Post List

  • October 20, 2014
  • 04:36 AM
  • 84 views

Reasons for visiting ER by those with autism

by Paul Whiteley in Questioning Answers

ER - Emergency Room - or as we call it here in Blighty Accident & Emergency (A & E), is never a particularly desirable place to visit given the emphasis on illness or injury of yourself or loved one. That being said, staff there do a sterling job sometimes under very stressful circumstances, responding to all-manner of complaints, some of which are life-threatening.The paper by Dorothea Iannuzzi and colleagues [1] sought to identify some of the medical reasons why ER visit........ Read more »

Iannuzzi DA, Cheng ER, Broder-Fingert S, & Bauman ML. (2014) Brief Report: Emergency Department Utilization by Individuals with Autism. Journal of autism and developmental disorders. PMID: 25261249  

  • October 20, 2014
  • 12:05 AM
  • 77 views

Novel NSAID has Differential Tissue Effects in the Treatment of Chronic Rotator Cuff Repairs

by Sarah Ilkhanipour Rooney in Sports Medicine Research (SMR): In the Lab & In the Field

Licofelone, a non-steroidal anti-inflammatory treatment, has tissue-specific effects. In a rotator cuff repair rat model, this drug reduces functional muscle regeneration but improves tendon healing.... Read more »

  • October 19, 2014
  • 07:11 PM
  • 101 views

Running Shoes Can Control Motion

by Craig Payne in Running Research Junkie

Running Shoes Can Control Motion... Read more »

  • October 19, 2014
  • 06:39 PM
  • 111 views

Pain is not a "Thing"

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

ResearchBlogging.org
I’m reading some fascinating books at the moment. I’m such a pain geek I take pain books away with me on holiday! Anyway, the two books to hit me between the eyeballs recently are The Pain Chronicles by Melanie Thernstrom (published 2010), and The Story of Pain by Joanna Bourke (published 2014). What makes both of these books fascinating is that these both look at the history of pain and pain management, and explore the “what it is like” to be in pai........ Read more »

Ashton-James, C., Richardson, D., Williams, A., Bianchi-Berthouze, N., & Dekker, P. (2014) Impact of pain behaviors on evaluations of warmth and competence. PAIN®. DOI: 10.1016/j.pain.2014.09.031  

  • October 19, 2014
  • 01:43 PM
  • 90 views

DNA Nanotech: The First Large DNA Crystals

by Gabriel in Lunatic Laboratories

DNA is the stuff of life as we know it, but it is the potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology, and more. Researchers have been working to master the ability to coax DNA molecules to self assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams. A dream that been going on for 20 years now and was just realized.... Read more »

Ke, Y., Ong, L., Sun, W., Song, J., Dong, M., Shih, W., & Yin, P. (2014) DNA brick crystals with prescribed depths. Nature Chemistry. DOI: 10.1038/nchem.2083  

  • October 19, 2014
  • 11:00 AM
  • 92 views

Ten years into the making, the HIV-1 mosaic vaccine finally goes into human trial

by EE Giorgi in CHIMERAS

© Bette Korber et al. I hope you will all forgive me if this week I'm gushing over my amazing mentor Bette Korber, as last week she shared some awesome news on Facebook:"A landmark in my life happened yesterday, a major step in a long story. A decade ago I had an idea for making an HIV vaccine that had the potential to work globally. After a struggle (in my first 2 failed proposals, reviewers declared what I proposed was impossible), I got an internal grant from Los Alamos to develop the idea (........ Read more »

Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD.... (2007) Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature medicine, 13(1), 100-6. PMID: 17187074  

Nkolola JP, Bricault CA, Cheung A, Shields J, Perry J, Kovacs JM, Giorgi E, van Winsen M, Apetri A, Brinkman-van der Linden EC.... (2014) Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer. Journal of virology, 88(17), 9538-52. PMID: 24965452  

Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, Liu J, Abbink P, Maxfield LF, Seaman MS.... (2013) Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys. Cell, 155(3), 531-9. PMID: 24243013  

Barouch DH, O'Brien KL, Simmons NL, King SL, Abbink P, Maxfield LF, Sun YH, La Porte A, Riggs AM, Lynch DM.... (2010) Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nature medicine, 16(3), 319-23. PMID: 20173752  

  • October 18, 2014
  • 02:55 PM
  • 99 views

New Genetic Test to help Solve Rare Disease Diagnosis

by Gabriel in Lunatic Laboratories

My sister suffers from a rare disease which causes small fiber polyneuropathy, or the killing of nerves in her hands and feet. As it progresses she has trouble standing or using her hands. If that was the worst of it, then it might be liveable given the time between severe attacks is years or more. Unfortunately, it also causes intense and mostly constant pain and burning sensations, pain so bad that conventional narcotic painkillers have trouble controlling it. After some time working with the ........ Read more »

Lee, H., Deignan, J., Dorrani, N., Strom, S., Kantarci, S., Quintero-Rivera, F., Das, K., Toy, T., Harry, B., Yourshaw, M.... (2014) Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders. JAMA. DOI: 10.1001/jama.2014.14604  

  • October 18, 2014
  • 09:45 AM
  • 81 views

Immunoglobulin E: not just a bystander in lupus?

by Aurelie in The Immuno Blog

IgE antibodies are mostly known for their pathophysiological role in allergic reactions and in certain immune deficiencies referred to as hyper-IgE syndromes. In a study published in The Journal of Experimental Medicine in September, Dema et al. find that IgE … Continue reading →... Read more »

Dema B, Charles N, Pellefigues C, Ricks TK, Suzuki R, Jiang C, Scheffel J, Hasni S, Hoffman V, Jablonski M.... (2014) Immunoglobulin E plays an immunoregulatory role in lupus. The Journal of experimental medicine. PMID: 25267791  

  • October 18, 2014
  • 09:34 AM
  • 111 views

Merit’s Liquidity

by nooffensebut in The Unsilenced Science

The latest SAT and ACT data suggest that America’s cognitive elite have been enjoying new geographic mobility, but difficult economic times push them out of the elite strata, contrary to a prediction of The Bell Curve by Richard Herrnstein and Charles Murray.... Read more »

nooffensebut. (2014) Parents’ Income is a Poor Predictor of SAT Score. Open Differential Psychology, 1-19. info:other/

  • October 18, 2014
  • 05:30 AM
  • 88 views

More epigenetics, EN-2 and autism... the plot thickens

by Paul Whiteley in Questioning Answers

I don't mind admitting that I was to some extent 'winging it' with my previous post on epigenetics and Engrailed-2 (EN-2) as a consequence of the findings reported by Jill James and colleagues [1] with autism in mind. Although an avid follower of the science of epigenetics when (cautiously) applied to autism, I am by no means any authority on the subject matter particularly when it comes to the nitty-gritty details. You can probably therefore expect similar things in my latest discussi........ Read more »

  • October 18, 2014
  • 01:42 AM
  • 62 views

Full-term developmet of quail chick by ICSI

by Mizushima S in the Node

The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in bird development, particularly the mechanism underlying fertilization, have not been elucidated in as much detail as those of other species of animals. The ooplasm in […]... Read more »

Mizushima, S., Hiyama, G., Shiba, K., Inaba, K., Dohra, H., Ono, T., Shimada, K., & Sasanami, T. (2014) The birth of quail chicks after intracytoplasmic sperm injection. Development, 141(19), 3799-3806. DOI: 10.1242/dev.111765  

  • October 17, 2014
  • 10:29 PM
  • 96 views

Translational Findings: Fruit fly contributions to research in circadian rhythms

by Bethany Christmann in Fly on the Wall

What are circadian rhythms, and why are they important to humans? Over the past century, technological innovations have changed human society dramatically, undeniably for the better. But the advent of jet travel, round-the-clock manufacturing, and internet communication has also had a disruptive effect on our bodies’ circadian rhythms. The word “circadian” comes from the latin […]... Read more »

  • October 17, 2014
  • 04:02 PM
  • 107 views

A look at Air Pollution and Your Body

by Gabriel in Lunatic Laboratories

We have all probably seen stories from China on the horrid air pollution there. Accompanying those reports of course are the statistics for air pollution that deaths have caused. For the record, the World Health Organization estimated that ambient air pollution caused 3.7 million premature deaths (worldwide) in 2012 alone – yet what exactly happens to your body when it encounters pollutants?... Read more »

  • October 17, 2014
  • 11:40 AM
  • 85 views

October 17, 2014

by Erin Campbell in HighMag Blog

For years the prettiest cells to image were flat cells in a dish. Thanks to the tireless work of many, beautiful high-resolution images can now come from tissue in a living organism. Today’s image is from a paper showing improved techniques for imaging fine cellular processes within large volumes, from the lab of recent Nobel prize winner, Eric Betzig. A material’s refractive index refers to how light travels through it; the simplest example being how light bends when passed through wat........ Read more »

Wang, K., Milkie, D., Saxena, A., Engerer, P., Misgeld, T., Bronner, M., Mumm, J., & Betzig, E. (2014) Rapid adaptive optical recovery of optimal resolution over large volumes. Nature Methods, 11(6), 625-628. DOI: 10.1038/nmeth.2925  

  • October 17, 2014
  • 08:55 AM
  • 108 views

People Are More Swayed by Things That Look Sciencey

by Elizabeth Preston in Inkfish

Anyone who’s paged through a women’s magazine will recognize this strategy: to make a product seem better, surround it with a scientific glow. “Clinical trials show lashes grow up to 400% fuller!” “27% reduction of dark spots in 10 weeks!” “Ceramides!” Does this actually help convince people to hand over their cash? A study using […]The post People Are More Swayed by Things That Look Sciencey appeared first on Inkfish.... Read more »

  • October 17, 2014
  • 06:50 AM
  • 84 views

The Friday Five for 10/17/2014

by Bill Sullivan in The 'Scope

Coolest science news stories of the week: stem cells to treat diabetes, fake testes, erasing memories, more!... Read more »

DeMartini DG, Ghoshal A, Pandolfi E, Weaver AT, Baum M, & Morse DE. (2013) Dynamic biophotonics: female squid exhibit sexually dimorphic tunable leucophores and iridocytes. The Journal of experimental biology, 216(Pt 19), 3733-41. PMID: 24006348  

Pagliuca, F., Millman, J., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J., Peterson, Q., Greiner, D., & Melton, D. (2014) Generation of Functional Human Pancreatic β Cells In Vitro. Cell, 159(2), 428-439. DOI: 10.1016/j.cell.2014.09.040  

  • October 17, 2014
  • 06:13 AM
  • 125 views

Large Sized Men Disadvantaged In Relationships

by Rangina Barakzai in United Academics

For decades men have been diffident and self-doubting about the size of their phallus. Well, luckily for the holders of the pocket rocket, there is a twist.... Read more »

  • October 17, 2014
  • 05:22 AM
  • 98 views

Altered ghrelin levels in boys with autism

by Paul Whiteley in Questioning Answers

"Honey, it's the '90s, remember?"Saudi Arabia and autism research? It must be at least one author from the research tag-team that is Mostafa and Al-Ayadhi.Indeed, in today's post it is Laila Al-Ayadhi featured on the paper by Felwah S. Al-Zaid and colleagues [1] (open-access) who concluded on: "a potential role for the hormone ghrelin in the pathogenesis of autism".Ghrelin, by the way, is often called the 'hunger hormone' as a result of its effects in relation to energy homoeostasis. A........ Read more »

  • October 17, 2014
  • 03:00 AM
  • 78 views

BHD lung cysts are not degenerative, but may cause pneumothorax

by Lizzie Perdeaux in BHD Research Blog

Although 90% of BHD patients develop lung cysts, there is very little information about the natural history of BHD lung cysts. In order to determine how lung cysts change over time, Johannesma et al. (2014a) compared the results of two … Continue reading →... Read more »

Johannesma PC, Houweling AC, van Waesberghe JH, van Moorselaar RJ, Starink TM, Menko FH, & Postmus PE. (2014) The pathogenesis of pneumothorax in Birt-Hogg-Dubé syndrome: A hypothesis. Respirology (Carlton, Vic.), 19(8), 1248-50. PMID: 25302759  

  • October 17, 2014
  • 03:00 AM
  • 39 views

"Place cells" discovered in the rat brain

by BPS Research Digest in BPS Research Digest

John O'KeefeImage: Nobelprize.orgThis month John O'Keefe, May-Britt Moser and Edvard Moser were awarded the Nobel Prize in Physiology or Medicine for their work identifying the brain's "GPS system" - the internal maps that allow us to understand our position in space. The Moser's discovery of grid cells this century built upon O'Keefe's earlier accomplishment at UCL in London, the discovery of place cells in the brain. Here, we look back to his 1971 "Short Communication" in the journal Brain Res........ Read more »

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