014
  • 04:01 PM
  • 87 views

Humanized FoxP2 and the timing of habits

by Björn Brembs in bjoern.brembs.blog

Last week, Elizabeth Pennisi asked me to comment on the recent paper from Schreiweis et al. entitled “Humanized FoxP2 accelerates learning by enhancing transitions from declarative to procedural performance”. Since I don’t know how much, if anything, of my answers […] ↓ Read the rest of this entry...... Read more »

Schreiweis, C., Bornschein, U., Burguiere, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C., Puliyadi, R.... (2014) Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1414542111  

  • September 15, 2014
  • 03:45 PM
  • 99 views

SARS-CoV Nucleocapsid protein and Mitochondria: a personal story

by thelonevirologist in Virology Tidbits

The SARS-CoV N protein has been reported to induce Mitochondria dependent apoptosis is some cell lines. Here results are reported from a study from 2004 which was never published, suggesting that SARS-CoV might induce mitochondrial fusion rather than fission. ... Read more »

Moshynskyy I, Viswanathan S, Vasilenko N, Lobanov V, Petric M, Babiuk LA, & Zakhartchouk AN. (2007) Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus. Virus research, 127(1), 116-21. PMID: 17448558  

Zhang L, Wei L, Jiang D, Wang J, Cong X, & Fei R. (2007) SARS-CoV nucleocapsid protein induced apoptosis of COS-1 mediated by the mitochondrial pathway. Artificial cells, blood substitutes, and immobilization biotechnology, 35(2), 237-53. PMID: 17453707  

Wlodkowic D, Skommer J, & Darzynkiewicz Z. (2012) Cytometry of apoptosis. Historical perspective and new advances. Experimental oncology, 34(3), 255-62. PMID: 23070010  

  • September 15, 2014
  • 12:58 PM
  • 120 views

The Genetic Roots of Schizophrenia

by Gabriel in Lunatic Laboratories

I have a friend who lost an eye — not in a war zone like you might suspect given my background — but to his brother. Yes, you read that correctly, his brother tried to kill him and in the process he lost his eye. I’ve told this story before, but whenever new schizophrenia research comes out I feel the need to tell it again. While he has forgiven his brother (partly because not long after, he was diagnosed as schizophrenic), he will not be able to see him again until he is released from pri........ Read more »

avier Arnedo, M.S.; Dragan M. Svrakic, M.D., Ph.D.; Coral del Val, Ph.D.; Rocío Romero-Zaliz, Ph.D.; Helena Hernández-Cuervo, M.D.; Molecular Genetics of Schizophrenia Consortium; Ayman H. Fanous, M.D.; Michele T. Pato, M.D.; Carlos N. Pato, M.D., Ph.D. (2014) Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies. The American Journal of Psychiatry. info:/10.1176/appi.ajp.2014.14040435

  • September 15, 2014
  • 12:06 PM
  • 99 views

Poop Transplants Let Pack Rats Eat Poison

by Elizabeth Preston in Inkfish

Can’t eat poison without dying? Maybe your gut microbes are to blame. Rodents in the Mojave Desert have evolved to eat toxic creosote bushes with the help of specialized gut bacteria. Although scientists had long suspected that bacteria might be key to the rats’ power, they proved it by feeding the rodents antibiotics and ground-up […]The post Poop Transplants Let Pack Rats Eat Poison appeared first on Inkfish.... Read more »

Kohl KD, Weiss RB, Cox J, Dale C, & Denise Dearing M. (2014) Gut microbes of mammalian herbivores facilitate intake of plant toxins. Ecology letters, 17(10), 1238-46. PMID: 25040855  

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